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Aliases for DGKH Gene

Aliases for DGKH Gene

  • Diacylglycerol Kinase Eta 2 3 3 5
  • Diglyceride Kinase Eta 3 4
  • DAG Kinase Eta 3 4
  • EC 4
  • DGK-Eta 4
  • DGKeta 3

External Ids for DGKH Gene

Previous GeneCards Identifiers for DGKH Gene

  • GC13U990039
  • GC13P041559
  • GC13P040420
  • GC13P041520
  • GC13P042622
  • GC13P023427

Summaries for DGKH Gene

Entrez Gene Summary for DGKH Gene

  • This gene encodes a member of the diacylglycerol kinase (DGK) enzyme family. Members of this family are involved in regulating intracellular concentrations of diacylglycerol and phosphatidic acid. Variation in this gene has been associated with bipolar disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2014]

GeneCards Summary for DGKH Gene

DGKH (Diacylglycerol Kinase Eta) is a Protein Coding gene. Diseases associated with DGKH include Adrenal Medulla Cancer and Extra-Adrenal Pheochromocytoma. Among its related pathways are Effects of PIP2 hydrolysis and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKD.

UniProtKB/Swiss-Prot for DGKH Gene

  • Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.

Tocris Summary for DGKH Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Additional gene information for DGKH Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKH Gene

Genomics for DGKH Gene

GeneHancer (GH) Regulatory Elements for DGKH Gene

Promoters and enhancers for DGKH Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J042046 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.4 +8.4 8381 2.9 SIN3A GLI4 ZNF2 ZNF48 YY1 ZNF121 GLIS2 E2F8 ZNF207 ZNF143 DGKH RNU6-74P VWA8 ENSG00000231530 GC13M042068
GH13J042039 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 650.7 +0.8 781 3.2 ATF1 SIN3A FEZF1 ZNF2 IRF4 ZNF48 GLIS2 ZNF213 ATF7 RUNX3 DGKH ENSG00000231530
GH13J042138 Promoter 0.8 EPDnew 650.2 +98.0 98003 0.1 BCL11A EED JUNB BATF IKZF2 ATF2 CREM DGKH GC13M042088 GC13M042182
GH13J041959 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 -78.5 -78511 4.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF207 ZHX2 VWA8 DGKH ENSG00000231530 RNU6-74P AKAP11 VWA8-AS1 GC13P041978
GH13J041644 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -391.4 -391444 8.9 PKNOX1 FOXA2 ZFP64 ARID4B FEZF1 ETS1 YY1 RXRA SP5 TSHZ1 RGCC VWA8 NAA16 OR7E155P OR7E37P RNU6-57P ENSG00000231530 DGKH GC13M041633 GC13M041702
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DGKH gene promoter:
  • GATA-3
  • GATA-2
  • GATA-1
  • TBP
  • SRF (504 AA)
  • SRF
  • aMEF-2
  • MEF-2A
  • NF-AT
  • NF-AT1

Genomic Locations for DGKH Gene

Genomic Locations for DGKH Gene
216,549 bases
Plus strand
216,543 bases
Plus strand

Genomic View for DGKH Gene

Genes around DGKH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKH Gene

Proteins for DGKH Gene

  • Protein details for DGKH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Diacylglycerol kinase eta
    Protein Accession:
    Secondary Accessions:
    • A2A2W7
    • A6NFX7
    • B4DZ34
    • Q5VZW0
    • Q6PI56
    • Q86XP2
    • Q8N3N0
    • Q8N7J9

    Protein attributes for DGKH Gene

    1220 amino acids
    Molecular mass:
    134866 Da
    Quaternary structure:
    • Isoform 1 forms homooligomers through the SAM domain. Isoform 1 is also able to form heterooligomers with SAM domain-containing isoforms of DGKD. Oligomerization of isoform 1 inhibits its catalytic activity. Interacts with RAF1 and BRAF.
    • Sequence=BAC05280.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DGKH Gene


neXtProt entry for DGKH Gene

Post-translational modifications for DGKH Gene

No data available for DME Specific Peptides for DGKH Gene

Domains & Families for DGKH Gene

Suggested Antigen Peptide Sequences for DGKH Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic diacylglycerol kinase family.
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKH: view

Function for DGKH Gene

Molecular function for DGKH Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Enzyme Numbers (IUBMB) for DGKH Gene

Phenotypes From GWAS Catalog for DGKH Gene

Gene Ontology (GO) - Molecular Function for DGKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity TAS --
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with DGKH: view
genes like me logo Genes that share phenotypes with DGKH: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKH

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKH

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DGKH Gene

Localization for DGKH Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKH Gene

Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKH gene
Compartment Confidence
endosome 5
plasma membrane 4
cytosol 4
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DGKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 12810723
GO:0005768 endosome IDA 12810723
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DGKH: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DGKH Gene

Pathways & Interactions for DGKH Gene

genes like me logo Genes that share pathways with DGKH: view

Gene Ontology (GO) - Biological Process for DGKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IMP 12810723
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with DGKH: view

No data available for SIGNOR curated interactions for DGKH Gene

Drugs & Compounds for DGKH Gene

(3) Drugs for DGKH Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(25) Additional Compounds for DGKH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(2) Tocris Compounds for DGKH Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKH: view

Transcripts for DGKH Gene

Unigene Clusters for DGKH Gene

Diacylglycerol kinase, eta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKH

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DGKH Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b · 34c · 34d
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for DGKH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DGKH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKH Gene

Protein differential expression in normal tissues from HIPED for DGKH Gene

This gene is overexpressed in Plasma (31.0), Lung (25.0), and Heart (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKH Gene

Protein tissue co-expression partners for DGKH Gene

NURSA nuclear receptor signaling pathways regulating expression of DGKH Gene:


SOURCE GeneReport for Unigene cluster for DGKH Gene:


mRNA Expression by UniProt/SwissProt for DGKH Gene:

Tissue specificity: Isoform 2 is ubiquitously expressed. Isoform 1 is expressed only in testis, kidney and colon.

