Free for academic non-profit institutions. Other users need a Commercial license
Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]
DHRS3 (Dehydrogenase/Reductase 3) is a Protein Coding gene. Diseases associated with DHRS3 include Amphetamine Abuse and Lipoid Proteinosis Of Urbach And Wiethe. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include nucleotide binding and electron transfer activity. An important paralog of this gene is HSD17B11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | TAS | 9705317 |
GO:0004745 | retinol dehydrogenase activity | IEA,IBA | 21873635 |
GO:0009055 | electron transfer activity | TAS | 9705317 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0005811 | lipid droplet | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0042622 | photoreceptor outer segment membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Drug metabolism - cytochrome P450 |
Retinol metabolism
.31
|
|
2 | Signaling by Retinoic Acid | ||
3 | Metabolism of fat-soluble vitamins | ||
4 | the visual cycle I (vertebrates) | ||
5 | Metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001523 | retinoid metabolic process | IBA,TAS | -- |
GO:0003151 | outflow tract morphogenesis | IEA | -- |
GO:0007601 | visual perception | TAS | 9705317 |
GO:0022900 | electron transport chain | IEA | -- |
GO:0030278 | regulation of ossification | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Retinal |
|
116-31-4, 564-87-4 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||
SP5: | - | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DHRS3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DHRS3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DHRS3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DHRS3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dhrs3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dhrs3 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DHRS3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DHRS3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DHRS3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dhrs3 30 |
|
||
Str.2573 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.13360 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dhrs3a 31 |
|
OneToMany | |
dhrs3b 30 31 |
|
OneToMany | |||
wufc04h12 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5264 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG15629 31 |
|
ManyToMany | |
CG14946 31 |
|
ManyToMany | |||
CG2254 31 |
|
ManyToMany | |||
CG9265 31 |
|
ManyToMany | |||
CG13833 31 |
|
ManyToMany | |||
CG17121 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | dhs-29 31 |
|
ManyToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
ManyToMany | |
TDA5 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1011540 | CNV | loss | 25217958 |
nsv1126179 | CNV | deletion | 24896259 |
nsv466172 | CNV | loss | 19166990 |
nsv466283 | CNV | gain | 19166990 |
nsv475134 | CNV | novel sequence insertion | 20440878 |
nsv475178 | CNV | novel sequence insertion | 20440878 |
nsv517848 | CNV | gain | 19592680 |
nsv521737 | CNV | loss | 19592680 |
nsv545442 | CNV | loss | 21841781 |
nsv545443 | CNV | gain | 21841781 |
nsv955253 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
amphetamine abuse |
|
|
lipoid proteinosis of urbach and wiethe |
|
|
neuroblastoma |
|
|
fundus albipunctatus |
|
|
fundus dystrophy |
|
|