The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript var... See more...

Aliases for DGKA Gene

Aliases for DGKA Gene

  • Diacylglycerol Kinase Alpha 2 3 4 5
  • DGK-Alpha 2 3 4
  • Diacylglycerol Kinase, Alpha 80kDa 2 3
  • 80 KDa Diacylglycerol Kinase 3 4
  • Diglyceride Kinase Alpha 3 4
  • DAG Kinase Alpha 3 4
  • EC 2.7.1.107 4 50
  • DAGK1 3 4
  • DAGK 3 4
  • Diacylglycerol Kinase, Alpha (80kD) 2
  • DGKA 5

External Ids for DGKA Gene

Previous HGNC Symbols for DGKA Gene

  • DAGK
  • DAGK1

Previous GeneCards Identifiers for DGKA Gene

  • GC12M056229
  • GC12U900027
  • GC12P056042
  • GC12P054611
  • GC12P056324
  • GC12P053363

Summaries for DGKA Gene

Entrez Gene Summary for DGKA Gene

  • The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]

GeneCards Summary for DGKA Gene

DGKA (Diacylglycerol Kinase Alpha) is a Protein Coding gene. Diseases associated with DGKA include Fibrosclerosis Of Breast and Lymphoproliferative Syndrome, X-Linked, 1. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and NAD+ kinase activity. An important paralog of this gene is DGKB.

UniProtKB/Swiss-Prot Summary for DGKA Gene

  • Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:2175712, PubMed:15544348). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:2175712, PubMed:15544348). Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (PubMed:15544348). Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129).

Tocris Summary for DGKA Gene

  • Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C'-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Gene Wiki entry for DGKA Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DGKA Gene

Genomics for DGKA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DGKA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055925 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 259.9 +6.0 6019 16.2 BCLAF1 SP1 ZNF654 MYC IKZF1 ZNF600 ZNF580 ZNF592 ZMYM3 ATF2 PYM1 DGKA BAZ2A DNAJC14 ZC3H10 TMEM198B RN7SL809P RNU6-343P PRIM1 CDK2
GH12J055955 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.9 +30.3 30303 5.2 JUND CEBPB DEK ZEB1 CTCF MAX ZNF217 MBD2 ELF1 CTBP1 HSALNG0091466 lnc-PYM1-2 lnc-PYM1-3 DGKA RPS26 ORMDL2 SARNP MMP19 RDH5 MYL6B
GH12J055908 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 -17.9 -17891 1.5 ZNF600 IKZF1 ARNT NKRF TEAD3 NCOR1 CREM BCL6 PRDM10 MLLT1 HSALNG0091456 lnc-PMEL-3 PYM1 GSTP1P1 HSALNG0091454 DGKA MMP19
GH12J055898 Enhancer 1 Ensembl ENCODE dbSUPER 0.3 -28.0 -28018 1 TAF9B RAD21 TAL1 STAT5A SMARCA4 EHMT2 EGR1 TCF12 NR2F6 TEAD4 GSTP1P1 lnc-DGKA-1 HSALNG0091454 DGKA MMP19
GH12J055919 Enhancer 0.7 Ensembl ENCODE 0.4 -7.7 -7718 1.2 ZNF217 JUND HNF4A ZNF664 DPF2 GLIS1 CREB1 FOS PYM1 DGKA HSALNG0091456 lnc-PMEL-3 HSALNG0091454 MMP19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGKA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DGKA

Top Transcription factor binding sites by QIAGEN in the DGKA gene promoter:
  • AREB6
  • c-Ets-1
  • c-Myb
  • Egr-2
  • p53

Genomic Locations for DGKA Gene

Latest Assembly
chr12:55,927,319-55,954,027
(GRCh38/hg38)
Size:
26,709 bases
Orientation:
Plus strand

