Aliases for DGKE Gene
External Ids for DGKE Gene
Previous GeneCards Identifiers for DGKE Gene
Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]
GeneCards Summary for DGKE Gene
DGKE (Diacylglycerol Kinase Epsilon) is a Protein Coding gene. Diseases associated with DGKE include Nephrotic Syndrome, Type 7 and Hemolytic-Uremic Syndrome. Among its related pathways are Phospholipase D signaling pathway and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKD.
UniProtKB/Swiss-Prot Summary for DGKE Gene
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.