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Aliases for DGKK Gene

Aliases for DGKK Gene

  • Diacylglycerol Kinase Kappa 2 3 3 5
  • 142 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Kappa 3 4
  • DAG Kinase Kappa 3 4
  • DGK-Kappa 3 4
  • EC 4

External Ids for DGKK Gene

Previous GeneCards Identifiers for DGKK Gene

  • GC0XM049944
  • GC0XM050128
  • GC0XM047555

Summaries for DGKK Gene

Entrez Gene Summary for DGKK Gene

  • The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

GeneCards Summary for DGKK Gene

DGKK (Diacylglycerol Kinase Kappa) is a Protein Coding gene. Diseases associated with DGKK include Hypospadias. Among its related pathways are Effects of PIP2 hydrolysis and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKD.

UniProtKB/Swiss-Prot for DGKK Gene

  • Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).

Tocris Summary for DGKK Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Additional gene information for DGKK Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKK Gene

Genomics for DGKK Gene

GeneHancer (GH) Regulatory Elements for DGKK Gene

Promoters and enhancers for DGKK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ050470 Promoter/Enhancer 1.1 EPDnew ENCODE 650.7 -0.2 -175 0.2 SP3 L3MBTL2 SUZ12 SP2 ZFHX2 GLIS2 POLR2A ZBTB48 KLF9 EGR2 DGKK GC0XM050588
GH0XJ050430 Enhancer 0.7 ENCODE 0.3 +39.1 39105 1.4 SOX13 FOXA2 CEBPG ZNF644 RARA TEAD3 FOSL1 ZNF335 NR2F6 CREM DGKK PIR58816
GH0XJ050432 Enhancer 0.6 ENCODE 0.3 +37.5 37542 1.7 DRAP1 SOX13 HMG20A ELF1 ZNF644 RARA KAT8 SKI NFIL3 SP1 DGKK PIR58816
GH0XJ050486 Enhancer 0.2 FANTOM5 0.4 -15.8 -15771 0.1 SHROOM4 DGKK GC0XM050588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DGKK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DGKK gene promoter:

Genomic Locations for DGKK Gene

Genomic Locations for DGKK Gene
105,332 bases
Minus strand

Genomic View for DGKK Gene

Genes around DGKK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKK Gene

Proteins for DGKK Gene

  • Protein details for DGKK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol kinase kappa
    Protein Accession:
    Secondary Accessions:
    • B2RP91

    Protein attributes for DGKK Gene

    1271 amino acids
    Molecular mass:
    141829 Da
    Quaternary structure:
    • Does not form homooligomers.

neXtProt entry for DGKK Gene

Post-translational modifications for DGKK Gene

  • Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGKK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DGKK Gene

Domains & Families for DGKK Gene

Gene Families for DGKK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DGKK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKK: view

Function for DGKK Gene

Molecular function for DGKK Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited in response to H(2)O(2).

Enzyme Numbers (IUBMB) for DGKK Gene

Phenotypes From GWAS Catalog for DGKK Gene

Gene Ontology (GO) - Molecular Function for DGKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity TAS,IDA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DGKK: view
genes like me logo Genes that share phenotypes with DGKK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKK

Clone Products

  • Addgene plasmids for DGKK

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGKK Gene

Localization for DGKK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKK Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Gene Ontology (GO) - Cellular Components for DGKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DGKK: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DGKK Gene

Pathways & Interactions for DGKK Gene

genes like me logo Genes that share pathways with DGKK: view

Interacting Proteins for DGKK Gene

Gene Ontology (GO) - Biological Process for DGKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IDA 16210324
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DGKK: view

No data available for SIGNOR curated interactions for DGKK Gene

Drugs & Compounds for DGKK Gene

(2) Drugs for DGKK Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(16) Additional Compounds for DGKK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)

(2) Tocris Compounds for DGKK Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKK: view

