This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016] See more...

Aliases for DHRS7 Gene

Aliases for DHRS7 Gene

  • Dehydrogenase/Reductase 7 2 3 5
  • Retinal Short-Chain Dehydrogenase/Reductase 4 2 3 4
  • Short Chain Dehydrogenase/Reductase Family 34C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 7 2 3
  • Dehydrogenase/Reductase SDR Family Member 7 3 4
  • SDR34C1 3 4
  • RetSDR4 3 4
  • Short Chain Dehydrogenase/Reductase Family 34C, Member 1 2
  • EC 1.1.-.- 4
  • RetDSR4 3
  • RETSDR4 4
  • CGI-86 3
  • DHRS7A 4

External Ids for DHRS7 Gene

Previous GeneCards Identifiers for DHRS7 Gene

  • GC14M058602
  • GC14M058603
  • GC14M059681
  • GC14M060610
  • GC14M040775

Summaries for DHRS7 Gene

Entrez Gene Summary for DHRS7 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]

GeneCards Summary for DHRS7 Gene

DHRS7 (Dehydrogenase/Reductase 7) is a Protein Coding gene. Diseases associated with DHRS7 include Glycogen Storage Disease Vii. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DHRS7B.

Additional gene information for DHRS7 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHRS7 Gene

Genomics for DHRS7 Gene

GeneHancer (GH) Regulatory Elements for DHRS7 Gene

Promoters and enhancers for DHRS7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J060163 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 523.2 +4.6 4553 3.4 CTCF SIN3A NRF1 POLR2G PHF8 ZFX ZNF10 POLR2A ZNF263 RBM34 DHRS7 lnc-C14orf39-3-001 PCNX4 lnc-C14orf39-3-002 SCOCP1 lnc-PPM1A-2
GH14J060210 Promoter/Enhancer 0.8 EPDnew Ensembl 500.3 -40.8 -40816 0.3 SCRT1 PRDM10 ZNF143 SCRT2 DHRS7 LOC101927702 PPM1A HSALNG0101694 lnc-DHRS7-3
GH14J060169 Promoter 0.3 EPDnew 500.7 -0.1 -52 0.1 DHRS7 lnc-C14orf39-3-002 piR-48759-089
GH14J060090 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.5 +76.1 76138 6.2 FOXK2 ZBTB40 EP300 ZSCAN5C SIN3A NRF1 TCF12 MYC USF1 POLR2G PCNX4 ENSG00000258553 LOC105370524 DHRS7 L3HYPDH TRMT5 piR-32214-191
GH14J060150 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 22.6 +17.9 17854 2.4 FOS CTBP1 MXI1 SIN3A MYC ELK1 GATA3 CEBPB POLR2A JUN DHRS7 PCNX4 RTN1 PPM1A SCOCP1 lnc-PPM1A-2 lnc-LRRC9-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHRS7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DHRS7

Top Transcription factor binding sites by QIAGEN in the DHRS7 gene promoter:
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C
  • TBP

Genomic Locations for DHRS7 Gene

Genomic Locations for DHRS7 Gene
chr14:60,144,119-60,169,856
(GRCh38/hg38)
Size:
25,738 bases
Orientation:
Minus strand
chr14:60,610,838-60,636,574
(GRCh37/hg19)
Size:
25,737 bases
Orientation:
Minus strand

Genomic View for DHRS7 Gene

Genes around DHRS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7 Gene

Proteins for DHRS7 Gene

  • Protein details for DHRS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y394-DHRS7_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 7
    Protein Accession:
    Q9Y394
    Secondary Accessions:
    • B2R896
    • Q9UKU2

    Protein attributes for DHRS7 Gene

    Size:
    339 amino acids
    Molecular mass:
    38299 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS7 Gene

Post-translational modifications for DHRS7 Gene

  • Ubiquitination at Lys123, Lys321, and Lys332
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DHRS7 Gene

Domains & Families for DHRS7 Gene

Gene Families for DHRS7 Gene

Protein Domains for DHRS7 Gene

Blocks:
  • Short-chain dehydrogenase/reductase SDR
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DHRS7 Gene

