Aliases for DGUOK Gene
External Ids for DGUOK Gene
Previous GeneCards Identifiers for DGUOK Gene
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGUOK Gene
DGUOK (Deoxyguanosine Kinase) is a Protein Coding gene. Diseases associated with DGUOK include Mitochondrial Dna Depletion Syndrome 3 and Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Recessive 4. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include nucleoside kinase activity and deoxyguanosine kinase activity. An important paralog of this gene is DCK.
UniProtKB/Swiss-Prot Summary for DGUOK Gene
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents.