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Aliases for DHRS7 Gene

Aliases for DHRS7 Gene

  • Dehydrogenase/Reductase 7 2 3 5
  • Retinal Short-Chain Dehydrogenase/Reductase 4 2 3 4
  • Short Chain Dehydrogenase/Reductase Family 34C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 7 2 3
  • SDR34C1 3 4
  • RetSDR4 3 4
  • Short Chain Dehydrogenase/Reductase Family 34C, Member 1 2
  • Dehydrogenase/Reductase SDR Family Member 7 3
  • EC 1.1.-.- 4
  • RetDSR4 3
  • RETSDR4 4
  • CGI-86 3
  • DHRS7A 4

External Ids for DHRS7 Gene

Previous GeneCards Identifiers for DHRS7 Gene

  • GC14M058602
  • GC14M058603
  • GC14M059681
  • GC14M060610
  • GC14M040775

Summaries for DHRS7 Gene

Entrez Gene Summary for DHRS7 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]

GeneCards Summary for DHRS7 Gene

DHRS7 (Dehydrogenase/Reductase 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DHRS7B.

Additional gene information for DHRS7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS7 Gene

Genomics for DHRS7 Gene

GeneHancer (GH) Regulatory Elements for DHRS7 Gene

Promoters and enhancers for DHRS7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J060163 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 673.2 +4.5 4462 3.2 ATF1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF207 DHRS7 PCNX4 GC14P060159 SCOCP1
GH14J060210 Promoter 0.7 EPDnew 650.3 -40.7 -40717 0.1 ZNF143 PRDM10 DHRS7 LOC101927702 PPM1A RPL17P2 GC14P060180
GH14J060169 Promoter 0.5 EPDnew 650.7 -0.1 -52 0.1 DHRS7 PSMA3P
GH14J060150 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +17.9 17854 2.4 PKNOX1 ZNF146 JUN MAX SIN3A CTBP1 GATA3 ELK1 POLR2A VEZF1 DHRS7 PCNX4 RTN1 PPM1A GC14P060159 SCOCP1 GC14P060140
GH14J060090 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 15.5 +76.1 76137 6.2 HDGF FOXA2 PKNOX1 MLX ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 PCNX4 LOC105370524 SCOCP1 DHRS7 L3HYPDH TRMT5 GC14P060140
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHRS7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS7 gene promoter:
  • POU2F2C
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • TBP

Genomic Locations for DHRS7 Gene

Genomic Locations for DHRS7 Gene
25,737 bases
Minus strand
25,737 bases
Minus strand

Genomic View for DHRS7 Gene

Genes around DHRS7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS7 Gene

Proteins for DHRS7 Gene

  • Protein details for DHRS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 7
    Protein Accession:
    Secondary Accessions:
    • B2R896
    • Q9UKU2

    Protein attributes for DHRS7 Gene

    339 amino acids
    Molecular mass:
    38299 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS7 Gene


neXtProt entry for DHRS7 Gene

Post-translational modifications for DHRS7 Gene

  • Ubiquitination at posLast=332332, Lys321, and Lys123
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DHRS7 Gene

Domains & Families for DHRS7 Gene

Gene Families for DHRS7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for DHRS7 Gene

Suggested Antigen Peptide Sequences for DHRS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS7: view

Function for DHRS7 Gene

Enzyme Numbers (IUBMB) for DHRS7 Gene

Gene Ontology (GO) - Molecular Function for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS7: view
genes like me logo Genes that share phenotypes with DHRS7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DHRS7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS7

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS7 Gene

Localization for DHRS7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS7 gene
Compartment Confidence
endoplasmic reticulum 3
mitochondrion 2
nucleus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DHRS7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHRS7 Gene

Pathways & Interactions for DHRS7 Gene

SuperPathways for DHRS7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS7: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS7 Gene

Drugs & Compounds for DHRS7 Gene

No Compound Related Data Available

Transcripts for DHRS7 Gene

Unigene Clusters for DHRS7 Gene

Dehydrogenase/reductase (SDR family) member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS7

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - - -
SP2: - -
SP3: - -

Relevant External Links for DHRS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS7 Gene

This gene is overexpressed in Muscle - Skeletal (x8.3) and Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for DHRS7 Gene

This gene is overexpressed in Nasal epithelium (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS7 Gene

Protein tissue co-expression partners for DHRS7 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS7 Gene:


SOURCE GeneReport for Unigene cluster for DHRS7 Gene:


Evidence on tissue expression from TISSUES for DHRS7 Gene

  • Muscle(4.5)
  • Eye(4.4)
  • Liver(4.4)
  • Skin(4.2)
  • Lung(3)
  • Nervous system(2.9)
  • Kidney(2.5)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with DHRS7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS7 Gene

Orthologs for DHRS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHRS7 34 33
  • 99.61 (n)
(Canis familiaris)
Mammalia DHRS7 34 33
  • 87.66 (n)
(Bos Taurus)
Mammalia DHRS7 34 33
  • 87.22 (n)
(Rattus norvegicus)
Mammalia RGD1565002 33
  • 79.06 (n)
(Mus musculus)
Mammalia Dhrs7 16 34 33
  • 78.63 (n)
(Monodelphis domestica)
Mammalia DHRS7 34
  • 76 (a)
(Gallus gallus)
Aves DHRS7 34 33
  • 71.24 (n)
(Anolis carolinensis)
Reptilia DHRS7 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs7 33
  • 65.35 (n)
Str.7096 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18967 33
(Danio rerio)
Actinopterygii dhrs7 34 33
  • 61.29 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2112 33
fruit fly
(Drosophila melanogaster)
Insecta CG31937 34 33
  • 47.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010696 33
  • 46.54 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03330 33
  • 50.12 (n)
(Oryza sativa)
Liliopsida Os11g0265400 33
  • 45.73 (n)
Species where no ortholog for DHRS7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHRS7 Gene

Gene Tree for DHRS7 (if available)
Gene Tree for DHRS7 (if available)
Evolutionary constrained regions (ECRs) for DHRS7: view image

Paralogs for DHRS7 Gene

(5) SIMAP similar genes for DHRS7 Gene using alignment to 5 proteins:

  • G3V5J0_HUMAN
  • H0YJ66_HUMAN
genes like me logo Genes that share paralogs with DHRS7: view

Variants for DHRS7 Gene

Sequence variations from dbSNP and Humsavar for DHRS7 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000054383 -- 60,145,203(-) C/A/T genic_downstream_transcript_variant, intron_variant
rs1000163854 -- 60,144,151(-) AATAATA/AATA 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000438300 -- 60,151,237(-) T/C intron_variant
rs1000444571 -- 60,152,788(-) T/C intron_variant
rs1000505381 -- 60,145,757(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS7 Gene

Variant ID Type Subtype PubMed ID
esv2671510 CNV deletion 23128226
esv3551618 CNV deletion 23714750
esv3634667 CNV loss 21293372
nsv1044390 CNV loss 25217958
nsv1293 CNV insertion 18451855

Variation tolerance for DHRS7 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS7 Gene

Disorders for DHRS7 Gene

Additional Disease Information for DHRS7

No disorders were found for DHRS7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS7 Gene

Publications for DHRS7 Gene

  1. Short-chain dehydrogenases/reductases in retina. (PMID: 10800688) Haeseleer F … Palczewski K (Methods in enzymology 2000) 2 3 4 58
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58

Products for DHRS7 Gene

Sources for DHRS7 Gene

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