DHRS4 Gene (Protein Coding)

Dehydrogenase/Reductase 4

GC14P023953
GIFtS:
44
See more...

Aliases for DHRS4 Gene

Aliases for DHRS4 Gene

  • Dehydrogenase/Reductase 4 2 3 5
  • SCAD-SRL 2 3 4
  • SDR25C2 2 3 4
  • NADPH-Dependent Carbonyl Reductase/NADP-Retinol Dehydrogenase 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C Member 2 3 4
  • Short-Chain Dehydrogenase/Reductase Family Member 4 3 4
  • NADPH-Dependent Retinol Dehydrogenase/Reductase 3 4
  • Peroxisomal Short-Chain Alcohol Dehydrogenase 3 4
  • Dehydrogenase/Reductase SDR Family Member 4 3 4
  • EC 1.1.1.184 4 51
  • SDR-SRL 2 3
  • HumNRDR 2 4
  • NRDR 3 4
  • PHCR 3 4
  • PSCD 3 4
  • CR 3 4
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 2 2
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 1 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 Like 2A 3
  • Dehydrogenase/Reductase (SDR Family) Member 4 2
  • FLJ11008 2
  • EC 1.1.1 51
  • SDR25C1 3
  • DHRS4 5

External Ids for DHRS4 Gene

Previous GeneCards Identifiers for DHRS4 Gene

  • GC14P018210
  • GC14P022413
  • GC14P023492
  • GC14P024422
  • GC14P004539

Summaries for DHRS4 Gene

GeneCards Summary for DHRS4 Gene

DHRS4 (Dehydrogenase/Reductase 4) is a Protein Coding gene. Diseases associated with DHRS4 include Anismus and Subclavian Steal Syndrome. Among its related pathways are Signaling by GPCR and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. An important paralog of this gene is DHRS4L2.

UniProtKB/Swiss-Prot Summary for DHRS4 Gene

  • Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Gene Wiki entry for DHRS4 Gene

Additional gene information for DHRS4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHRS4 Gene

Genomics for DHRS4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for DHRS4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHRS4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DHRS4

Top Transcription factor binding sites by QIAGEN in the DHRS4 gene promoter:
  • HEN1
  • Pax-4a
  • SRF
  • SRF (504 AA)

Genomic Locations for DHRS4 Gene

Genomic Locations for DHRS4 Gene
chr14:23,953,734-23,969,279
(GRCh38/hg38)
Size:
15,546 bases
Orientation:
Plus strand
chr14:24,422,795-24,438,488
(GRCh37/hg19)
Size:
15,694 bases
Orientation:
Plus strand

Genomic View for DHRS4 Gene

Genes around DHRS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DHRS4 Gene

Proteins for DHRS4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DHRS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTZ2-DHRS4_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 4
    Protein Accession:
    Q9BTZ2
    Secondary Accessions:
    • B2RB10
    • B7WNS9
    • D3YTB8
    • E2QRL8
    • O95162
    • Q20CR0
    • Q2LC19
    • Q2LE81
    • Q58IU4
    • Q6E0Y1
    • Q6UWU3
    • Q71UQ6
    • Q8TD03
    • Q9H3N5
    • Q9NV08

    Protein attributes for DHRS4 Gene

    Size:
    278 amino acids
    Molecular mass:
    29537 Da
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=AAD02292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAL61824.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB18775.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG37057.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Inhibited by kaempferol, quercetin, genistein and myristic acid.
    • [Isoform 7]: Mainly localized in the nucleus.
    • [Isoform 8]: Enhanced dicarbonyl reductase activity. high expression in liver.

    Three dimensional structures from OCA and Proteopedia for DHRS4 Gene

    Alternative splice isoforms for DHRS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS4 Gene

Protein Expression for DHRS4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for DHRS4 Gene

Q9BTZ2:
  • DILVSNAAVNPFFG
  • TEEVWDK
  • NIRVNCLAPGLIKT
  • SSRKQQNVD
  • NKVALVT
  • VCHVGKAEDRE
  • APGLIKT
  • CAGIVSFLCSEDASYITGETVVV

Post-translational modifications for DHRS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHRS4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DHRS4 Gene

Gene Families for DHRS4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DHRS4 Gene

InterPro:
Blocks:
  • Short-chain dehydrogenase/reductase SDR
  • Glucose/ribitol dehydrogenase family signature
ProtoNet:

Suggested Antigen Peptide Sequences for DHRS4 Gene

GenScript: Design optimal peptide antigens:
  • Short-chain dehydrogenase/reductase family member 4 (DHRS4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BTZ2

UniProtKB/Swiss-Prot:

DHRS4_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS4: view

Function for DHRS4 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for DHRS4 Gene

UniProtKB/Swiss-Prot Function:
Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH; Xref=Rhea:RHEA:19257, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.184;.

