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Aliases for DHX34 Gene

Aliases for DHX34 Gene

  • DExH-Box Helicase 34 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 34 2 3
  • DEAH-Box Helicase 34 2 3
  • DEAH Box Protein 34 3 4
  • DDX34 3 4
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 34 3
  • Probable ATP-Dependent RNA Helicase DHX34 3
  • Probable ATP-Dependent Helicase DHX34 3
  • EC 3.6.4.13 4
  • KIAA0134 4
  • HRH1 3

External Ids for DHX34 Gene

Previous HGNC Symbols for DHX34 Gene

  • DDX34

Previous GeneCards Identifiers for DHX34 Gene

  • GC19P052532
  • GC19P052547
  • GC19P052544
  • GC19P047853
  • GC19P044277

Summaries for DHX34 Gene

Entrez Gene Summary for DHX34 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX34 Gene

DHX34 (DExH-Box Helicase 34) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX8.

UniProtKB/Swiss-Prot for DHX34 Gene

  • Probable ATP-binding RNA helicase.

Additional gene information for DHX34 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX34 Gene

Genomics for DHX34 Gene

GeneHancer (GH) Regulatory Elements for DHX34 Gene

Promoters and enhancers for DHX34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J047348 Promoter/Enhancer 1.5 Ensembl ENCODE 667.9 +0.1 117 1.9 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B DHX34 ZC3H4 ENSG00000269321 ENSG00000268810 BICRA BSPH1 TPRX2P ELSPBP1 SLC1A5 NOP53-AS1
GH19J047309 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 65.4 -36.5 -36543 7.5 MLX DMAP1 YY1 SLC30A9 E2F8 SP3 MEF2D GLIS1 RCOR2 NBN C5AR1 DHX34 ZC3H4 C5AR2 CCDC9 NAPA BICRA NOP53-AS1 NOP53 PPP5C
GH19J047369 Enhancer 1 FANTOM5 Ensembl ENCODE 57.7 +21.1 21096 2 CTCF PKNOX1 MAX FOS ZIC2 MYC DHX34 C5AR1 ZC3H4 C5AR2 CCDC9 NAPA PIR41927 GC19P047354 GC19P047388
GH19J047105 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.1 -239.0 -238984 9.2 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZC3H4 ENSG00000268810 BICRA CCDC9 C5AR2 NOP53-AS1 PRKD2 NOP53 SNORD23 ENSG00000268746
GH19J047388 Enhancer 1 FANTOM5 Ensembl ENCODE 47.5 +40.1 40098 2 PKNOX1 RFX1 CREB1 MAX MNT MYC GC19P047388 DHX34 C5AR1 C5AR2 ZC3H4 CCDC9 NAPA BICRA BBC3 MEIS3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX34 gene promoter:
  • Msx-1

Genomic Locations for DHX34 Gene

Genomic Locations for DHX34 Gene
chr19:47,349,281-47,382,704
(GRCh38/hg38)
Size:
33,424 bases
Orientation:
Plus strand
chr19:47,852,538-47,885,961
(GRCh37/hg19)
Size:
33,424 bases
Orientation:
Plus strand

Genomic View for DHX34 Gene

Genes around DHX34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX34 Gene

Proteins for DHX34 Gene

  • Protein details for DHX34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14147-DHX34_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DHX34
    Protein Accession:
    Q14147
    Secondary Accessions:
    • B4DMY8

    Protein attributes for DHX34 Gene

    Size:
    1143 amino acids
    Molecular mass:
    128120 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA09483.2; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAG60050.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DHX34 Gene

Post-translational modifications for DHX34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX34 Gene

No data available for DME Specific Peptides for DHX34 Gene

Domains & Families for DHX34 Gene

Gene Families for DHX34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14147

UniProtKB/Swiss-Prot:

DHX34_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX34: view

Function for DHX34 Gene

Molecular function for DHX34 Gene

UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DHX34 Gene

Gene Ontology (GO) - Molecular Function for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DHX34: view
genes like me logo Genes that share phenotypes with DHX34: view

Animal Model Products

miRNA for DHX34 Gene

miRTarBase miRNAs that target DHX34

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX34 Gene

Localization for DHX34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX34 gene
Compartment Confidence
nucleus 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DHX34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX34 Gene

