Free for academic non-profit institutions. Other users need a Commercial license

DGCR5 Gene(RNA Gene)

DiGeorge Syndrome Critical Region Gene 5

GCID:
GC22P018995
GIFtS:
21
Genes Participants
UDN Logo

Aliases for DGCR5 Gene

Subcategory (RNA class) for DGCR5 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for DGCR5 Gene

  • DiGeorge Syndrome Critical Region Gene 5 2 3
  • DiGeorge Syndrome Critical Region Gene 5 (Non-Protein Coding) 2 3 5
  • Long Intergenic Non-Protein Coding RNA 37 2 3
  • Cadherin EGF LAG Seven-Pass G-Type Receptor 1 Pseudogene 3
  • Non-Protein Coding RNA 37 2
  • NCRNA00037 3
  • LINC00037 3

External Ids for DGCR5 Gene

Previous GeneCards Identifiers for DGCR5 Gene

  • GC22U990094
  • GC22P015899
  • GC22P017332
  • GC22P017347
  • GC22P018958
  • GC22P002579
  • GC22P018971
  • GC22P018973
  • GC22P018983

Summaries for DGCR5 Gene

GeneCards Summary for DGCR5 Gene

DGCR5 (DiGeorge Syndrome Critical Region Gene 5) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with DGCR5 include Digeorge Syndrome and Velocardiofacial Syndrome.

Gene Wiki entry for DGCR5 Gene

Additional gene information for DGCR5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DGCR5 Gene

Genomics for DGCR5 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for DGCR5 Gene

Promoters and enhancers for DGCR5 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22J018970 Promoter/Enhancer 1.2 Ensembl ENCODE 656 +0.1 103 0.8 CTCF RB1 SIN3A ZNF384 ZNF335 E2F1 ZFHX2 CTBP1 POLR2A EZH2 DGCR5 ENSG00000283406 PRODH ENSG00000283583
GH22J018923 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.7 -40.3 -40319 13.4 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF121 GLIS2 FOS RUNX3 PRODH DGCR6 DGCR5 MICAL3 TUBA8 GC22P018969 ENSG00000284294 ENSG00000283809
GH22J018967 Enhancer 1 Ensembl ENCODE 9.3 -2.5 -2548 1.4 HDAC1 RB1 ARID4B ZBTB40 RARA ZNF766 ZNF143 KLF11 USF2 NCOA1 PRODH DGCR5 ENSG00000280418
GH22J018975 Enhancer 0.4 ENCODE 11.1 +5.6 5588 1.2 MCM3 ZFP36 HNF4A RPL7AP70 DGCR5 DGCR11 DGCR6 PRODH ENSG00000283406 ENSG00000283583
GH22J018950 Enhancer 0.4 dbSUPER 8 -19.7 -19725 1.3 SP1 RXRA HNF4A DGCR6 PRODH DGCR5 GC22P018979 ENSG00000280418
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DGCR5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DGCR5 gene promoter:
  • HNF-4alpha1
  • deltaCREB
  • CREB
  • Egr-1
  • Egr-4
  • AML1a
  • Pax-5
  • p53

Genomic Locations for DGCR5 Gene

Genomic Locations for DGCR5 Gene
chr22:18,970,498-19,031,242
(GRCh38/hg38)
Size:
60,745 bases
Orientation:
Plus strand
chr22:18,958,027-19,018,755
(GRCh37/hg19)
Size:
60,729 bases
Orientation:
Plus strand

Genomic View for DGCR5 Gene

Genes around DGCR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DGCR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DGCR5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DGCR5 Gene

Proteins for DGCR5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for DGCR5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DGCR5 Gene

Domains & Families for DGCR5 Gene

Gene Families for DGCR5 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DGCR5: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DGCR5 Gene

Function for DGCR5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for DGCR5 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DGCR5 Gene

Localization for DGCR5 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DGCR5 Gene

Pathways & Interactions for DGCR5 Gene

SuperPathways for DGCR5 Gene

PathCards logo More details on SuperPathways for DGCR5
No Data Available

Interacting Proteins for DGCR5 Gene

Gene Ontology (GO) - Biological Process for DGCR5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DGCR5 Gene

Drugs & Compounds for DGCR5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DGCR5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DGCR5 Gene

(9) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Unigene Clusters for DGCR5 Gene

DiGeorge syndrome critical region gene 5 (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DGCR5 Gene

No ASD Table

Relevant External Links for DGCR5 Gene

GeneLoc Exon Structure for
DGCR5
ECgene alternative splicing isoforms for
DGCR5

Expression for DGCR5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DGCR5 Gene

mRNA expression in normal human tissues for DGCR5 Gene
mRNA expression by GTEx for DGCR5 GenemRNA expression by BioGPS for DGCR5 Gene

mRNA differential expression in normal tissues according to GTEx for DGCR5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x6.3), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of DGCR5 Gene:

DGCR5

SOURCE GeneReport for Unigene cluster for DGCR5 Gene:

Hs.646438
genes like me logo Genes that share expression patterns with DGCR5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DGCR5 Gene

