This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins a... See more...

Aliases for DGKG Gene

Aliases for DGKG Gene

  • Diacylglycerol Kinase Gamma 2 3 4 5
  • Diacylglycerol Kinase, Gamma 90kDa 2 3
  • Diglyceride Kinase Gamma 3 4
  • DAG Kinase Gamma 3 4
  • EC 2.7.1.107 4 52
  • DAGK3 3 4
  • Diacylglycerol Kinase, Gamma (90kD) 2
  • Diacylglyerol Kinase Gamma 3
  • DGK-GAMMA 3
  • DGK-Gamma 4

External Ids for DGKG Gene

Previous HGNC Symbols for DGKG Gene

  • DAGK3

Previous GeneCards Identifiers for DGKG Gene

  • GC03M182638
  • GC03M187124
  • GC03M187269
  • GC03M187187
  • GC03M187349
  • GC03M185823
  • GC03M183274

Summaries for DGKG Gene

Entrez Gene Summary for DGKG Gene

  • This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKG Gene

DGKG (Diacylglycerol Kinase Gamma) is a Protein Coding gene. Diseases associated with DGKG include Fanconi Anemia, Complementation Group A. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKB.

UniProtKB/Swiss-Prot Summary for DGKG Gene

  • Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.

Tocris Summary for DGKG Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKG Gene

Additional gene information for DGKG Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DGKG Gene

Genomics for DGKG Gene

GeneHancer (GH) Regulatory Elements for DGKG Gene

Promoters and enhancers for DGKG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J186361 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.5 533 2.2 ZBTB26 MXI1 EZH2 SP2 NANOG POLR2A SPI1 ZFHX2 ZNF777 ZNF335 DGKG lnc-ETV5-5
GH03J186280 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 500.2 +81.0 81024 1.2 FOS BHLHE40 YY1 lnc-ETV5-4 DGKG ETV5 ETV5-AS1 lnc-ETV5-3
GH03J186230 Enhancer 0.3 FANTOM5 10.5 +131.6 131562 0.3 YBX1 ETV5 TRA2B DGKG lnc-DNAJB11-4 lnc-ETV5-2
GH03J186283 Enhancer 0.6 FANTOM5 Ensembl 2.1 +78.4 78433 1.6 FOS HIC1 ATF3 ZNF629 ETV5 ETV5-AS1 DGKG lnc-ETV5-4 lnc-ETV5-5
GH03J186013 Enhancer 0.2 FANTOM5 2.4 +348.8 348790 0.2 DGKG RF00994-712 RF00017-4200
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DGKG

Top Transcription factor binding sites by QIAGEN in the DGKG gene promoter:
  • AML1a
  • Evi-1
  • Ik-1
  • ITF-2
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • RFX1
  • Tal-1beta
  • XBP-1

Genomic Locations for DGKG Gene

Genomic Locations for DGKG Gene
chr3:186,105,668-186,362,234
(GRCh38/hg38)
Size:
256,567 bases
Orientation:
Minus strand
chr3:185,823,457-186,080,026
(GRCh37/hg19)
Size:
256,570 bases
Orientation:
Minus strand

Genomic View for DGKG Gene

Genes around DGKG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKG Gene

Proteins for DGKG Gene

  • Protein details for DGKG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49619-DGKG_HUMAN
    Recommended name:
    Diacylglycerol kinase gamma
    Protein Accession:
    P49619
    Secondary Accessions:
    • B2RAH4
    • Q2M1H4
    • Q5FWG1

    Protein attributes for DGKG Gene

    Size:
    791 amino acids
    Molecular mass:
    89124 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: May be inactive.

    Alternative splice isoforms for DGKG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKG Gene

Selected DME Specific Peptides for DGKG Gene

P49619:
  • CGGDGTVGW
  • NNYFSIGVDASIAHRFH
  • TSETFAA
  • PEKFNSR
  • VNPKSGG
  • NKLWYFE
  • PLGTGNDL
  • PMQVDGE
  • DKLEFMFRLYD
  • LEVVGLEGA
  • PLLVLLG

Post-translational modifications for DGKG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DGKG Gene

Domains & Families for DGKG Gene

Gene Families for DGKG Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DGKG Gene

GenScript: Design optimal peptide antigens:
  • Diglyceride kinase gamma (DGKG_HUMAN)
  • Diacylglyerol kinase gamma (Q2M589_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49619

UniProtKB/Swiss-Prot:

DGKG_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKG: view

Function for DGKG Gene

Molecular function for DGKG Gene

UniProtKB/Swiss-Prot Function:
Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Requires phosphatidylserine for maximal activity.
GENATLAS Biochemistry:
diacylglycerol kinase gamma,90kDa,predominantly expressed in the retina and brain

Enzyme Numbers (IUBMB) for DGKG Gene

Phenotypes From GWAS Catalog for DGKG Gene

Gene Ontology (GO) - Molecular Function for DGKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,IDA 22627129
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with DGKG: view
genes like me logo Genes that share phenotypes with DGKG: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKG

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKG

Clone Products

  • Addgene plasmids for DGKG

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DGKG Gene

Localization for DGKG Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKG Gene

Cytoplasm. Membrane. Note=Can be loosely bound to the membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKG gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DGKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DGKG: view

