The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 201... See more...

Aliases for DGKZ Gene

Aliases for DGKZ Gene

  • Diacylglycerol Kinase Zeta 2 3 4 5
  • DAGK6 2 3 4
  • Diacylglycerol Kinase, Zeta 104kDa 2 3
  • Diglyceride Kinase Zeta 3 4
  • DAG Kinase Zeta 3 4
  • EC 2.7.1.107 4 50
  • DGK-ZETA 2 3
  • HDGKzeta 2 3
  • DAGK5 2 3
  • DGK-Zeta 4
  • DGKZ 5

External Ids for DGKZ Gene

Previous GeneCards Identifiers for DGKZ Gene

  • GC11P048153
  • GC11P047058
  • GC11P046398
  • GC11P046333
  • GC11P046318
  • GC11P046311
  • GC11P046061
  • GC11P046354

Summaries for DGKZ Gene

Entrez Gene Summary for DGKZ Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

GeneCards Summary for DGKZ Gene

DGKZ (Diacylglycerol Kinase Zeta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and NAD+ kinase activity. An important paralog of this gene is DGKI.

UniProtKB/Swiss-Prot Summary for DGKZ Gene

  • Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity).
  • [Isoform 1]: Regulates RASGRP1 activity.
  • [Isoform 2]: Does not regulate RASGRP1 activity.

Tocris Summary for DGKZ Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKZ Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DGKZ Gene

Genomics for DGKZ Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DGKZ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J046344 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.4 +17.0 17001 10.4 SP1 ZNF654 MYC ZNF600 ZNF592 POLR2A ZIC2 ZBTB10 YY1 NONO DGKZ C11orf49 MDK CHRM4 LINC02489 CREB3L1 AMBRA1 PACSIN3 ATG13 ZNF408
GH11J046359 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 250.3 +29.6 29646 5.4 MYC ZNF600 ZNF592 POLR2A ZNF10 ZIC2 SMAD5 DEK BHLHE40 SIX4 DGKZ ZNF408 ATG13 NONHSAG008203.2-002 MDK NONHSAG008203.2-001
GH11J046330 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 250.7 -0.2 -220 5 ZNF223 SIN3A SP2 PRDM10 SPI1 PKNOX1 EGR1 ZNF652 ZFP36 MEIS2 DGKZ LINC02489 CREB3L1 MDK AMBRA1 ATG13 C11orf49 HSALNG0083986 HSALNG0083984
GH11J046270 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -56.4 -56404 12.2 NCOR1 ZNF600 IKZF1 ZNF592 CEBPA NFIC ZIC2 REST FOXA1 SMAD5 CREB3L1 LINC02489 DGKZ CHST1 MADD LRP4 ARHGAP1 PACSIN3 HSALNG0083980 PHF21A
GH11J046288 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -38.3 -38330 11.9 SP1 MYC NCOR1 IKZF1 JUND ZNF592 CEBPA ZNF223 POLR2A NFIC DGKZ AMBRA1 ENSG00000244313 MDK ZNF408 CHST1 LRP4 CKAP5 MADD C11orf49
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKZ on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DGKZ

Top Transcription factor binding sites by QIAGEN in the DGKZ gene promoter:
  • C/EBPalpha
  • ER-alpha
  • NF-1
  • STAT3

Genomic Locations for DGKZ Gene

Latest Assembly
chr11:46,332,905-46,380,554
(GRCh38/hg38)
Size:
47,650 bases
Orientation:
Plus strand

Previous Assembly
chr11:46,354,476-46,402,104
(GRCh37/hg19 by Entrez Gene)
Size:
47,629 bases
Orientation:
Plus strand

chr11:46,354,455-46,402,104
(GRCh37/hg19 by Ensembl)
Size:
47,650 bases
Orientation:
Plus strand

Genomic View for DGKZ Gene

Genes around DGKZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKZ Gene

Proteins for DGKZ Gene

  • Protein details for DGKZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13574-DGKZ_HUMAN
    Recommended name:
    Diacylglycerol kinase zeta
    Protein Accession:
    Q13574
    Secondary Accessions:
    • B7Z2M9
    • B7Z6M3
    • E9PPW4
    • F6UCU9
    • G3V0F6
    • J3KNJ6
    • O00542
    • Q6ZVG7
    • Q8IVW9

