Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded b... See more...

Aliases for DGKB Gene

Aliases for DGKB Gene

  • Diacylglycerol Kinase Beta 2 3 4 5
  • Diacylglycerol Kinase, Beta 90kDa 2 3
  • 90 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Beta 3 4
  • DAG Kinase Beta 3 4
  • EC 2.7.1.107 4 50
  • DGK-BETA 2 3
  • KIAA0718 2 4
  • DAGK2 3 4
  • DGK 2 3
  • Diacylglycerol Kinase, Beta (90kD) 2
  • DGK-Beta 4
  • EC 2.7.1 50
  • DGKB 5

External Ids for DGKB Gene

Previous HGNC Symbols for DGKB Gene

  • DAGK2

Previous GeneCards Identifiers for DGKB Gene

  • GC07M013831
  • GC07M013931
  • GC07M013960
  • GC07M014153
  • GC07M014066

Summaries for DGKB Gene

Entrez Gene Summary for DGKB Gene

  • Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

GeneCards Summary for DGKB Gene

DGKB (Diacylglycerol Kinase Beta) is a Protein Coding gene. Diseases associated with DGKB include Hermansky-Pudlak Syndrome 1 and Maturity-Onset Diabetes Of The Young. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and diacylglycerol kinase activity. An important paralog of this gene is DGKG.

UniProtKB/Swiss-Prot Summary for DGKB Gene

  • Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).
  • [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity.

Tocris Summary for DGKB Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DGKB Gene

Genomics for DGKB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DGKB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J014974 Promoter 0.4 EPDnew 250.7 0.0 -16 0.1 POLR2A DGKB lnc-DGKB-1 AGMO
GH07J015031 Promoter 0.3 EPDnew 250.2 -57.0 -56983 0.1 lnc-LRRC72-9 DGKB piR-35031-041 AGMO
GH07J014834 Enhancer 1 FANTOM5 ENCODE CraniofacialAtlas 39.3 +139.1 139087 3.1 ZNF600 JUND ZIC2 CEBPB MAX STAT3 BATF POLR2A TRIM28 L3MBTL2 DGKB ENSG00000226323 MK280144-608 lnc-AGMO-2-002 ETV1
GH07J014845 Enhancer 0.3 Ensembl 33 +128.5 128457 1.2 RAD51 TOE1 DGKB ENSG00000226323 MK280144-608 RF00017-5544 lnc-AGMO-2-002 ETV1
GH07J014902 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 5.5 +72.3 72257 2.4 POLR2A TAF1 TRIM28 EGR2 ZFHX2 WT1 lnc-AGMO-2-002 DGKB ETV1 RF00017-5544
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DGKB

Top Transcription factor binding sites by QIAGEN in the DGKB gene promoter:
  • AML1a
  • FOXL1
  • NF-E2
  • NF-E2 p45
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • YY1

Genomic Locations for DGKB Gene

Latest Assembly
chr7:14,145,049-14,974,858
(GRCh38/hg38)
Size:
829,810 bases
Orientation:
Minus strand

Previous Assembly
chr7:14,184,674-15,014,483
(GRCh37/hg19 by Entrez Gene)
Size:
829,810 bases
Orientation:
Minus strand

chr7:14,184,674-15,014,402
(GRCh37/hg19 by Ensembl)
Size:
829,729 bases
Orientation:
Minus strand

Genomic View for DGKB Gene

Genes around DGKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKB Gene

Proteins for DGKB Gene

  • Protein details for DGKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6T7-DGKB_HUMAN
    Recommended name:
    Diacylglycerol kinase beta
    Protein Accession:
    Q9Y6T7
    Secondary Accessions:
    • A4D116
    • A4D117
    • A8MXU2
    • O75241
    • Q2M377
    • Q75MF9
    • Q75MU7
    • Q86UI5
    • Q86UM9
    • Q9UQ29

    Protein attributes for DGKB Gene

    Size:
    804 amino acids
    Molecular mass:
    90595 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAS07533.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DGKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKB Gene

Selected DME Specific Peptides for DGKB Gene

Q9Y6T7:
  • GRRLAQCS
  • YSLSGNGP
  • KFQYLLNPRQV
  • KSGGKQG
  • HGGSNLWG
  • NNYFSIGVDASIAHRFH
  • CGGDGTVGW
  • HVWRLKHF
  • KPAYCNLCLNML
  • PEKFNSR
  • VNPKSGG
  • PLGTGNDL
  • FFRDVPD
  • DKLEFMFRLYD
  • PMQIDGEPWMQ
  • LEVVGLEGA
  • LKFASQD
  • PLLVLLG

Post-translational modifications for DGKB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for DGKB
  • Santa Cruz Biotechnology (SCBT) Antibodies for DGKB

Domains & Families for DGKB Gene

Gene Families for DGKB Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DGKB Gene

GenScript: Design optimal peptide antigens:
  • DGKB protein (B7ZL83_HUMAN)
  • Diglyceride kinase beta (DGKB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6T7

UniProtKB/Swiss-Prot:

DGKB_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKB: view

Function for DGKB Gene

Molecular function for DGKB Gene

UniProtKB/Swiss-Prot Function:
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence={ECO:0000269|PubMed:11719522};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40339, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77097, ChEBI:CHEBI:77098, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:11719522};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P49621};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P49621};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P49621};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by calcium.
GENATLAS Biochemistry:
diacylglycerol kinase,beta,homolog to rat diacylglycerol

Enzyme Numbers (IUBMB) for DGKB Gene

Phenotypes From GWAS Catalog for DGKB Gene

Gene Ontology (GO) - Molecular Function for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IDA 22627129
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DGKB: view
genes like me logo Genes that share phenotypes with DGKB: view

Animal Models for research

  • Taconic Biosciences Mouse Models for DGKB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKB

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DGKB Gene

Localization for DGKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKB Gene

Cell junction, synapse, postsynaptic cell membrane. Peripheral membrane protein. Cell membrane. Peripheral membrane protein. Cytoplasm. Note=Translocation to the plasma membrane is induced by phorbol esters. {ECO:0000269 PubMed:11719522}.
[Isoform 2]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKB gene
Compartment Confidence
cytosol 5
plasma membrane 4
mitochondrion 2
nucleus 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,TAS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DGKB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DGKB Gene

Pathways & Interactions for DGKB Gene

genes like me logo Genes that share pathways with DGKB: view

UniProtKB/Swiss-Prot Q9Y6T7-DGKB_HUMAN

  • Pathway: Lipid metabolism; glycerolipid metabolism.

Gene Ontology (GO) - Biological Process for DGKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006654 phosphatidic acid biosynthetic process ISS --
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway IEA --
GO:0009617 response to bacterium IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DGKB: view

No data available for SIGNOR curated interactions for DGKB Gene

Drugs & Compounds for DGKB Gene

(9) Drugs for DGKB Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-Tocopherol succinate Approved, Vet_approved Nutra Target 0
ATP Investigational Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
antipsychotics Pharma 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(153) Additional Compounds for DGKB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(2) Tocris Compounds for DGKB Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(1) ApexBio Compounds for DGKB Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
genes like me logo Genes that share compounds with DGKB: view

Drug products for research

Transcripts for DGKB Gene

mRNA/cDNA for DGKB Gene

20 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKB

Alternative Splicing Database (ASD) splice patterns (SP) for DGKB Gene

No ASD Table

Relevant External Links for DGKB Gene

GeneLoc Exon Structure for
DGKB

Expression for DGKB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKB Gene

mRNA differential expression in normal tissues according to GTEx for DGKB Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.0), Brain - Caudate (basal ganglia) (x9.3), Brain - Nucleus accumbens (basal ganglia) (x8.3), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Frontal Cortex (BA9) (x4.4).

