Aliases for DHRS4 Gene
Aliases for DHRS4 Gene
- Dehydrogenase/Reductase 4 2 3 5
- NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase 3 4
- Short Chain Dehydrogenase/Reductase Family 25C Member 2 3 4
- Short-Chain Dehydrogenase/Reductase Family Member 4 3 4
- NADPH-Dependent Retinol Dehydrogenase/Reductase 3 4
- Peroxisomal Short-Chain Alcohol Dehydrogenase 3 4
- SCAD-SRL 3 4
- SDR25C2 3 4
- NRDR 3 4
- PHCR 3 4
- PSCD 3 4
- CR 3 4
- Short Chain Dehydrogenase/Reductase Family 25C, Member 1 3
- Short Chain Dehydrogenase/Reductase Family 25C, Member 2 2
- Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A 3
- Dehydrogenase/Reductase (SDR Family) Member 4 2
- Dehydrogenase/Reductase SDR Family Member 4 3
- EC 1.1.1.184 4
- SDR-SRL 3
- SDR25C1 3
- HumNRDR 4
External Ids for DHRS4 Gene
- HGNC: 16985
- Entrez Gene: 10901
- Ensembl: ENSG00000157326
- OMIM: 611596
- UniProtKB: Q9BTZ2
Previous GeneCards Identifiers for DHRS4 Gene
- GC14P018210
- GC14P022413
- GC14P023492
- GC14P024422
- GC14P004539
Summaries for DHRS4 Gene
GeneCards Summary for DHRS4 Gene
DHRS4 (Dehydrogenase/Reductase 4) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and the visual cycle I (vertebrates). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. An important paralog of this gene is DHRS4L2.
UniProtKB/Swiss-Prot for DHRS4 Gene
-
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS4 Gene
Genomics for DHRS4 Gene
GeneHancer (GH) Regulatory Elements for DHRS4 Gene
Promoters and enhancers for DHRS4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DHRS4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DHRS4 gene promoter:
-
- SRF (504 AA)
- SRF
- Pax-4a
- HEN1
Regulatory Element Products
Genomic Locations for DHRS4 Gene
Genomic Locations for DHRS4 Gene
- chr14:23,953,586-23,969,279
- (GRCh38/hg38)
- Size:
- 15,694 bases
- Orientation:
- Plus strand
- chr14:24,422,795-24,438,488
- (GRCh37/hg19)
- Size:
- 15,694 bases
- Orientation:
- Plus strand
Genomic View for DHRS4 Gene
Genes around DHRS4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
- 14q11.2 by Ensembl
DHRS4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DHRS4 Gene
Proteins for DHRS4 Gene
-
Protein details for DHRS4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BTZ2-DHRS4_HUMAN
- Recommended name:
- Dehydrogenase/reductase SDR family member 4
- Protein Accession:
- Q9BTZ2
- B2RB10
- B7WNS9
- D3YTB8
- E2QRL8
- O95162
- Q20CR0
- Q2LC19
- Q2LE81
- Q58IU4
- Q6E0Y1
- Q6UWU3
- Q71UQ6
- Q8TD03
- Q9H3N5
- Q9NV08
Protein attributes for DHRS4 Gene
- Size:
- 278 amino acids
- Molecular mass:
- 29537 Da
- Quaternary structure:
-
- Homotetramer.
- Miscellaneous:
-
- Inhibited by kaempferol, quercetin, genistein and myristic acid.