Previous Assembly
chr12:56,324,946-56,347,807
(GRCh37/hg19 by Entrez Gene)
Size:
22,862 bases
Orientation:
Plus strand

chr12:56,321,103-56,347,811
(GRCh37/hg19 by Ensembl)
Size:
26,709 bases
Orientation:
Plus strand

Genomic View for DGKA Gene

Genes around DGKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DGKA Gene

Proteins for DGKA Gene

  • Protein details for DGKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23743-DGKA_HUMAN
    Recommended name:
    Diacylglycerol kinase alpha
    Protein Accession:
    P23743
    Secondary Accessions:
    • O75481
    • O75482
    • O75483
    • O95217
    • Q3ZE25
    • Q8IZ56
    • Q8N5Q2

    Protein attributes for DGKA Gene

    Size:
    735 amino acids
    Molecular mass:
    82630 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for DGKA Gene

    Alternative splice isoforms for DGKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DGKA Gene

Selected DME Specific Peptides for DGKA Gene

P23743:
  • TTKTLPMQ
  • KSGGKQG
  • HGGSNLWG
  • NNYFSIGVDASIAHRFH
  • CGGDGTVGW
  • ITDPDILKTCVPD
  • DFAQLQKY
  • PEKFNSR
  • VNPKSGG
  • GLHCVWCHLEIHDDCL
  • SGRCDRCQKKIR
  • PCEVSTYAKSRKDIGVQ
  • NKLWYFE
  • ECDCGLLRDHILPP
  • DRNGILDS
  • PLGTGNDL
  • PEDKLEFTFKLYD
  • SDKRLEVVG
  • VYCNLCE
  • ILPPSSI
  • PMQIDGEPWMQ
  • LEVVGLEGA
  • GKQGLSC
  • WDVSELRPILQEMM
  • EFATSESIFSTCKKLEES
  • PLLVLLG
  • TVEICGK

Post-translational modifications for DGKA Gene

  • Ubiquitination at Lys18, Lys239, Lys249, Lys263, Lys353, Lys411, Lys484, Lys493, and Lys634
  • Modification sites at PhosphoSitePlus

Domains & Families for DGKA Gene

Gene Families for DGKA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DGKA Gene

GenScript: Design optimal peptide antigens:
  • Diglyceride kinase alpha (DGKA_HUMAN)
  • Diacylglycerol kinase alpha (O75484_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23743

UniProtKB/Swiss-Prot:

DGKA_HUMAN :
  • Belongs to the eukaryotic diacylglycerol kinase family.
Family:
  • Belongs to the eukaryotic diacylglycerol kinase family.
genes like me logo Genes that share domains with DGKA: view

Function for DGKA Gene

Molecular function for DGKA Gene

UniProtKB/Swiss-Prot Function:
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:2175712, PubMed:15544348). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:2175712, PubMed:15544348). Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (PubMed:15544348). Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616, ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:63324, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:72859, ChEBI:CHEBI:82929, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43416, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:64839, ChEBI:CHEBI:75466, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(9Z-octadecenoyl)-glycerol + ATP = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:63328, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:73990, ChEBI:CHEBI:77593, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40327, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52333, ChEBI:CHEBI:74546, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40323, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75728, ChEBI:CHEBI:77091, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1,2-didecanoyl-sn-glycerol + ATP = 1,2-didecanoyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:43428, ChEBI:CHEBI:15378, ChEBI:CHEBI:18155, ChEBI:CHEBI:30616, ChEBI:CHEBI:78227, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P20192};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:44072, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:52595, ChEBI:CHEBI:73332, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41676, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:75936, ChEBI:CHEBI:78385, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P51556};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40403, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77184, ChEBI:CHEBI:77186, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:40407, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:77185, ChEBI:CHEBI:77187, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15544348, ECO:0000269|PubMed:2175712};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+); Xref=Rhea:RHEA:41672, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:34115, ChEBI:CHEBI:77580, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:P51556};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by calcium and phosphatidylserine.
GENATLAS Biochemistry:
diacylglycerol kinase,86kDa,putative modulator of protein kinase C,in signal transduction

