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Aliases for DHRS4L2 Gene

Aliases for DHRS4L2 Gene

  • Dehydrogenase/Reductase 4 Like 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 25C Member 3 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2 2 3
  • SDR25C3 3 4
  • NADP(H)-Dependent Retinol Dehydrogenase/Reductase Short Isoform-Like Protein 3
  • NADPH-Dependent Retinol Dehydrogenase/Reductase-Like Protein 2 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 3 2
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A3 3
  • Dehydrogenase/Reductase SDR Family Member 4-Like 2 3
  • EC 56
  • EC 1.1.-.- 4
  • EC 1.1.1 56

External Ids for DHRS4L2 Gene

Previous GeneCards Identifiers for DHRS4L2 Gene

  • GC14U900021
  • GC14P022448
  • GC14P023527
  • GC14P024458
  • GC14P004556
  • GC14P024444
  • GC14P023970
  • GC14P023971
  • GC14P024065

Summaries for DHRS4L2 Gene

Entrez Gene Summary for DHRS4L2 Gene

  • This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

GeneCards Summary for DHRS4L2 Gene

DHRS4L2 (Dehydrogenase/Reductase 4 Like 2) is a Protein Coding gene. Among its related pathways are Metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DHRS4.

UniProtKB/Swiss-Prot for DHRS4L2 Gene

  • Probable oxidoreductase.

Additional gene information for DHRS4L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4L2 Gene

Genomics for DHRS4L2 Gene

GeneHancer (GH) Regulatory Elements for DHRS4L2 Gene

Promoters and enhancers for DHRS4L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I023988 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 569.4 +19.3 19343 1.9 ELF3 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 BATF ZNF48 RAD21 DHRS4L2 DHRS4-AS1 PIR45783 DHRS4L1
GH14I023969 Promoter 1.6 EPDnew Ensembl 564.5 +0.2 227 0.6 FOXA2 RB1 ARID4B DMAP1 ZNF48 THAP11 MIXL1 MXD4 MIER2 KAT8 DHRS4L2 DHRS4L1 NYNRIN DHRS4-AS1 PIR45783
GH14I024035 Promoter/Enhancer 1.5 Ensembl ENCODE 12.7 +66.7 66723 1.7 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF213 PIR58946 ACIN1 DHRS4L1 RNA5SP383 KHNYN TM9SF1 C14orf119 LOC102724814 DHRS4L2 RNF31
GH14I024006 Enhancer 1 Ensembl ENCODE 17.2 +37.1 37127 2 FOXA2 KLF17 SIN3A ZNF2 ZNF335 RCOR1 EGR2 ZNF398 ZEB2 ZNF610 DHRS4L1 DHRS4L2 C14orf93 ADCY4 DHRS4-AS1
GH14I024032 Enhancer 1.1 Ensembl ENCODE 13.4 +63.5 63461 1 PKNOX1 FOXA2 MLX ARID4B SIN3A TCF12 FOS RXRA REST KAT8 DHRS4L2 DHRS4 PCK2 NRL PIR58946 DHRS4L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHRS4L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS4L2 gene promoter:

Genomic Locations for DHRS4L2 Gene

Genomic Locations for DHRS4L2 Gene
36,535 bases
Plus strand

Genomic View for DHRS4L2 Gene

Genes around DHRS4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS4L2 Gene

Proteins for DHRS4L2 Gene

  • Protein details for DHRS4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 4-like 2
    Protein Accession:
    Secondary Accessions:
    • Q3YLD4

    Protein attributes for DHRS4L2 Gene

    230 amino acids
    Molecular mass:
    24586 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS4L2 Gene


neXtProt entry for DHRS4L2 Gene

Selected DME Specific Peptides for DHRS4L2 Gene


Post-translational modifications for DHRS4L2 Gene

No Post-translational modifications

Domains & Families for DHRS4L2 Gene

Gene Families for DHRS4L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4L2: view

Function for DHRS4L2 Gene

Molecular function for DHRS4L2 Gene

UniProtKB/Swiss-Prot Function:
Probable oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS4L2 Gene

Gene Ontology (GO) - Molecular Function for DHRS4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS4L2: view
genes like me logo Genes that share phenotypes with DHRS4L2: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS4L2 Gene

Localization for DHRS4L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS4L2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS4L2 gene
Compartment Confidence
mitochondrion 4
extracellular 3
peroxisome 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRS4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with DHRS4L2: view

Pathways & Interactions for DHRS4L2 Gene

genes like me logo Genes that share pathways with DHRS4L2: view

Pathways by source for DHRS4L2 Gene

2 KEGG pathways for DHRS4L2 Gene

Interacting Proteins for DHRS4L2 Gene

Gene Ontology (GO) - Biological Process for DHRS4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS4L2: view

No data available for SIGNOR curated interactions for DHRS4L2 Gene

Drugs & Compounds for DHRS4L2 Gene

(1) Drugs for DHRS4L2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Matairesinol Experimental Pharma Target 0
genes like me logo Genes that share compounds with DHRS4L2: view

