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Aliases for DGKD Gene

Aliases for DGKD Gene

  • Diacylglycerol Kinase Delta 2 3 3 5
  • Diacylglycerol Kinase, Delta 130kDa 2 3
  • Diglyceride Kinase Delta 3 4
  • DAG Kinase Delta 3 4
  • DGK-Delta 3 4
  • Diacylglycerol Kinase, Delta (130kD) 2
  • 130 KDa Diacylglycerol Kinase 4
  • Diglyceride Kinase 2
  • EC 2.7.1.107 4
  • DGKdelta 3
  • KIAA0145 4
  • Dgkd-2 3

External Ids for DGKD Gene

Previous GeneCards Identifiers for DGKD Gene

  • GC02P232271
  • GC02P232944
  • GC02P234279
  • GC02P234549
  • GC02P234045
  • GC02P233927
  • GC02P226097
  • GC02P234272

Summaries for DGKD Gene

Entrez Gene Summary for DGKD Gene

  • This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKD Gene

DGKD (Diacylglycerol Kinase Delta) is a Protein Coding gene. Among its related pathways are Effects of PIP2 hydrolysis and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD+ kinase activity. An important paralog of this gene is DGKH.

UniProtKB/Swiss-Prot for DGKD Gene

  • May function as signaling molecule.

  • Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.

Tocris Summary for DGKD Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKD Gene

Additional gene information for DGKD Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGKD Gene

Genomics for DGKD Gene

GeneHancer (GH) Regulatory Elements for DGKD Gene

Promoters and enhancers for DGKD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233348 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659.7 -0.1 -133 11.5 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 DGKD ENSG00000259793 ATG16L1 USP40 SAG SCARNA5 GIGYF2 SCARNA6 INPP5D
GH02J233412 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 660.7 +67.3 67266 18.4 PKNOX1 CLOCK FOXA2 ARNT SIN3A FOS KLF13 REST ZNF592 SMARCA4 DGKD USP40 SAG ATG16L1 SCARNA6 SCARNA5 INPP5D LOC105373929 PIR59405 ENSG00000201013
GH02J233384 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 669.6 +32.3 32290 5.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 RUNX3 NFKBIZ RXRA DGKD ATG16L1 USP40 SAG SCARNA5 SCARNA6 GC02M233380 ENSG00000201013 PIR59405
GH02J233330 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.8 -22.0 -21961 3.2 MAX STAT5A ZBTB40 IRF4 YY1 EGR1 POLR2A EED ZNF143 ATF7 DGKD ATG16L1 SAG SCARNA6 SCARNA5 ENSG00000259793
GH02J233378 Enhancer 0.7 dbSUPER 20.2 +25.7 25720 3.6 EBF1 CEBPG CTBP1 GLIS2 NFATC1 PRDM10 RUNX3 CREM GATAD2A CBFA2T3 ENSG00000201013 GC02M233380 DGKD ATG16L1 SCARNA5 SAG PIR59405
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DGKD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DGKD gene promoter:

Genomic Locations for DGKD Gene

Genomic Locations for DGKD Gene
chr2:233,354,507-233,472,104
(GRCh38/hg38)
Size:
117,598 bases
Orientation:
Plus strand
chr2:234,263,153-234,380,750
(GRCh37/hg19)

Genomic View for DGKD Gene

Genes around DGKD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKD Gene

Proteins for DGKD Gene

  • Protein details for DGKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16760-DGKD_HUMAN
    Recommended name:
    Diacylglycerol kinase delta
    Protein Accession:
    Q16760
    Secondary Accessions:
    • Q14158
    • Q6PK55
    • Q8NG53

    Protein attributes for DGKD Gene

    Size:
    1214 amino acids
    Molecular mass:
    134525 Da
    Quaternary structure:
    • The two isoforms are able to form homo- and hetero-oligomer structures (at least tetramers). Isoform 2 interacts with AP2A2.

    Three dimensional structures from OCA and Proteopedia for DGKD Gene

    Alternative splice isoforms for DGKD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKD Gene

Post-translational modifications for DGKD Gene

No data available for DME Specific Peptides for DGKD Gene

Domains & Families for DGKD Gene

Gene Families for DGKD Gene

Suggested Antigen Peptide Sequences for DGKD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16760

UniProtKB/Swiss-Prot:

DGKD_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKD: view

Function for DGKD Gene

Molecular function for DGKD Gene

UniProtKB/Swiss-Prot Function:
May function as signaling molecule.
UniProtKB/Swiss-Prot Function:
Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Partially inhibited by phosphatidylserine.

Enzyme Numbers (IUBMB) for DGKD Gene

Phenotypes From GWAS Catalog for DGKD Gene

Gene Ontology (GO) - Molecular Function for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,TAS 8626538
GO:0005515 protein binding IPI 23414517
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with DGKD: view
genes like me logo Genes that share phenotypes with DGKD: view

Animal Models for DGKD Gene

MGI Knock Outs for DGKD:
  • Dgkd Dgkd<tm1Mtop>

Animal Model Products

  • Taconic Biosciences Mouse Models for DGKD

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKD

Clone Products

  • Addgene plasmids for DGKD

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKD Gene

Localization for DGKD Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKD Gene

Isoform 2: Cytoplasm.
Isoform 1: Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKD gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS 11309392
GO:0005737 cytoplasm IEA,IDA 12200442
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with DGKD: view