GenScript: Design optimal peptide antigens:
  • Retinal short-chain dehydrogenase/reductase 4 (DHRS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y394

UniProtKB/Swiss-Prot:

DHRS7_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7: view

Function for DHRS7 Gene

Enzyme Numbers (IUBMB) for DHRS7 Gene

Phenotypes From GWAS Catalog for DHRS7 Gene

Gene Ontology (GO) - Molecular Function for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS7: view
genes like me logo Genes that share phenotypes with DHRS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHRS7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS7

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS7 Gene

Localization for DHRS7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS7 gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DHRS7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHRS7 Gene

Pathways & Interactions for DHRS7 Gene

PathCards logo

SuperPathways for DHRS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS7 Gene

Drugs & Compounds for DHRS7 Gene

No Compound Related Data Available

Transcripts for DHRS7 Gene

mRNA/cDNA for DHRS7 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS7

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for DHRS7 Gene

GeneLoc Exon Structure for
DHRS7

Expression for DHRS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHRS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS7 Gene

This gene is overexpressed in Muscle - Skeletal (x8.3) and Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for DHRS7 Gene

This gene is overexpressed in Nasal epithelium (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS7 Gene



Protein tissue co-expression partners for DHRS7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DHRS7

SOURCE GeneReport for Unigene cluster for DHRS7 Gene:

Hs.59719

Evidence on tissue expression from TISSUES for DHRS7 Gene

  • Muscle(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Skin(4.2)
  • Lung(3)
  • Nervous system(2.9)
  • Kidney(2.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with DHRS7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS7 Gene

Orthologs for DHRS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS7 31 30
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DHRS7 31 30
  • 87.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHRS7 31 30
  • 87.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565002 30
  • 79.06 (n)
mouse
(Mus musculus)
Mammalia Dhrs7 17 31 30
  • 78.63 (n)
oppossum
(Monodelphis domestica)
Mammalia DHRS7 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS7 31 30
  • 71.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS7 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7 30
  • 65.35 (n)
Str.7096 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18967 30
zebrafish
(Danio rerio)
Actinopterygii dhrs7 31 30
  • 61.29 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2112 30
fruit fly
(Drosophila melanogaster)
Insecta CG31937 31 30
  • 47.23 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010696 30
  • 46.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03330 30
  • 50.12 (n)
rice
(Oryza sativa)
Liliopsida Os11g0265400 30
  • 45.73 (n)
Species where no ortholog for DHRS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHRS7 Gene

ENSEMBL:
Gene Tree for DHRS7 (if available)
TreeFam:
Gene Tree for DHRS7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHRS7: view image

Paralogs for DHRS7 Gene

(5) SIMAP similar genes for DHRS7 Gene using alignment to 5 proteins:

  • DHRS7_HUMAN
  • G3V5J0_HUMAN
  • H0YJ66_HUMAN
  • H0YJE4_HUMAN
  • H0YJR8_HUMAN
genes like me logo Genes that share paralogs with DHRS7: view

Variants for DHRS7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DHRS7 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs34583017 - p.Arg218Gln

Additional dbSNP identifiers (rs#s) for DHRS7 Gene

Structural Variations from Database of Genomic Variants (DGV) for DHRS7 Gene

Variant ID Type Subtype PubMed ID
esv2671510 CNV deletion 23128226
esv3551618 CNV deletion 23714750
esv3634667 CNV loss 21293372
nsv1044390 CNV loss 25217958
nsv1293 CNV insertion 18451855

Variation tolerance for DHRS7 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS7 Gene

Disorders for DHRS7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DHRS7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
glycogen storage disease vii
  • gsd7
- elite association - COSMIC cancer census association via MalaCards
Search DHRS7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DHRS7

genes like me logo Genes that share disorders with DHRS7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHRS7 Gene

Publications for DHRS7 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 54
  2. Short-chain dehydrogenases/reductases in retina. (PMID: 10800688) Haeseleer F … Palczewski K (Methods in enzymology 2000) 2 3 4 54
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 54

Products for DHRS7 Gene

Sources for DHRS7 Gene