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Aliases for DHRS2 Gene

Aliases for DHRS2 Gene

  • Dehydrogenase/Reductase 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 25C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 2 2 3
  • Dicarbonyl Reductase HEP27 3 4
  • Protein D 3 4
  • SDR25C1 3 4
  • Dehydrogenase/Reductase SDR Family Member 2, Mitochondrial 3
  • Short Chain Dehydrogenase/Reductase Family 25C, Member 1 2
  • Short-Chain Alcohol Dehydrogenase Family Member 3
  • Dehydrogenase/Reductase Member 2 3
  • EC 1.1.1.- 4
  • HEP27 3

External Ids for DHRS2 Gene

Previous GeneCards Identifiers for DHRS2 Gene

  • GC14P021478
  • GC14P017892
  • GC14P022089
  • GC14P022095
  • GC14P023175
  • GC14P024099
  • GC14P004222
  • GC14P023638
  • GC14P023641
  • GC14P023662
  • GC14P023704
  • GC14P023874
  • GC14P023933
  • GC14P024044
  • GC14P024160

Summaries for DHRS2 Gene

Entrez Gene Summary for DHRS2 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for DHRS2 Gene

DHRS2 (Dehydrogenase/Reductase 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is DHRS4.

UniProtKB/Swiss-Prot for DHRS2 Gene

  • Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.

Gene Wiki entry for DHRS2 Gene

Additional gene information for DHRS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS2 Gene

Genomics for DHRS2 Gene

GeneHancer (GH) Regulatory Elements for DHRS2 Gene

Promoters and enhancers for DHRS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023636 Promoter 1.2 EPDnew 650.4 +6.2 6230 0.1 ARID4B ZNF48 ETS1 TCF12 SLC30A9 ZNF207 NFKBIZ SP5 NFYC ZHX2 PIR53509 DHRS2
GH14J023630 Promoter 0.6 EPDnew 650.7 0.0 -19 0.1 GATA3 DHRS2 DHRS4L1 ENSG00000274002
GH14J023692 Enhancer 1.2 Ensembl ENCODE 6.7 +64.8 64765 5.7 PKNOX1 CLOCK NEUROD1 SIN3A FEZF1 DMAP1 ZBTB7B ZNF48 ZNF766 ZNF207 KHNYN ACIN1 RNA5SP383 TM9SF1 RNF31 TINF2 LOC102724814 CIDEB PRMT5 RBM23
GH14J023663 Enhancer 0.7 FANTOM5 ENCODE 11.2 +33.8 33849 1.8 GLIS1 SCRT2 MNT DHRS2 NFATC4 DHRS4 NGDN LOC105370407 LOC105370408
GH14J023666 Enhancer 0.7 ENCODE 8.4 +36.0 35972 0.2 CTCF THRB RAD21 TEAD3 GATAD1 ZNF143 SMC3 THAP11 TFE3 NFIA DHRS2 LOC105370407 LOC105370408
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHRS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS2 gene promoter:

Genomic Locations for DHRS2 Gene

Genomic Locations for DHRS2 Gene
chr14:23,630,115-23,645,639
(GRCh38/hg38)
Size:
15,525 bases
Orientation:
Plus strand
chr14:24,099,324-24,114,848
(GRCh37/hg19)

Genomic View for DHRS2 Gene

Genes around DHRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS2 Gene

Proteins for DHRS2 Gene

  • Protein details for DHRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13268-DHRS2_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 2, mitochondrial
    Protein Accession:
    Q13268
    Secondary Accessions:
    • D3DS54
    • Q53GS4
    • Q7Z789
    • Q9H2R2

    Protein attributes for DHRS2 Gene

    Size:
    280 amino acids
    Molecular mass:
    29927 Da
    Quaternary structure:
    • Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to degradation.

    Alternative splice isoforms for DHRS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS2 Gene

Post-translational modifications for DHRS2 Gene

  • Ubiquitination at posLast=234234 and Lys224
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DHRS2 Gene

Domains & Families for DHRS2 Gene

Gene Families for DHRS2 Gene

Suggested Antigen Peptide Sequences for DHRS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13268

UniProtKB/Swiss-Prot:

DHRS2_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS2: view

Function for DHRS2 Gene

Molecular function for DHRS2 Gene

UniProtKB/Swiss-Prot Function:
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione {ECO:0000269 PubMed:16685466}; KM=1.1 mM for 2,3-Heptanedione {ECO:0000269 PubMed:16685466}; KM=0.8 mM for 3,4-Hexanedione {ECO:0000269 PubMed:16685466}; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as substrate {ECO:0000269 PubMed:16685466}; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate {ECO:0000269 PubMed:16685466}; Vmax=0.35 mmol/min/mg enzyme with 3,4-Hexanedione as substrate {ECO:0000269 PubMed:16685466};
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4 and CSF2 in monocytes/macrophages. Down-regulated by bacterial lipopolysaccharides (LPS) and TNF in monocytice-derived dendritic cells. Up-regulated by MYB.

