This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2... See more...

Aliases for DHRS12 Gene

Aliases for DHRS12 Gene

  • Dehydrogenase/Reductase 12 2 3 5
  • Short-Chain Dehydrogenase/Reductase Family 40C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 12 2 3
  • Dehydrogenase/Reductase SDR Family Member 12 3 4
  • SDR40C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 40C, Member 1 2
  • EC 1.1.-.- 4

External Ids for DHRS12 Gene

Previous GeneCards Identifiers for DHRS12 Gene

  • GC13M051241
  • GC13M052342
  • GC13M033131
  • GC13M051756

Summaries for DHRS12 Gene

Entrez Gene Summary for DHRS12 Gene

  • This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for DHRS12 Gene

DHRS12 (Dehydrogenase/Reductase 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and coenzyme binding. An important paralog of this gene is RDH11.

UniProtKB/Swiss-Prot Summary for DHRS12 Gene

Additional gene information for DHRS12 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHRS12 Gene

Genomics for DHRS12 Gene

GeneHancer (GH) Regulatory Elements for DHRS12 Gene

Promoters and enhancers for DHRS12 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHRS12 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DHRS12

Genomic Locations for DHRS12 Gene

Genomic Locations for DHRS12 Gene
chr13:51,767,993-51,804,199
(GRCh38/hg38)
Size:
36,207 bases
Orientation:
Minus strand
chr13:52,342,129-52,378,293
(GRCh37/hg19)
Size:
36,165 bases
Orientation:
Minus strand

Genomic View for DHRS12 Gene

Genes around DHRS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS12 Gene

Proteins for DHRS12 Gene

  • Protein details for DHRS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJE2-DHR12_HUMAN
    Recommended name:
    Dehydrogenase/reductase SDR family member 12
    Protein Accession:
    A0PJE2
    Secondary Accessions:
    • Q96GB2
    • Q9H8H1

    Protein attributes for DHRS12 Gene

    Size:
    317 amino acids
    Molecular mass:
    35146 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DHRS12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHRS12 Gene

Post-translational modifications for DHRS12 Gene

No Post-translational modifications

Other Protein References for DHRS12 Gene

No data available for DME Specific Peptides for DHRS12 Gene

Domains & Families for DHRS12 Gene

Gene Families for DHRS12 Gene

Protein Domains for DHRS12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DHRS12 Gene

GenScript: Design optimal peptide antigens:
  • Dehydrogenase/reductase SDR family member 12 (DHR12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A0PJE2

UniProtKB/Swiss-Prot:

DHR12_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS12: view

Function for DHRS12 Gene

Molecular function for DHRS12 Gene

UniProtKB/Swiss-Prot Function:
Putative oxidoreductase.

Enzyme Numbers (IUBMB) for DHRS12 Gene

Phenotypes From GWAS Catalog for DHRS12 Gene

Gene Ontology (GO) - Molecular Function for DHRS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with DHRS12: view
genes like me logo Genes that share phenotypes with DHRS12: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DHRS12 Gene

Localization for DHRS12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS12 gene
Compartment Confidence
mitochondrion 2
cytosol 1
peroxisome 0
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DHRS12 Gene

Pathways & Interactions for DHRS12 Gene

PathCards logo

SuperPathways for DHRS12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHRS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DHRS12: view

No data available for Pathways by source and SIGNOR curated interactions for DHRS12 Gene

Drugs & Compounds for DHRS12 Gene

No Compound Related Data Available

Transcripts for DHRS12 Gene

mRNA/cDNA for DHRS12 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: - -
SP8: - -
SP9: -

Relevant External Links for DHRS12 Gene

GeneLoc Exon Structure for
DHRS12

Expression for DHRS12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHRS12 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS12 Gene

This gene is overexpressed in Whole Blood (x5.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DHRS12

SOURCE GeneReport for Unigene cluster for DHRS12 Gene:

Hs.266728

Evidence on tissue expression from TISSUES for DHRS12 Gene

  • Kidney(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DHRS12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS12 Gene

Orthologs for DHRS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHRS12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHRS12 31 30
  • 98.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DHRS12 31 30
  • 86.44 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DHRS12 31
  • 12 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHRS12 31 30
  • 70.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHRS12 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs12 30
  • 69.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15580 30
zebrafish
(Danio rerio)
Actinopterygii dhrs12 31 30
  • 64.88 (n)
OneToOne
wufj52f06 30
worm
(Caenorhabditis elegans)
Secernentea dhs-17 31
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ENV9 31
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G09750 30
  • 51.66 (n)
rice
(Oryza sativa)
Liliopsida Os06g0590301 30
  • 49.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToOne
Species where no ortholog for DHRS12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS12 Gene

ENSEMBL:
Gene Tree for DHRS12 (if available)
TreeFam:
Gene Tree for DHRS12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DHRS12: view image

Paralogs for DHRS12 Gene

(3) SIMAP similar genes for DHRS12 Gene using alignment to 1 proteins:

  • DHR12_HUMAN
genes like me logo Genes that share paralogs with DHRS12: view

Variants for DHRS12 Gene

Additional dbSNP identifiers (rs#s) for DHRS12 Gene

Structural Variations from Database of Genomic Variants (DGV) for DHRS12 Gene

Variant ID Type Subtype PubMed ID
dgv1652n100 CNV loss 25217958
dgv3146n54 CNV loss 21841781
esv1177213 CNV deletion 17803354
esv2096973 CNV deletion 18987734
esv26805 CNV gain+loss 19812545
esv2747420 CNV deletion 23290073
esv2747421 CNV deletion 23290073
esv2747422 CNV deletion 23290073
esv3892343 CNV gain 25118596
nsv1069755 CNV deletion 25765185
nsv1078204 CNV insertion 25765185
nsv1124896 CNV deletion 24896259
nsv1148485 CNV deletion 26484159
nsv1151135 CNV insertion 26484159
nsv561646 CNV gain 21841781
nsv561647 CNV gain 21841781
nsv561648 CNV loss 21841781
nsv64332 CNV deletion 16902084
nsv821576 CNV deletion 20802225
nsv832612 CNV gain 17160897

Variation tolerance for DHRS12 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHRS12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHRS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DHRS12 Gene

Disorders for DHRS12 Gene

Additional Disease Information for DHRS12

No disorders were found for DHRS12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHRS12 Gene

Publications for DHRS12 Gene

  1. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 54
  4. Isolation and characterization of proteins associated with histone H3 tails in vivo. (PMID: 17403666) Heo K … An W (The Journal of biological chemistry 2007) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for DHRS12 Gene

Sources for DHRS12 Gene