Pathways & Interactions for DHX34 Gene

SuperPathways for DHX34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000956 nuclear-transcribed mRNA catabolic process IMP 23828042
GO:0006396 RNA processing IBA --
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 23828042
genes like me logo Genes that share ontologies with DHX34: view

No data available for Pathways by source and SIGNOR curated interactions for DHX34 Gene

Drugs & Compounds for DHX34 Gene

(3) Drugs for DHX34 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DHX34 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX34: view

Transcripts for DHX34 Gene

mRNA/cDNA for DHX34 Gene

Unigene Clusters for DHX34 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX34 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10:

ExUns: 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for DHX34 Gene

GeneLoc Exon Structure for
DHX34
ECgene alternative splicing isoforms for
DHX34

Expression for DHX34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHX34 Gene

This gene is overexpressed in Whole Blood (x13.2).

Protein differential expression in normal tissues from HIPED for DHX34 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3), Salivary gland (9.8), Adrenal (8.6), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DHX34 Gene



NURSA nuclear receptor signaling pathways regulating expression of DHX34 Gene:

DHX34

SOURCE GeneReport for Unigene cluster for DHX34 Gene:

Hs.151706

Evidence on tissue expression from TISSUES for DHX34 Gene

  • Bone marrow(4.2)
  • Lung(4.2)
  • Liver(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DHX34: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX34 Gene

Orthologs for DHX34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHX34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX34 34 33
  • 99.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHX34 34 33
  • 87.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DHX34 34 33
  • 87.62 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx34 33
  • 84.97 (n)
mouse
(Mus musculus)
Mammalia Dhx34 16 34 33
  • 84.87 (n)
oppossum
(Monodelphis domestica)
Mammalia DHX34 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX34 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX34 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx34 33
  • 61.54 (n)
zebrafish
(Danio rerio)
Actinopterygii dhx34 34 33
  • 62.59 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001338 33
  • 55.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32533 34 33
  • 55.04 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea smgl-2 34 33
  • 48.95 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP2 34
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToOne
Species where no ortholog for DHX34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX34 Gene

ENSEMBL:
Gene Tree for DHX34 (if available)
TreeFam:
Gene Tree for DHX34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHX34: view image

Paralogs for DHX34 Gene

Paralogs for DHX34 Gene

(6) SIMAP similar genes for DHX34 Gene using alignment to 2 proteins:

  • DHX34_HUMAN
  • H7C504_HUMAN

Pseudogenes.org Pseudogenes for DHX34 Gene

genes like me logo Genes that share paralogs with DHX34: view

Variants for DHX34 Gene

Sequence variations from dbSNP and Humsavar for DHX34 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000183111 -- 47,362,888(+) C/T intron_variant
rs1000239821 -- 47,364,505(+) G/C intron_variant
rs1000273276 -- 47,365,495(+) G/A intron_variant
rs1000286981 -- 47,359,378(+) C/A intron_variant
rs1000481843 -- 47,354,372(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX34 Gene

Variant ID Type Subtype PubMed ID
esv2758765 CNV loss 17122850
esv3583445 CNV loss 25503493
nsv1062949 CNV gain 25217958
nsv428366 CNV loss 18775914
nsv474520 CNV novel sequence insertion 20440878
nsv474975 CNV novel sequence insertion 20440878
nsv479067 CNV novel sequence insertion 20440878
nsv516890 CNV loss 19592680
nsv517901 CNV loss 19592680
nsv521341 CNV gain 19592680
nsv961229 CNV duplication 23825009
nsv9738 CNV gain 18304495

Variation tolerance for DHX34 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.48; 77.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX34 Gene

Human Gene Mutation Database (HGMD)
DHX34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX34 Gene

Disorders for DHX34 Gene

Additional Disease Information for DHX34

No disorders were found for DHX34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX34 Gene

Publications for DHX34 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 58
  2. A transcript map of the chromosome 19q-arm glioma tumor suppressor region. (PMID: 10708517) Smith JS … Jenkins RB (Genomics 2000) 2 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation. (PMID: 26841701) Melero R … Llorca O (Nature communications 2016) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for DHX34 Gene

Sources for DHX34 Gene

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