This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally... See more...

Aliases for DHX29 Gene

Aliases for DHX29 Gene

  • DExH-Box Helicase 29 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 29 2 3
  • ATP-Dependent RNA Helicase DHX29 3 4
  • Nucleic Acid Helicase DDXx 3 4
  • DEAH-Box Helicase 29 2 3
  • DEAH Box Protein 29 3 4
  • DDX29 3 4
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 29 3
  • EC 3.6.4.13 4
  • EC 3.6.1 50
  • DHX29 5

External Ids for DHX29 Gene

Previous HGNC Symbols for DHX29 Gene

  • DDX29

Previous GeneCards Identifiers for DHX29 Gene

  • GC05M054522
  • GC05M054567
  • GC05M054587
  • GC05M054552
  • GC05M051525

Summaries for DHX29 Gene

Entrez Gene Summary for DHX29 Gene

  • This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]

GeneCards Summary for DHX29 Gene

DHX29 (DExH-Box Helicase 29) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX57.

UniProtKB/Swiss-Prot Summary for DHX29 Gene

  • ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHX29 Gene

Genomics for DHX29 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DHX29 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX29 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DHX29

Top Transcription factor binding sites by QIAGEN in the DHX29 gene promoter:
  • ATF-2
  • CRE-BP1
  • CUTL1
  • E2F
  • E2F-1
  • FOXC1
  • Hlf
  • NF-kappaB1
  • Pax-4a
  • RORalpha1

Genomic Locations for DHX29 Gene

Latest Assembly
chr5:55,256,055-55,307,694
(GRCh38/hg38)
Size:
51,640 bases
Orientation:
Minus strand

Previous Assembly
chr5:54,551,883-54,603,522
(GRCh37/hg19 by Entrez Gene)
Size:
51,640 bases
Orientation:
Minus strand

chr5:54,552,073-54,603,550
(GRCh37/hg19 by Ensembl)
Size:
51,478 bases
Orientation:
Minus strand

Genomic View for DHX29 Gene

Genes around DHX29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX29 Gene

Proteins for DHX29 Gene

  • Protein details for DHX29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z478-DHX29_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DHX29
    Protein Accession:
    Q7Z478
    Secondary Accessions:
    • O75549
    • Q63HN0
    • Q63HN3
    • Q8IWW2
    • Q8N3A1
    • Q9UMH2

    Protein attributes for DHX29 Gene

    Size:
    1369 amino acids
    Molecular mass:
    155236 Da
    Quaternary structure:
    • Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.

neXtProt entry for DHX29 Gene

Selected DME Specific Peptides for DHX29 Gene

Q7Z478:
  • GAVLIFLPG
  • VLATNIAET
  • VDEVHER
  • GVLLRKL
  • TQPRRISA

Post-translational modifications for DHX29 Gene

  • Ubiquitination at Lys494
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX29 Gene

Domains & Families for DHX29 Gene

Gene Families for DHX29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DHX29 Gene

InterPro:
Blocks:
  • ATP-dependent helicase, DEAH-box
  • Helicase-associated region

Suggested Antigen Peptide Sequences for DHX29 Gene

GenScript: Design optimal peptide antigens:
  • Nucleic acid helicase DDXx (DHX29_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z478

UniProtKB/Swiss-Prot:

DHX29_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX29: view

Function for DHX29 Gene

Molecular function for DHX29 Gene

UniProtKB/Swiss-Prot Function:
ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000255|HAMAP-Rule:MF_03068};.

Enzyme Numbers (IUBMB) for DHX29 Gene

Phenotypes From GWAS Catalog for DHX29 Gene

Gene Ontology (GO) - Molecular Function for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003724 RNA helicase activity IEA --
GO:0003743 translation initiation factor activity IEA --
genes like me logo Genes that share ontologies with DHX29: view
genes like me logo Genes that share phenotypes with DHX29: view

Animal Models for DHX29 Gene

MGI Knock Outs for DHX29:
  • Dhx29 Dhx29<tm1.1(KOMP)Vlcg>

Animal Models for research

  • Taconic Biosciences Mouse Models for DHX29

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHX29

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DHX29 Gene

Localization for DHX29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX29 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX29 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0016282 eukaryotic 43S preinitiation complex IDA 23706745
GO:0022627 cytosolic small ribosomal subunit IDA 20018725
genes like me logo Genes that share ontologies with DHX29: view