Pathways & Interactions for DGKG Gene

genes like me logo Genes that share pathways with DGKG: view

SIGNOR curated interactions for DGKG Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DGKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,TAS 8034597
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway IEA --
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
GO:0035556 intracellular signal transduction IEA,IBA 21873635
genes like me logo Genes that share ontologies with DGKG: view

Drugs & Compounds for DGKG Gene

(4) Drugs for DGKG Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphatidyl serine Approved, Investigational Nutra Target 0
PHOSPHATIDYLSERINE Pharma 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(140) Additional Compounds for DGKG Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
PA(16:0/16:0)
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
  • 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
  • Dipalmitoyl phosphatidic acid
  • PA(32:0)
7091-44-3

(2) Tocris Compounds for DGKG Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2
genes like me logo Genes that share compounds with DGKG: view

Transcripts for DGKG Gene

mRNA/cDNA for DGKG Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKG

Clone Products

  • Addgene plasmids for DGKG

Alternative Splicing Database (ASD) splice patterns (SP) for DGKG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -
SP2: - - -
SP3: - - - -
SP4:

ExUns: 24 ^ 25 ^ 26a · 26b ^ 27
SP1: -
SP2:
SP3: -
SP4:

Relevant External Links for DGKG Gene

GeneLoc Exon Structure for
DGKG

Expression for DGKG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKG Gene

This gene is overexpressed in Brain - Cerebellum (x5.5), Brain - Cerebellar Hemisphere (x5.4), Esophagus - Muscularis (x5.2), and Esophagus - Gastroesophageal Junction (x5.0).

Protein differential expression in normal tissues from HIPED for DGKG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.8) and Platelet (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DGKG Gene



Protein tissue co-expression partners for DGKG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DGKG

SOURCE GeneReport for Unigene cluster for DGKG Gene:

Hs.683449

mRNA Expression by UniProt/SwissProt for DGKG Gene:

P49619-DGKG_HUMAN
Tissue specificity: Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

Evidence on tissue expression from TISSUES for DGKG Gene

  • Nervous system(4.7)
  • Liver(4)
genes like me logo Genes that share expression patterns with DGKG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKG Gene

Orthologs for DGKG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKG 31 30
  • 99.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DGKG 31 30
  • 91.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DGKG 31 30
  • 91.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dgkg 17 31 30
  • 87.77 (n)
rat
(Rattus norvegicus)
Mammalia Dgkg 30
  • 87.18 (n)
oppossum
(Monodelphis domestica)
Mammalia DGKG 31
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKG 31 30
  • 70.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKG 31
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC567728 30
  • 66.03 (n)
DGKG 31
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dgk 31 32
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dgk-3 31 32
  • 46 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0425300 30
  • 50.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10986 31
  • 49 (a)
OneToMany
Species where no ortholog for DGKG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DGKG Gene

ENSEMBL:
Gene Tree for DGKG (if available)
TreeFam:
Gene Tree for DGKG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DGKG: view image

Paralogs for DGKG Gene

Paralogs for DGKG Gene

(4) SIMAP similar genes for DGKG Gene using alignment to 4 proteins:

  • DGKG_HUMAN
  • F5GX27_HUMAN
  • H7C0L0_HUMAN
  • Q2M589_HUMAN
genes like me logo Genes that share paralogs with DGKG: view

Variants for DGKG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DGKG Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
716768 Benign: not provided 186,211,795(-) C/T SYNONYMOUS_VARIANT
775207 Benign: not provided 186,288,840(-) T/C SYNONYMOUS_VARIANT
VAR_036119 A breast cancer sample p.Glu706Lys
rs1004588 - p.Thr142Ser
rs2193587 - p.Arg316Lys

Additional dbSNP identifiers (rs#s) for DGKG Gene

Structural Variations from Database of Genomic Variants (DGV) for DGKG Gene

Variant ID Type Subtype PubMed ID
dgv1433e212 CNV loss 25503493
esv1567505 CNV insertion 17803354
esv2664472 CNV deletion 23128226
esv2726335 CNV deletion 23290073
esv2726336 CNV deletion 23290073
esv3303903 CNV mobile element insertion 20981092
esv3430021 CNV insertion 20981092
esv3569152 CNV loss 25503493
esv3598985 CNV loss 21293372
esv3598986 CNV gain 21293372
esv3598987 CNV loss 21293372
nsv1078812 CNV insertion 25765185
nsv1111256 CNV tandem duplication 24896259
nsv1146437 CNV insertion 26484159
nsv4150 CNV insertion 18451855
nsv820248 CNV loss 19587683
nsv822367 CNV loss 20364138
nsv950024 CNV duplication 24416366

Variation tolerance for DGKG Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKG Gene

Disorders for DGKG Gene

MalaCards: The human disease database

(1) MalaCards diseases for DGKG Gene - From: DISEASES

Disorder Aliases PubMed IDs
fanconi anemia, complementation group a
  • fanca
- elite association - COSMIC cancer census association via MalaCards
Search DGKG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DGKG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DGKG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGKG Gene

Publications for DGKG Gene

  1. Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells. (PMID: 8034597) Kai M … Kanoh H (The Journal of biological chemistry 1994) 2 3 4 23 54
  2. Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma. (PMID: 16905533) Yamaguchi Y … Saito N (The Journal of biological chemistry 2006) 3 23 26 54
  3. Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1). (PMID: 10071200) Stöhr H … Weber BH (Human genetics 1999) 3 4 23 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 41 54

Products for DGKG Gene

Sources for DGKG Gene