Enzyme Numbers (IUBMB) for DGKA Gene

Phenotypes From GWAS Catalog for DGKA Gene

Gene Ontology (GO) - Molecular Function for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA,IDA 2175712
GO:0005509 calcium ion binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DGKA: view
genes like me logo Genes that share phenotypes with DGKA: view

Animal Models for DGKA Gene

MGI Knock Outs for DGKA:

miRNA for DGKA Gene

miRTarBase miRNAs that target DGKA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKA

Clone products for research

  • Addgene plasmids for DGKA

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DGKA Gene

Localization for DGKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DGKA Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DGKA gene
Compartment Confidence
cytosol 5
plasma membrane 4
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
endosome 2
mitochondrion 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 2175712
GO:0005886 plasma membrane TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DGKA: view

Pathways & Interactions for DGKA Gene

genes like me logo Genes that share pathways with DGKA: view

UniProtKB/Swiss-Prot P23743-DGKA_HUMAN

  • Pathway: Lipid metabolism; glycerolipid metabolism.

SIGNOR curated interactions for DGKA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DGKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process IDA 2175712
GO:0007165 signal transduction IEA --
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DGKA: view

Drugs & Compounds for DGKA Gene

(7) Drugs for DGKA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 553,561
alpha-Tocopherol succinate Approved, Vet_approved Nutra Target 0
ATP Investigational Nutra 0
Dioctanoylglycol Pharma Diacylglycerol kinase inhibitor 0
R 59-022 Pharma Diacylglycerol kinase inhibitor; increases PKC activity 0

(149) Additional Compounds for DGKA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
DG(16:0/24:0/0:0)
  • 1-Palmitoyl-2-lignoceroyl-sn-glycerol
  • DAG(16:0/24:0)
  • DAG(40:0)
  • DG(16:0/24:0)
  • DG(40:0)
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z)-icos-11-enoic acid
  • Diacylglycerol(15:0/0:0/20:1)
  • DAG(35:1)
  • Diacylglycerol(35:1)
  • DG(15:0/0:0/20:1W9)
Diglycerides Group B
  • Diglyceride
  • DG(32:4)
  • DG(14:1/18:3)
  • DAG(14:1/18:3)
  • Diacylglycerol(32:4)
257891-89-7
Diglycerides Group C
  • (2S)-1-Hydroxy-3-(palmitoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • 1,2-DG 16:0/20:4(omega-6)
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycerol
  • 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
  • DAG(16:0/20:4)
91125-76-7, 29541-66-0, 51621-26-2

(2) Tocris Compounds for DGKA Gene

Compound Action Cas Number
Dioctanoylglycol Diacylglycerol kinase inhibitor 627-86-1
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity 93076-89-2

(2) ApexBio Compounds for DGKA Gene

Compound Action Cas Number
Dioctanoylglycol 627-86-1
R 59-022 93076-89-2
genes like me logo Genes that share compounds with DGKA: view

Drug products for research

Transcripts for DGKA Gene

mRNA/cDNA for DGKA Gene

12 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
49 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DGKA

Clone products for research

  • Addgene plasmids for DGKA

Alternative Splicing Database (ASD) splice patterns (SP) for DGKA Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - - - - -
SP11: - -
SP12:
SP13: - - - -
SP14: - - - - -
SP15: - - - -
SP16:
SP17:
SP18:

ExUns: 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:

Relevant External Links for DGKA Gene

GeneLoc Exon Structure for
DGKA

Expression for DGKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DGKA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DGKA Gene

This gene is overexpressed in Whole Blood (x5.1) and Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for DGKA Gene

This gene is overexpressed in Lymph node (24.5), Peripheral blood mononuclear cells (11.7), Tlymphocyte (11.0), and CD4 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DGKA Gene



Protein tissue co-expression partners for DGKA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DGKA

SOURCE GeneReport for Unigene cluster for DGKA Gene:

Hs.524488

mRNA Expression by UniProt/SwissProt for DGKA Gene:

P23743-DGKA_HUMAN
Tissue specificity: Expressed in lymphocytes.

