Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008] See more...

Aliases for DGKE Gene

Aliases for DGKE Gene

  • Diacylglycerol Kinase Epsilon 2 3 4 5
  • Diacylglycerol Kinase, Epsilon 64kDa 2 3
  • Diglyceride Kinase Epsilon 3 4
  • DAG Kinase Epsilon 3 4
  • EC 2.7.1.107 4 52
  • DGK-Epsilon 3 4
  • DAGK5 3 4
  • Diacylglycerol Kinase, Epsilon (64kD) 2
  • AHUS7 3
  • DAGK6 3
  • NPHS7 3
  • DGK 3

External Ids for DGKE Gene

Previous GeneCards Identifiers for DGKE Gene

  • GC17P054648
  • GC17P057392
  • GC17P055253
  • GC17P055386
  • GC17P052266
  • GC17P054911
  • GC17P050271

Summaries for DGKE Gene

Entrez Gene Summary for DGKE Gene

  • Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKE Gene

DGKE (Diacylglycerol Kinase Epsilon) is a Protein Coding gene. Diseases associated with DGKE include Nephrotic Syndrome, Type 7 and Hemolytic-Uremic Syndrome. Among its related pathways are Signaling by GPCR and RET signaling. Gene Ontology (GO) annotations related to this gene include NAD+ kinase activity and diacylglycerol kinase activity. An important paralog of this gene is DGKB.

UniProtKB/Swiss-Prot Summary for DGKE Gene

  • Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.

Tocris Summary for DGKE Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Additional gene information for DGKE Gene

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DGKE Gene

Genomics for DGKE Gene

GeneHancer (GH) Regulatory Elements for DGKE Gene

Promoters and enhancers for DGKE Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKE on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DGKE

Top Transcription factor binding sites by QIAGEN in the DGKE gene promoter:
  • aMEF-2
  • AREB6
  • FOXO3
  • FOXO3a
  • FOXO3b
  • HEN1
  • MEF-2A
  • MIF-1
  • NRF-2
  • RFX1

Genomic Locations for DGKE Gene

Genomic Locations for DGKE Gene
chr17:56,834,099-56,869,567
(GRCh38/hg38)
Size:
35,469 bases
Orientation:
Plus strand
chr17:54,911,460-54,946,036
(GRCh37/hg19)
Size:
34,577 bases
Orientation:
Plus strand

Genomic View for DGKE Gene

Genes around DGKE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKE Gene

Proteins for DGKE Gene

  • Protein details for DGKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52429-DGKE_HUMAN
    Recommended name:
    Diacylglycerol kinase epsilon
    Protein Accession:
    P52429
    Secondary Accessions:
    • Q8TBM4
    • Q9UKQ3

    Protein attributes for DGKE Gene

    Size:
    567 amino acids
    Molecular mass:
    63927 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DGKE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKE Gene

Selected DME Specific Peptides for DGKE Gene

P52429:
  • CGGDGTVGW
  • PLGTGNDL
  • PMQVDGE

Post-translational modifications for DGKE Gene

  • Ubiquitination at Lys357
  • Modification sites at PhosphoSitePlus

Domains & Families for DGKE Gene

Gene Families for DGKE Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DGKE Gene

Blocks:
  • Diacylglycerol kinase accessory domain (presumed)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DGKE Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75840, highly similar to Homo sapiens diacylglycerol kinase, epsilon 64kDa (DGKE), mRNA (A1L4Q0_HUMAN)
  • Diglyceride kinase epsilon (DGKE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52429

UniProtKB/Swiss-Prot:

DGKE_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKE: view

Function for DGKE Gene

Molecular function for DGKE Gene

UniProtKB/Swiss-Prot Function:
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107;.
GENATLAS Biochemistry:
diacylglycerol kinase epsilon,expressed predominantly in the testis and the retina,converting diacylglycerol to phosphatidic acid,involved in the phosphorylation of arachidonate containing diacylglycerol,

Enzyme Numbers (IUBMB) for DGKE Gene

Phenotypes From GWAS Catalog for DGKE Gene

Gene Ontology (GO) - Molecular Function for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IDA,IEA 18004883
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IDA,IEA 18004883
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DGKE: view
genes like me logo Genes that share phenotypes with DGKE: view

Human Phenotype Ontology for DGKE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DGKE Gene

MGI Knock Outs for DGKE:

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKE

CRISPR Products

miRNA for DGKE Gene

Clone Products

  • Addgene plasmids for DGKE

No data available for Transcription Factor Targets and HOMER Transcription for DGKE Gene

Localization for DGKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKE Gene

Membrane; Multi-pass membrane protein. Membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKE gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 23542698
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with DGKE: view

Pathways & Interactions for DGKE Gene

genes like me logo Genes that share pathways with DGKE: view

Gene Ontology (GO) - Biological Process for DGKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway IEA --
GO:0008654 phospholipid biosynthetic process TAS 8626589
GO:0016310 phosphorylation IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with DGKE: view

No data available for SIGNOR curated interactions for DGKE Gene

Drugs & Compounds for DGKE Gene

(5) Drugs for DGKE Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(26) Additional Compounds for DGKE Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-arachidonyl-3-behenoyl-sn-glycerol
  • DAG(42:0)
  • Diacylglycerol(20:0/0:0/22:0)
  • DG(42:0)
  • Diglyceride
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-Stearoyl-2-palmitoyl-sn-glycerol
  • DAG(18:0/16:0)
  • DAG(34:0)
  • DG(18:0/16:0)
  • DG(34:0)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(2) Tocris Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(1) ApexBio Compounds for DGKE Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
genes like me logo Genes that share compounds with DGKE: view

Drug Products

Transcripts for DGKE Gene

mRNA/cDNA for DGKE Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for DGKE

Alternative Splicing Database (ASD) splice patterns (SP) for DGKE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3:

Relevant External Links for DGKE Gene

GeneLoc Exon Structure for
DGKE

Expression for DGKE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DGKE Gene

This gene is overexpressed in Retina (45.5) and Testis (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKE Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DGKE

SOURCE GeneReport for Unigene cluster for DGKE Gene:

Hs.239514

mRNA Expression by UniProt/SwissProt for DGKE Gene:

P52429-DGKE_HUMAN
Tissue specificity: Expressed predominantly in testis. Expressed in endothelium, platelets and podocytes (at protein level).

Evidence on tissue expression from TISSUES for DGKE Gene

  • Heart(4.1)
  • Nervous system(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKE Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • respiratory
  • urinary
Regions:
Thorax:
  • lung
Abdomen:
  • kidney
Pelvis:
  • urinary bladder
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with DGKE: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DGKE Gene

Orthologs for DGKE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKE 31 30
  • 99.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DGKE 31 30
  • 91.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DGKE 31 30
  • 90.96 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dgke 17 31 30
  • 87.23 (n)
oppossum
(Monodelphis domestica)
Mammalia DGKE 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGKE 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKE 31 30
  • 77.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKE 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgke 30
  • 72.7 (n)
zebrafish
(Danio rerio)
Actinopterygii dgke 31 30
  • 68.09 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006768 30
  • 49.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dgkepsilon 31 30
  • 48.26 (n)
OneToOne
Dgk&egr; 32
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea dgk-2 31 32 30
  • 48.7 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DGK1 30
  • 47.29 (n)
rice
(Oryza sativa)
Liliopsida Os12g0576900 30
  • 47.77 (n)
Species where no ortholog for DGKE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKE Gene

ENSEMBL:
Gene Tree for DGKE (if available)
TreeFam:
Gene Tree for DGKE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DGKE: view image

Paralogs for DGKE Gene

Paralogs for DGKE Gene