External Ids for DHFR Gene
Previous GeneCards Identifiers for DHFR Gene
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
GeneCards Summary for DHFR Gene
DHFR (Dihydrofolate Reductase) is a Protein Coding gene. Diseases associated with DHFR include Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency and Megaloblastic Anemia. Among its related pathways are eNOS activation and regulation and Nucleotide Metabolism. Gene Ontology (GO) annotations related to this gene include mRNA binding and NADP binding. An important paralog of this gene is DHFR2.
UniProtKB/Swiss-Prot Summary for DHFR Gene
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. It catalyzes tetrahydrofolate regeneration by reduction of dihydrofolate, using NADPH as a cofactor. DHFR has a key role in cell growth and proliferation.