Evidence on tissue expression from TISSUES for DGKA Gene

  • Nervous system(4.8)
  • Blood(4.5)
  • Skin(2.8)
  • Lymph node(2.8)
  • Spleen(2.7)
  • Intestine(2.6)
  • Bone marrow(2.3)
genes like me logo Genes that share expression patterns with DGKA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DGKA Gene

Orthologs for DGKA Gene

This gene was present in the common ancestor of animals.

Orthologs for DGKA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DGKA 29 30
  • 99.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DGKA 29 30
  • 92.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DGKA 29 30
  • 91.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dgka 29 16 30
  • 83.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dgka 29
  • 83.43 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia DGKA 30
  • 73 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 59 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia DGKA 30
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dgka 29
  • 64.79 (n)
Zebrafish
(Danio rerio)
Actinopterygii dgkaa 29 30
  • 64.6 (n)
OneToMany
DGKA (1 of 2) 30
  • 50 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6786 29
Fruit Fly
(Drosophila melanogaster)
Insecta Dgk 30 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea dgk-3 30 31
  • 44 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10986 30
  • 44 (a)
OneToMany
Species where no ortholog for DGKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DGKA Gene

ENSEMBL:
Gene Tree for DGKA (if available)
TreeFam:
Gene Tree for DGKA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DGKA: view image
Alliance of Genome Resources:
Additional Orthologs for DGKA

Paralogs for DGKA Gene

Paralogs for DGKA Gene

(6) SIMAP similar genes for DGKA Gene using alignment to 12 proteins:

  • DGKA_HUMAN
  • C9JM35_HUMAN
  • F8VNZ9_HUMAN
  • F8VWX8_HUMAN
  • F8W1H7_HUMAN
  • F8W1M3_HUMAN
  • G3V312_HUMAN
  • G3V327_HUMAN
  • G3V4E1_HUMAN
  • G3V4I3_HUMAN
  • H0YJE7_HUMAN
  • H0YJH4_HUMAN
genes like me logo Genes that share paralogs with DGKA: view

Variants for DGKA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DGKA Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs17118135 Benign: not provided 55,939,426(+) C/T
NM_001345.5(DGKA):c.606C>T (p.Asp202=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs77325724 Benign: not provided 55,940,920(+) T/G
NM_001345.5(DGKA):c.1041T>G (p.Asn347Lys)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR
rs17852990 -- p.His538Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DGKA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DGKA Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832424 CNV loss 17160897

Variation tolerance for DGKA Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DGKA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGKA
Leiden Open Variation Database (LOVD)
DGKA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DGKA Gene

Disorders for DGKA Gene

MalaCards: The human disease database

(2) MalaCards diseases for DGKA Gene - From: COP

Disorder Aliases PubMed IDs
fibrosclerosis of breast
  • fibrosis of the breast
lymphoproliferative syndrome, x-linked, 1
  • xlp1
- elite association - COSMIC cancer census association via MalaCards
Search DGKA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DGKA

genes like me logo Genes that share disorders with DGKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGKA Gene

Publications for DGKA Gene

  1. Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12. (PMID: 8180475) Hart TC … Van Dyke TE (Mammalian genome : official journal of the International Mammalian Genome Society 1994) 2 3 4
  2. Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis. (PMID: 7959783) Hart TC … Pettenati MJ (Genomics 1994) 2 3 4
  3. Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains. (PMID: 30653270) Takahashi D … Sakane F (Protein science : a publication of the Protein Society 2019) 3 4
  4. Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. (PMID: 22627129) Gellett AM … Lynch KR (Biochemical and biophysical research communications 2012) 3 4
  5. Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. (PMID: 20160093) Chianale F … Graziani A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 22

Products for DGKA Gene