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Aliases for DGKZ Gene

Aliases for DGKZ Gene

  • Diacylglycerol Kinase Zeta 2 3 3 5
  • Diacylglycerol Kinase, Zeta 104kDa 2 3
  • Diglyceride Kinase Zeta 3 4
  • DAG Kinase Zeta 3 4
  • DAGK6 3 4
  • EC 4
  • DGK-ZETA 3
  • HDGKzeta 3
  • DGK-Zeta 4
  • DAGK5 3

External Ids for DGKZ Gene

Previous GeneCards Identifiers for DGKZ Gene

  • GC11P048153
  • GC11P047058
  • GC11P046398
  • GC11P046333
  • GC11P046318
  • GC11P046311
  • GC11P046061
  • GC11P046354

Summaries for DGKZ Gene

Entrez Gene Summary for DGKZ Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

GeneCards Summary for DGKZ Gene

DGKZ (Diacylglycerol Kinase Zeta) is a Protein Coding gene. Among its related pathways are Effects of PIP2 hydrolysis and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and NAD+ kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot for DGKZ Gene

  • Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.

Tocris Summary for DGKZ Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKZ Gene

Additional gene information for DGKZ Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKZ Gene

Genomics for DGKZ Gene

GeneHancer (GH) Regulatory Elements for DGKZ Gene

Promoters and enhancers for DGKZ Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J046344 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.4 +17.0 17001 10.4 HDGF SMAD1 FOXA2 ARNT SIN3A ZNF2 YY1 E2F8 ZNF143 SP3 GC11P046351 DGKZ C11orf49 LOC105376662 ENSG00000255314 SNORD67 ENSG00000255447 ENSG00000254514 MDK CHRM4
GH11J046359 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.3 +29.6 29646 5.4 HDGF PKNOX1 CLOCK NEUROD1 SIN3A ZNF766 GLIS2 ZNF143 FOS ATF7 DGKZ ZNF408 AMBRA1 ENSG00000270060 ATG13 MIR4688 GC11P046351
GH11J046332 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 650.7 +0.5 525 1.3 MEIS2 PKNOX1 SUZ12 SP2 SIN3A DPF2 ZFHX2 POLR2A EGR2 DGKZ ATG13 GC11P046351
GH11J046330 Enhancer 1.1 Ensembl ENCODE dbSUPER 650.7 -1.5 -1465 2.5 BCOR MEIS2 PKNOX1 SUZ12 ZNF140 ZNF223 SIN3A ZMYM3 ZNF335 ZFHX2 GC11P046331 DGKZ CREB3L1 LINC02489 MDK AMBRA1 ATG13
GH11J046334 Enhancer 0.4 Ensembl dbSUPER 650.7 +1.4 1396 0.2 DGKZ C11orf49 GC11P046351
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKZ on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DGKZ gene promoter:
  • STAT3
  • NF-1
  • C/EBPalpha
  • ER-alpha

Genomic Locations for DGKZ Gene

Genomic Locations for DGKZ Gene
47,650 bases
Plus strand
47,650 bases
Plus strand

Genomic View for DGKZ Gene

Genes around DGKZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKZ Gene

Proteins for DGKZ Gene

  • Protein details for DGKZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol kinase zeta
    Protein Accession:
    Secondary Accessions:
    • B7Z2M9
    • B7Z6M3
    • E9PPW4
    • F6UCU9
    • G3V0F6
    • J3KNJ6
    • O00542
    • Q6ZVG7
    • Q8IVW9

    Protein attributes for DGKZ Gene

    1117 amino acids
    Molecular mass:
    124128 Da
    Quaternary structure:
    • Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS.
    • Sequence=AAB60859.1; Type=Frameshift; Positions=166, 167; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DGKZ Gene

    Alternative splice isoforms for DGKZ Gene

neXtProt entry for DGKZ Gene

Post-translational modifications for DGKZ Gene

  • Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DGKZ Gene

Domains & Families for DGKZ Gene

Gene Families for DGKZ Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKZ: view

Function for DGKZ Gene

Molecular function for DGKZ Gene

UniProtKB/Swiss-Prot Function:
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Enzyme Numbers (IUBMB) for DGKZ Gene

Phenotypes From GWAS Catalog for DGKZ Gene

Gene Ontology (GO) - Molecular Function for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,TAS --
GO:0005515 protein binding IPI 17664281
GO:0005524 ATP binding IEA,TAS --
GO:0016301 kinase activity IDA 18004883
genes like me logo Genes that share ontologies with DGKZ: view
genes like me logo Genes that share phenotypes with DGKZ: view

Animal Models for DGKZ Gene

MGI Knock Outs for DGKZ:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKZ

miRNA for DGKZ Gene

Clone Products

  • Addgene plasmids for DGKZ

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKZ Gene

Localization for DGKZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKZ Gene

Cytoplasm. Nucleus. Cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKZ gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 15157668
GO:0005737 cytoplasm TAS 11309392
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DGKZ: view