Protein differential expression in normal tissues from HIPED for DGKB Gene

This gene is overexpressed in Lymph node (32.0) and CD4 Tcells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DGKB Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DGKB

SOURCE GeneReport for Unigene cluster for DGKB Gene:

Hs.567255

mRNA Expression by UniProt/SwissProt for DGKB Gene:

Q9Y6T7-DGKB_HUMAN
Tissue specificity: [Isoform 1]: Specifically expressed in brain but also detected in uterus (PubMed:11719522). In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus (PubMed:11719522).

Evidence on tissue expression from TISSUES for DGKB Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with DGKB: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKB Gene

Orthologs for DGKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DGKB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DGKB 29 30
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DGKB 29 30
  • 94.56 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DGKB 29 30
  • 94.02 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DGKB 30
  • 91 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dgkb 29
  • 90.18 (n)
Mouse
(Mus musculus)
Mammalia Dgkb 29 16 30
  • 90.02 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 89 (a)
OneToMany
-- 30
  • 86 (a)
OneToMany
Chicken
(Gallus gallus)
Aves DGKB 29 30
  • 83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DGKB 30
  • 88 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dgkb 29
  • 76.65 (n)
Zebrafish
(Danio rerio)
Actinopterygii dgkb 29 30
  • 68.97 (n)
OneToOne
Dr.19975 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006762 29
  • 59.83 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Dgk 29 30 31
  • 58.44 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dgk-3 29 30 31
  • 58.04 (n)
OneToMany
Rice
(Oryza sativa)
Liliopsida Os.20201 29
Corn
(Zea mays)
Liliopsida Zm.4984 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10986 30
  • 55 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12076 29
Species where no ortholog for DGKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DGKB Gene

ENSEMBL:
Gene Tree for DGKB (if available)
TreeFam:
Gene Tree for DGKB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DGKB: view image
Alliance of Genome Resources:
Additional Orthologs for DGKB

Paralogs for DGKB Gene

Paralogs for DGKB Gene

(6) SIMAP similar genes for DGKB Gene using alignment to 7 proteins:

  • DGKB_HUMAN
  • B5MBY2_HUMAN
  • B5MCD5_HUMAN
  • B7ZL83_HUMAN
  • C9JA18_HUMAN
  • C9JTC0_HUMAN
  • F8WD28_HUMAN
genes like me logo Genes that share paralogs with DGKB: view

Variants for DGKB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DGKB Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs34616903 -- p.Gly789Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DGKB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DGKB Gene