Evidence on tissue expression from TISSUES for DGKH Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with DGKH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKH Gene

Orthologs for DGKH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DGKH 34 33
  • 99.51 (n)
(Canis familiaris)
Mammalia DGKH 34 33
  • 92.08 (n)
(Bos Taurus)
Mammalia DGKH 34 33
  • 89.79 (n)
(Mus musculus)
Mammalia Dgkh 16 34 33
  • 86.76 (n)
(Rattus norvegicus)
Mammalia Dgkh 33
  • 85.92 (n)
(Ornithorhynchus anatinus)
Mammalia DGKH 34
  • 83 (a)
(Monodelphis domestica)
Mammalia DGKH 34
  • 79 (a)
(Gallus gallus)
Aves DGKH 34 33
  • 80.45 (n)
(Anolis carolinensis)
Reptilia DGKH 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkh 33
  • 77.18 (n)
(Danio rerio)
Actinopterygii dgkh 34 33
  • 71.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002226 33
  • 52.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34384 34 33
  • 52.72 (n)
(Caenorhabditis elegans)
Secernentea dgk-4 34
  • 31 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3334 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2680 34
  • 48 (a)
Species where no ortholog for DGKH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKH Gene

Gene Tree for DGKH (if available)
Gene Tree for DGKH (if available)
Evolutionary constrained regions (ECRs) for DGKH: view image

Paralogs for DGKH Gene

Paralogs for DGKH Gene

(2) SIMAP similar genes for DGKH Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DGKH: view

Variants for DGKH Gene

Sequence variations from dbSNP and Humsavar for DGKH Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000016288 -- 42,076,143(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000033561 -- 42,218,042(+) C/T intron_variant
rs1000054051 -- 42,047,594(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000079835 -- 42,163,160(+) A/G intron_variant
rs1000085702 -- 42,217,665(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DGKH Gene

Variant ID Type Subtype PubMed ID
dgv104e215 CNV deletion 23714750
dgv961n106 CNV deletion 24896259
esv1238821 CNV deletion 17803354
esv2150531 CNV deletion 18987734
esv2646739 CNV deletion 19546169
esv2661097 CNV deletion 23128226
esv2747310 CNV deletion 23290073
esv2747311 CNV deletion 23290073
esv2747312 CNV deletion 23290073
esv2747313 CNV deletion 23290073
esv2759934 CNV loss 17122850
esv2952 CNV loss 18987735
esv3305161 CNV mobile element insertion 20981092
esv3323658 CNV insertion 20981092
esv3360672 CNV insertion 20981092
esv3580618 CNV loss 25503493
esv3631888 CNV loss 21293372
esv3631889 CNV gain 21293372
nsv1016 CNV insertion 18451855
nsv1070167 CNV deletion 25765185
nsv1134305 CNV deletion 24896259
nsv1153684 CNV deletion 26484159
nsv455866 CNV loss 19166990
nsv455867 CNV loss 19166990
nsv510333 OTHER sequence alteration 20534489
nsv519614 CNV loss 19592680
nsv523454 CNV loss 19592680
nsv561542 CNV loss 21841781
nsv561543 CNV loss 21841781
nsv819965 CNV loss 19587683
nsv832588 CNV gain 17160897
nsv832589 CNV loss 17160897
nsv832590 CNV gain 17160897
nsv9070 CNV gain 18304495
nsv958130 CNV deletion 24416366
nsv976109 CNV duplication 23825009

Variation tolerance for DGKH Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.83; 83.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKH Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKH Gene

Disorders for DGKH Gene

MalaCards: The human disease database

(3) MalaCards diseases for DGKH Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
adrenal medulla cancer
  • adrenal medulla neoplasm
extra-adrenal pheochromocytoma
  • extraadrenal pheochromocytoma
bipolar disorder
  • major affective disorder 1
- elite association - COSMIC cancer census association via MalaCards
Search DGKH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DGKH

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DGKH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGKH Gene

Publications for DGKH Gene

  1. No association between DGKH and bipolar disorder in a Scandinavian case-control sample. (PMID: 19478689) Tesli M … Djurovic S (Psychiatric genetics 2009) 3 22 44 58
  2. Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. (PMID: 19710016) Yasuda S … Sakane F (The Journal of biological chemistry 2009) 3 4 22 58
  3. Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients. (PMID: 19818381) Manchia M … Del Zompo M (Neuroscience letters 2009) 3 22 44 58
  4. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. (PMID: 17486107) Baum AE … McMahon FJ (Molecular psychiatry 2008) 3 22 44 58
  5. Identification and characterization of two splice variants of human diacylglycerol kinase eta. (PMID: 12810723) Murakami T … Kanoh H (The Journal of biological chemistry 2003) 3 4 22 58

Products for DGKH Gene

Sources for DGKH Gene

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