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Aliases for DHX29 Gene

Aliases for DHX29 Gene

  • DExH-Box Helicase 29 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 29 2 3
  • Nucleic Acid Helicase DDXx 3 4
  • DEAH-Box Helicase 29 2 3
  • DEAH Box Protein 29 3 4
  • DDX29 3 4
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 29 3
  • ATP-Dependent RNA Helicase DHX29 3
  • EC 3.6.4.13 4

External Ids for DHX29 Gene

Previous HGNC Symbols for DHX29 Gene

  • DDX29

Previous GeneCards Identifiers for DHX29 Gene

  • GC05M054522
  • GC05M054567
  • GC05M054587
  • GC05M054552
  • GC05M051525

Summaries for DHX29 Gene

Entrez Gene Summary for DHX29 Gene

  • This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]

GeneCards Summary for DHX29 Gene

DHX29 (DExH-Box Helicase 29) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX57.

UniProtKB/Swiss-Prot for DHX29 Gene

  • ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

Additional gene information for DHX29 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX29 Gene

Genomics for DHX29 Gene

GeneHancer (GH) Regulatory Elements for DHX29 Gene

Promoters and enhancers for DHX29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J055305 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 678.2 +0.2 206 4.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 MTREX DHX29 SLC38A9 ENSG00000264281 CCNO RNF138P1 GC05P055257
GH05J055463 Enhancer 0.9 FANTOM5 66.3 -156.4 -156381 0.3 ZNF493 ZFP64 MZF1 ZNF155 ZNF121 ZNF23 ZNF138 KLF7 ZNF202 ZNF680 DHX29 MTREX SLC38A9 GPX8 RNF138P1 ENSG00000264281 LOC100419851 FLJ31104 ENSG00000279883 GC05M055421
GH05J054516 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 24.4 +788.0 787951 6.2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF213 ZNF207 ZNF143 SNX18 PIR32129 MTREX DHX29 LOC100130990 HSPB3 PIR52196
GH05J055226 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 24.2 +80.6 80607 2.2 ARID4B SIN3A ZNF2 YY1 ZNF213 ZNF143 KLF13 SP3 REST SMARCB1 MCIDAS MTREX DHX29 SLC38A9 LOC105378973 ENSG00000249016 RNA5SP183 HNRNPH1P3 LINC01033 FLJ31104
GH05J054308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.9 +997.6 997551 4.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ARL15 DHX29 MTREX LINC01033 LINC02105 ENSG00000249016 ENSG00000279638
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX29 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX29 gene promoter:
  • NF-kappaB1
  • RORalpha1
  • Hlf
  • FOXC1
  • CUTL1
  • Pax-4a
  • E2F
  • E2F-1
  • CRE-BP1
  • ATF-2

Genomic Locations for DHX29 Gene

Genomic Locations for DHX29 Gene
chr5:55,256,245-55,307,722
(GRCh38/hg38)
Size:
51,478 bases
Orientation:
Minus strand
chr5:54,552,073-54,603,550
(GRCh37/hg19)
Size:
51,478 bases
Orientation:
Minus strand

Genomic View for DHX29 Gene

Genes around DHX29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX29 Gene

Proteins for DHX29 Gene

  • Protein details for DHX29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z478-DHX29_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DHX29
    Protein Accession:
    Q7Z478
    Secondary Accessions:
    • O75549
    • Q63HN0
    • Q63HN3
    • Q8IWW2
    • Q8N3A1
    • Q9UMH2

    Protein attributes for DHX29 Gene

    Size:
    1369 amino acids
    Molecular mass:
    155236 Da
    Quaternary structure:
    • Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

neXtProt entry for DHX29 Gene

Post-translational modifications for DHX29 Gene

  • Ubiquitination at posLast=494494
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX29 Gene

No data available for DME Specific Peptides for DHX29 Gene

Domains & Families for DHX29 Gene

Gene Families for DHX29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for DHX29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z478

UniProtKB/Swiss-Prot:

DHX29_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX29: view

Function for DHX29 Gene

Molecular function for DHX29 Gene

UniProtKB/Swiss-Prot Function:
ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.

