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Aliases for DGKQ Gene

Aliases for DGKQ Gene

  • Diacylglycerol Kinase Theta 2 3 5
  • Diacylglycerol Kinase, Theta 110kDa 2 3
  • Diglyceride Kinase Theta 3 4
  • DAG Kinase Theta 3 4
  • EC 2.7.1.107 4 56
  • DGK-Theta 3 4
  • DAGK4 3 4
  • Testis Tissue Sperm-Binding Protein Li 38a 3
  • Diacylglycerol Kinase, Theta (110kD) 2
  • DAGK7 3
  • DAGK 3

External Ids for DGKQ Gene

Previous HGNC Symbols for DGKQ Gene

  • DAGK4

Previous GeneCards Identifiers for DGKQ Gene

  • GC04M000959
  • GC04P000832
  • GC04M000944

Summaries for DGKQ Gene

Entrez Gene Summary for DGKQ Gene

  • The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKQ Gene

DGKQ (Diacylglycerol Kinase Theta) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include kinase binding and phospholipase binding. An important paralog of this gene is DGKB.

UniProtKB/Swiss-Prot for DGKQ Gene

  • Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.

Tocris Summary for DGKQ Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKQ Gene

Additional gene information for DGKQ Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKQ Gene

Genomics for DGKQ Gene

GeneHancer (GH) Regulatory Elements for DGKQ Gene

Promoters and enhancers for DGKQ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I000969 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 612.3 +14.9 14945 4.1 KLF17 ZBTB40 ZNF335 GLIS2 EGR1 EGR2 SMARCA5 SP3 ZBTB11 ZNF592 DGKQ SLC26A1 GAK GC04P000975 PIR57975
GH04I000986 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 611.8 -0.2 -201 2.1 HDGF ATF1 SIN3A DMAP1 POLR2B GLIS2 ZNF207 ZNF143 ATF7 SP3 DGKQ IDUA SLC26A1 GC04P000992
GH04I000985 Enhancer 0.8 ENCODE 568.9 +1.6 1577 0.2 HDAC1 ATF1 TAF9B RB1 ARID4B SIN3A ZSCAN9 RAD21 YY1 GLIS2 DGKQ IDUA GC04P000984 SLC26A1
GH04I000991 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 40.4 -6.2 -6168 2.7 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 POLR2B SP5 SLC26A1 GC04P000992 DGKQ TMEM175 ENSG00000251639 RNF212 ENSG00000250321 IDUA
GH04I000929 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.9 +55.3 55266 3.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF207 ZNF143 SP3 GAK TMEM175 DGKQ CRIPAK PCGF3 MAEA PIGG ENSG00000281016 ENSG00000254094 ENSG00000273179
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DGKQ on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DGKQ gene promoter:

Genomic Locations for DGKQ Gene

Genomic Locations for DGKQ Gene
chr4:958,884-986,895
(GRCh38/hg38)
Size:
28,012 bases
Orientation:
Minus strand
chr4:952,675-980,683
(GRCh37/hg19)

Genomic View for DGKQ Gene

Genes around DGKQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKQ Gene

Proteins for DGKQ Gene

  • Protein details for DGKQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52824-DGKQ_HUMAN
    Recommended name:
    Diacylglycerol kinase theta
    Protein Accession:
    P52824
    Secondary Accessions:
    • Q6P3W4

    Protein attributes for DGKQ Gene

    Size:
    942 amino acids
    Molecular mass:
    101155 Da
    Quaternary structure:
    • Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires the LXXLL motif 1 and LXXLL motif 2 in DGKQ.

neXtProt entry for DGKQ Gene

Selected DME Specific Peptides for DGKQ Gene

P52824:
  • CGGDGTVGW
  • VNPKSGG
  • PLGTGNDL
  • PVQVDGE

Post-translational modifications for DGKQ Gene

Domains & Families for DGKQ Gene

Gene Families for DGKQ Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DGKQ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52824

UniProtKB/Swiss-Prot:

DGKQ_HUMAN :
  • The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1.
  • Belongs to the eukaryotic diacylglycerol kinase family.
Domain:
  • The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKQ: view

Function for DGKQ Gene

Molecular function for DGKQ Gene

GENATLAS Biochemistry:
diacylglycerol kinase,110kDa,expressed in retina
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by binding to RHOA. Not inhibited by phosphatidylserine.
UniProtKB/Swiss-Prot Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.

Enzyme Numbers (IUBMB) for DGKQ Gene

Phenotypes From GWAS Catalog for DGKQ Gene

Gene Ontology (GO) - Molecular Function for DGKQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,TAS --
GO:0005515 protein binding IPI 10066731
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with DGKQ: view
genes like me logo Genes that share phenotypes with DGKQ: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGKQ Gene

Localization for DGKQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKQ Gene

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (PubMed:15632189). Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKQ gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
endosome 4

Gene Ontology (GO) - Cellular Components for DGKQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 15632189
GO:0005737 cytoplasm IEA,IDA 15632189
GO:0005768 endosome IDA 22732145
GO:0005829 cytosol IDA 10066731
genes like me logo Genes that share ontologies with DGKQ: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DGKQ Gene

