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This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
DHDH (Dihydrodiol Dehydrogenase) is a Protein Coding gene. Diseases associated with DHDH include Malignant Choroid Melanoma and Myasthenic Syndrome, Congenital, 7, Presynaptic. Among its related pathways are Metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity. An important paralog of this gene is GFOD1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008746 | NAD(P)+ transhydrogenase activity | TAS | 10477285 |
GO:0009055 | electron transfer activity | TAS | 10477285 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0047115 | trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | IEA | -- |
GO:0047837 | D-xylose 1-dehydrogenase (NADP+) activity | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism | ||
2 | Drug metabolism - cytochrome P450 | ||
3 | Porphyrin and chlorophyll metabolism | ||
4 | Benzene metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | TAS | 10477285 |
GO:0022900 | electron transport chain | IEA | -- |
GO:0042843 | D-xylose catabolic process | IBA | 21873635 |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
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1,2-Dihydronaphthalene-1,2-diol |
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D-Xylono-1,5-lactone |
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Hydrogen Ion |
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Naphthalene-1,2-diol |
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trans-1,2-Dihydrobenzene-1,2-diol |
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103302-38-1 |
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This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
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Chimpanzee (Pan troglodytes) |
Mammalia | DHDH 30 31 |
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OneToOne | |
Cow (Bos Taurus) |
Mammalia | DHDH 30 31 |
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OneToOne | |
Dog (Canis familiaris) |
Mammalia | DHDH 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dhdh 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dhdh 30 |
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Oppossum (Monodelphis domestica) |
Mammalia | DHDH 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DHDH 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
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OneToMany | |||
-- 31 |
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OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dhdh 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | zgc:101723 30 |
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DHDH (1 of 2) 31 |
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OneToMany | |||
dhdhl 31 |
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OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG3609 30 31 32 |
|
OneToMany | |
CG3597 31 32 |
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OneToMany | |||
CG13280 31 32 |
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OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009945 30 |
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Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 33 |
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Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G09670 30 |
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Rice (Oryza sativa) |
Liliopsida | Os10g0403700 30 |
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Bread mold (Neurospora crassa) |
Ascomycetes | NCU01704 30 |
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Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC513.06c 30 |
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Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
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OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs757900117 | Uncertain Significance: Malignant tumor of prostate | 48,939,693(+) | A/T | MISSENSE_VARIANT | |
rs10401800 | - | p.Ala2Pro | |||
rs11666105 | - | p.Val247Ala | |||
rs2270941 | - | p.Ser66Asn | |||
rs35453148 | - | p.Val200Met |
Disorder | Aliases | PubMed IDs |
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malignant choroid melanoma |
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myasthenic syndrome, congenital, 7, presynaptic |
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vitreous detachment |
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rubeosis iridis |
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retinal perforation |
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