Aliases for DGCR5 Gene
Subcategory (RNA class) for DGCR5 Gene
non-coding RNA
Quality Score for this RNA gene is
3
Aliases for DGCR5 Gene
External Ids for DGCR5 Gene
- HGNC: 16757
- Entrez Gene: 26220
- Ensembl: ENSG00000237517
Previous GeneCards Identifiers for DGCR5 Gene
- GC22U990094
- GC22P015899
- GC22P017332
- GC22P017347
- GC22P018958
- GC22P002579
- GC22P018971
- GC22P018973
Summaries for DGCR5 Gene
GeneCards Summary for DGCR5 Gene
DGCR5 (DiGeorge Syndrome Critical Region Gene 5 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with DGCR5 include Digeorge Syndrome.
Additional gene information for DGCR5 Gene
- Monarch Initiative
- Search for DGCR5 at DataMed
- Search for DGCR5 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGCR5 Gene
Genomics for DGCR5 Gene
GeneHancer (GH) Regulatory Elements for DGCR5 Gene
Promoters and enhancers for DGCR5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22I018970 | Promoter/Enhancer | 1.2 | Ensembl ENCODE | 556 | +0.1 | 103 | 0.8 | CTCF RB1 SIN3A ZNF384 ZNF335 E2F1 ZFHX2 CTBP1 POLR2A EZH2 | DGCR5 ENSG00000283406 PRODH ENSG00000283583 | |
| GH22I018923 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 7.7 | -40.3 | -40319 | 13.4 | HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF121 GLIS2 FOS RUNX3 | PRODH DGCR6 DGCR5 MICAL3 TUBA8 GC22P018961 ENSG00000284294 ENSG00000283809 | |
| GH22I018967 | Enhancer | 1 | Ensembl ENCODE | 9.3 | -2.5 | -2548 | 1.4 | HDAC1 RB1 ARID4B ZBTB40 RARA ZNF766 ZNF143 KLF11 USF2 NCOA1 | PRODH DGCR5 ENSG00000280418 | |
| GH22I018975 | Enhancer | 0.4 | ENCODE | 11.1 | +5.6 | 5588 | 1.2 | MCM3 ZFP36 HNF4A | RPL7AP70 DGCR5 DGCR11 DGCR6 PRODH ENSG00000283406 ENSG00000283583 | |
| GH22I018950 | Enhancer | 0.4 | dbSUPER | 8 | -19.7 | -19725 | 1.3 | RXRA HNF4A | DGCR6 PRODH DGCR5 GC22P018966 ENSG00000280418 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DGCR5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DGCR5 gene promoter:
Regulatory Element Products
Genomic Locations for DGCR5 Gene
Genomic Locations for DGCR5 Gene
- chr22:18,970,498-19,031,242
- (GRCh38/hg38)
- Size:
- 60,745 bases
- Orientation:
- Plus strand
- chr22:18,958,027-19,018,755
- (GRCh37/hg19)
Genomic View for DGCR5 Gene
Genes around DGCR5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by Ensembl
- 22q11.21 by Entrez Gene
- 22q11.21 by HGNC
DGCR5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DGCR5 Gene
Proteins for DGCR5 Gene
Post-translational modifications for DGCR5 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for DGCR5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DGCR5
- Origene Custom Protein Services for DGCR5
- Search GeneTex for Proteins for DGCR5
No data available for DME Specific Peptides for DGCR5 Gene
Domains & Families for DGCR5 Gene
Gene Families for DGCR5 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DGCR5 Gene
Function for DGCR5 Gene
Phenotypes From GWAS Catalog for DGCR5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DGCR5
-
- Search ViGene Biosciences for DGCR5
CRISPR Products
- Browse CRISPR knockouts for DGCR5
- Applied Biological Materials CRISPR for DGCR5
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for DGCR5
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for DGCR5
- Browse OriGene Inhibitory RNA Products For DGCR5
- Search ViGene Biosciences for DGCR5
Clone Products
- GenScript: Custom all cDNA clones Services for DGCR5
- VectorBuilder custom plasmid, inducible vectors for DGCR5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DGCR5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DGCR5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGCR5 Gene
Localization for DGCR5 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DGCR5 Gene
Transcripts for DGCR5 Gene
mRNA/cDNA for DGCR5 Gene
- (9) Additional mRNA sequences :
- (80) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DGCR5 Gene
CRISPR Products
- Browse CRISPR knockouts for DGCR5
- Applied Biological Materials CRISPR for DGCR5
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for DGCR5
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for DGCR5
- Browse OriGene Inhibitory RNA Products For DGCR5
- Search ViGene Biosciences for DGCR5
Clone Products
- GenScript: Custom all cDNA clones Services for DGCR5
- VectorBuilder custom plasmid, inducible vectors for DGCR5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DGCR5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DGCR5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for DGCR5 Gene
mRNA differential expression in normal tissues according to GTEx for DGCR5 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x6.3), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.5).
NURSA nuclear receptor signaling pathways regulating expression of DGCR5 Gene:
DGCR5SOURCE GeneReport for Unigene cluster for DGCR5 Gene:
Hs.646438Primer Products
-
OriGene qPCR primer pairs for DGCR5
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGCR5 Gene
Orthologs for DGCR5 Gene
No data available for Orthologs for DGCR5 Gene
Paralogs for DGCR5 Gene
No data available for Paralogs for DGCR5 Gene
Variants for DGCR5 Gene
| SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016669 | -- | 19,015,356(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000018519 | -- | 18,972,598(+) | G/A | intron_variant | |
| rs1000033315 | -- | 19,015,072(+) | G/A/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000058897 | -- | 19,009,068(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000074991 | -- | 18,985,332(+) | A/C | intron_variant |
Additional Variant Information for DGCR5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DGCR5 Gene
Disorders for DGCR5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| digeorge syndrome |
|
|
Search DGCR5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DGCR5
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DGCR5 Gene
Publications for DGCR5 Gene
- Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma. (PMID: 27898409) Huang R … Sun B (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016) 2 3 58
- Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K … Gieger C (Nature 2011) 3 44 58
- Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome. (PMID: 8659529) Sutherland HF … Scambler PJ (American journal of human genetics 1996) 2 3 58
- An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 58
- Long non-coding RNAs in Huntington's disease neurodegeneration. (PMID: 22202438) Johnson R (Neurobiology of disease 2012) 3 58
Products for DGCR5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Activity Assays
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DGCR5
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- OriGene qPCR primer pairs for DGCR5
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Custom all cDNA clones Services for DGCR5
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for DGCR5
- VectorBuilder custom plasmid, inducible vectors for DGCR5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DGCR5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for DGCR5
- Search GeneTex for Proteins for DGCR5
- Search ViGene Biosciences for DGCR5
Sources for DGCR5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
