This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing re... See more...

Aliases for DGKD Gene

Aliases for DGKD Gene

  • Diacylglycerol Kinase Delta 2 3 4 5
  • Diacylglycerol Kinase, Delta 130kDa 2 3
  • Diglyceride Kinase Delta 3 4
  • DAG Kinase Delta 3 4
  • EC 2.7.1.107 4 50
  • DGK-Delta 3 4
  • DGKdelta 2 3
  • KIAA0145 2 4
  • Diacylglycerol Kinase, Delta (130kD) 2
  • 130 KDa Diacylglycerol Kinase 4
  • Diglyceride Kinase 2
  • Dgkd-2 3
  • DGKD 5

External Ids for DGKD Gene

Previous GeneCards Identifiers for DGKD Gene

  • GC02P232271
  • GC02P232944
  • GC02P234279
  • GC02P234549
  • GC02P234045
  • GC02P233927
  • GC02P226097
  • GC02P234272

Summaries for DGKD Gene

Entrez Gene Summary for DGKD Gene

  • This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DGKD Gene

DGKD (Diacylglycerol Kinase Delta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD+ kinase activity. An important paralog of this gene is DGKH.

UniProtKB/Swiss-Prot Summary for DGKD Gene

  • Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279).

Tocris Summary for DGKD Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKD Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DGKD Gene

Genomics for DGKD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DGKD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J233348 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 259.6 -0.1 -120 11.5 ZNF207 NCOR1 IKZF1 ZNF600 JUND KLF9 POLR2A ZIC2 CHD4 YY1 DGKD ENSG00000259793 ATG16L1 USP40 SAG SCARNA5 GIGYF2 SCARNA6 INPP5D
GH02J233412 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 260.7 +67.3 67279 18.4 SP1 ZNF600 MYC NCOR1 JUND ZNF592 ZIC2 BCL11A CEBPB MBD2 DGKD USP40 SAG ATG16L1 SCARNA6 SCARNA5 INPP5D ENSG00000237126 lnc-SAG-6 HSALNG0023088
GH02J233384 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 269.6 +32.3 32303 5.3 CEBPA ATF3 CHD4 YY1 REST THAP11 FOXA2 KDM6A SMAD4 RXRA DGKD HSALNG0023088 ATG16L1 USP40 SAG SCARNA5 SCARNA6 lnc-SAG-6
GH02J233330 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 18.8 -21.9 -21948 3.2 YY1 GABPA IRF4 CBFB MAX BHLHE40 SPI1 MYC POLR2A ELF1 DGKD ATG16L1 SAG SCARNA6 SCARNA5 HSALNG0023086 HSALNG0023085
GH02J233378 Enhancer 0.7 dbSUPER 20.2 +25.7 25733 3.6 CEBPA EBF1 NFATC1 ATF2 GLIS1 CEBPG ZFP36 NFIL3 KDM1A ZNF629 ENSG00000201013 DGKD ATG16L1 SCARNA5 SAG HSALNG0023088 USP40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DGKD

Top Transcription factor binding sites by QIAGEN in the DGKD gene promoter:
  • E47
  • GATA-1
  • HNF-4alpha1
  • HNF-4alpha2
  • LCR-F1
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)
  • RREB-1
  • S8

Genomic Locations for DGKD Gene

Latest Assembly
chr2:233,354,494-233,472,104
(GRCh38/hg38)
Size:
117,611 bases
Orientation:
Plus strand

Previous Assembly
chr2:234,263,140-234,380,744
(GRCh37/hg19 by Entrez Gene)
Size:
117,605 bases
Orientation:
Plus strand

chr2:234,263,153-234,380,750
(GRCh37/hg19 by Ensembl)
Size:
117,598 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr2(PATCHES):299,832-335,841 (+)

Genomic View for DGKD Gene

Genes around DGKD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKD Gene

Proteins for DGKD Gene

  • Protein details for DGKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16760-DGKD_HUMAN
    Recommended name:
    Diacylglycerol kinase delta
    Protein Accession:
    Q16760
    Secondary Accessions:
    • Q14158
    • Q6PK55
    • Q8NG53

    Protein attributes for DGKD Gene

    Size:
    1214 amino acids
    Molecular mass:
    134525 Da
    Quaternary structure:
    • Homooligomer (PubMed:12200442, PubMed:12084710). Monomer (PubMed:12084710). Interacts with AP2A2; regulates clathrin-dependent endocytosis (PubMed:17880279).

