Aliases for DHODH Gene
External Ids for DHODH Gene
Previous GeneCards Identifiers for DHODH Gene
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
GeneCards Summary for DHODH Gene
DHODH (Dihydroorotate Dehydrogenase (Quinone)) is a Protein Coding gene. Diseases associated with DHODH include Postaxial Acrofacial Dysostosis and Acrofacial Dysostosis. Among its related pathways are Metabolism and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include drug binding and ubiquinone binding. An important paralog of this gene is DPYD.
UniProtKB/Swiss-Prot Summary for DHODH Gene
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.