The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008] See more...

Aliases for DHX15 Gene

Aliases for DHX15 Gene

  • DEAH-Box Helicase 15 2 3 5
  • Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 15 2 3
  • DEAH (Asp-Glu-Ala-His) Box Polypeptide 15 2 3
  • DEAH (Asp-Glu-Ala-His) Box Helicase 15 2 3
  • ATP-Dependent RNA Helicase #46 3 4
  • DEAH Box Protein 15 3 4
  • DDX15 3 4
  • DBP1 3 4
  • Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX15 3
  • RNA Helicase 2 3
  • DEAD/H Box-15 3
  • EC 3.6.4.13 4
  • EC 3.6.1 52
  • PrPp43p 3
  • PRPF43 3
  • PRP43 3
  • HRH2 3

External Ids for DHX15 Gene

Previous HGNC Symbols for DHX15 Gene

  • DDX15

Previous GeneCards Identifiers for DHX15 Gene

  • GC04M024217
  • GC04M024279
  • GC04M024205
  • GC04M024138
  • GC04M024529
  • GC04M023871

Summaries for DHX15 Gene

Entrez Gene Summary for DHX15 Gene

  • The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DHX15 Gene

DHX15 (DEAH-Box Helicase 15) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX8.

UniProtKB/Swiss-Prot Summary for DHX15 Gene

  • Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.

Gene Wiki entry for DHX15 Gene

Additional gene information for DHX15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHX15 Gene

Genomics for DHX15 Gene

GeneHancer (GH) Regulatory Elements for DHX15 Gene

Promoters and enhancers for DHX15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J024582 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 530.8 +1.0 1015 4.4 ZBTB40 SIN3A NRF1 MYC POLR2G SP1 GTF2E2 PHF8 ZFX POLR2A DHX15 lnc-CCDC149-1 ANAPC4 ZCCHC4 LINC02473 RF00017-4278 lnc-CCDC149-2 RN7SL16P
GH04J025312 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 25 -728.5 -728547 2.1 RXRA EP300 ZNF217 CTCF MYC TCF12 POLR2G SP1 GTF2E2 SIX5 ZCCHC4 ANAPC4 DHX15 PI4K2B piR-35277
GH04J025233 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 22.2 -650.3 -650307 3.8 HNRNPK CTCF SIN3A NRF1 USF1 POLR2G NCOR1 PHF8 ZFX ZIC2 PI4K2B LOC105374535 lnc-SEPSECS-4 ANAPC4 ZCCHC4 DHX15 piR-39098-167
GH04J025158 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.5 -576.0 -576035 3.9 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 POLR2G USF1 SP1 NCOR1 PHF8 PI4K2B SEPSECS SEPSECS-AS1 ANAPC4 DHX15 ZCCHC4
GH04J024642 Enhancer 0.9 Ensembl ENCODE 19.2 -59.9 -59898 4.2 TCF12 FOS TRIM28 TEAD1 ATF2 OSR2 WT1 CREB1 ZNF316 ZBTB17 DHX15 LINC02473 lnc-DHX15-3 piR-50443-282
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHX15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DHX15

Top Transcription factor binding sites by QIAGEN in the DHX15 gene promoter:
  • c-Myc
  • FOXF2
  • GATA-1
  • GATA-2
  • GATA-3
  • HFH-1
  • Max
  • Pax-4a
  • SREBP-1c

Genomic Locations for DHX15 Gene

Genomic Locations for DHX15 Gene
chr4:24,517,441-24,584,603
(GRCh38/hg38)
Size:
67,163 bases
Orientation:
Minus strand
chr4:24,519,064-24,586,184
(GRCh37/hg19)
Size:
67,121 bases
Orientation:
Minus strand

Genomic View for DHX15 Gene

Genes around DHX15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX15 Gene

Proteins for DHX15 Gene

  • Protein details for DHX15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43143-DHX15_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
    Protein Accession:
    O43143
    Secondary Accessions:
    • Q9NQT7

    Protein attributes for DHX15 Gene

    Size:
    795 amino acids
    Molecular mass:
    90933 Da
    Quaternary structure:
    • Interacts with SSB/La (PubMed:12458796). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (PubMed:15146077). Identified in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors; the association may be transient. Interacts with TFIP11; indicative for a recruitment to the IL complex (PubMed:19103666). Interacts with GPATCH2 (PubMed:19432882).

    Three dimensional structures from OCA and Proteopedia for DHX15 Gene

neXtProt entry for DHX15 Gene

Selected DME Specific Peptides for DHX15 Gene

O43143:
  • GYFMQVAHLERTGHYLTVKDNQVV
  • LDEAHERT
  • QWCYDNFI
  • RVESLLV
  • FLTGQEE
  • DYLEAAIRTVIQIHM
  • TYPEILRSNLGSVVLQLKKLG
  • LYNEFVLTTKN
  • LHPSTVLDHKPEW
  • LKVIVMSAT
  • MSATLDAGKFQ
  • EPERDYLEAA
  • TQPRRVAA
  • TNIAETS
  • VGYSIRF
  • EFPLDPQL
  • FDFMDPP
  • TDGMLLRE
  • MDPPAPET
  • DEAHERTL
  • IAPQYYD
  • HPVEIFYT
  • ADEAKMRFAHIDGDHLTLLNVYHAFKQN
  • LKKLGIDDLVHFD
  • DPGFAKQ
  • EACKRIKREVD
  • HSAHSTH
  • GKTTQIPQ
  • RSDLKVI
  • LGQEVGY
  • EMQDNTYPEILRSNLG
  • TGSGKTTQ

Post-translational modifications for DHX15 Gene

  • Ubiquitination at Lys143, Lys230, Lys234, Lys463, Lys491, and Lys790
  • Modification sites at PhosphoSitePlus

Other Protein References for DHX15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHX15 Gene

Gene Families for DHX15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DHX15 Gene

Blocks:
  • ATP-dependent helicase, DEAH-box
  • Helicase-associated region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DHX15 Gene

GenScript: Design optimal peptide antigens:
  • DEAH box protein 15 (DHX15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43143

UniProtKB/Swiss-Prot:

DHX15_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
genes like me logo Genes that share domains with DHX15: view

Function for DHX15 Gene

Molecular function for DHX15 Gene

UniProtKB/Swiss-Prot Function:
Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence=. ;.