Pathways & Interactions for DGKZ Gene

genes like me logo Genes that share pathways with DGKZ: view

Gene Ontology (GO) - Biological Process for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration NAS 15157668
genes like me logo Genes that share ontologies with DGKZ: view

No data available for SIGNOR curated interactions for DGKZ Gene

Drugs & Compounds for DGKZ Gene

(4) Drugs for DGKZ Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(22) Additional Compounds for DGKZ Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
  • 2-palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic Acid(0:0/16:0)
  • LPA(16:0)
  • 2-hexadecanoyl-phosphatidic acid

(2) Tocris Compounds for DGKZ Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKZ: view

Transcripts for DGKZ Gene

Unigene Clusters for DGKZ Gene

Diacylglycerol kinase, zeta:
Representative Sequences:

Clone Products

  • Addgene plasmids for DGKZ

Alternative Splicing Database (ASD) splice patterns (SP) for DGKZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP13: - - - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
SP7: -

Relevant External Links for DGKZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGKZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKZ Gene

This gene is overexpressed in Brain - Cortex (x4.6) and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for DGKZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.9), Heart (13.8), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKZ Gene

Protein tissue co-expression partners for DGKZ Gene

NURSA nuclear receptor signaling pathways regulating expression of DGKZ Gene:


SOURCE GeneReport for Unigene cluster for DGKZ Gene:


mRNA Expression by UniProt/SwissProt for DGKZ Gene:

Tissue specificity: Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.

Evidence on tissue expression from TISSUES for DGKZ Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Heart(4.4)
  • Liver(4.1)
  • Kidney(3.2)
genes like me logo Genes that share expression patterns with DGKZ: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKZ Gene

Orthologs for DGKZ Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DGKZ 34 33
  • 99.67 (n)
(Bos Taurus)
Mammalia DGKZ 34 33
  • 91.91 (n)
(Canis familiaris)
Mammalia DGKZ 34 33
  • 89.84 (n)
(Rattus norvegicus)
Mammalia Dgkz 33
  • 88.9 (n)
(Mus musculus)
Mammalia Dgkz 16 34 33
  • 86.29 (n)
(Monodelphis domestica)
Mammalia DGKZ 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia DGKZ 34
  • 77 (a)
(Gallus gallus)
Aves DGKZ 34 33
  • 78.05 (n)
(Anolis carolinensis)
Reptilia DGKZ 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkz 33
  • 69.66 (n)
(Danio rerio)
Actinopterygii dgkza 34 33
  • 65.92 (n)
dgkzb 34
  • 61 (a)
Dr.11340 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000519 33
  • 58.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta rdgA 34 35 33
  • 53.04 (n)
(Caenorhabditis elegans)
Secernentea dgk-5 34 33
  • 47.98 (n)
K06A1.6 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for DGKZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKZ Gene

Gene Tree for DGKZ (if available)
Gene Tree for DGKZ (if available)
Evolutionary constrained regions (ECRs) for DGKZ: view image

Paralogs for DGKZ Gene

Paralogs for DGKZ Gene

(2) SIMAP similar genes for DGKZ Gene using alignment to 11 proteins:

  • E9PK94_HUMAN
  • F5H033_HUMAN
  • Q7Z5X8_HUMAN Pseudogenes for DGKZ Gene

genes like me logo Genes that share paralogs with DGKZ: view

Variants for DGKZ Gene

Sequence variations from dbSNP and Humsavar for DGKZ Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs869312943 uncertain-significance, Inborn genetic diseases 46,372,813(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000002643 -- 46,380,726(+) C/A downstream_transcript_variant
rs1000018838 -- 46,342,300(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000059396 -- 46,375,070(+) G/T intron_variant
rs1000097772 -- 46,351,619(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DGKZ Gene

Variant ID Type Subtype PubMed ID
esv3626183 CNV gain 21293372
esv3626185 CNV loss 21293372
nsv309 CNV deletion 18451855
nsv554201 CNV loss 21841781
nsv554202 CNV loss 21841781
nsv554203 CNV loss 21841781
nsv825867 CNV gain 20364138
nsv951610 CNV deletion 24416366

Variation tolerance for DGKZ Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.25; 92.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKZ Gene

Disorders for DGKZ Gene

Additional Disease Information for DGKZ

No disorders were found for DGKZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKZ Gene

Publications for DGKZ Gene

  1. Molecular cloning and characterization of a novel human diacylglycerol kinase zeta. (PMID: 8626588) Bunting M … Prescott SM (The Journal of biological chemistry 1996) 2 3 4 22 58
  2. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PMID: 17351151) Rincón E … Mérida I (Molecular & cellular proteomics : MCP 2007) 3 4 22 58
  3. Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. (PMID: 11257115) Topham MK … Prescott SM (The Journal of cell biology 2001) 3 4 22 58
  4. Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. (PMID: 11352924) Hogan A … Gee SH (The Journal of biological chemistry 2001) 3 4 22 58
  5. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. (PMID: 9716136) Topham MK … Prescott SM (Nature 1998) 3 4 22 58

Products for DGKZ Gene

Sources for DGKZ Gene

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