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Aliases for DHRSX Gene

Aliases for DHRSX Gene

  • Dehydrogenase/Reductase X-Linked 2 3 5
  • Dehydrogenase/Reductase SDR Family Member On Chromosome X 3 4
  • Short Chain Dehydrogenase/Reductase Family 46C Member 1 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C Member 6 3 4
  • Dehydrogenase/Reductase (SDR Family) X Chromosome 2 3
  • Dehydrogenase/Reductase (SDR Family) Y-Linked 2 3
  • CXorf11 3 4
  • SDR46C1 3 4
  • DHRS5X 3 4
  • DHRSXY 3 4
  • SDR7C6 3 4
  • Short Chain Dehydrogenase/Reductase Family 46C, Member 1 2
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 6 2
  • Dehydrogenase/Reductase (SDR Family) X-Linked 3
  • EC 1.1.-.- 4
  • DHRS5Y 3
  • DHRSY 3

External Ids for DHRSX Gene

Previous GeneCards Identifiers for DHRSX Gene

  • GC0XM001605
  • GC0YU900009
  • GC00U921559
  • GC0XM000082

Summaries for DHRSX Gene

GeneCards Summary for DHRSX Gene

DHRSX (Dehydrogenase/Reductase X-Linked) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH13.

UniProtKB/Swiss-Prot for DHRSX Gene

  • Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851).

Gene Wiki entry for DHRSX Gene

Additional gene information for DHRSX Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRSX Gene

Genomics for DHRSX Gene

GeneHancer (GH) Regulatory Elements for DHRSX Gene

Promoters and enhancers for DHRSX Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ002499 Promoter/Enhancer 2 EPDnew Ensembl dbSUPER 600.7 +0.9 873 4.2 ZFX ELF3 NKRF ZNF121 CEBPG RERE POLR2A TFE3 ZBTB7A SP1 DHRSX ZBED1 DHRSX-IT1
GH0XJ002502 Promoter 1.7 EPDnew Ensembl 600.7 -1.7 -1727 0.6 ZKSCAN8 CBFA2T2 ZNF148 ZNF384 NCOA3 BACH1 YY1 TRIM24 SP7 ZNF639 DHRSX ZBED1 LOC101928092
GH0XJ002707 Enhancer 1.2 FANTOM5 dbSUPER 1.9 -206.6 -206591 0.3 ELF3 MNT CEBPG MAFK ELF1 SP1 CREM MLLT1 RAD21 IKZF1 ZBED1 DHRSX CD99 ARSD XG
GH0XJ002696 Promoter/Enhancer 1.5 FANTOM5 Ensembl dbSUPER 1.4 -195.9 -195927 1.4 CREM ZBED1 IKZF1 IKZF2 TRIM22 CTBP1 ETV6 CBFB EED RUNX3 CD99 ZBED1 DHRSX XG
GH0XJ002430 Enhancer 0.7 FANTOM5 Ensembl 2.3 +69.7 69673 3.8 ZNF121 CEBPB ZNF146 POLR2A ZBED1 DHRSX DHRSX-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHRSX on UCSC Golden Path with GeneCards custom track

Genomic Locations for DHRSX Gene

Genomic Locations for DHRSX Gene
281,469 bases
Minus strand
283,300 bases
Minus strand

Genomic View for DHRSX Gene

Genes around DHRSX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRSX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRSX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRSX Gene

Proteins for DHRSX Gene

  • Protein details for DHRSX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member on chromosome X
    Protein Accession:
    Secondary Accessions:
    • Q6UWC7
    • Q8WUS4
    • Q96GR8
    • Q9NTF6

    Protein attributes for DHRSX Gene

    330 amino acids
    Molecular mass:
    36443 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

neXtProt entry for DHRSX Gene

Post-translational modifications for DHRSX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRSX Gene

No data available for DME Specific Peptides for DHRSX Gene

Domains & Families for DHRSX Gene

Gene Families for DHRSX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for DHRSX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRSX: view

Function for DHRSX Gene

Molecular function for DHRSX Gene

UniProtKB/Swiss-Prot Function:
Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851).

