Aliases for DGAT1 Gene
External Ids for DGAT1 Gene
Previous HGNC Symbols for DGAT1 Gene
Previous GeneCards Identifiers for DGAT1 Gene
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. [provided by RefSeq, Jul 2013]
GeneCards Summary for DGAT1 Gene
DGAT1 (Diacylglycerol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with DGAT1 include Diarrhea 7, Protein-Losing Enteropathy Type and Congenital Diarrhea 7 With Exudative Enteropathy. Among its related pathways are Glycerophospholipid biosynthesis and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and 2-acylglycerol O-acyltransferase activity. An important paralog of this gene is SOAT1.
UniProtKB/Swiss-Prot Summary for DGAT1 Gene
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:16214399, PubMed:18768481, PubMed:28420705, PubMed:9756920, PubMed:32433611, PubMed:32433610). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (PubMed:18768481). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:16214399). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).
Diacylglycerol O-Acyltransferases (DGATs), EC 220.127.116.11, are enzymes that catalyze the final step of triglyceride (TG) synthesis, the covalent attachment of fatty acyl-CoA and diacylglycerol (DAG). There have been two DGAT isoforms identified to date, DGAT1 and DGAT2.