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Aliases for DGLUCY Gene

Aliases for DGLUCY Gene

  • D-Glutamate Cyclase 2 3 5
  • C14orf159 3 4
  • UPF0317 Protein C14orf159, Mitochondrial 3
  • Chromosome 14 Open Reading Frame 159 2
  • D-Glutamate Cyclase, Mitochondrial 3
  • EC 4

External Ids for DGLUCY Gene

Previous HGNC Symbols for DGLUCY Gene

  • C14orf159

Summaries for DGLUCY Gene

GeneCards Summary for DGLUCY Gene

DGLUCY (D-Glutamate Cyclase) is a Protein Coding gene. Among its related pathways are D-Glutamine and D-glutamate metabolism.

UniProtKB/Swiss-Prot for DGLUCY Gene

  • D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.

Gene Wiki entry for DGLUCY Gene

Additional gene information for DGLUCY Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGLUCY Gene

Genomics for DGLUCY Gene

GeneHancer (GH) Regulatory Elements for DGLUCY Gene

Promoters and enhancers for DGLUCY Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J091112 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 677.6 +56.8 56797 8.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B DGLUCY TRIP11 PPP4R3A NRDE2 RNU7-30P ATXN3 RPS6KA5 RPS18P2 RPL21P11 GC14P091127
GH14J091107 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 21.1 +48.9 48889 3.1 PKNOX1 CLOCK NFIB ZSCAN4 BATF ZNF335 ETV6 IKZF2 RUNX3 ZNF680 DGLUCY RPS6KA5 CCDC88C PPP4R3A GPR68 GC14P091127 GC14P091092
GH14J091123 Enhancer 1.3 Ensembl ENCODE dbSUPER 13.5 +65.9 65927 5.3 HDAC1 PKNOX1 CLOCK NFIB NEUROD1 SIN3A BMI1 ZBTB40 ZNF121 ZNF766 SNORA11B GC14P091127 DGLUCY PPP4R3A ATXN3 TTC7B GC14P091092
GH14J091154 Enhancer 0.9 ENCODE 18.5 +94.9 94905 1.2 SMAD1 FEZF1 ZNF121 GLIS2 ZNF213 TSHZ1 ZNF518A ZNF610 ZSCAN16 GLIS1 DGLUCY RPL21P11 SNORA11B RPS6KA5 ATXN3 RPS18P2 GC14P091148 GC14P091227
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGLUCY on UCSC Golden Path with GeneCards custom track

Genomic Locations for DGLUCY Gene

Genomic Locations for DGLUCY Gene
165,300 bases
Plus strand
165,300 bases
Plus strand

Genomic View for DGLUCY Gene

Genes around DGLUCY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGLUCY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGLUCY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGLUCY Gene

Proteins for DGLUCY Gene

  • Protein details for DGLUCY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    D-glutamate cyclase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B3KUI7
    • Q86SW3
    • Q86SX8
    • Q86SX9
    • Q86T08
    • Q86TV5
    • Q96GW5
    • Q9H7G0
    • Q9H8Y9
    • Q9H9W6

    Protein attributes for DGLUCY Gene

    616 amino acids
    Molecular mass:
    66437 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14932.1; Type=Frameshift; Positions=436, 582; Evidence={ECO:0000305};

    Alternative splice isoforms for DGLUCY Gene

neXtProt entry for DGLUCY Gene

Post-translational modifications for DGLUCY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DGLUCY Gene

Domains & Families for DGLUCY Gene

Gene Families for DGLUCY Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DGLUCY Gene

Suggested Antigen Peptide Sequences for DGLUCY Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the D-glutamate cyclase family.
  • Belongs to the D-glutamate cyclase family.
genes like me logo Genes that share domains with DGLUCY: view

Function for DGLUCY Gene

Molecular function for DGLUCY Gene

UniProtKB/Swiss-Prot Function:
D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.
UniProtKB/Swiss-Prot CatalyticActivity:
D-glutamate = 5-oxo-D-proline + H(2)O.

