DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD... See more...

Aliases for DHX34 Gene

Aliases for DHX34 Gene

  • DExH-Box Helicase 34 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 34 2 3
  • Probable ATP-Dependent RNA Helicase DHX34 3 4
  • DEAH-Box Helicase 34 2 3
  • DEAH Box Protein 34 3 4
  • DDX34 3 4
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 34 3
  • Probable ATP-Dependent Helicase DHX34 3
  • EC 3.6.4.13 4
  • KIAA0134 4
  • EC 3.6.1 54
  • HRH1 3

External Ids for DHX34 Gene

Previous HGNC Symbols for DHX34 Gene

  • DDX34

Previous GeneCards Identifiers for DHX34 Gene

  • GC19P052532
  • GC19P052547
  • GC19P052544
  • GC19P047853
  • GC19P044277

Summaries for DHX34 Gene

Entrez Gene Summary for DHX34 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX34 Gene

DHX34 (DExH-Box Helicase 34) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX57.

UniProtKB/Swiss-Prot Summary for DHX34 Gene

Additional gene information for DHX34 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHX34 Gene

Genomics for DHX34 Gene

GeneHancer (GH) Regulatory Elements for DHX34 Gene

Promoters and enhancers for DHX34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047348 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 767.8 +0.3 251 2.1 ZNF785 SIN3A ZBTB40 SP1 CTCF POLR2A USF2 HCFC1 MYC NFYC DHX34 lnc-MEIS3-1 ZC3H4 ENSG00000268810 ENSG00000269321 BICRA BSPH1 TPRX2P ELSPBP1 SLC1A5
GH19J047309 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 65.4 -38.7 -38729 2.8 MYC MAX ZNF121 NFIB ELF3 MLLT1 CEBPG IKZF1 CEBPA REST C5AR1 DHX34 C5AR2 CCDC9 ZC3H4 NAPA piR-38716-072 piR-48389-012 lnc-C5AR1-3
GH19J047312 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 42.4 -35.7 -35736 1.7 GTF3C2 ZBTB40 LCORL MLX RBPJ SMARCE1 NR2F1 NR2F6 MIXL1 CC2D1A ZC3H4 DHX34 BICRA C5AR2 CCDC9 C5AR1 NOP53-AS1 NAPA ENSG00000268810 NOP53
GH19J047314 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 33.2 -33.7 -33715 1.8 SIN3A LCORL MLX RBPJ SMARCE1 POLR2A USF2 NR2F1 NR2F6 ATF1 C5AR1 DHX34 ZC3H4 C5AR2 CCDC9 BICRA NAPA piR-48389-012 piR-38716-072 lnc-C5AR1-3
GH19J047369 Enhancer 0.9 FANTOM5 Ensembl ENCODE 57.7 +21.4 21416 2.6 MYC MAX ZIC2 PKNOX1 FOS CTCF DHX34 C5AR1 ZC3H4 C5AR2 CCDC9 NAPA NOP53 BICRA HSALNG0126770 piR-48928
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX34 gene promoter:
  • Msx-1

Genomic Locations for DHX34 Gene

Genomic Locations for DHX34 Gene
chr19:47,349,281-47,382,704
(GRCh38/hg38)
Size:
33,424 bases
Orientation:
Plus strand
chr19:47,852,538-47,885,961
(GRCh37/hg19)
Size:
33,424 bases
Orientation:
Plus strand

Genomic View for DHX34 Gene

Genes around DHX34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX34 Gene

Proteins for DHX34 Gene

  • Protein details for DHX34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14147-DHX34_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX34
    Protein Accession:
    Q14147
    Secondary Accessions:
    • B4DMY8

    Protein attributes for DHX34 Gene

    Size:
    1143 amino acids
    Molecular mass:
    128120 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09483.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAG60050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DHX34 Gene

Selected DME Specific Peptides for DHX34 Gene

Q14147:
  • GRAGRTGPG
  • VDEVHER
  • ILSTNIAE
  • GDTGCGK
  • VILMSAT
  • TNIAETS

Post-translational modifications for DHX34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX34 Gene

Domains & Families for DHX34 Gene

Gene Families for DHX34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX34 Gene

GenScript: Design optimal peptide antigens:
  • DEAH box protein 34 (DHX34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14147

UniProtKB/Swiss-Prot:

DHX34_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX34: view

Function for DHX34 Gene

Molecular function for DHX34 Gene

UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;.

