Aliases for DHRS13 Gene

Aliases for DHRS13 Gene

  • Dehydrogenase/Reductase 13 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 7C Member 5 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 13 2 3
  • Dehydrogenase/Reductase SDR Family Member 13 3 4
  • SDR7C5 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 5 2
  • EC 1.1.-.- 4

External Ids for DHRS13 Gene

Previous GeneCards Identifiers for DHRS13 Gene

  • GC17M024249
  • GC17M027224
  • GC17M023433

Summaries for DHRS13 Gene

GeneCards Summary for DHRS13 Gene

DHRS13 (Dehydrogenase/Reductase 13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH13.

UniProtKB/Swiss-Prot Summary for DHRS13 Gene

Additional gene information for DHRS13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHRS13 Gene

Genomics for DHRS13 Gene

GeneHancer (GH) Regulatory Elements for DHRS13 Gene

Promoters and enhancers for DHRS13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHRS13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS13 gene promoter:
  • AhR
  • AP-4
  • AREB6
  • Arnt
  • CUTL1
  • HOXA5
  • HSF1 (long)
  • HSF1short
  • Sox5

Genomic Locations for DHRS13 Gene

Genomic Locations for DHRS13 Gene
5,299 bases
Minus strand
5,291 bases
Minus strand

Genomic View for DHRS13 Gene

Genes around DHRS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS13 Gene

Proteins for DHRS13 Gene

  • Protein details for DHRS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dehydrogenase/reductase SDR family member 13
    Protein Accession:
    Secondary Accessions:
    • B4DJC5
    • Q96BH7

    Protein attributes for DHRS13 Gene

    377 amino acids
    Molecular mass:
    40849 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS13 Gene


neXtProt entry for DHRS13 Gene

Post-translational modifications for DHRS13 Gene

  • Ubiquitination at Lys201
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DHRS13 Gene

Domains & Families for DHRS13 Gene

Gene Families for DHRS13 Gene

Suggested Antigen Peptide Sequences for DHRS13 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51214, weakly similar to Retinol dehydrogenase 12 (EC 1.1.1.-) (B4DJC5_HUMAN)
  • Dehydrogenase/reductase SDR family member 13 (DHR13_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS13: view

Function for DHRS13 Gene

Molecular function for DHRS13 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS13 Gene

Phenotypes From GWAS Catalog for DHRS13 Gene

Gene Ontology (GO) - Molecular Function for DHRS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS13: view
genes like me logo Genes that share phenotypes with DHRS13: view

Animal Model Products

CRISPR Products

miRNA for DHRS13 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRS13 Gene

Localization for DHRS13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS13 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS13 gene
Compartment Confidence
extracellular 3
cytosol 2
plasma membrane 0
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DHRS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DHRS13: view

Pathways & Interactions for DHRS13 Gene

PathCards logo

SuperPathways for DHRS13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS13: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS13 Gene

Drugs & Compounds for DHRS13 Gene

No Compound Related Data Available

Transcripts for DHRS13 Gene

mRNA/cDNA for DHRS13 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5

Relevant External Links for DHRS13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS13 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS13 Gene

This gene is overexpressed in Whole Blood (x13.2).

Protein differential expression in normal tissues from HIPED for DHRS13 Gene

This gene is overexpressed in Lung (11.4), Retina (10.3), Platelet (8.7), Adrenal (8.6), and Breast (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS13 Gene

Protein tissue co-expression partners for DHRS13 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS13 Gene:


SOURCE GeneReport for Unigene cluster for DHRS13 Gene:


Evidence on tissue expression from TISSUES for DHRS13 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with DHRS13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS13 Gene

Orthologs for DHRS13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHRS13 33 32
  • 99.66 (n)
(Canis familiaris)
Mammalia DHRS13 32
  • 88.8 (n)
-- 33
  • 36 (a)
(Bos Taurus)
Mammalia DHRS13 33 32
  • 87.2 (n)
(Mus musculus)
Mammalia Dhrs13 17 33 32
  • 84.45 (n)
(Rattus norvegicus)
Mammalia RGD1305508 32
  • 81.14 (n)
(Ornithorhynchus anatinus)
Mammalia DHRS13 33
  • 76 (a)
(Monodelphis domestica)
Mammalia DHRS13 33
  • 73 (a)
(Gallus gallus)
Aves DHRS13 33
  • 50 (a)
(Anolis carolinensis)
Reptilia DHRS13 33
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs13 32
  • 60.4 (n)
(Danio rerio)
Actinopterygii dhrs13a.3 33 32
  • 55.78 (n)
dhrs13a.1 33
  • 51 (a)
dhrs13l1 33
  • 50 (a)
dhrs13a.2 33
  • 49 (a)
dhrs13b 33
  • 47 (a)
CU638740.1 33
  • 43 (a)
DHRS13 (5 of 7) 33
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31235 33
  • 28 (a)
(Caenorhabditis elegans)
Secernentea dhs-22 33
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 33
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 22 (a)
Species where no ortholog for DHRS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS13 Gene

Gene Tree for DHRS13 (if available)
Gene Tree for DHRS13 (if available)
Evolutionary constrained regions (ECRs) for DHRS13: view image

Paralogs for DHRS13 Gene

Paralogs for DHRS13 Gene

(4) SIMAP similar genes for DHRS13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DHRS13: view

Variants for DHRS13 Gene

Sequence variations from dbSNP and Humsavar for DHRS13 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000197598 -- 28,897,409(-) G/A downstream_transcript_variant
rs1000399316 -- 28,900,578(-) C/A intron_variant
rs1000781749 -- 28,904,677(-) T/A upstream_transcript_variant
rs1001747134 -- 28,901,101(-) G/A coding_sequence_variant, missense_variant
rs1002158520 -- 28,900,808(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS13 Gene

Variant ID Type Subtype PubMed ID
nsv457719 CNV loss 19166990
nsv574662 CNV loss 21841781

Variation tolerance for DHRS13 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS13 Gene

Disorders for DHRS13 Gene

Additional Disease Information for DHRS13

No disorders were found for DHRS13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS13 Gene

Publications for DHRS13 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 56
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 56
  3. Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved. (PMID: 30619736) Hussain T … Aldaz CM (Frontiers in oncology 2018) 3 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for DHRS13 Gene

Sources for DHRS13 Gene