Transcripts for DHRS4L2 Gene

Unigene Clusters for DHRS4L2 Gene

Dehydrogenase/reductase (SDR family) member 4 like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4L2 Gene

No ASD Table

Relevant External Links for DHRS4L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS4L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS4L2 Gene

Protein differential expression in normal tissues from HIPED for DHRS4L2 Gene

This gene is overexpressed in Heart (61.4) and Skin (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DHRS4L2 Gene

Protein tissue co-expression partners for DHRS4L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS4L2 Gene:


SOURCE GeneReport for Unigene cluster for DHRS4L2 Gene:


Evidence on tissue expression from TISSUES for DHRS4L2 Gene

  • Intestine(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DHRS4L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS4L2 Gene

Orthologs for DHRS4L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS4L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DHRS4 34
  • 63 (a)
(Canis familiaris)
Mammalia DHRS4 34
  • 63 (a)
(Mus musculus)
Mammalia Dhrs4 34
  • 61 (a)
(Pan troglodytes)
Mammalia DHRS4L1 34
  • 60 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
-- 34
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
(Danio rerio)
Actinopterygii DHRS2 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10672 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea dhs-13 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
-- 34
  • 21 (a)
Species where no ortholog for DHRS4L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHRS4L2 Gene

Gene Tree for DHRS4L2 (if available)
Gene Tree for DHRS4L2 (if available)

Paralogs for DHRS4L2 Gene

Paralogs for DHRS4L2 Gene Pseudogenes for DHRS4L2 Gene

genes like me logo Genes that share paralogs with DHRS4L2: view

Variants for DHRS4L2 Gene

Sequence variations from dbSNP and Humsavar for DHRS4L2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000018297 -- 23,999,391(+) T/A intron_variant
rs1000350673 -- 23,982,010(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000406302 -- 23,982,106(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000450623 -- 23,987,701(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000693919 -- 23,983,110(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS4L2 Gene

Variant ID Type Subtype PubMed ID
nsv983807 CNV duplication 23825009
nsv983806 CNV duplication 23825009
nsv976322 CNV duplication 23825009
nsv9124 CNV loss 18304495
nsv91 CNV deletion 15895083
nsv89 CNV deletion 15895083
nsv84893 CNV deletion 16902084
nsv826901 CNV loss 20364138
nsv564048 CNV loss 21841781
nsv564047 CNV loss 21841781
nsv564046 CNV loss 21841781
nsv513749 CNV insertion 21212237
nsv512352 CNV loss 21212237
nsv511030 OTHER complex 20534489
nsv510630 CNV deletion 20534489
nsv509528 CNV insertion 20534489
nsv482169 CNV gain 20164927
nsv436830 CNV insertion 17901297
nsv436726 CNV insertion 17901297
nsv1218 CNV insertion 18451855
nsv1217 CNV deletion 18451855
nsv1052180 CNV loss 25217958
esv988372 CNV deletion 20482838
esv3892478 CNV loss 25118596
esv3892477 CNV loss 25118596
esv3633796 CNV gain 21293372
esv3633795 CNV loss 21293372
esv3633794 CNV loss 21293372
esv3633793 CNV loss 21293372
esv3633792 CNV loss 21293372
esv3633791 CNV gain 21293372
esv3633790 CNV loss 21293372
esv3581079 CNV loss 25503493
esv3551252 CNV deletion 23714750
esv33403 CNV loss 17666407
esv28806 CNV loss 19812545
esv2748488 CNV deletion 23290073
esv2748487 CNV deletion 23290073
esv2421714 CNV deletion 20811451
esv1586699 CNV deletion 17803354
dgv618e212 CNV loss 25503493
dgv617e212 CNV loss 25503493
dgv36e203 CNV gain+loss 21179565
dgv3580n54 CNV loss 21841781
dgv20n47 CNV gain 21111241
dgv1848n100 CNV gain 25217958
dgv1847n100 CNV gain 25217958
dgv1846n100 CNV loss 25217958
dgv1845n100 CNV loss 25217958
dgv1844n100 CNV gain 25217958
dgv1843n100 CNV gain+loss 25217958
dgv1842n100 CNV loss 25217958
dgv1841n100 CNV gain+loss 25217958
dgv1840n100 CNV gain+loss 25217958
dgv1839n100 CNV loss 25217958
dgv1838n100 CNV gain 25217958
dgv1837n100 CNV loss 25217958

Variation tolerance for DHRS4L2 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.47; 94.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS4L2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS4L2 Gene

Disorders for DHRS4L2 Gene

Additional Disease Information for DHRS4L2

No disorders were found for DHRS4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4L2 Gene

Publications for DHRS4L2 Gene

  1. Non-EST based prediction of exon skipping and intron retention events using Pfam information. (PMID: 16204458) Hiller M … Backofen R (Nucleic acids research 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. (PMID: 23036705) Gabrielli F … Tofanelli S (Gene 2012) 3 58

Products for DHRS4L2 Gene

Sources for DHRS4L2 Gene

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