Transcripts for DGKK Gene

mRNA/cDNA for DGKK Gene

(1) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DGKK Gene

Diacylglycerol kinase, kappa:
Representative Sequences:

Clone Products

  • Addgene plasmids for DGKK

Alternative Splicing Database (ASD) splice patterns (SP) for DGKK Gene

No ASD Table

Relevant External Links for DGKK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGKK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKK Gene

This gene is overexpressed in Pituitary (x17.4), Brain - Nucleus accumbens (basal ganglia) (x16.3), Brain - Hypothalamus (x6.4), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for DGKK Gene

This gene is overexpressed in Kidney (27.0), Pancreas (22.8), and Lung (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKK Gene

Protein tissue co-expression partners for DGKK Gene

NURSA nuclear receptor signaling pathways regulating expression of DGKK Gene:


SOURCE GeneReport for Unigene cluster for DGKK Gene:


mRNA Expression by UniProt/SwissProt for DGKK Gene:

Tissue specificity: Expressed in testis, and to a lesser extent in placenta.
genes like me logo Genes that share expression patterns with DGKK: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKK Gene

Orthologs for DGKK Gene

This gene was present in the common ancestor of chordates.

Orthologs for DGKK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DGKK 33
  • 99.65 (n)
(Canis familiaris)
Mammalia DGKK 33
  • 87.61 (n)
(Bos Taurus)
Mammalia DGKK 33
  • 86.39 (n)
(Rattus norvegicus)
Mammalia Dgkk 33
  • 83.65 (n)
(Mus musculus)
Mammalia Dgkk 16 33
  • 81.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2361 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2361 33
Species where no ortholog for DGKK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DGKK Gene

Gene Tree for DGKK (if available)
Gene Tree for DGKK (if available)
Evolutionary constrained regions (ECRs) for DGKK: view image

Paralogs for DGKK Gene

Paralogs for DGKK Gene

(2) SIMAP similar genes for DGKK Gene using alignment to 2 proteins:

  • L8EC67_HUMAN
genes like me logo Genes that share paralogs with DGKK: view

Variants for DGKK Gene

Sequence variations from dbSNP and Humsavar for DGKK Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000088844 -- 50,406,574(-) A/G intron_variant
rs1000138952 -- 50,414,581(-) G/A intron_variant
rs1000291715 -- 50,464,935(-) C/T intron_variant
rs1000368108 -- 50,388,475(-) C/G intron_variant
rs1000486939 -- 50,454,864(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DGKK Gene

Variant ID Type Subtype PubMed ID
nsv1075728 CNV deletion 25765185
nsv1141063 CNV deletion 24896259
nsv508771 CNV insertion 20534489
nsv523598 CNV gain 19592680

Additional Variant Information for DGKK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DGKK Gene

Disorders for DGKK Gene

MalaCards: The human disease database

(1) MalaCards diseases for DGKK Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • familial hypospadias
- elite association - COSMIC cancer census association via MalaCards
Search DGKK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DGKK

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DGKK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGKK Gene

Publications for DGKK Gene

  1. Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa. (PMID: 16210324) Imai S … Sakane F (The Journal of biological chemistry 2005) 2 3 4 58
  2. Common variants in DGKK are strongly associated with risk of hypospadias. (PMID: 21113153) van der Zanden LF … Knoers NV (Nature genetics 2011) 3 44 58
  3. Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons. (PMID: 27233938) Tabet R … Moine H (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 58
  4. Expression Analysis of DGKK during External Genitalia Formation. (PMID: 26162297) Shen J … Choudhry S (The Journal of urology 2015) 3 58
  5. Diacylglycerol kinase κ (DGKK) variants and hypospadias in Han Chinese: association and meta-analysis. (PMID: 25327554) Ma Q … Geng H (BJU international 2015) 3 58

Products for DGKK Gene

  • Addgene plasmids for DGKK

Sources for DGKK Gene

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