    Protein attributes for DGKZ Gene

    Size:
    928 amino acids
    Molecular mass:
    103981 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with the PDZ domain of the syntrophin SNTG1 and that of SNX27 (PubMed:11352924, PubMed:17351151). Interacts with IRS1 in the absence of insulin; insulin stimulation decreases this interaction (By similarity). Found in a ternary complex with IRS1 and PIP5K1A in the absence of insulin (By similarity). Interacts with PIP5K1A (PubMed:15157668).
    • [Isoform 1]: Forms a signaling complex with RASGRP1 and HRAS.
    SequenceCaution:
    • Sequence=AAB60859.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Minor isoform.
    • [Isoform 1]: Major isoform.

    Three dimensional structures from OCA and Proteopedia for DGKZ Gene

    Alternative splice isoforms for DGKZ Gene

neXtProt entry for DGKZ Gene

Selected DME Specific Peptides for DGKZ Gene

Q13574:
  • RIDRAQEHL
  • CGGDGTVGW
  • SLAALQVGGHGERL
  • HHDFEPQRHDDGY
  • PEKFNSR
  • VNPKSGG
  • CGKGFQQKF
  • PLGTGNDL
  • IEEPCSLG
  • DLTPKIQ
  • WYLNPRQVFDLSQ
  • FVRHHWVHRRRQ
  • PVQVDGE
  • ETNVSGD
  • FHSKEIVAISCSWCKQA

Post-translational modifications for DGKZ Gene

  • Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DGKZ Gene

Gene Families for DGKZ Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DGKZ Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53489, highly similar to Diacylglycerol kinase zeta (EC 2.7.1.107) (B7Z6M3_HUMAN)
  • Diglyceride kinase zeta (DGKZ_HUMAN)
  • cDNA FLJ42603 fis, clone BRACE3011421, highly similar to Diacylglycerol kinase, zeta (EC 2.7.1.107) (Q6ZVG7_HUMAN)
  • DGKZ protein (Q7Z5X8_HUMAN)
  • Diacylglycerol kinase, zeta 104kDa (Q8IVW9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13574

UniProtKB/Swiss-Prot:

DGKZ_HUMAN :
  • The PDZ-binding motif mediates interaction with PDZ domain-containing proteins like SNTG1 and SNX27.
  • Belongs to the eukaryotic diacylglycerol kinase family.
Domain:
  • The PDZ-binding motif mediates interaction with PDZ domain-containing proteins like SNTG1 and SNX27.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKZ: view

Function for DGKZ Gene

Molecular function for DGKZ Gene

UniProtKB/Swiss-Prot Function:
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:9159104, PubMed:15544348, PubMed:18004883, PubMed:19744926, PubMed:22108654, PubMed:22627129, PubMed:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PubMed:9159104, PubMed:19744926, PubMed:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PubMed:15544348, PubMed:19744926, PubMed:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PubMed:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 1]: Regulates RASGRP1 activity.
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Does not regulate RASGRP1 activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:18004883, ECO:0000269|PubMed:19744926, ECO:0000269|PubMed:22108654, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:23949095, ECO:0000269|PubMed:8626588, ECO:0000269|PubMed:9159104};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8626588};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-ditetradecanoyl-sn-glycerol + ATP = 1,2-ditetradecanoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43444, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:80651, ChEBI:CHEBI:83550, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8626588, ECO:0000269|PubMed:9159104};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43416, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:64839, ChEBI:CHEBI:75466, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8626588, ECO:0000269|PubMed:9159104};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40335, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:72864, ChEBI:CHEBI:77096, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:19744926};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43424, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74560, ChEBI:CHEBI:75468, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8626588, ECO:0000269|PubMed:9159104};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:18004883, ECO:0000269|PubMed:19744926, ECO:0000269|PubMed:22108654, ECO:0000269|PubMed:8626588, ECO:0000269|PubMed:9159104};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40359, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77129, ChEBI:CHEBI:77130, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:22108654};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:18004883, ECO:0000269|PubMed:19744926, ECO:0000269|PubMed:22108654, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:23949095, ECO:0000269|PubMed:8626588, ECO:0000269|PubMed:9159104};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + ATP = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43420, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:74551, ChEBI:CHEBI:75447, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8626588, ECO:0000269|PubMed:9159104};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1-eicosanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40331, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77093, ChEBI:CHEBI:77094, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:19744926};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol + ATP = 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40351, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77125, ChEBI:CHEBI:77126, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:22108654};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:44072, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52595, ChEBI:CHEBI:73332, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41676, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75936, ChEBI:CHEBI:78385, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:22627129};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40403, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77184, ChEBI:CHEBI:77186, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40407, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77185, ChEBI:CHEBI:77187, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41672, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:34115, ChEBI:CHEBI:77580, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:22627129};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by 1,2-diacyl-sn-glycero-3-phosphate/phosphatidic acid irrespective of its acyl chain composition.