Enzyme Numbers (IUBMB) for DHRSX Gene

Gene Ontology (GO) - Molecular Function for DHRSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRSX: view
genes like me logo Genes that share phenotypes with DHRSX: view

Animal Model Products

CRISPR Products

miRNA for DHRSX Gene

miRTarBase miRNAs that target DHRSX

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRSX

Clone Products

  • Applied Biological Materials (abm): Clones for DHRSX - Now 50% OFF >
  • * DHRSX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DHRSX tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRSX Gene

Localization for DHRSX Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRSX Gene

Secreted. Note=Secreted in a non-classical form. A signal peptide sequence at position 1-31 is predicted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRSX gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 25076851
genes like me logo Genes that share ontologies with DHRSX: view

Pathways & Interactions for DHRSX Gene

PathCards logo

SuperPathways for DHRSX Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IBA,IMP 25076851
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRSX: view

No data available for Pathways by source and SIGNOR curated interactions for DHRSX Gene

Drugs & Compounds for DHRSX Gene

No Compound Related Data Available

Transcripts for DHRSX Gene

mRNA/cDNA for DHRSX Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for DHRSX Gene

Dehydrogenase/reductase (SDR family) X-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRSX

Clone Products

  • Applied Biological Materials (abm): Clones for DHRSX - Now 50% OFF >
  • * DHRSX as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DHRSX tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DHRSX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - -
SP3: -
SP4: -

Relevant External Links for DHRSX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRSX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRSX Gene

Protein differential expression in normal tissues from HIPED for DHRSX Gene

This gene is overexpressed in Nasal epithelium (54.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRSX Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRSX Gene:


SOURCE GeneReport for Unigene cluster for DHRSX Gene:


mRNA Expression by UniProt/SwissProt for DHRSX Gene:

Tissue specificity: Widely expressed. Highly expressed in the pancreas.

Evidence on tissue expression from TISSUES for DHRSX Gene

  • Nervous system(4.5)
  • Intestine(4.3)
  • Pancreas(3.5)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with DHRSX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRSX Gene

Orthologs for DHRSX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRSX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHRSX 35
  • 96 (a)
(Canis familiaris)
Mammalia DHRSX 35 34
  • 79.87 (n)
(Bos Taurus)
Mammalia DHRSX 34
  • 77.6 (n)
MGC152281 35
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia DHRSX 35
  • 74 (a)
(Monodelphis domestica)
Mammalia DHRSX 35
  • 67 (a)
(Mus musculus)
Mammalia Dhrsx 17 34
  • 63.27 (n)
CAAA01118383.1 35
  • 56 (a)
(Rattus norvegicus)
Mammalia Dhrsx 34
  • 59.62 (n)
(Gallus gallus)
Aves DHRSX 35 34
  • 71.28 (n)
(Anolis carolinensis)
Reptilia DHRSX 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrsx 34
  • 66.67 (n)
(Danio rerio)
Actinopterygii dhrsx 35 34
  • 60.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011810 34
  • 51.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11200 35 34
  • 51.02 (n)
(Caenorhabditis elegans)
Secernentea dhs-1 35
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
Species where no ortholog for DHRSX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRSX Gene

Gene Tree for DHRSX (if available)
Gene Tree for DHRSX (if available)
Evolutionary constrained regions (ECRs) for DHRSX: view image

Paralogs for DHRSX Gene

Paralogs for DHRSX Gene

(9) SIMAP similar genes for DHRSX Gene using alignment to 5 proteins:

  • C9JB06_HUMAN
  • H7C5T6_HUMAN
  • H7C613_HUMAN
genes like me logo Genes that share paralogs with DHRSX: view

Variants for DHRSX Gene

Sequence variations from dbSNP and Humsavar for DHRSX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000002895 -- 2,369,991(-) T/C intron_variant
rs1000012343 -- 2,388,320(-) A/G intron_variant
rs1000032695 -- 2,429,343(-) T/C intron_variant
rs1000048346 -- 2,342,234(-) G/A intron_variant
rs1000065975 -- 2,220,153(-) CC/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRSX Gene

Variant ID Type Subtype PubMed ID
dgv1309e201 CNV deletion 23290073
dgv4336n106 CNV deletion 24896259
dgv4337n106 CNV deletion 24896259
esv1991441 CNV deletion 18987734
esv2159685 CNV deletion 18987734
esv22584 CNV gain 19812545
esv23482 CNV loss 19812545
esv2356582 CNV deletion 18987734
esv25220 CNV loss 19812545
esv2658918 CNV deletion 23128226
esv2659495 CNV deletion 23128226
esv2660086 CNV deletion 23128226
esv2663112 CNV deletion 23128226
esv2663505 CNV deletion 23128226
esv2663710 CNV deletion 23128226
esv2664729 CNV deletion 23128226
esv2666881 CNV deletion 23128226
esv2669209 CNV deletion 23128226
esv2673036 CNV deletion 23128226
esv2674467 CNV deletion 23128226
esv2674998 CNV deletion 23128226
esv2676100 CNV deletion 23128226
esv2678233 CNV deletion 23128226
esv2739833 CNV deletion 23290073
esv2739834 CNV deletion 23290073
esv2739835 CNV deletion 23290073
esv2739837 CNV deletion 23290073
esv2739838 CNV deletion 23290073
esv2739841 CNV deletion 23290073
esv2739843 CNV deletion 23290073
esv2739845 CNV deletion 23290073
esv2739846 CNV deletion 23290073
esv2739847 CNV deletion 23290073
esv2739848 CNV deletion 23290073
esv2739849 CNV deletion 23290073
esv2739850 CNV deletion 23290073
esv2739852 CNV deletion 23290073
esv2739853 CNV deletion 23290073
esv2739854 CNV deletion 23290073
esv2739855 CNV deletion 23290073
esv2739856 CNV deletion 23290073
esv2739857 CNV deletion 23290073
esv2739858 CNV deletion 23290073
esv2739859 CNV deletion 23290073
esv2739860 CNV deletion 23290073
esv2739861 CNV deletion 23290073
esv2739863 CNV deletion 23290073
esv2739864 CNV deletion 23290073
esv2739865 CNV deletion 23290073
esv2741137 CNV deletion 23290073
esv2758855 CNV gain 17122850
esv2982198 CNV insertion 24192839
esv29996 CNV loss 17803354
esv3336612 CNV duplication 20981092
esv3558526 CNV deletion 23714750
esv3558528 CNV deletion 23714750
esv3558530 CNV deletion 23714750
esv3558531 CNV deletion 23714750
esv3558533 CNV deletion 23714750
nsv10009 CNV gain 18304495
nsv10010 CNV gain 18304495
nsv1075303 CNV deletion 25765185
nsv1075707 CNV deletion 25765185
nsv1076241 CNV deletion 25765185
nsv1076739 CNV duplication 25765185
nsv1077257 CNV deletion 25765185
nsv1078103 CNV duplication 25765185
nsv1078149 CNV duplication 25765185
nsv1078665 CNV duplication 25765185
nsv1122259 CNV deletion 24896259
nsv1125146 CNV duplication 24896259
nsv1132750 CNV duplication 24896259
nsv1137685 CNV deletion 24896259
nsv1140010 CNV duplication 24896259
nsv1140090 CNV duplication 24896259
nsv1140091 CNV duplication 24896259
nsv1141661 CNV duplication 24896259
nsv1145280 CNV deletion 24896259
nsv1146767 CNV duplication 26484159
nsv1147379 CNV duplication 26484159
nsv1152521 CNV duplication 26484159
nsv1152788 CNV duplication 26484159
nsv1153600 CNV duplication 26484159
nsv953396 CNV deletion 24416366
nsv953397 CNV deletion 24416366
nsv953725 CNV deletion 24416366
nsv953726 CNV deletion 24416366
nsv9929 CNV gain 18304495
nsv9930 CNV gain 18304495

Variation tolerance for DHRSX Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRSX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRSX Gene

Disorders for DHRSX Gene

Additional Disease Information for DHRSX

No disorders were found for DHRSX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRSX Gene

Publications for DHRSX Gene

  1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. (PMID: 11731500) Gianfrancesco F … D'Urso M (Genome research 2001) 2 3 4 23 58
  2. DHRSX, a novel non-classical secretory protein associated with starvation induced autophagy. (PMID: 25076851) Zhang G … Wang L (International journal of medical sciences 2014) 3 4 58
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for DHRSX Gene

Sources for DHRSX Gene

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