Enzyme Numbers (IUBMB) for DHX34 Gene

Phenotypes From GWAS Catalog for DHX34 Gene

Gene Ontology (GO) - Molecular Function for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA 21873635
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0034458 3'-5' RNA helicase activity IBA 21873635
genes like me logo Genes that share ontologies with DHX34: view
genes like me logo Genes that share phenotypes with DHX34: view

Animal Model Products

CRISPR Products

miRNA for DHX34 Gene

miRTarBase miRNAs that target DHX34

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX34 Gene

Localization for DHX34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX34 gene
Compartment Confidence
nucleus 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DHX34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX34 Gene

Pathways & Interactions for DHX34 Gene

PathCards logo

SuperPathways for DHX34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA 21873635
GO:0000956 nuclear-transcribed mRNA catabolic process IMP 23828042
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 23828042
genes like me logo Genes that share ontologies with DHX34: view

No data available for Pathways by source and SIGNOR curated interactions for DHX34 Gene

Drugs & Compounds for DHX34 Gene

(3) Drugs for DHX34 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DHX34 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX34: view

Transcripts for DHX34 Gene

mRNA/cDNA for DHX34 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DHX34 Gene

GeneLoc Exon Structure for
DHX34
ECgene alternative splicing isoforms for
DHX34

Expression for DHX34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHX34 Gene

This gene is overexpressed in Whole Blood (x13.2).

Protein differential expression in normal tissues from HIPED for DHX34 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3), Salivary gland (9.8), Adrenal (8.6), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DHX34 Gene



NURSA nuclear receptor signaling pathways regulating expression of DHX34 Gene:

DHX34

SOURCE GeneReport for Unigene cluster for DHX34 Gene:

Hs.151706

Evidence on tissue expression from TISSUES for DHX34 Gene

  • Bone marrow(4.2)
  • Lung(4.2)
  • Liver(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DHX34: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX34 Gene

Orthologs for DHX34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX34 33 32
  • 99.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHX34 33 32
  • 87.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DHX34 33 32
  • 87.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx34 32
  • 84.97 (n)
mouse
(Mus musculus)
Mammalia Dhx34 17 33 32
  • 84.87 (n)
oppossum
(Monodelphis domestica)
Mammalia DHX34 33
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX34 33
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX34 33
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx34 32
  • 61.54 (n)
zebrafish
(Danio rerio)
Actinopterygii dhx34 33 32
  • 62.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001338 32
  • 55.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32533 33 32
  • 55.04 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea smgl-2 33 32
  • 48.95 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP2 33
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 51 (a)
OneToOne
Species where no ortholog for DHX34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX34 Gene

ENSEMBL:
Gene Tree for DHX34 (if available)
TreeFam:
Gene Tree for DHX34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHX34: view image

Paralogs for DHX34 Gene

(6) SIMAP similar genes for DHX34 Gene using alignment to 2 proteins:

  • DHX34_HUMAN
  • H7C504_HUMAN

Pseudogenes.org Pseudogenes for DHX34 Gene

genes like me logo Genes that share paralogs with DHX34: view

Variants for DHX34 Gene

Sequence variations from dbSNP and Humsavar for DHX34 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000183111 -- 47,362,888(+) C/T intron_variant
rs1000239821 -- 47,364,505(+) G/C intron_variant
rs1000273276 -- 47,365,495(+) G/A intron_variant
rs1000286981 -- 47,359,378(+) C/A intron_variant
rs1000481843 -- 47,354,372(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX34 Gene

Variant ID Type Subtype PubMed ID
esv2758765 CNV loss 17122850
esv3583445 CNV loss 25503493
nsv1062949 CNV gain 25217958
nsv428366 CNV loss 18775914
nsv474520 CNV novel sequence insertion 20440878
nsv474975 CNV novel sequence insertion 20440878
nsv479067 CNV novel sequence insertion 20440878
nsv516890 CNV loss 19592680
nsv517901 CNV loss 19592680
nsv521341 CNV gain 19592680
nsv961229 CNV duplication 23825009
nsv9738 CNV gain 18304495

Variation tolerance for DHX34 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX34 Gene

Human Gene Mutation Database (HGMD)
DHX34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX34 Gene

Disorders for DHX34 Gene

Additional Disease Information for DHX34

No disorders were found for DHX34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX34 Gene

Publications for DHX34 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 56
  2. A transcript map of the chromosome 19q-arm glioma tumor suppressor region. (PMID: 10708517) Smith JS … Jenkins RB (Genomics 2000) 2 3 56
  3. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 56
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 56
  5. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3 56

Products for DHX34 Gene

Sources for DHX34 Gene