Enzyme Numbers (IUBMB) for DGKZ Gene

Phenotypes From GWAS Catalog for DGKZ Gene

Gene Ontology (GO) - Molecular Function for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001727 lipid kinase activity IDA --
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,IDA 15544348
GO:0005515 protein binding IPI 15157668
genes like me logo Genes that share ontologies with DGKZ: view
genes like me logo Genes that share phenotypes with DGKZ: view

Animal Models for DGKZ Gene

MGI Knock Outs for DGKZ:

Animal Models for research

  • Taconic Biosciences Mouse Models for DGKZ

miRNA for DGKZ Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKZ

Clone products for research

  • Addgene plasmids for DGKZ

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKZ Gene

Localization for DGKZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKZ Gene

Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKZ gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 15157668
GO:0005737 cytoplasm IEA,TAS 11309392
GO:0005829 cytosol IEA,IDA 22627129
GO:0005886 plasma membrane TAS --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with DGKZ: view

Pathways & Interactions for DGKZ Gene

genes like me logo Genes that share pathways with DGKZ: view

UniProtKB/Swiss-Prot Q13574-DGKZ_HUMAN

  • Pathway: Lipid metabolism; glycerolipid metabolism.

SIGNOR curated interactions for DGKZ Gene

Other effect:

Gene Ontology (GO) - Biological Process for DGKZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process TAS 15157668
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway IEA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration NAS 15157668
genes like me logo Genes that share ontologies with DGKZ: view

Drugs & Compounds for DGKZ Gene

(5) Drugs for DGKZ Gene - From: DrugBank, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-Tocopherol succinate Approved, Vet_approved Nutra Target 0
ATP Investigational Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(23) Additional Compounds for DGKZ Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(2) Tocris Compounds for DGKZ Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKZ: view

Transcripts for DGKZ Gene

mRNA/cDNA for DGKZ Gene

7 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKZ

Clone products for research

  • Addgene plasmids for DGKZ

Alternative Splicing Database (ASD) splice patterns (SP) for DGKZ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - - -
SP14:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for DGKZ Gene

GeneLoc Exon Structure for
DGKZ

Expression for DGKZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKZ Gene

This gene is overexpressed in Brain - Cortex (x4.6) and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for DGKZ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.9), Heart (13.8), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKZ Gene



Protein tissue co-expression partners for DGKZ Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DGKZ

SOURCE GeneReport for Unigene cluster for DGKZ Gene:

Hs.502461

mRNA Expression by UniProt/SwissProt for DGKZ Gene:

Q13574-DGKZ_HUMAN
Tissue specificity: Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas.