Pathways & Interactions for DGKQ Gene

genes like me logo Genes that share pathways with DGKQ: view

Gene Ontology (GO) - Biological Process for DGKQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006111 regulation of gluconeogenesis IMP 23767959
GO:0006357 regulation of transcription by RNA polymerase II IDA 17664281
GO:0006654 phosphatidic acid biosynthetic process IMP 23610160
GO:0007165 signal transduction IEA --
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with DGKQ: view

No data available for SIGNOR curated interactions for DGKQ Gene

Drugs & Compounds for DGKQ Gene

(27) Drugs for DGKQ Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(52) Additional Compounds for DGKQ Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-pentadecanoyl-sn-glycerol
  • DAG(14:0/15:0)
  • DAG(29:0)
  • DG(14:0/15:0)
  • DG(29:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonoyl-sn-glycerol
  • DAG(16:1/20:4)
  • DAG(16:1n7/20:4n6)
  • DAG(16:1w7/20:4w6)
  • DAG(36:5)
Diglycerides Group C
  • 1-Pentadecanoyl-3-behenoyl-sn-glycerol
  • 1-Pentadecanoyl-3-docosanoyl-sn-glycerol
  • DAG(15:0/0:0/22:0)
  • DAG(37:0)
  • DG(37:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(2) Tocris Compounds for DGKQ Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(2) ApexBio Compounds for DGKQ Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
R 59-022 93076-89-2
genes like me logo Genes that share compounds with DGKQ: view

Drug Products

Transcripts for DGKQ Gene

Unigene Clusters for DGKQ Gene

Diacylglycerol kinase, theta 110kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKQ Gene

No ASD Table

Relevant External Links for DGKQ Gene

GeneLoc Exon Structure for
DGKQ
ECgene alternative splicing isoforms for
DGKQ

Expression for DGKQ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKQ Gene

Protein differential expression in normal tissues from HIPED for DGKQ Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8), CD8 Tcells (15.5), Frontal cortex (11.5), and Serum (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DGKQ Gene



NURSA nuclear receptor signaling pathways regulating expression of DGKQ Gene:

DGKQ

SOURCE GeneReport for Unigene cluster for DGKQ Gene:

Hs.584858

Evidence on tissue expression from TISSUES for DGKQ Gene

  • Eye(2.1)
genes like me logo Genes that share expression patterns with DGKQ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKQ Gene

Orthologs for DGKQ Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKQ 33
  • 96.75 (n)
dog
(Canis familiaris)
Mammalia DGKQ 33 34
  • 83.61 (n)
cow
(Bos Taurus)
Mammalia DGKQ 33 34
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Dgkq 33
  • 80.72 (n)
mouse
(Mus musculus)
Mammalia Dgkq 33 16 34
  • 80.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DGKQ 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGKQ 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKQ 33 34
  • 66.37 (n)
lizard
(Anolis carolinensis)
Reptilia DGKQ 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkq 33
  • 62.43 (n)
zebrafish
(Danio rerio)
Actinopterygii DGKQ 34
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31140 33
  • 54.09 (n)
CG34384 34
  • 11 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004209 33
  • 51.23 (n)
worm
(Caenorhabditis elegans)
Secernentea dgk-1 35 33
  • 46.04 (n)
dgk-4 34
  • 14 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.11251 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2680 34
  • 16 (a)
OneToMany
Species where no ortholog for DGKQ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKQ Gene

ENSEMBL:
Gene Tree for DGKQ (if available)
TreeFam:
Gene Tree for DGKQ (if available)

Paralogs for DGKQ Gene

Paralogs for DGKQ Gene

(1) SIMAP similar genes for DGKQ Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DGKQ: view

Variants for DGKQ Gene

Sequence variations from dbSNP and Humsavar for DGKQ Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000212392 -- 963,512(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000260949 -- 960,082(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs10003371 -- 973,318(-) G/A/T coding_sequence_variant, synonymous_variant
rs1000350886 -- 961,929(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000363006 -- 975,208(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DGKQ Gene

Variant ID Type Subtype PubMed ID
dgv5079n100 CNV gain 25217958
esv2726741 CNV deletion 23290073
esv28042 CNV loss 19812545
esv29984 CNV loss 17803354
esv3575667 CNV gain 25503493
nsv1003219 CNV gain 25217958
nsv1008352 CNV gain 25217958
nsv1074661 CNV deletion 25765185
nsv1147237 CNV deletion 26484159
nsv4196 CNV deletion 18451855
nsv469998 CNV loss 18288195
nsv593226 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv822428 CNV gain 20364138
nsv950327 CNV deletion 24416366

Variation tolerance for DGKQ Gene

Residual Variation Intolerance Score: 9.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKQ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKQ

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKQ Gene

Disorders for DGKQ Gene

Additional Disease Information for DGKQ

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DGKQ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKQ Gene

Publications for DGKQ Gene

  1. Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. (PMID: 15632189) van Baal J … van Blitterswijk WJ (The Journal of biological chemistry 2005) 3 4 22 58
  2. Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus. (PMID: 12799190) Tabellini G … Martelli AM (Experimental cell research 2003) 3 4 22 58
  3. Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA. (PMID: 10066731) Houssa B … van Blitterswijk WJ (The Journal of biological chemistry 1999) 3 4 22 58
  4. Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. (PMID: 9099683) Houssa B … van Blitterswijk WJ (The Journal of biological chemistry 1997) 2 3 22 58
  5. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. (PMID: 22438815) Lill CM … Bertram L (PLoS genetics 2012) 3 44 58

Products for DGKQ Gene

Sources for DGKQ Gene

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