Aliases for DHFRP1 Gene

Aliases for DHFRP1 Gene

  • Dihydrofolate Reductase Pseudogene 1 2 3 5
  • HDHFR-Psi 3 2 3
  • DHFRP1 5

External Ids for DHFRP1 Gene

Previous GeneCards Identifiers for DHFRP1 Gene

  • GC18U990010
  • GC02P082937
  • GC18M022002
  • GC18M023747

Summaries for DHFRP1 Gene

GeneCards Summary for DHFRP1 Gene

DHFRP1 (Dihydrofolate Reductase Pseudogene 1) is a Pseudogene. Among its related pathways are E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include mRNA binding and NADP binding.

Additional gene information for DHFRP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DHFRP1 Gene

Genomics for DHFRP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DHFRP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J026171 Promoter 0.3 Ensembl 600.7 +0.2 156 0.4 DHFRP1 lnc-SS18-8 piR-57460-303 PSMA8 TAF4B
GH18J026168 Enhancer 0.6 Ensembl 0.7 +2.9 2856 1 IKZF2 TRIM22 DPF2 RELB ZBTB40 ARNT NBN NR2F1 TBX21 ATF7 DHFRP1 lnc-SS18-8 piR-57460-303 PSMA8 TAF4B
GH18J026190 Enhancer 0.7 ENCODE 0.4 -19.8 -19848 1.7 TCF12 IKZF2 EED ARID3A DPF2 RELB RUNX3 ASH2L MCM5 NBN SS18 piR-57460-304 DHFRP1 TAF4B PSMA8
GH18J026183 Enhancer 0.2 Ensembl 0.4 -11.9 -11944 0.2 SS18 DHFRP1 piR-57460-304 TAF4B PSMA8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DHFRP1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for DHFRP1 Gene

Genomic Locations for DHFRP1 Gene
chr18:26,167,862-26,171,357
(GRCh38/hg38)
Size:
3,496 bases
Orientation:
Minus strand
chr18:23,747,826-23,751,321
(GRCh37/hg19)
Size:
3,496 bases
Orientation:
Minus strand

Genomic View for DHFRP1 Gene

Genes around DHFRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHFRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHFRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHFRP1 Gene

Proteins for DHFRP1 Gene

Post-translational modifications for DHFRP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DHFRP1 Gene

Domains & Families for DHFRP1 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DHFRP1 Gene

Function for DHFRP1 Gene

Molecular function for DHFRP1 Gene

GENATLAS Biochemistry:
dihydrofolate reductase,pseudogene 1

Gene Ontology (GO) - Molecular Function for DHFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000900 translation repressor activity, mRNA regulatory element binding IDA 8490020
GO:0003729 mRNA binding IDA 21876184
GO:0004146 dihydrofolate reductase activity IDA, ISS, IBA, NAS 6687716
GO:0005542 folic acid binding IDA 2303423
GO:0008144 drug binding IDA 12096917
genes like me logo Genes that share ontologies with DHFRP1: view

Phenotypes for DHFRP1 Gene

genes like me logo Genes that share phenotypes with DHFRP1: view

Animal Model Products

CRISPR Products

miRNA for DHFRP1 Gene

miRTarBase miRNAs that target DHFRP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHFRP1 Gene

Localization for DHFRP1 Gene

Gene Ontology (GO) - Cellular Components for DHFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA, IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DHFRP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DHFRP1 Gene

Pathways & Interactions for DHFRP1 Gene

PathCards logo

SuperPathways for DHFRP1 Gene

genes like me logo Genes that share pathways with DHFRP1: view

Pathways by source for DHFRP1 Gene

1 BioSystems pathway for DHFRP1 Gene

Gene Ontology (GO) - Biological Process for DHFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0006729 tetrahydrobiopterin biosynthetic process IMP, ISS --
GO:0006730 one-carbon metabolic process IEA --
GO:0017148 negative regulation of translation IDA 8490020
GO:0031103 axon regeneration ISS --
genes like me logo Genes that share ontologies with DHFRP1: view

No data available for Interacting Proteins and SIGNOR curated interactions for DHFRP1 Gene

Drugs & Compounds for DHFRP1 Gene

(2) Drugs for DHFRP1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1825
Pralatrexate Approved, Investigational Pharma Antifolate,a folate analog, RFC-1 targeted DHFR inhibitor 0

(2) ApexBio Compounds for DHFRP1 Gene

Compound Action Cas Number
Methotrexate Folate antagonist,inhibits DFHR 1959-05-2
Pralatrexate Antifolate,a folate analog 146464-95-1
genes like me logo Genes that share compounds with DHFRP1: view

Drug Products

Transcripts for DHFRP1 Gene

mRNA/cDNA for DHFRP1 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DHFRP1 Gene

No ASD Table

Relevant External Links for DHFRP1 Gene

GeneLoc Exon Structure for
DHFRP1

Expression for DHFRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DHFRP1 Gene

genes like me logo Genes that share expression patterns with DHFRP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHFRP1 Gene

Orthologs for DHFRP1 Gene

Evolution for DHFRP1 Gene

ENSEMBL:
Gene Tree for DHFRP1 (if available)
TreeFam:
Gene Tree for DHFRP1 (if available)

No data available for Orthologs for DHFRP1 Gene

Paralogs for DHFRP1 Gene

No data available for Paralogs for DHFRP1 Gene

Variants for DHFRP1 Gene

Additional Variant Information for DHFRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHFRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for DHFRP1 Gene

Disorders for DHFRP1 Gene

No disorders were found for DHFRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for DHFRP1 Gene

Publications for DHFRP1 Gene

  1. Chromosomal organization of the human dihydrofolate reductase genes: dispersion, selective amplification, and a novel form of polymorphism. (PMID: 6089182) Anagnou NP … Nienhuis AW (Proceedings of the National Academy of Sciences of the United States of America 1984) 2 3
  2. A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA. (PMID: 6306253) Masters JN … Attardi G (Journal of molecular biology 1983) 2 3
  3. Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. (PMID: 23707606) Whitsett J … Vasquez-Vivar J (Free radical biology & medicine 2013) 3
  4. An artifact derived from a pseudogene led to the discovery of microRNA binding site polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene. (PMID: 22201119) Hayashi H … Itoh K (Drug metabolism and pharmacokinetics 2012) 3
  5. The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional. (PMID: 21876184) McEntee G … Parle-McDermott A (Proceedings of the National Academy of Sciences of the United States of America 2011) 3

Products for DHFRP1 Gene

Sources for DHFRP1 Gene