Evidence on tissue expression from TISSUES for DGKZ Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Heart(4.4)
  • Liver(4.3)
  • Kidney(3.6)
  • Spleen(2.3)
  • Lymph node(2.1)
  • Bone marrow(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with DGKZ: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKZ Gene

Orthologs for DGKZ Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKZ Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DGKZ 29 30
  • 99.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DGKZ 29 30
  • 91.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DGKZ 29 30
  • 89.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dgkz 29
  • 88.9 (n)
Mouse
(Mus musculus)
Mammalia Dgkz 29 16 30
  • 86.29 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DGKZ 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DGKZ 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DGKZ 29 30
  • 78.05 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DGKZ 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dgkz 29
  • 69.66 (n)
Zebrafish
(Danio rerio)
Actinopterygii dgkza 29 30
  • 65.92 (n)
OneToMany
dgkzb 30
  • 61 (a)
OneToMany
Dr.11340 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000519 29
  • 58.55 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta rdgA 29 30 31
  • 53.04 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dgk-5 29 30
  • 47.98 (n)
OneToMany
K06A1.6 31
  • 39 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 48 (a)
OneToMany
Species where no ortholog for DGKZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DGKZ Gene

ENSEMBL:
Gene Tree for DGKZ (if available)
TreeFam:
Gene Tree for DGKZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DGKZ: view image
Alliance of Genome Resources:
Additional Orthologs for DGKZ

Paralogs for DGKZ Gene

Paralogs for DGKZ Gene

(2) SIMAP similar genes for DGKZ Gene using alignment to 11 proteins:

  • DGKZ_HUMAN
  • A8MVN1_HUMAN
  • E9PK94_HUMAN
  • E9PKT3_HUMAN
  • E9PNL8_HUMAN
  • E9PNZ3_HUMAN
  • F5H033_HUMAN
  • F6UCU9_HUMAN
  • H0YDN6_HUMAN
  • H0YEG2_HUMAN
  • Q7Z5X8_HUMAN

Pseudogenes.org Pseudogenes for DGKZ Gene

genes like me logo Genes that share paralogs with DGKZ: view

Variants for DGKZ Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DGKZ Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
1005235 Uncertain Significance: not provided 46,366,293(+) G/A
NM_201532.3(DGKZ):c.213-998G>A
MISSENSE_VARIANT,INTRON
1041256 Uncertain Significance: not provided 46,373,100(+) G/A
NM_201532.3(DGKZ):c.1373G>A (p.Arg458Gln)
MISSENSE
931644 Uncertain Significance: See cases 46,376,119(+) C/T
NM_201532.3(DGKZ):c.2113C>T (p.Arg705Cys)
MISSENSE
rs111613271 Benign: not provided 46,371,757(+) C/T
NM_201532.3(DGKZ):c.861C>T (p.Ser287=)
SYNONYMOUS
rs11820791 Benign: not provided 46,366,333(+) T/C
NM_201532.3(DGKZ):c.213-958T>C
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DGKZ Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DGKZ Gene

Variant ID Type Subtype PubMed ID
esv3626183 CNV gain 21293372
esv3626185 CNV loss 21293372
nsv309 CNV deletion 18451855
nsv554201 CNV loss 21841781
nsv554202 CNV loss 21841781
nsv554203 CNV loss 21841781
nsv825867 CNV gain 20364138
nsv951610 CNV deletion 24416366

Variation tolerance for DGKZ Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.25; 92.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKZ Gene

Human Gene Mutation Database (HGMD)
DGKZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKZ
Leiden Open Variation Database (LOVD)
DGKZ

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKZ Gene

Disorders for DGKZ Gene

Additional Disease Information for DGKZ

No disorders were found for DGKZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKZ Gene

Publications for DGKZ Gene

  1. Molecular cloning and characterization of a novel human diacylglycerol kinase zeta. (PMID: 8626588) Bunting M … Prescott SM (The Journal of biological chemistry 1996) 2 3 4 22
  2. Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. (PMID: 17351151) Rincón E … Mérida I (Molecular & cellular proteomics : MCP 2007) 3 4 22
  3. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. (PMID: 15157668) Luo B … Topham MK (Cellular signalling 2004) 3 4 22
  4. Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. (PMID: 11257115) Topham MK … Prescott SM (The Journal of cell biology 2001) 3 4 22
  5. Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. (PMID: 11352924) Hogan A … Gee SH (The Journal of biological chemistry 2001) 3 4 22

Products for DGKZ Gene