Enzyme Numbers (IUBMB) for DHRS2 Gene

Gene Ontology (GO) - Molecular Function for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity IDA 16685466
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS2: view
genes like me logo Genes that share phenotypes with DHRS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS2

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS2 Gene

Localization for DHRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS2 Gene

Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS2 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 1847869
GO:0005635 nuclear envelope IDA 11997086
GO:0005737 cytoplasm IDA 11944995
GO:0005739 mitochondrion IDA,IEA 19443906
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with DHRS2: view

Pathways & Interactions for DHRS2 Gene

SuperPathways for DHRS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008207 C21-steroid hormone metabolic process NAS 7556196
GO:0008285 negative regulation of cell proliferation NAS 1847869
GO:0009636 response to toxic substance IDA 16685466
GO:0034599 cellular response to oxidative stress IDA 19443906
GO:0043011 myeloid dendritic cell differentiation IEP 11944995
genes like me logo Genes that share ontologies with DHRS2: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS2 Gene

Drugs & Compounds for DHRS2 Gene

(2) Drugs for DHRS2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cortisone Pharma 79

(9) Additional Compounds for DHRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DHRS2: view

Transcripts for DHRS2 Gene

Unigene Clusters for DHRS2 Gene

Dehydrogenase/reductase (SDR family) member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DHRS2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: -
SP8: - - - - - -

Relevant External Links for DHRS2 Gene

GeneLoc Exon Structure for
DHRS2
ECgene alternative splicing isoforms for
DHRS2

Expression for DHRS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DHRS2 Gene

This gene is overexpressed in Bladder (x42.8).

Protein differential expression in normal tissues from HIPED for DHRS2 Gene

This gene is overexpressed in Breast (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS2 Gene



NURSA nuclear receptor signaling pathways regulating expression of DHRS2 Gene:

DHRS2

SOURCE GeneReport for Unigene cluster for DHRS2 Gene:

Hs.272499

mRNA Expression by UniProt/SwissProt for DHRS2 Gene:

Q13268-DHRS2_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.

Evidence on tissue expression from TISSUES for DHRS2 Gene

  • Liver(4.9)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with DHRS2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS2 Gene

Orthologs for DHRS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DHRS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS2 34 33
  • 97.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC490616 33
  • 82.26 (n)
DHRS2 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 63 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dhrs2 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 46 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia DCXR 34
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DHRS2 34
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10672 34 35
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-13 34
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
Species where no ortholog for DHRS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DHRS2 Gene

ENSEMBL:
Gene Tree for DHRS2 (if available)
TreeFam:
Gene Tree for DHRS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHRS2: view image

Paralogs for DHRS2 Gene

Paralogs for DHRS2 Gene

(7) SIMAP similar genes for DHRS2 Gene using alignment to 4 proteins:

  • DHRS2_HUMAN
  • C9JZP6_HUMAN
  • H0YJG9_HUMAN
  • H0YJP4_HUMAN

Pseudogenes.org Pseudogenes for DHRS2 Gene

genes like me logo Genes that share paralogs with DHRS2: view

Variants for DHRS2 Gene

Sequence variations from dbSNP and Humsavar for DHRS2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs148991912 A colorectal cancer sample 23,645,225(+) C/A/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1000375600 -- 23,637,110(+) A/G intron_variant
rs1000421704 -- 23,645,535(+) G/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000530521 -- 23,641,635(+) G/A intron_variant, non_coding_transcript_variant
rs1000664007 -- 23,637,000(+) T/C intron_variant

Variation tolerance for DHRS2 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DHRS2 Gene

Disorders for DHRS2 Gene

Additional Disease Information for DHRS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DHRS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS2 Gene

Publications for DHRS2 Gene

  1. Genomic organization of the human gene HEP27: alternative promoter usage in HepG2 cells and monocyte-derived dendritic cells. (PMID: 11944995) Heinz S … Rehli M (Genomics 2002) 2 3 4 22 58
  2. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. (PMID: 7556196) Gabrielli F … Melli M (European journal of biochemistry 1995) 2 3 4 22 58
  3. Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue. (PMID: 16685466) Shafqat N … Oppermann U (Cellular and molecular life sciences : CMLS 2006) 2 3 4 58
  4. Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. (PMID: 20547751) Deisenroth C … Zhang Y (Molecular and cellular biology 2010) 3 4 58
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 58

Products for DHRS2 Gene

Sources for DHRS2 Gene

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