Enzyme Numbers (IUBMB) for DHRS4 Gene

Phenotypes From GWAS Catalog for DHRS4 Gene

Gene Ontology (GO) - Molecular Function for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000253 3-keto sterol reductase activity IDA 18571493
GO:0004090 carbonyl reductase (NADPH) activity IEA,IDA 18571493
GO:0016491 oxidoreductase activity IEA --
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA 19442656
GO:0018455 alcohol dehydrogenase [NAD(P)+] activity IDA 18571493
genes like me logo Genes that share ontologies with DHRS4: view
genes like me logo Genes that share phenotypes with DHRS4: view

Animal Models for DHRS4 Gene

MGI Knock Outs for DHRS4:

Animal Model Products

CRISPR Products

miRNA for DHRS4 Gene

miRTarBase miRNAs that target DHRS4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS4

Clone Products

  • Addgene plasmids for DHRS4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHRS4 Gene

Localization for DHRS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS4 Gene

Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not.
[Isoform 7]: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS4 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
nucleus 5
endoplasmic reticulum 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion ISS --
GO:0005777 peroxisome IEA,IDA 17230527
GO:0005778 peroxisomal membrane IDA 10333503
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with DHRS4: view

Pathways & Interactions for DHRS4 Gene

genes like me logo Genes that share pathways with DHRS4: view

Pathways by source for DHRS4 Gene

2 BioSystems pathways for DHRS4 Gene
3 KEGG pathways for DHRS4 Gene
2 GeneGo (Thomson Reuters) pathways for DHRS4 Gene
  • Prostaglandin 2 biosynthesis and metabolism FM
  • Retinol metabolism

Gene Ontology (GO) - Biological Process for DHRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process IDA 18571493
GO:0006625 protein targeting to peroxisome TAS --
GO:0008202 steroid metabolic process IDA 18571493
GO:0042180 cellular ketone metabolic process IDA 18571493
GO:0055114 oxidation-reduction process TAS 10333503
genes like me logo Genes that share ontologies with DHRS4: view

No data available for SIGNOR curated interactions for DHRS4 Gene

Drugs & Compounds for DHRS4 Gene

Products:

  1. Drug

(6) Drugs for DHRS4 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Target, substrate 685
Menadione Approved Nutra 327
NADPH Experimental Pharma 0
Myristic acid Experimental Pharma 0
NADP Experimental Pharma 0

(2) Additional Compounds for DHRS4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DHRS4: view

Transcripts for DHRS4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DHRS4 Gene

6 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS4

Clone Products

  • Addgene plasmids for DHRS4

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - -

Relevant External Links for DHRS4 Gene

GeneLoc Exon Structure for
DHRS4

Expression for DHRS4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHRS4 Gene

mRNA expression in normal human tissues for DHRS4 Gene
mRNA expression by BioGPS for DHRS4 GenemRNA expression by GTEx for DHRS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DHRS4 Gene

This gene is overexpressed in Gallbladder (18.7), Liver (7.7), and Kidney (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS4 Gene



Protein tissue co-expression partners for DHRS4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DHRS4

SOURCE GeneReport for Unigene cluster for DHRS4 Gene:

Hs.528385

mRNA Expression by UniProt/SwissProt for DHRS4 Gene:

Q9BTZ2-DHRS4_HUMAN
Tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues.

Evidence on tissue expression from TISSUES for DHRS4 Gene

  • Liver(4.6)
  • Muscle(4.5)
  • Lung(4.4)
  • Nervous system(3.9)
  • Kidney(2.5)
  • Skin(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with DHRS4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS4 Gene

