Aliases for DHX16 Gene
External Ids for DHX16 Gene
Previous HGNC Symbols for DHX16 Gene
Previous GeneCards Identifiers for DHX16 Gene
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]
GeneCards Summary for DHX16 Gene
DHX16 (DEAH-Box Helicase 16) is a Protein Coding gene. Diseases associated with DHX16 include Neuromuscular Disease And Ocular Or Auditory Anomalies With Or Without Seizures and Corpus Callosum, Agenesis Of. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX8.
UniProtKB/Swiss-Prot Summary for DHX16 Gene
Required for pre-mRNA splicing as component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.