Aliases for DGLUCY Gene

Aliases for DGLUCY Gene

  • D-Glutamate Cyclase 2 3 5
  • D-Glutamate Cyclase, Mitochondrial 3 4
  • C14orf159 3 4
  • UPF0317 Protein C14orf159, Mitochondrial 3
  • Chromosome 14 Open Reading Frame 159 2
  • EC 4
  • FLJ39975 2
  • DGLUCY 5

External Ids for DGLUCY Gene

Previous HGNC Symbols for DGLUCY Gene

  • C14orf159

Summaries for DGLUCY Gene

GeneCards Summary for DGLUCY Gene

DGLUCY (D-Glutamate Cyclase) is a Protein Coding gene. Diseases associated with DGLUCY include Dystonia 23. Among its related pathways are Metabolism and D-Glutamine and D-glutamate metabolism.

UniProtKB/Swiss-Prot Summary for DGLUCY Gene

Gene Wiki entry for DGLUCY Gene

Additional gene information for DGLUCY Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DGLUCY Gene

Genomics for DGLUCY Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DGLUCY Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGLUCY on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DGLUCY

Genomic Locations for DGLUCY Gene

Genomic Locations for DGLUCY Gene
165,350 bases
Plus strand
165,300 bases
Plus strand

Genomic View for DGLUCY Gene

Genes around DGLUCY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGLUCY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGLUCY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGLUCY Gene

Proteins for DGLUCY Gene

  • Protein details for DGLUCY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    D-glutamate cyclase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B3KUI7
    • Q86SW3
    • Q86SX8
    • Q86SX9
    • Q86T08
    • Q86TV5
    • Q96GW5
    • Q9H7G0
    • Q9H8Y9
    • Q9H9W6

    Protein attributes for DGLUCY Gene

    616 amino acids
    Molecular mass:
    66437 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14932.1; Type=Frameshift; Evidence={ECO:0000305};
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for DGLUCY Gene

neXtProt entry for DGLUCY Gene

Post-translational modifications for DGLUCY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DGLUCY Gene

Domains & Families for DGLUCY Gene

Gene Families for DGLUCY Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DGLUCY Gene

  • Protein of unknown function DUF1445

Suggested Antigen Peptide Sequences for DGLUCY Gene

GenScript: Design optimal peptide antigens:
  • UPF0317 protein C14orf159, mitochondrial (CN159_HUMAN)
  • C14orf159 protein (Q6IA66_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the D-glutamate cyclase family.
  • Belongs to the D-glutamate cyclase family.
genes like me logo Genes that share domains with DGLUCY: view

Function for DGLUCY Gene

Molecular function for DGLUCY Gene

UniProtKB/Swiss-Prot Function:
D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=D-glutamate = 5-oxo-D-proline + H2O; Xref=Rhea:RHEA:22360, ChEBI:CHEBI:15377, ChEBI:CHEBI:29986, ChEBI:CHEBI:57948; EC=; Evidence={ECO:0000250|UniProtKB:Q8BH86};.

Enzyme Numbers (IUBMB) for DGLUCY Gene

Phenotypes From GWAS Catalog for DGLUCY Gene

Gene Ontology (GO) - Molecular Function for DGLUCY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0016829 lyase activity IEA --
GO:0047820 D-glutamate cyclase activity IBA,ISS --
genes like me logo Genes that share ontologies with DGLUCY: view
genes like me logo Genes that share phenotypes with DGLUCY: view

Animal Models for DGLUCY Gene

MGI Knock Outs for DGLUCY:
  • Dglucy Dglucy<tm1b(KOMP)Wtsi>

miRNA for DGLUCY Gene

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGLUCY Gene

Localization for DGLUCY Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGLUCY Gene

Mitochondrion matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGLUCY gene
Compartment Confidence
mitochondrion 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DGLUCY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix ISS --
genes like me logo Genes that share ontologies with DGLUCY: view

Pathways & Interactions for DGLUCY Gene

PathCards logo

SuperPathways for DGLUCY Gene

genes like me logo Genes that share pathways with DGLUCY: view

Pathways by source for DGLUCY Gene

Gene Ontology (GO) - Biological Process for DGLUCY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006536 glutamate metabolic process IBA,ISS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DGLUCY: view

No data available for SIGNOR curated interactions for DGLUCY Gene

Drugs & Compounds for DGLUCY Gene

No Compound Related Data Available

Transcripts for DGLUCY Gene


32 NCBI additional mRNA sequence :
35 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGLUCY Gene

No ASD Table

Relevant External Links for DGLUCY Gene

GeneLoc Exon Structure for

Expression for DGLUCY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DGLUCY

Evidence on tissue expression from TISSUES for DGLUCY Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Spleen(4.3)
  • Lung(4.3)
  • Liver(4.2)
  • Eye(4.2)
  • Heart(2.3)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with DGLUCY: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGLUCY Gene

Orthologs for DGLUCY Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DGLUCY Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14H14orf159 30
  • 99.03 (n)
C14orf159 31
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1311756 30
  • 79.53 (n)
(Mus musculus)
Mammalia 9030617O03Rik 30 31
  • 78.93 (n)
Dglucy 17
(Monodelphis domestica)
Mammalia C14orf159 31
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf159 31
  • 62 (a)
(Bos Taurus)
Mammalia C14orf159 31
  • 58 (a)
(Gallus gallus)
Aves C5H14ORF159 30
  • 62.85 (n)
C14orf159 31
  • 59 (a)
(Anolis carolinensis)
Reptilia C14orf159 31
  • 56 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c14orf159 30
  • 59.72 (n)
Str.20422 30
(Danio rerio)
Actinopterygii c14orf159 30
  • 59.74 (n)
C17H14orf159 31
  • 51 (a)
wufj56e06 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6256 30
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C19041g 30
  • 41.04 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC5H10.01 30
  • 42.68 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
-- 31
  • 29 (a)
-- 31
  • 28 (a)
Species where no ortholog for DGLUCY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DGLUCY Gene

Gene Tree for DGLUCY (if available)
Gene Tree for DGLUCY (if available)

Paralogs for DGLUCY Gene

No data available for Paralogs for DGLUCY Gene

Variants for DGLUCY Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DGLUCY Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs10142502 - p.Arg10Cys
rs12895348 - p.Ala372Thr
rs2295524 - p.Asp502Asn
rs34302825 - p.Ser237Asn
rs34523602 - p.Asp507Asn

Additional dbSNP identifiers (rs#s) for DGLUCY Gene

Structural Variations from Database of Genomic Variants (DGV) for DGLUCY Gene

Variant ID Type Subtype PubMed ID
dgv141n21 CNV gain 19592680
esv1001290 CNV deletion 20482838
esv3584776 CNV gain 24956385
nsv1046924 CNV gain 25217958
nsv1053543 CNV gain 25217958
nsv1394 CNV insertion 18451855
nsv819108 CNV loss 19587683
nsv832857 CNV loss 17160897

Variation tolerance for DGLUCY Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGLUCY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGLUCY Gene

Disorders for DGLUCY Gene

MalaCards: The human disease database

(1) MalaCards diseases for DGLUCY Gene - From: DISEASES

Disorder Aliases PubMed IDs
dystonia 23
  • dyt23
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with DGLUCY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGLUCY Gene

Publications for DGLUCY Gene

  1. D-Glutamate is metabolized in the heart mitochondria. (PMID: 28266638) Ariyoshi M … Matoba S (Scientific reports 2017) 2 3
  2. Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase. (PMID: 27907125) Sohn YS … Oh BH (PloS one 2016) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for DGLUCY Gene

Sources for DGLUCY Gene