- SequenceCaution:
-
- Sequence=AAD02292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for DHRS4 Gene
Post-translational modifications for DHRS4 Gene
Other Protein References for DHRS4 Gene
Antibody Products
- Novus Biologicals Antibodies for DHRS4
- Invitrogen Antibodies for DHRS4 (AFLGC-DHRS4)
- GeneTex DHRS4 Antibody for DHRS4
-
Boster Bio Antibodies for DHRS4
Protein Products
-
OriGene Purified Proteins for DHRS4
- Search Origene for MassSpec and Protein Over-expression Lysates for DHRS4
- Origene Custom Protein Services for DHRS4
- ProSpec Recombinant Proteins for DHRS4
- Search GeneTex for Proteins for DHRS4
-
Abcam proteins for DHRS4
Assay Products
No data available for DME Specific Peptides for DHRS4 Gene
Domains & Families for DHRS4 Gene
Gene Families for DHRS4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DHRS4 Gene
Suggested Antigen Peptide Sequences for DHRS4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BTZ2UniProtKB/Swiss-Prot:
DHRS4_HUMAN :- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
- Family:
-
- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Function for DHRS4 Gene
Molecular function for DHRS4 Gene
- UniProtKB/Swiss-Prot Function:
- Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- R-CHOH-R + NADP(+) = R-CO-R + NADPH.
Enzyme Numbers (IUBMB) for DHRS4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000253 | 3-keto sterol reductase activity | IDA | 18571493 |
| GO:0004090 | carbonyl reductase (NADPH) activity | IDA,IEA | 18571493 |
| GO:0005102 | signaling receptor binding | IPI | 20178365 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | IDA | 19442656 |
Phenotypes for DHRS4 Gene
- MGI mutant phenotypes for DHRS4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DHRS4:
-
- Increased shRNA abundance (Z-score > 2)
- Multipolar spindles
- G0/1 arrest
- Increased G1 DNA content
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
Animal Models for DHRS4 Gene
- MGI Knock Outs for DHRS4:
-
- Dhrs4 Dhrs4<tm1Lex>
Animal Model Products
-
Taconic Biosciences Mouse Models for DHRS4
- Cyagen custom Knockout/knockin (KOKI) mouse models for DHRS4
-
CRISPR Products
-
OriGene CRISPR knockouts for DHRS4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DHRS4
- genomics-online: gRNA clones - Search results for available DHRS4 gene related products
- Applied Biological Materials CRISPR for DHRS4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DHRS4
- GenScript: Design CRISPR guide RNA sequences for DHRS4
miRNA for DHRS4 Gene
- miRTarBase miRNAs that target DHRS4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DHRS4
- Browse OriGene Inhibitory RNA Products For DHRS4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS4
- genomics-online: shRNA clones - Search results for available DHRS4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DHRS4
- Addgene plasmids for DHRS4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DHRS4
- genomics-online: cdna clones - Search results for available DHRS4 gene related products
- orf clones - Search results for available DHRS4 gene related products
- Applied Biological Materials Clones for DHRS4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DHRS4
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHRS4 Gene
Localization for DHRS4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DHRS4 Gene
- Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
- Isoform 7: Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| peroxisome | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 4 |
| cytosol | 2 |
- Nuclear membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005739 | mitochondrion | ISS | -- |
| GO:0005777 | peroxisome | IDA,IEA | 17230527 |
| GO:0005778 | peroxisomal membrane | IDA | 10333503 |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
Pathways & Interactions for DHRS4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Signaling by Retinoic Acid | ||
| 3 | the visual cycle I (vertebrates) | ||
| 4 | Metabolism | ||
| 5 | Peroxisome | ||
Pathways by source for DHRS4 Gene
2 BioSystems pathways for DHRS4 Gene
3 Reactome pathways for DHRS4 Gene
3 KEGG pathways for DHRS4 Gene
2 GeneGo (Thomson Reuters) pathways for DHRS4 Gene
Interacting Proteins for DHRS4 Gene
GPS-Prot Interaction Network for DHRS4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006066 | alcohol metabolic process | IDA | 18571493 |
| GO:0008202 | steroid metabolic process | IDA | 18571493 |
| GO:0042180 | cellular ketone metabolic process | IDA | 18571493 |
| GO:0042572 | retinol metabolic process | IEA | -- |
| GO:0051262 | protein tetramerization | IDA | 18571493 |
No data available for SIGNOR curated interactions for DHRS4 Gene