Pathways & Interactions for DHX29 Gene

genes like me logo Genes that share pathways with DHX29: view

Pathways by source for DHX29 Gene

2 Cell Signaling Technology pathways for DHX29 Gene

Gene Ontology (GO) - Biological Process for DHX29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IMP 23047696
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0042255 ribosome assembly IMP 20018725
GO:0045948 positive regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with DHX29: view

No data available for SIGNOR curated interactions for DHX29 Gene

Drugs & Compounds for DHX29 Gene

(3) Drugs for DHX29 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Phosphate Experimental Pharma 0
ATP Investigational Nutra 0

(1) Additional Compounds for DHX29 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with DHX29: view

Transcripts for DHX29 Gene

mRNA/cDNA for DHX29 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHX29

Alternative Splicing Database (ASD) splice patterns (SP) for DHX29 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DHX29 Gene

GeneLoc Exon Structure for
DHX29

Expression for DHX29 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHX29 Gene

Protein differential expression in normal tissues from HIPED for DHX29 Gene

This gene is overexpressed in Milk (13.0) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX29 Gene



Protein tissue co-expression partners for DHX29 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DHX29

SOURCE GeneReport for Unigene cluster for DHX29 Gene:

Hs.593268

Evidence on tissue expression from TISSUES for DHX29 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Lung(3.7)
  • Kidney(3)
  • Intestine(2.9)
genes like me logo Genes that share expression patterns with DHX29: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX29 Gene

Orthologs for DHX29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX29 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DHX29 29 30
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DHX29 29 30
  • 92.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DHX29 29 30
  • 92.38 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 88 (a)
OneToMany
-- 30
  • 82 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia DHX29 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100362324 29
  • 85.95 (n)
Mouse
(Mus musculus)
Mammalia Dhx29 29 16 30
  • 84.97 (n)
OneToOne
Chicken
(Gallus gallus)
Aves DHX29 29 30
  • 77.34 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DHX29 30
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dhx29 29
  • 67.95 (n)
Str.17378 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.6004 29
Zebrafish
(Danio rerio)
Actinopterygii DHX29 30
  • 62 (a)
OneToOne
LOC553505 29
  • 61.43 (n)
Dr.9383 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG8915 30
  • 29 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G58060 29
  • 49.94 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0432300 29
  • 49.87 (n)
Species where no ortholog for DHX29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DHX29 Gene

ENSEMBL:
Gene Tree for DHX29 (if available)
TreeFam:
Gene Tree for DHX29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHX29: view image
Alliance of Genome Resources:
Additional Orthologs for DHX29

Paralogs for DHX29 Gene

(4) SIMAP similar genes for DHX29 Gene using alignment to 2 proteins:

  • DHX29_HUMAN
  • H0Y8L1_HUMAN

Pseudogenes.org Pseudogenes for DHX29 Gene

genes like me logo Genes that share paralogs with DHX29: view

Variants for DHX29 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DHX29 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs149543515 Not Provided: not provided 55,295,401(-) T/C
NM_019030.4(DHX29):c.629A>G (p.Tyr210Cys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs193920824 Uncertain Significance: Malignant tumor of prostate 55,290,250(-) T/A
NM_019030.4(DHX29):c.875A>T (p.Glu292Val)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs17854904 -- p.Pro630His
rs35874395 -- p.Asp309Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DHX29 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DHX29 Gene

Variant ID Type Subtype PubMed ID
esv2730188 CNV deletion 23290073
esv2730189 CNV deletion 23290073
nsv1027090 CNV gain 25217958
nsv598180 CNV gain 21841781
nsv830302 CNV gain 17160897

Variation tolerance for DHX29 Gene

Residual Variation Intolerance Score: 7.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX29
Leiden Open Variation Database (LOVD)
DHX29

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX29 Gene

Disorders for DHX29 Gene

Additional Disease Information for DHX29

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for DHX29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX29 Gene

Publications for DHX29 Gene

  1. Structure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29. (PMID: 23706745) Hashem Y … Frank J (Cell 2013) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  3. Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. (PMID: 19109895) Pisareva VP … Pestova TV (Cell 2008) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for DHX29 Gene

Sources for DHX29 Gene