Enzyme Numbers (IUBMB) for DHX15 Gene

Phenotypes From GWAS Catalog for DHX15 Gene

Gene Ontology (GO) - Molecular Function for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA 21873635
GO:0003724 RNA helicase activity IEA,TAS --
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DHX15: view
genes like me logo Genes that share phenotypes with DHX15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHX15

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX15 Gene

Localization for DHX15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHX15 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX15 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9388478
GO:0005654 nucleoplasm TAS --
GO:0005689 U12-type spliceosomal complex IDA 15146077
GO:0005730 nucleolus IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with DHX15: view

Pathways & Interactions for DHX15 Gene

genes like me logo Genes that share pathways with DHX15: view

Pathways by source for DHX15 Gene

1 KEGG pathway for DHX15 Gene

Gene Ontology (GO) - Biological Process for DHX15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing TAS 7935475
GO:0008380 RNA splicing IC 15146077
GO:0009636 response to toxic substance IEA --
GO:0043279 response to alkaloid IEA --
genes like me logo Genes that share ontologies with DHX15: view

No data available for SIGNOR curated interactions for DHX15 Gene

Drugs & Compounds for DHX15 Gene

(3) Drugs for DHX15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for DHX15 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with DHX15: view

Transcripts for DHX15 Gene

mRNA/cDNA for DHX15 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHX15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX15 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: -
SP2: - -
SP3:
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13: - - -
SP14: -
SP15:
SP16:

ExUns: 16a · 16b · 16c ^ 17a · 17b · 17c ^ 18a · 18b · 18c · 18d
SP1:
SP2: - -
SP3:
SP4: -
SP5: - -
SP6: - -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15: - - -
SP16:

Relevant External Links for DHX15 Gene

GeneLoc Exon Structure for
DHX15

Expression for DHX15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHX15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHX15 Gene

This gene is overexpressed in Lymph node (9.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX15 Gene



Protein tissue co-expression partners for DHX15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DHX15

SOURCE GeneReport for Unigene cluster for DHX15 Gene:

Hs.696074

mRNA Expression by UniProt/SwissProt for DHX15 Gene:

O43143-DHX15_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DHX15 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Lung(3.2)
  • Blood(2.7)
  • Kidney(2.7)
  • Heart(2.4)
  • Bone marrow(2)
  • Eye(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with DHX15: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX15 Gene

Orthologs for DHX15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX15 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia DHX15 31
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX15 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DHX15 31 30
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DHX15 31 30
  • 96.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHX15 31 30
  • 95.51 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx15 30
  • 93.42 (n)
mouse
(Mus musculus)
Mammalia Dhx15 17 31 30
  • 93.21 (n)
chicken
(Gallus gallus)
Aves DHX15 31 30
  • 85.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX15 31
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx15 30
  • 80.39 (n)
Str.8082 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5587 30
zebrafish
(Danio rerio)
Actinopterygii dhx15 31 30
  • 73.86 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8963 30
fruit fly
(Drosophila melanogaster)
Insecta CG11107 31 30
  • 67.23 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011149 30
  • 65.87 (n)
worm
(Caenorhabditis elegans)
Secernentea F56D2.6 31 30
  • 65.32 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP43 33 31 30
  • 64.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00561g 30
  • 61.47 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR180C 30
  • 60.84 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62310 30
  • 66.43 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9698 30
rice
(Oryza sativa)
Liliopsida Os03g0314100 30
  • 65.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp43 30
  • 61.65 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01612 30
  • 58.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.5594 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5594 30
Species where no ortholog for DHX15 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHX15 Gene

ENSEMBL:
Gene Tree for DHX15 (if available)
TreeFam:
Gene Tree for DHX15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHX15: view image

Paralogs for DHX15 Gene

(9) SIMAP similar genes for DHX15 Gene using alignment to 1 proteins:

  • DHX15_HUMAN
genes like me logo Genes that share paralogs with DHX15: view

Variants for DHX15 Gene

Additional dbSNP identifiers (rs#s) for DHX15 Gene

Structural Variations from Database of Genomic Variants (DGV) for DHX15 Gene

Variant ID Type Subtype PubMed ID
dgv5157n100 CNV gain 25217958
nsv1136825 CNV deletion 24896259
nsv289788 CNV deletion 16902084
nsv950559 CNV duplication 24416366

Variation tolerance for DHX15 Gene

Residual Variation Intolerance Score: 7.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DHX15 Gene

Disorders for DHX15 Gene

Additional Disease Information for DHX15

No disorders were found for DHX15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX15 Gene

Publications for DHX15 Gene

  1. Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family. (PMID: 9388478) Imamura O … Furuichi Y (Biochemical and biophysical research communications 1997) 2 3 4 54
  2. Isolation and characterization of post-splicing lariat-intron complexes. (PMID: 19103666) Yoshimoto R … Ohno M (Nucleic acids research 2009) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will CL … Lührmann R (RNA (New York, N.Y.) 2004) 3 4 54
  5. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PMID: 12458796) Fouraux MA … Pruijn GJ (RNA (New York, N.Y.) 2002) 3 4 54

Products for DHX15 Gene

Sources for DHX15 Gene