Enzyme Numbers (IUBMB) for DHX29 Gene

Phenotypes From GWAS Catalog for DHX29 Gene

Gene Ontology (GO) - Molecular Function for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0003724 RNA helicase activity IEA --
GO:0003743 translation initiation factor activity IEA --
GO:0004004 ATP-dependent RNA helicase activity IEA,IBA --
genes like me logo Genes that share ontologies with DHX29: view
genes like me logo Genes that share phenotypes with DHX29: view

Animal Models for DHX29 Gene

MGI Knock Outs for DHX29:
  • Dhx29 Dhx29<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for DHX29

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DHX29 Gene

Localization for DHX29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX29 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX29 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005739 mitochondrion IBA,IEA --
GO:0016282 eukaryotic 43S preinitiation complex IDA 23706745
genes like me logo Genes that share ontologies with DHX29: view

Pathways & Interactions for DHX29 Gene

genes like me logo Genes that share pathways with DHX29: view

Pathways by source for DHX29 Gene

2 Cell Signaling Technology pathways for DHX29 Gene

Gene Ontology (GO) - Biological Process for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0045948 positive regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with DHX29: view

No data available for SIGNOR curated interactions for DHX29 Gene

Drugs & Compounds for DHX29 Gene

(3) Drugs for DHX29 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for DHX29 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX29: view

Transcripts for DHX29 Gene

mRNA/cDNA for DHX29 Gene

Unigene Clusters for DHX29 Gene

DEAH (Asp-Glu-Ala-His) box polypeptide 29:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX29 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DHX29 Gene

GeneLoc Exon Structure for
DHX29
ECgene alternative splicing isoforms for
DHX29

Expression for DHX29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX29 Gene

Protein differential expression in normal tissues from HIPED for DHX29 Gene

This gene is overexpressed in Milk (13.0) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX29 Gene



Protein tissue co-expression partners for DHX29 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHX29 Gene:

DHX29

SOURCE GeneReport for Unigene cluster for DHX29 Gene:

Hs.593268

Evidence on tissue expression from TISSUES for DHX29 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Lung(3.4)
  • Intestine(2.9)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with DHX29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX29 Gene

Orthologs for DHX29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX29 34 33
  • 99.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DHX29 34 33
  • 92.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHX29 34 33
  • 92.38 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX29 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100362324 33
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Dhx29 16 34 33
  • 84.97 (n)
chicken
(Gallus gallus)
Aves DHX29 34 33
  • 77.34 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX29 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx29 33
  • 67.95 (n)
Str.17378 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6004 33
zebrafish
(Danio rerio)
Actinopterygii DHX29 34
  • 62 (a)
OneToOne
LOC553505 33
  • 61.43 (n)
Dr.9383 33
fruit fly
(Drosophila melanogaster)
Insecta CG8915 34
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G58060 33
  • 49.94 (n)
rice
(Oryza sativa)
Liliopsida Os04g0432300 33
  • 49.87 (n)
Species where no ortholog for DHX29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX29 Gene

ENSEMBL:
Gene Tree for DHX29 (if available)
TreeFam:
Gene Tree for DHX29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHX29: view image

Paralogs for DHX29 Gene

Paralogs for DHX29 Gene

(4) SIMAP similar genes for DHX29 Gene using alignment to 2 proteins:

  • DHX29_HUMAN
  • H0Y8L1_HUMAN

Pseudogenes.org Pseudogenes for DHX29 Gene

genes like me logo Genes that share paralogs with DHX29: view

Variants for DHX29 Gene

Sequence variations from dbSNP and Humsavar for DHX29 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs193920824 uncertain-significance, Malignant tumor of prostate 55,290,250(-) T/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000010383 -- 55,256,976(-) G/T intron_variant
rs1000022515 -- 55,290,773(-) G/A intron_variant
rs1000023832 -- 55,295,149(-) G/A intron_variant
rs1000026456 -- 55,256,627(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX29 Gene

Variant ID Type Subtype PubMed ID
esv2730188 CNV deletion 23290073
esv2730189 CNV deletion 23290073
nsv1027090 CNV gain 25217958
nsv598180 CNV gain 21841781
nsv830302 CNV gain 17160897

Variation tolerance for DHX29 Gene

Residual Variation Intolerance Score: 7.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX29

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX29 Gene

Disorders for DHX29 Gene

Additional Disease Information for DHX29

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DHX29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX29 Gene

Publications for DHX29 Gene

  1. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. (PMID: 23706745) Hashem Y … Frank J (Cell 2013) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. (PMID: 19109895) Pisareva VP … Pestova TV (Cell 2008) 3 4 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DHX29 Gene

Sources for DHX29 Gene

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