Aliases for DGKQ Gene
External Ids for DGKQ Gene
Previous HGNC Symbols for DGKQ Gene
Previous GeneCards Identifiers for DGKQ Gene
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGKQ Gene
DGKQ (Diacylglycerol Kinase Theta) is a Protein Coding gene. Among its related pathways are Effects of PIP2 hydrolysis and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include kinase binding and phospholipase binding. An important paralog of this gene is DGKB.
UniProtKB/Swiss-Prot for DGKQ Gene
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.