Orthologs for DHRS4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia DHRS4 30 31
  • 98.68 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia DHRS4 30 31
  • 86.69 (n)
 OneToMany
Cow
(Bos Taurus)
 Mammalia DHRS4 30 31
  • 84.05 (n)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Dhrs4 30
  • 80.7 (n)
Mouse
(Mus musculus)
 Mammalia Dhrs4 30 17 31
  • 80.34 (n)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 62 (a)
 ManyToMany
-- 31
  • 58 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 58 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves DHRS4 30
  • 62.25 (n)
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 65 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia dhrs4 30
  • 62.93 (n)
Str.11257 30
Zebrafish
(Danio rerio)
 Actinopterygii DHRS2 31
  • 60 (a)
 OneToMany
zgc:65987 30
  • 59.72 (n)
-- 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.4702 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007475 30
  • 58.47 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG10672 30 31
  • 54.34 (n)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea dhs-13 30 31
  • 52.88 (n)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes -- 33
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons IBR1 30
  • 53.31 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.3445 30
Rice
(Oryza sativa)
 Liliopsida Os09g0133200 30
  • 56.78 (n)
Os.8274 30
Barley
(Hordeum vulgare)
 Liliopsida Hv.3716 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.3359 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 50 (a)
 ManyToMany
-- 31
  • 29 (a)
 ManyToMany
Species where no ortholog for DHRS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DHRS4 Gene

ENSEMBL:
Gene Tree for DHRS4 (if available)
TreeFam:
Gene Tree for DHRS4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHRS4: view image

Paralogs for DHRS4 Gene

Paralogs for DHRS4 Gene

(8) SIMAP similar genes for DHRS4 Gene using alignment to 6 proteins:

  • DHRS4_HUMAN
  • E2QRI3_HUMAN
  • F5GWZ1_HUMAN
  • H0YNP7_HUMAN
  • H7BYG2_HUMAN
  • J3QST2_HUMAN

Pseudogenes.org Pseudogenes for DHRS4 Gene

genes like me logo Genes that share paralogs with DHRS4: view

Variants for DHRS4 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DHRS4 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
736886 Likely Benign: not provided 23,955,097(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
768639 Likely Benign: not provided 23,959,985(+) T/C SYNONYMOUS_VARIANT,INTRON_VARIANT
778993 Benign: not provided 23,966,355(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
790140 Benign: not provided 23,953,822(+) C/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1043442 - p.Ala31Thr

Additional dbSNP identifiers (rs#s) for DHRS4 Gene

Structural Variations from Database of Genomic Variants (DGV) for DHRS4 Gene

Variant ID Type Subtype PubMed ID
dgv1837n100 CNV loss 25217958
dgv1838n100 CNV gain 25217958
dgv1839n100 CNV loss 25217958
dgv1840n100 CNV gain+loss 25217958
dgv1841n100 CNV gain+loss 25217958
dgv36e203 CNV gain+loss 21179565
esv2421714 CNV deletion 20811451
esv27040 CNV loss 19812545
esv2748487 CNV deletion 23290073
esv33403 CNV loss 17666407
esv3633790 CNV loss 21293372
esv3633791 CNV gain 21293372
esv3633792 CNV loss 21293372
nsv1052180 CNV loss 25217958
nsv1217 CNV deletion 18451855
nsv1218 CNV insertion 18451855
nsv509528 CNV insertion 20534489
nsv511030 OTHER complex 20534489
nsv564046 CNV loss 21841781
nsv564047 CNV loss 21841781
nsv89 CNV deletion 15895083
nsv9124 CNV loss 18304495
nsv974316 CNV duplication 23825009
nsv983806 CNV duplication 23825009

Variation tolerance for DHRS4 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS4 Gene

Disorders for DHRS4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DHRS4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anismus
subclavian steal syndrome
  • subclavian artery stenosis
peroxisomal acyl-coa oxidase deficiency
  • straight-chain acyl-coa oxidase deficiency
superior semicircular canal dehiscence
  • canal dehiscence syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DHRS4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DHRS4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DHRS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHRS4 Gene

Publications for DHRS4 Gene

  1. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. (PMID: 10333503) Fransen M … Subramani S (The Biochemical journal 1999) 2 3 4
  2. Identification of a novel isoform of DHRS4 protein with a nuclear localization signal. (PMID: 22227495) Su Z … Huang D (Gene 2012) 3 4
  3. Human NRDRB1, an alternatively spliced isoform of NADP(H)-dependent retinol dehydrogenase/reductase enhanced enzymatic activity of benzil. (PMID: 23128527) Yan Y … Huang D (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3

ExternalLinks

View latest publications for DHRS4 gene in Mastermind

Products for DHRS4 Gene

  • Addgene plasmids for DHRS4

Sources for DHRS4 Gene