Orthologs for DGCR5 Gene

Evolution for DGCR5 Gene

ENSEMBL:
Gene Tree for DGCR5 (if available)
TreeFam:
Gene Tree for DGCR5 (if available)

No data available for Orthologs for DGCR5 Gene

Paralogs for DGCR5 Gene

No data available for Paralogs for DGCR5 Gene

Variants for DGCR5 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for DGCR5 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000016669 -- 19,015,356(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000018519 -- 18,972,598(+) G/A intron_variant
rs1000033315 -- 19,015,072(+) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000058897 -- 19,009,068(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000074991 -- 18,985,332(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DGCR5 Gene

Variant ID Type Subtype PubMed ID
dgv1283e212 CNV gain 25503493
dgv1284e212 CNV gain 25503493
dgv1285e212 CNV loss 25503493
dgv169n111 CNV duplication 26073780
dgv173e55 CNV gain 17911159
dgv174e55 CNV gain 17911159
dgv42e213 CNV gain 24956385
dgv43e213 CNV gain 24956385
dgv4466n100 CNV gain+loss 25217958
dgv4467n100 CNV gain 25217958
dgv4468n100 CNV gain+loss 25217958
dgv4469n100 CNV gain 25217958
dgv4471n100 CNV gain 25217958
dgv4472n100 CNV loss 25217958
dgv4473n100 CNV gain+loss 25217958
dgv4474n100 CNV gain 25217958
dgv4476n100 CNV gain 25217958
dgv4477n100 CNV gain 25217958
dgv541n27 CNV gain 19166990
dgv542n27 CNV loss 19166990
dgv543n27 CNV gain 19166990
dgv7969n54 CNV gain 21841781
dgv7971n54 CNV gain 21841781
dgv7972n54 CNV gain+loss 21841781
dgv7973n54 CNV gain 21841781
dgv7975n54 CNV loss 21841781
dgv7976n54 CNV gain 21841781
dgv7977n54 CNV gain 21841781
dgv7978n54 CNV loss 21841781
dgv823e214 CNV loss 21293372
dgv824e214 CNV gain 21293372
dgv99e203 CNV gain+loss 21179565
esv1669610 CNV deletion 17803354
esv2081719 CNV deletion 18987734
esv23076 CNV gain+loss 19812545
esv2658270 CNV deletion 23128226
esv2751935 CNV loss 17911159
esv2758824 CNV gain+loss 17122850
esv3233904 CNV deletion 24192839
esv32687 CNV gain+loss 17666407
esv3557920 CNV deletion 23714750
esv3575418 CNV gain 25503493
esv3575424 CNV gain 25503493
esv3575425 CNV gain 25503493
esv3584483 CNV gain 24956385
esv3584491 CNV gain 24956385
esv3647249 CNV loss 21293372
esv3647250 CNV gain 21293372
esv3647253 CNV loss 21293372
esv3647254 CNV loss 21293372
esv3893431 CNV gain+loss 25118596
esv3893432 CNV gain 25118596
esv3893433 CNV gain 25118596
nsv1065578 CNV gain 25217958
nsv1067175 CNV loss 25217958
nsv1114306 CNV deletion 24896259
nsv1136346 CNV deletion 24896259
nsv1160726 CNV duplication 26073780
nsv442503 CNV gain 18776908
nsv459336 CNV loss 19166990
nsv471179 CNV gain 18288195
nsv471180 CNV loss 18288195
nsv516997 CNV gain+loss 19592680
nsv588155 CNV gain 21841781
nsv588166 CNV loss 21841781
nsv588203 CNV gain+loss 21841781
nsv588209 CNV gain 21841781
nsv588210 CNV gain+loss 21841781
nsv588211 CNV gain 21841781
nsv588212 CNV gain 21841781
nsv588213 CNV gain 21841781
nsv588215 CNV loss 21841781
nsv953021 CNV deletion 24416366
nsv955510 CNV deletion 24416366
nsv966073 CNV duplication 23825009
nsv966074 CNV duplication 23825009

Additional Variant Information for DGCR5 Gene

Human Gene Mutation Database (HGMD)
DGCR5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DGCR5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DGCR5 Gene

Disorders for DGCR5 Gene

MalaCards: The human disease database

(8) MalaCards diseases for DGCR5 Gene - From: LncRNADisease, HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
digeorge syndrome
  • dgs
velocardiofacial syndrome
  • cayler cardiofacial syndrome
huntington disease
  • hd
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
lung cancer susceptibility 3
  • lncr3
- elite association - COSMIC cancer census association via MalaCards
Search DGCR5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DGCR5

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DGCR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DGCR5 Gene

Publications for DGCR5 Gene

  1. Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma. (PMID: 27898409) Huang R … Sun B (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016) 2 3 58
  2. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K … Gieger C (Nature 2011) 3 44 58
  3. Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome. (PMID: 8659529) Sutherland HF … Scambler PJ (American journal of human genetics 1996) 2 3 58
  4. LINC00037 Inhibits Proliferation of Renal Cell Carcinoma Cells in an Epidermal Growth Factor Receptor-Dependent Way. (PMID: 29393141) Gong X … Zheng W (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 58
  5. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 58

Products for DGCR5 Gene

Sources for DGCR5 Gene

Content
Loading form....