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Aliases for DHRS13 Gene

Aliases for DHRS13 Gene

  • Dehydrogenase/Reductase 13 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 7C Member 5 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 13 2 3
  • SDR7C5 3 4
  • Short Chain Dehydrogenase/Reductase Family 7C, Member 5 2
  • Dehydrogenase/Reductase SDR Family Member 13 3
  • EC 1.1.-.- 4

External Ids for DHRS13 Gene

Previous GeneCards Identifiers for DHRS13 Gene

  • GC17M024249
  • GC17M027224
  • GC17M023433

Summaries for DHRS13 Gene

GeneCards Summary for DHRS13 Gene

DHRS13 (Dehydrogenase/Reductase 13) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH12.

UniProtKB/Swiss-Prot for DHRS13 Gene

  • Putative oxidoreductase.

Additional gene information for DHRS13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS13 Gene

Genomics for DHRS13 Gene

GeneHancer (GH) Regulatory Elements for DHRS13 Gene

Promoters and enhancers for DHRS13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I028901 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.5 453 2.2 CLOCK YBX1 DMAP1 IRF4 ZNF213 ZNF143 ZNF263 SP3 NFYC SSRP1 DHRS13 SUPT6H LOC101927018 NUFIP2 PHF12 ENSG00000264577 ENSG00000265908 SDF2 ENSG00000265205 PIGS
GH17I028904 Enhancer 0.9 ENCODE dbSUPER 550.8 -1.6 -1613 0.4 HDAC1 MEIS2 PKNOX1 USF1 FOXK2 POLR2A ZBTB48 VEZF1 SIRT6 CBFA2T2 DHRS13 TMEM199 LOC101927018
GH17I028863 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 42.9 +37.7 37735 3.3 HDGF SMAD1 ARNT ARID4B IRF4 ZNF766 CBX5 JUNB REST ZNF592 DHRS13 RPL23A PROCA1 NUFIP2 SUPT6H PHF12 ENSG00000264577 ENSG00000265908 FLOT2 TLCD1
GH17I028807 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 +92.6 92632 6.8 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FAM222B TRAF4 LOC101927018 ERAL1 FLOT2 DHRS13 TLCD1 NEK8 SNORD4B SNORD42A
GH17I028854 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 +48.0 48013 1.7 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 FAM222B ERAL1 FLOT2 DHRS13 SNORD4A SNORD42A SNORD4B PROCA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHRS13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHRS13 gene promoter:

Genomic Locations for DHRS13 Gene

Genomic Locations for DHRS13 Gene
chr17:28,897,781-28,903,071
(GRCh38/hg38)
Size:
5,291 bases
Orientation:
Minus strand
chr17:27,224,799-27,230,089
(GRCh37/hg19)

Genomic View for DHRS13 Gene

Genes around DHRS13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS13 Gene

Proteins for DHRS13 Gene

  • Protein details for DHRS13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX07-DHR13_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 13
    Protein Accession:
    Q6UX07
    Secondary Accessions:
    • B4DJC5
    • Q96BH7

    Protein attributes for DHRS13 Gene

    Size:
    377 amino acids
    Molecular mass:
    40849 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS13 Gene

Post-translational modifications for DHRS13 Gene

  • Ubiquitination at posLast=201201
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DHRS13 Gene

Domains & Families for DHRS13 Gene

Gene Families for DHRS13 Gene

Suggested Antigen Peptide Sequences for DHRS13 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UX07

UniProtKB/Swiss-Prot:

DHR13_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS13: view

Function for DHRS13 Gene

Molecular function for DHRS13 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS13 Gene

Phenotypes From GWAS Catalog for DHRS13 Gene

Gene Ontology (GO) - Molecular Function for DHRS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS13: view
genes like me logo Genes that share phenotypes with DHRS13: view

miRNA for DHRS13 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHRS13 Gene

Localization for DHRS13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS13 gene
Compartment Confidence
extracellular 4
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DHRS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with DHRS13: view

Pathways & Interactions for DHRS13 Gene

SuperPathways for DHRS13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS13: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS13 Gene

Drugs & Compounds for DHRS13 Gene

No Compound Related Data Available

Transcripts for DHRS13 Gene

Unigene Clusters for DHRS13 Gene

Dehydrogenase/reductase (SDR family) member 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2:

Relevant External Links for DHRS13 Gene

GeneLoc Exon Structure for
DHRS13
ECgene alternative splicing isoforms for
DHRS13

Expression for DHRS13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS13 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS13 Gene

This gene is overexpressed in Whole Blood (x13.2).

Protein differential expression in normal tissues from HIPED for DHRS13 Gene

This gene is overexpressed in Lung (11.4), Retina (10.3), Platelet (8.7), Adrenal (8.6), and Breast (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DHRS13 Gene



Protein tissue co-expression partners for DHRS13 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHRS13 Gene:

DHRS13

SOURCE GeneReport for Unigene cluster for DHRS13 Gene:

Hs.631760

Evidence on tissue expression from TISSUES for DHRS13 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with DHRS13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS13 Gene

Orthologs for DHRS13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS13 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia DHRS13 33
  • 88.8 (n)
-- 34
  • 36 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia DHRS13 33 34
  • 87.2 (n)
mouse
(Mus musculus)
Mammalia Dhrs13 33 16 34
  • 84.45 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305508 33
  • 81.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS13 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHRS13 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS13 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS13 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs13 33
  • 60.4 (n)
zebrafish
(Danio rerio)
Actinopterygii dhrs13a.3 33 34
  • 55.78 (n)
dhrs13a.1 34
  • 51 (a)
OneToMany
dhrs13l1 34
  • 50 (a)
OneToMany
dhrs13a.2 34
  • 49 (a)
OneToMany
dhrs13b 34
  • 47 (a)
OneToMany
CU638740.1 34
  • 43 (a)
OneToMany
DHRS13 (5 of 7) 34
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31235 34
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-22 34
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
ManyToMany
Species where no ortholog for DHRS13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS13 Gene

ENSEMBL:
Gene Tree for DHRS13 (if available)
TreeFam:
Gene Tree for DHRS13 (if available)

Paralogs for DHRS13 Gene

Paralogs for DHRS13 Gene

(4) SIMAP similar genes for DHRS13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DHRS13: view

Variants for DHRS13 Gene

Sequence variations from dbSNP and Humsavar for DHRS13 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000197598 -- 28,897,409(-) G/A downstream_transcript_variant
rs1000399316 -- 28,900,578(-) C/A intron_variant
rs1000781749 -- 28,904,677(-) T/A upstream_transcript_variant
rs1001747134 -- 28,901,101(-) G/A coding_sequence_variant, missense_variant
rs1002158520 -- 28,900,808(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS13 Gene

Variant ID Type Subtype PubMed ID
nsv457719 CNV loss 19166990
nsv574662 CNV loss 21841781

Variation tolerance for DHRS13 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS13 Gene

Disorders for DHRS13 Gene

Additional Disease Information for DHRS13

No disorders were found for DHRS13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS13 Gene

Publications for DHRS13 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for DHRS13 Gene

Sources for DHRS13 Gene

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