Enzyme Numbers (IUBMB) for DGLUCY Gene

Phenotypes From GWAS Catalog for DGLUCY Gene

Gene Ontology (GO) - Molecular Function for DGLUCY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0016829 lyase activity IEA --
GO:0047820 D-glutamate cyclase activity ISS --
genes like me logo Genes that share ontologies with DGLUCY: view
genes like me logo Genes that share phenotypes with DGLUCY: view

Animal Models for DGLUCY Gene

MGI Knock Outs for DGLUCY:
  • Dglucy Dglucy<tm1b(KOMP)Wtsi>

Animal Model Products

miRNA for DGLUCY Gene

miRTarBase miRNAs that target DGLUCY

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGLUCY Gene

Localization for DGLUCY Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGLUCY Gene

Mitochondrion matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGLUCY gene
Compartment Confidence
mitochondrion 5
cytosol 4
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DGLUCY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix ISS --
genes like me logo Genes that share ontologies with DGLUCY: view

Pathways & Interactions for DGLUCY Gene

genes like me logo Genes that share pathways with DGLUCY: view

Pathways by source for DGLUCY Gene

1 KEGG pathway for DGLUCY Gene

Interacting Proteins for DGLUCY Gene

Gene Ontology (GO) - Biological Process for DGLUCY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006536 glutamate metabolic process ISS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DGLUCY: view

No data available for SIGNOR curated interactions for DGLUCY Gene

Drugs & Compounds for DGLUCY Gene

No Compound Related Data Available

Transcripts for DGLUCY Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGLUCY Gene

No ASD Table

Relevant External Links for DGLUCY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGLUCY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of DGLUCY Gene:


Evidence on tissue expression from TISSUES for DGLUCY Gene

  • Nervous system(4.9)
  • Blood(4.3)
  • Lung(4.3)
  • Spleen(4.3)
  • Eye(4.2)
  • Liver(4.2)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DGLUCY: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGLUCY Gene

Orthologs for DGLUCY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DGLUCY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14H14orf159 33
  • 99.03 (n)
C14orf159 34
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1311756 33
  • 79.53 (n)
(Mus musculus)
Mammalia 9030617O03Rik 34 33
  • 78.93 (n)
Dglucy 16
(Monodelphis domestica)
Mammalia C14orf159 34
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf159 34
  • 62 (a)
(Bos Taurus)
Mammalia C14orf159 34
  • 58 (a)
(Gallus gallus)
Aves C5H14ORF159 33
  • 62.85 (n)
C14orf159 34
  • 59 (a)
(Anolis carolinensis)
Reptilia C14orf159 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf159 33
  • 59.72 (n)
Str.20422 33
(Danio rerio)
Actinopterygii c14orf159 33
  • 59.74 (n)
C17H14orf159 34
  • 51 (a)
wufj56e06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6256 33
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C19041g 33
  • 41.04 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC5H10.01 33
  • 42.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
Species where no ortholog for DGLUCY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DGLUCY Gene

Gene Tree for DGLUCY (if available)
Gene Tree for DGLUCY (if available)

Paralogs for DGLUCY Gene

No data available for Paralogs for DGLUCY Gene

Variants for DGLUCY Gene

Sequence variations from dbSNP and Humsavar for DGLUCY Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000026482 -- 91,159,046(+) G/A intron_variant
rs1000045287 -- 91,118,678(+) A/G intron_variant
rs1000132106 -- 91,133,469(+) C/T intron_variant
rs1000147028 -- 91,182,367(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000165267 -- 91,191,295(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DGLUCY Gene

Variant ID Type Subtype PubMed ID
dgv141n21 CNV gain 19592680
esv1001290 CNV deletion 20482838
esv3584776 CNV gain 24956385
nsv1046924 CNV gain 25217958
nsv1053543 CNV gain 25217958
nsv1394 CNV insertion 18451855
nsv819108 CNV loss 19587683
nsv832857 CNV loss 17160897

Variation tolerance for DGLUCY Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGLUCY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGLUCY Gene

Disorders for DGLUCY Gene

No disorders were found for DGLUCY Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGLUCY Gene

Publications for DGLUCY Gene

  1. D-Glutamate is metabolized in the heart mitochondria. (PMID: 28266638) Ariyoshi M … Matoba S (Scientific reports 2017) 2 3 58
  2. Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase. (PMID: 27907125) Sohn YS … Oh BH (PloS one 2016) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for DGLUCY Gene

Sources for DGLUCY Gene

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