Drugs & Compounds for DHRS4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vitamin A | Approved, Vet_approved | Nutra | Target | 529 | ||
| Menadione | Approved | Nutra | 257 | |||
| Myristic acid | Experimental | Pharma | 0 | |||
| Genistein | Investigational | Pharma | Potentiation, Activator, Agonist | AR agonist, EGFR kinase inhibitor. Also estrogen and PPARgamma ligand | 58 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| NADP |
|
53-59-8 |
|
Drug Products
Transcripts for DHRS4 Gene
mRNA/cDNA for DHRS4 Gene
- (8) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (336) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000313250 1443 bps (uc001wla.5)
- ENST00000558263 1089 bps (uc032avu.2)
- ENST00000543741 1340 bps (uc010aky.4)
- ENST00000397075 727 bps (uc032avv.2)
- ENST00000397074 785 bps (uc032avw.2)
Unigene Clusters for DHRS4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DHRS4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DHRS4
- genomics-online: gRNA clones - Search results for available DHRS4 gene related products
- Applied Biological Materials CRISPR for DHRS4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DHRS4
- GenScript: Design CRISPR guide RNA sequences for DHRS4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DHRS4
- Browse OriGene Inhibitory RNA Products For DHRS4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS4
- genomics-online: shRNA clones - Search results for available DHRS4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for DHRS4
- Addgene plasmids for DHRS4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DHRS4
- genomics-online: cdna clones - Search results for available DHRS4 gene related products
- orf clones - Search results for available DHRS4 gene related products
- Applied Biological Materials Clones for DHRS4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - |
Expression for DHRS4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Gallbladder (18.7), Liver (7.7), and Kidney (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DHRS4 Gene:
DHRS4SOURCE GeneReport for Unigene cluster for DHRS4 Gene:
Hs.528385mRNA Expression by UniProt/SwissProt for DHRS4 Gene:
Q9BTZ2-DHRS4_HUMAN
Tissue specificity:
Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.
Evidence on tissue expression from TISSUES for DHRS4 Gene
- Liver(4.6)
- Lung(4.5)
- Muscle(4.3)
- Nervous system(3.4)
Primer Products
-
OriGene qPCR primer pairs for DHRS4
-
OriGene qPCR primer pairs and template standards for DHRS4
- genomics-online: primer clones - Search results for available DHRS4 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS4 Gene
Orthologs for DHRS4 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DHRS4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DHRS4 34 33 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | DHRS4 34 33 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Dhrs4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dhrs4 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | DHRS4 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dhrs4 33 |
|
||
| Str.11257 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | DHRS2 34 |
|
OneToMany | |
| zgc:65987 33 |
|
||||
| -- 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4702 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007475 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10672 34 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | dhs-13 34 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 36 |
|
|
|
| thale cress (Arabidopsis thaliana) |
eudicotyledons | IBR1 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3445 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0133200 33 |
|
||
| Os.8274 33 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.3359 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3716 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for DHRS4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for DHRS4 Gene
- ENSEMBL:
- Gene Tree for DHRS4 (if available)
- TreeFam:
- Gene Tree for DHRS4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DHRS4: view image
Paralogs for DHRS4 Gene
Paralogs for DHRS4 Gene
(8) SIMAP similar genes for DHRS4 Gene using alignment to 6 proteins:
- DHRS4_HUMAN
- E2QRI3_HUMAN
- F5GWZ1_HUMAN
- H0YNP7_HUMAN
- H7BYG2_HUMAN
- J3QST2_HUMAN
Pseudogenes.org Pseudogenes for DHRS4 Gene
Variants for DHRS4 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000147013 | -- | 23,954,276(+) | G/A/C | intron_variant | |
| rs1000533366 | -- | 23,951,858(+) | G/A/T | upstream_transcript_variant | |
| rs1000987488 | -- | 23,952,050(+) | C/G | upstream_transcript_variant | |
| rs1001262882 | -- | 23,955,638(+) | A/T | intron_variant | |
| rs1001315120 | -- | 23,955,891(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1837n100 | CNV | loss | 25217958 |
| dgv1838n100 | CNV | gain | 25217958 |
| dgv1839n100 | CNV | loss | 25217958 |
| dgv1840n100 | CNV | gain+loss | 25217958 |
| dgv1841n100 | CNV | gain+loss | 25217958 |
| dgv36e203 | CNV | gain+loss | 21179565 |
| esv2421714 | CNV | deletion | 20811451 |
| esv27040 | CNV | loss | 19812545 |
| esv2748487 | CNV | deletion | 23290073 |
| esv33403 | CNV | loss | 17666407 |
| esv3633790 | CNV | loss | 21293372 |
| esv3633791 | CNV | gain | 21293372 |
| esv3633792 | CNV | loss | 21293372 |
| nsv1052180 | CNV | loss | 25217958 |
| nsv1217 | CNV | deletion | 18451855 |
| nsv1218 | CNV | insertion | 18451855 |
| nsv509528 | CNV | insertion | 20534489 |
| nsv511030 | OTHER | complex | 20534489 |
| nsv564046 | CNV | loss | 21841781 |
| nsv564047 | CNV | loss | 21841781 |
| nsv89 | CNV | deletion | 15895083 |
| nsv9124 | CNV | loss | 18304495 |
| nsv974316 | CNV | duplication | 23825009 |
| nsv983806 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.04;
75.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DHRS4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DHRS4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS4 Gene
Disorders for DHRS4 Gene
Additional Disease Information for DHRS4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for DHRS4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS4 Gene
Publications for DHRS4 Gene
- Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M … Subramani S (The Biochemical journal 1999) 2 3 4 58
- Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of benzil. (PMID: 23128527) Yan Y … Huang D (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012) 3 4 58
- Identification of a novel isoform of DHRS4 protein with a nuclear localization signal. (PMID: 22227495) Su Z … Huang D (Gene 2012) 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 58
Products for DHRS4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- OriGene Purified Proteins for DHRS4
- Search Origene for MassSpec and Protein Over-expression Lysates for DHRS4
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for DHRS4
- Browse OriGene Inhibitory RNA Products For DHRS4
- OriGene qPCR primer pairs for DHRS4
- OriGene qPCR primer pairs and template standards for DHRS4
- OriGene CRISPR knockouts for DHRS4
- OriGene ORF clones in human for DHRS4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DHRS4
- GenScript: Next-day shipping of latest version cDNA ORF clones for DHRS4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DHRS4
- GenScript Custom Assay Services for DHRS4
- GenScript Custom overexpressing Cell Line Services for DHRS4
- GenScript: Design CRISPR guide RNA sequences for DHRS4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DHRS4
- Sino Biological Human cDNA Clone for DHRS4
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for DHRS4
- Novus Biologicals proteins and lysates for DHRS4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam proteins for DHRS4
- Find your target
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- ProSpec Recombinant Proteins for DHRS4
- Taconic Biosciences Mouse Models for DHRS4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DHRS4 (AFLGC-DHRS4)
- Cyagen custom Knockout/knockin (KOKI) mouse models for DHRS4
- Addgene plasmids for DHRS4
- antibodies-online: Search results for 37 available DHRS4 Antibodies ranked by validation data
- Compare Top DHRS4 Antibodies
- antibodies-online: Search results for available DHRS4 related products ranked by validation data
- antibodies-online: Search results for 9 available DHRS4 Proteins ranked by validation data
- Compare Top DHRS4 Proteins
- Quality Products:
- GeneTex DHRS4 Antibody for DHRS4
- Search GeneTex for Proteins for DHRS4
- Horizon Cell Lines for DHRS4
- genomics-online: cdna clones - Search results for available DHRS4 gene related products
- orf clones - Search results for available DHRS4 gene related products
- genomics-online: gRNA clones - Search results for available DHRS4 gene related products
- genomics-online: primer clones - Search results for available DHRS4 gene related products
- genomics-online: shRNA clones - Search results for available DHRS4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DHRS4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DHRS4
- GeneCopoeia miRNA 3'UTR Target clone products for DHRS4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS4
- Boster Bio Antibodies for DHRS4
- Browse Boster Bio ELISA Kits
Sources for DHRS4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt