Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DHRS7C Gene

Aliases for DHRS7C Gene

  • Dehydrogenase/Reductase 7C 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 32C Member 2 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 7C 2 3
  • SDR32C2 3 4
  • Short Chain Dehydrogenase/Reductase Family 32C, Member 2 2
  • Dehydrogenase/Reductase SDR Family Member 7C 3
  • EC 1.1.-.- 4

External Ids for DHRS7C Gene

Previous GeneCards Identifiers for DHRS7C Gene

  • GC17M009616

Summaries for DHRS7C Gene

GeneCards Summary for DHRS7C Gene

DHRS7C (Dehydrogenase/Reductase 7C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and retinol dehydrogenase activity. An important paralog of this gene is DHRS7B.

UniProtKB/Swiss-Prot for DHRS7C Gene

  • Putative oxidoreductase.

Additional gene information for DHRS7C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7C Gene

Genomics for DHRS7C Gene

GeneHancer (GH) Regulatory Elements for DHRS7C Gene

Promoters and enhancers for DHRS7C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I009790 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 550.8 +0.1 77 1.1 DHRS7C GC17P009789 ENSG00000278944 ENSG00000282882
GH17I009837 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.5 -46.4 -46377 1.3 KLF17 SIN3A FEZF1 RAD21 ZNF335 SMARCC2 RCOR1 SMARCC1 ZNF280D ZC3H11A GC17M009835 GC17P009839 MAGOH2P ADPRM ENSG00000261433 DHRS7C GLP2R
GH17I009835 Enhancer 0.9 ENCODE dbSUPER 11.1 -44.5 -44507 1.3 JUN MAX SIN3A RAD21 BRCA1 CTBP1 GATA3 POLR2A SMC3 FOSL2 GC17M009835 DHRS7C GLP2R GC17M009822
GH17I009761 Enhancer 0.8 dbSUPER 12.1 +25.6 25619 8.1 CTCF PKNOX1 MXI1 JUN MAX BRCA1 RAD21 RFX5 ZNF664 POLR2A ENSG00000282882 ENSG00000261433 DHRS7C MAGOH2P USP43 ADPRM GC17M009779
GH17I009828 Enhancer 0.8 FANTOM5 dbSUPER 11.3 -37.1 -37127 0.4 STAT1 MAFF POLR2A CEBPB EP300 TCF7L2 DHRS7C GC17M009822 GLP2R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHRS7C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS7C gene promoter:

Genomic Locations for DHRS7C Gene

Genomic Locations for DHRS7C Gene
20,144 bases
Minus strand

Genomic View for DHRS7C Gene

Genes around DHRS7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7C Gene

Proteins for DHRS7C Gene

  • Protein details for DHRS7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 7C
    Protein Accession:
    Secondary Accessions:
    • B7ZW74
    • B9EJH3

    Protein attributes for DHRS7C Gene

    312 amino acids
    Molecular mass:
    34878 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI47025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI47026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS7C Gene


neXtProt entry for DHRS7C Gene

Post-translational modifications for DHRS7C Gene

No Post-translational modifications

Other Protein References for DHRS7C Gene

No data available for DME Specific Peptides for DHRS7C Gene

Domains & Families for DHRS7C Gene

Gene Families for DHRS7C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for DHRS7C Gene

Suggested Antigen Peptide Sequences for DHRS7C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7C: view

Function for DHRS7C Gene

Molecular function for DHRS7C Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS7C Gene

Gene Ontology (GO) - Molecular Function for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004745 retinol dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

Phenotypes for DHRS7C Gene

genes like me logo Genes that share phenotypes with DHRS7C: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS7C Gene

Localization for DHRS7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS7C Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS7C gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
plasma membrane 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0014801 longitudinal sarcoplasmic reticulum IEA --
GO:0033017 sarcoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DHRS7C Gene

Pathways & Interactions for DHRS7C Gene

SuperPathways for DHRS7C Gene

No Data Available

Interacting Proteins for DHRS7C Gene

Gene Ontology (GO) - Biological Process for DHRS7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7C: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS7C Gene

Drugs & Compounds for DHRS7C Gene

No Compound Related Data Available

Transcripts for DHRS7C Gene

mRNA/cDNA for DHRS7C Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DHRS7C Gene

Dehydrogenase/reductase (SDR family) member 7C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7C Gene

No ASD Table

Relevant External Links for DHRS7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS7C Gene

mRNA differential expression in normal tissues according to GTEx for DHRS7C Gene

This gene is overexpressed in Heart - Atrial Appendage (x23.2), Muscle - Skeletal (x18.4), and Heart - Left Ventricle (x9.6).

Protein differential expression in normal tissues from HIPED for DHRS7C Gene

This gene is overexpressed in Heart (37.6) and Esophagus (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHRS7C Gene

Protein tissue co-expression partners for DHRS7C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHRS7C Gene:


SOURCE GeneReport for Unigene cluster for DHRS7C Gene:


Evidence on tissue expression from TISSUES for DHRS7C Gene

  • Muscle(2.2)
genes like me logo Genes that share expression patterns with DHRS7C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS7C Gene

Orthologs for DHRS7C Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS7C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHRS7C 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia DHRS7C 33 34
  • 89.92 (n)
(Bos Taurus)
Mammalia DHRS7C 33 34
  • 88.8 (n)
(Mus musculus)
Mammalia Dhrs7c 33 16 34
  • 88.09 (n)
(Rattus norvegicus)
Mammalia Dhrs7c 33
  • 87.29 (n)
(Monodelphis domestica)
Mammalia DHRS7C 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia DHRS7C 34
  • 65 (a)
(Gallus gallus)
Aves DHRS7C 33 34
  • 73.45 (n)
(Anolis carolinensis)
Reptilia DHRS7C 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7c 33
  • 70.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18984 33
(Danio rerio)
Actinopterygii dhrs7cb 33 34
  • 64.19 (n)
dhrs7ca 34
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8653 33
fruit fly
(Drosophila melanogaster)
Insecta CG7601 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea dhs-30 34
  • 30 (a)
T25G12.13 34
  • 27 (a)
C33E10.10 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for DHRS7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS7C Gene

Gene Tree for DHRS7C (if available)
Gene Tree for DHRS7C (if available)

Paralogs for DHRS7C Gene

Paralogs for DHRS7C Gene

(1) SIMAP similar genes for DHRS7C Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS7C: view

Variants for DHRS7C Gene

Sequence variations from dbSNP and Humsavar for DHRS7C Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000113368 -- 9,778,195(-) T/C intron_variant
rs1000272721 -- 9,772,586(-) G/A intron_variant
rs1000311905 -- 9,783,159(-) T/C intron_variant
rs1000371908 -- 9,789,049(-) G/A intron_variant
rs1000557956 -- 9,784,735(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS7C Gene

Variant ID Type Subtype PubMed ID
dgv176n21 CNV loss 19592680
esv3639922 CNV loss 21293372
esv3639923 CNV loss 21293372
nsv1976 CNV deletion 18451855
nsv510697 CNV deletion 20534489
nsv528877 CNV loss 19592680
nsv833358 CNV gain 17160897
nsv833360 CNV loss 17160897
nsv833361 CNV gain 17160897

Variation tolerance for DHRS7C Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS7C Gene

Disorders for DHRS7C Gene

Additional Disease Information for DHRS7C

No disorders were found for DHRS7C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS7C Gene

Publications for DHRS7C Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 58
  2. DHRS7c, a novel cardiomyocyte-expressed gene that is down-regulated by adrenergic stimulation and in heart failure. (PMID: 22143674) Lu B … Silljé HH (European journal of heart failure 2012) 3 58
  3. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J … Elledge SJ (Cell 2009) 3 58
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for DHRS7C Gene

Sources for DHRS7C Gene

Loading form....