Variant ID Type Subtype PubMed ID
dgv3496n106 CNV deletion 24896259
dgv3497n106 CNV deletion 24896259
dgv3498n106 CNV deletion 24896259
dgv3746e59 CNV duplication 20981092
dgv422e215 CNV deletion 23714750
esv1008785 CNV deletion 20482838
esv1008799 CNV deletion 20482838
esv1248437 CNV insertion 17803354
esv1543610 CNV deletion 17803354
esv1572679 CNV deletion 17803354
esv1770636 CNV deletion 17803354
esv2009841 CNV deletion 18987734
esv2035361 CNV deletion 18987734
esv2144200 CNV deletion 18987734
esv22096 CNV loss 19812545
esv2227136 CNV deletion 18987734
esv2367407 CNV deletion 18987734
esv2372428 CNV deletion 18987734
esv2516570 CNV insertion 19546169
esv2589671 CNV deletion 19546169
esv2590385 CNV deletion 19546169
esv2609849 CNV insertion 19546169
esv2648403 CNV deletion 19546169
esv26569 CNV loss 19812545
esv2657075 CNV deletion 23128226
esv2665678 CNV deletion 23128226
esv2673931 CNV deletion 23128226
esv2676590 CNV deletion 23128226
esv2734011 CNV deletion 23290073
esv2734012 CNV deletion 23290073
esv2734013 CNV deletion 23290073
esv2734014 CNV deletion 23290073
esv2734015 CNV deletion 23290073
esv2734016 CNV deletion 23290073
esv2734018 CNV deletion 23290073
esv2734019 CNV deletion 23290073
esv2734020 CNV deletion 23290073
esv2734021 CNV deletion 23290073
esv2734022 CNV deletion 23290073
esv2734023 CNV deletion 23290073
esv2734024 CNV deletion 23290073
esv27782 CNV gain+loss 19812545
esv3304669 CNV mobile element insertion 20981092
esv3310074 CNV mobile element insertion 20981092
esv3361892 CNV insertion 20981092
esv3373354 CNV insertion 20981092
esv3385896 CNV insertion 20981092
esv3393920 CNV insertion 20981092
esv3432121 CNV insertion 20981092
esv3541223 CNV deletion 23714750
esv3541224 CNV deletion 23714750
esv3541229 CNV deletion 23714750
esv3541230 CNV deletion 23714750
esv3571661 CNV loss 25503493
esv3571662 CNV loss 25503493
esv3612306 CNV gain 21293372
esv3612310 CNV gain 21293372
esv3612311 CNV loss 21293372
esv3612313 CNV gain 21293372
esv3612316 CNV gain 21293372
esv3612319 CNV loss 21293372
esv3612320 CNV gain 21293372
esv3612322 CNV gain 21293372
esv3711 CNV loss 18987735
esv3891062 CNV gain+loss 25118596
esv3891064 CNV gain 25118596
esv4153 CNV loss 18987735
esv7200 CNV loss 19470904
nsv1015581 CNV loss 25217958
nsv1015777 CNV loss 25217958
nsv1020722 CNV loss 25217958
nsv1021056 CNV gain 25217958
nsv1022267 CNV loss 25217958
nsv1023616 CNV gain 25217958
nsv1024192 CNV loss 25217958
nsv1025437 CNV loss 25217958
nsv1033406 CNV loss 25217958
nsv1073702 CNV deletion 25765185
nsv1074074 CNV deletion 25765185
nsv1074646 CNV deletion 25765185
nsv1075011 CNV deletion 25765185
nsv1076869 CNV deletion 25765185
nsv1109444 CNV deletion 24896259
nsv1114918 CNV deletion 24896259
nsv1124175 CNV deletion 24896259
nsv1137193 CNV deletion 24896259
nsv1146427 CNV deletion 26484159
nsv1147057 CNV deletion 26484159
nsv1150451 CNV deletion 26484159
nsv478237 CNV novel sequence insertion 20440878
nsv511949 CNV loss 21212237
nsv518783 CNV loss 19592680
nsv606280 CNV loss 21841781
nsv606281 CNV loss 21841781
nsv606282 CNV loss 21841781
nsv606283 CNV gain 21841781
nsv606284 CNV gain 21841781
nsv8052 CNV loss 18304495
nsv8053 CNV gain+loss 18304495
nsv8054 CNV gain 18304495
nsv821255 CNV deletion 20802225
nsv821652 CNV loss 15273396
nsv956009 CNV deletion 24416366
nsv957581 CNV deletion 24416366
nsv970798 CNV duplication 23825009

Variation tolerance for DGKB Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKB Gene

Human Gene Mutation Database (HGMD)
DGKB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKB
Leiden Open Variation Database (LOVD)
DGKB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKB Gene

Disorders for DGKB Gene

MalaCards: The human disease database

(2) MalaCards diseases for DGKB Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search DGKB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DGKB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DGKB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGKB Gene

Publications for DGKB Gene

  1. Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties. (PMID: 11719522) Caricasole A … Terstappen GC (The Journal of biological chemistry 2002) 3 4 22
  2. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J … Barroso I (Nature genetics 2010) 3 40
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 40
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40

Products for DGKB Gene

Sources for DGKB Gene