Aliases for DGKB Gene
External Ids for DGKB Gene
Previous HGNC Symbols for DGKB Gene
Previous GeneCards Identifiers for DGKB Gene
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
GeneCards Summary for DGKB Gene
DGKB (Diacylglycerol Kinase Beta) is a Protein Coding gene. Among its related pathways are Effects of PIP2 hydrolysis and Glycerolipid metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKG.
UniProtKB/Swiss-Prot for DGKB Gene
Exhibits high phosphorylation activity for long-chain diacylglycerols.
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.