Pathways & Interactions for DGKD Gene

genes like me logo Genes that share pathways with DGKD: view

Gene Ontology (GO) - Biological Process for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA,TAS 8626538
GO:0007173 epidermal growth factor receptor signaling pathway NAS 12200442
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway NAS 12200442
GO:0007275 multicellular organism development NAS 12200442
genes like me logo Genes that share ontologies with DGKD: view

No data available for SIGNOR curated interactions for DGKD Gene

Drugs & Compounds for DGKD Gene

(6) Drugs for DGKD Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphatidyl serine Approved, Investigational Nutra Target 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
PHOSPHATIDYLSERINE Pharma 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(149) Additional Compounds for DGKD Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(2) Tocris Compounds for DGKD Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(1) ApexBio Compounds for DGKD Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
genes like me logo Genes that share compounds with DGKD: view

Drug Products

Transcripts for DGKD Gene

Unigene Clusters for DGKD Gene

Diacylglycerol kinase, delta 130kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKD

Clone Products

  • Addgene plasmids for DGKD

Alternative Splicing Database (ASD) splice patterns (SP) for DGKD Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - -
SP2: - -
SP3:
SP4:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for DGKD Gene

GeneLoc Exon Structure for
DGKD
ECgene alternative splicing isoforms for
DGKD

Expression for DGKD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGKD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKD Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for DGKD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.2), Heart (18.4), and Skin (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKD Gene



Protein tissue co-expression partners for DGKD Gene

NURSA nuclear receptor signaling pathways regulating expression of DGKD Gene:

DGKD

SOURCE GeneReport for Unigene cluster for DGKD Gene:

Hs.471675

mRNA Expression by UniProt/SwissProt for DGKD Gene:

Q16760-DGKD_HUMAN
Tissue specificity: Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.

Evidence on tissue expression from TISSUES for DGKD Gene

  • Nervous system(4.6)
  • Bone marrow(4.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with DGKD: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKD Gene

Orthologs for DGKD Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DGKD 34 33
  • 99.51 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DGKH 34
  • 93 (a)
OneToOne
DGKD 33
  • 86.88 (n)
dog
(Canis familiaris)
Mammalia DGKD 34 33
  • 89.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dgkd 33
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Dgkd 16 34 33
  • 86.88 (n)
oppossum
(Monodelphis domestica)
Mammalia DGKD 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DGKD 34 33
  • 80.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DGKD 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dgkd 33
  • 72.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13329 33
zebrafish
(Danio rerio)
Actinopterygii si:dkey-172j4.3 34
  • 64 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34384 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F42A9.1a 35
  • 38 (a)
F42A9.1b 35
  • 38 (a)
dgk-4 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2680 34
  • 49 (a)
OneToMany
Species where no ortholog for DGKD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DGKD Gene

ENSEMBL:
Gene Tree for DGKD (if available)
TreeFam:
Gene Tree for DGKD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DGKD: view image

Paralogs for DGKD Gene

Paralogs for DGKD Gene

(2) SIMAP similar genes for DGKD Gene using alignment to 6 proteins:

  • DGKD_HUMAN
  • C9JY42_HUMAN
  • H7BZR7_HUMAN
  • H7C0L1_HUMAN
  • Q53SE4_HUMAN
  • Q53SV4_HUMAN
genes like me logo Genes that share paralogs with DGKD: view

Variants for DGKD Gene

Sequence variations from dbSNP and Humsavar for DGKD Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs386352297 uncertain-significance, not provided 233,434,787(+) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000021365 -- 233,463,847(+) G/A genic_downstream_transcript_variant, intron_variant, splice_acceptor_variant
rs1000038707 -- 233,383,864(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000061251 -- 233,412,976(+) AATTTGCCATTA/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000092030 -- 233,384,076(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DGKD Gene

Variant ID Type Subtype PubMed ID
dgv495n27 CNV loss 19166990
dgv7339n54 CNV loss 21841781
esv1994590 CNV deletion 18987734
esv26406 CNV gain 19812545
esv2657296 CNV deletion 23128226
esv2663070 CNV deletion 23128226
esv2673713 CNV deletion 23128226
esv2721654 CNV deletion 23290073
esv2721655 CNV deletion 23290073
esv2721656 CNV deletion 23290073
esv28401 CNV loss 19812545
esv3594675 CNV loss 21293372
nsv1073022 CNV deletion 25765185
nsv1112340 CNV deletion 24896259
nsv1136315 CNV deletion 24896259
nsv1136482 CNV deletion 24896259
nsv584700 CNV gain 21841781
nsv584703 CNV gain 21841781

Variation tolerance for DGKD Gene

Residual Variation Intolerance Score: 2.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKD Gene

Human Gene Mutation Database (HGMD)
DGKD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKD Gene

Disorders for DGKD Gene

Additional Disease Information for DGKD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DGKD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKD Gene

Publications for DGKD Gene

  1. Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases. (PMID: 8626538) Sakane F … Kanoh H (The Journal of biological chemistry 1996) 2 3 4 22 25 58
  2. Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. (PMID: 12200442) Sakane F … Kanoh H (The Journal of biological chemistry 2002) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PMID: 20705733) O'Seaghdha CM … Köttgen A (Human molecular genetics 2010) 3 44 58
  5. Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha. (PMID: 17880279) Kawasaki T … Saito N (The Biochemical journal 2008) 4 22 58

Products for DGKD Gene

  • Addgene plasmids for DGKD

Sources for DGKD Gene

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