    Three dimensional structures from OCA and Proteopedia for DGKD Gene

    Alternative splice isoforms for DGKD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKD Gene

Selected DME Specific Peptides for DGKD Gene

Q16760:
  • MWYGVLG
  • EHPEKCRSR
  • QVDGEAW
  • PLGTGNDL
  • SHARPTYCNVCR
  • KTCGSVLRLQDW
  • VFVNSKSG
  • RRDLKDLG
  • LEVVAVF
  • EKCVMNNYFGIG
  • PVQVDGE
  • LSGVTSHGLSCEVCK
  • GDGSVGWVLSEID
  • HHRIAQC
  • EGNLPVS

Post-translational modifications for DGKD Gene

  • [Isoform 1]: Phosphorylated (PubMed:12084710). Phosphorylation by PKC induced by phorbol esters prevents homooligomerization and promotes association with membranes (PubMed:12084710).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DGKD Gene

Gene Families for DGKD Gene

Protein Domains for DGKD Gene

InterPro:
Blocks:
  • Sterile alpha motif SAM
  • Sterile alpha motif homology 2
  • Pleckstrin-like
  • Protein kinase C, phorbol ester/diacylglycerol binding
  • Diacylglycerol kinase accessory domain (presumed)

Suggested Antigen Peptide Sequences for DGKD Gene

GenScript: Design optimal peptide antigens:
  • Diglyceride kinase delta (DGKD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16760

UniProtKB/Swiss-Prot:

DGKD_HUMAN :
  • The SAM domain mediates homooligomerization.
  • Belongs to the eukaryotic diacylglycerol kinase family.
Domain:
  • The SAM domain mediates homooligomerization.
  • The PH domain mediates association with membranes.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKD: view

Function for DGKD Gene

Molecular function for DGKD Gene

UniProtKB/Swiss-Prot Function:
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence={ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:23949095};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:17880279};.
UniProtKB/Swiss-Prot Induction:
[Isoform 2]: Up-regulated by phorbol esters and EGF.
UniProtKB/Swiss-Prot Induction:
[Isoform 1]: Down-regulated by phorbol esters.

Enzyme Numbers (IUBMB) for DGKD Gene

Phenotypes From GWAS Catalog for DGKD Gene

Gene Ontology (GO) - Molecular Function for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,TAS 8626538
GO:0005515 protein binding IPI 17880279
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DGKD: view
genes like me logo Genes that share phenotypes with DGKD: view

Animal Models for DGKD Gene

MGI Knock Outs for DGKD:
  • Dgkd Dgkd<tm1Mtop>

Animal Models for research

  • Taconic Biosciences Mouse Models for DGKD

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKD

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKD Gene

Localization for DGKD Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKD Gene

Membrane, clathrin-coated pit. Cytoplasm.
[Isoform 1]: Cell membrane. Peripheral membrane protein. Cytoplasm. Note=Isoform 1 translocation from cytoplasm to the plasma membrane is induced by phorbol esters (PubMed:12200442). Phorbol esters induce the conversion into the monomeric form which can translocate to the plasma membrane (PubMed:12084710). {ECO:0000269 PubMed:12084710, ECO:0000269 PubMed:12200442}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKD gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 11309392
GO:0005737 cytoplasm IEA,IDA 12200442
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0005905 clathrin-coated pit IEA,IDA 17880279
genes like me logo Genes that share ontologies with DGKD: view

Pathways & Interactions for DGKD Gene

genes like me logo Genes that share pathways with DGKD: view

UniProtKB/Swiss-Prot Q16760-DGKD_HUMAN

  • Pathway: Lipid metabolism; glycerolipid metabolism.

SIGNOR curated interactions for DGKD Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DGKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process IDA 17880279
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA,TAS 8626538
GO:0007173 epidermal growth factor receptor signaling pathway NAS 12200442
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway NAS 12200442
genes like me logo Genes that share ontologies with DGKD: view

Drugs & Compounds for DGKD Gene

(7) Drugs for DGKD Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-Tocopherol succinate Approved, Vet_approved Nutra Target 0
Phosphatidyl serine Investigational Nutra Target 0
ATP Investigational Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
PHOSPHATIDYLSERINE Pharma 0

(150) Additional Compounds for DGKD Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(2) Tocris Compounds for DGKD Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(1) ApexBio Compounds for DGKD Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
genes like me logo Genes that share compounds with DGKD: view

Drug products for research

Transcripts for DGKD Gene

mRNA/cDNA for DGKD Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKD

Alternative Splicing Database (ASD) splice patterns (SP) for DGKD Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - -
SP2: - -
SP3:
SP4:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for DGKD Gene

GeneLoc Exon Structure for
DGKD

Expression for DGKD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKD Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for DGKD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.2), Heart (18.4), and Skin (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKD Gene



Protein tissue co-expression partners for DGKD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DGKD

SOURCE GeneReport for Unigene cluster for DGKD Gene:

Hs.471675

mRNA Expression by UniProt/SwissProt for DGKD Gene:

Q16760-DGKD_HUMAN
Tissue specificity: [Isoform 2]: Widely expressed.

