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DHRS4 (Dehydrogenase/Reductase 4) is a Protein Coding gene. Diseases associated with DHRS4 include Anismus and Subclavian Steal Syndrome. Among its related pathways are Signaling by GPCR and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. An important paralog of this gene is DHRS4L2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000253 | 3-keto sterol reductase activity | IDA | 18571493 |
GO:0004090 | carbonyl reductase (NADPH) activity | IEA,IDA | 18571493 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | IDA | 19442656 |
GO:0018455 | alcohol dehydrogenase [NAD(P)+] activity | IDA | 18571493 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005739 | mitochondrion | ISS | -- |
GO:0005777 | peroxisome | IEA,IDA | 17230527 |
GO:0005778 | peroxisomal membrane | IDA | 10333503 |
GO:0005782 | peroxisomal matrix | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 |
Retinol metabolism
.31
|
|
2 | Signaling by Retinoic Acid | ||
3 | the visual cycle I (vertebrates) | ||
4 | Metabolism | ||
5 | Peroxisome |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006066 | alcohol metabolic process | IDA | 18571493 |
GO:0006625 | protein targeting to peroxisome | TAS | -- |
GO:0008202 | steroid metabolic process | IDA | 18571493 |
GO:0042180 | cellular ketone metabolic process | IDA | 18571493 |
GO:0055114 | oxidation-reduction process | TAS | 10333503 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DHRS4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DHRS4 30 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | DHRS4 30 31 |
|
OneToMany | |
Rat (Rattus norvegicus) |
Mammalia | Dhrs4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dhrs4 30 17 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | DHRS4 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dhrs4 30 |
|
||
Str.11257 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | DHRS2 31 |
|
OneToMany | |
zgc:65987 30 |
|
||||
-- 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4702 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007475 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10672 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | dhs-13 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 33 |
|
|
|
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | IBR1 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3445 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0133200 30 |
|
||
Os.8274 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.3716 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.3359 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
736886 | Likely Benign: not provided | 23,955,097(+) | G/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
768639 | Likely Benign: not provided | 23,959,985(+) | T/C | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
778993 | Benign: not provided | 23,966,355(+) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
790140 | Benign: not provided | 23,953,822(+) | C/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
rs1043442 | - | p.Ala31Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1837n100 | CNV | loss | 25217958 |
dgv1838n100 | CNV | gain | 25217958 |
dgv1839n100 | CNV | loss | 25217958 |
dgv1840n100 | CNV | gain+loss | 25217958 |
dgv1841n100 | CNV | gain+loss | 25217958 |
dgv36e203 | CNV | gain+loss | 21179565 |
esv2421714 | CNV | deletion | 20811451 |
esv27040 | CNV | loss | 19812545 |
esv2748487 | CNV | deletion | 23290073 |
esv33403 | CNV | loss | 17666407 |
esv3633790 | CNV | loss | 21293372 |
esv3633791 | CNV | gain | 21293372 |
esv3633792 | CNV | loss | 21293372 |
nsv1052180 | CNV | loss | 25217958 |
nsv1217 | CNV | deletion | 18451855 |
nsv1218 | CNV | insertion | 18451855 |
nsv509528 | CNV | insertion | 20534489 |
nsv511030 | OTHER | complex | 20534489 |
nsv564046 | CNV | loss | 21841781 |
nsv564047 | CNV | loss | 21841781 |
nsv89 | CNV | deletion | 15895083 |
nsv9124 | CNV | loss | 18304495 |
nsv974316 | CNV | duplication | 23825009 |
nsv983806 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
anismus |
|
|
subclavian steal syndrome |
|
|
peroxisomal acyl-coa oxidase deficiency |
|
|
superior semicircular canal dehiscence |
|
|