Evidence on tissue expression from TISSUES for DGKD Gene

  • Nervous system(4.7)
  • Bone marrow(4.4)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with DGKD: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKD Gene

Orthologs for DGKD Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DGKD 29 30
  • 99.51 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 98 (a)
OneToMany
-- 30
  • 90 (a)
OneToMany
-- 30
  • 79 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia DGKH 30
  • 93 (a)
OneToOne
DGKD 29
  • 86.88 (n)
Dog
(Canis familiaris)
Mammalia DGKD 29 30
  • 89.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dgkd 29
  • 87.01 (n)
Mouse
(Mus musculus)
Mammalia Dgkd 29 16 30
  • 86.88 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DGKD 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DGKD 29 30
  • 80.85 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DGKD 30
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dgkd 29
  • 72.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13329 29
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-172j4.3 30
  • 64 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG34384 30
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea F42A9.1a 31
  • 38 (a)
F42A9.1b 31
  • 38 (a)
dgk-4 30
  • 31 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2680 30
  • 49 (a)
OneToMany
Species where no ortholog for DGKD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DGKD Gene

ENSEMBL:
Gene Tree for DGKD (if available)
TreeFam:
Gene Tree for DGKD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DGKD: view image
Alliance of Genome Resources:
Additional Orthologs for DGKD

Paralogs for DGKD Gene

Paralogs for DGKD Gene

(2) SIMAP similar genes for DGKD Gene using alignment to 6 proteins:

  • DGKD_HUMAN
  • C9JY42_HUMAN
  • H7BZR7_HUMAN
  • H7C0L1_HUMAN
  • Q53SE4_HUMAN
  • Q53SV4_HUMAN
genes like me logo Genes that share paralogs with DGKD: view

Variants for DGKD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DGKD Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
872656 Uncertain Significance: not provided 233,458,369(+) T/C
NM_152879.3(DGKD):c.2666T>C (p.Ile889Thr)
MISSENSE
rs113452563 Benign: not provided 233,451,017(+) C/T
NM_152879.3(DGKD):c.2134C>T (p.Leu712=)
SYNONYMOUS
rs113483143 Uncertain Significance: not provided 233,449,298(+) C/T
NM_152879.3(DGKD):c.1810C>T (p.Arg604Trp)
MISSENSE
rs114591819 Likely Benign: not provided 233,459,813(+) C/T
NM_152879.3(DGKD):c.2751C>T (p.Asp917=)
SYNONYMOUS
rs139714904 Benign: not provided 233,468,417(+) C/T
NM_152879.3(DGKD):c.3425-6C>T
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DGKD Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DGKD Gene

Variant ID Type Subtype PubMed ID
dgv495n27 CNV loss 19166990
dgv7339n54 CNV loss 21841781
esv1994590 CNV deletion 18987734
esv26406 CNV gain 19812545
esv2657296 CNV deletion 23128226
esv2663070 CNV deletion 23128226
esv2673713 CNV deletion 23128226
esv2721654 CNV deletion 23290073
esv2721655 CNV deletion 23290073
esv2721656 CNV deletion 23290073
esv28401 CNV loss 19812545
esv3594675 CNV loss 21293372
nsv1073022 CNV deletion 25765185
nsv1112340 CNV deletion 24896259
nsv1136315 CNV deletion 24896259
nsv1136482 CNV deletion 24896259
nsv584700 CNV gain 21841781
nsv584703 CNV gain 21841781

Variation tolerance for DGKD Gene

Residual Variation Intolerance Score: 2.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKD Gene

Human Gene Mutation Database (HGMD)
DGKD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKD
Leiden Open Variation Database (LOVD)
DGKD

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKD Gene

Disorders for DGKD Gene

Additional Disease Information for DGKD

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for DGKD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DGKD Gene

Publications for DGKD Gene

  1. Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases. (PMID: 8626538) Sakane F … Kanoh H (The Journal of biological chemistry 1996) 2 3 4 22 25
  2. Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha. (PMID: 17880279) Kawasaki T … Saito N (The Biochemical journal 2008) 3 4 22
  3. Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions. (PMID: 12200442) Sakane F … Kanoh H (The Journal of biological chemistry 2002) 3 4 22
  4. Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method. (PMID: 23949095) Sato M … Sakane F (Pharmacology 2013) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

Products for DGKD Gene

Sources for DGKD Gene