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Aliases for DEXI Gene
Aliases for DEXI Gene
External Ids for DEXI Gene
- HGNC: 13267
- Entrez Gene: 28955
- Ensembl: ENSG00000182108
- OMIM: 617901
- UniProtKB: O95424
Previous GeneCards Identifiers for DEXI Gene
- GC16M010989
- GC16M010930
- GC16M011024
Summaries for DEXI Gene
GeneCards Summary for DEXI Gene
DEXI (Dexi Homolog) is a Protein Coding gene. Diseases associated with DEXI include Angelman Syndrome.
Additional gene information for DEXI Gene
- HGNC(13267)
- Entrez Gene(28955)
- Ensembl(ENSG00000182108)
- OMIM(617901)
- UniProtKB(O95424)
- Open Targets Platform(ENSG00000182108)
- Search for DEXI at DataMed
- Search for DEXI at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DEXI Gene
Genomics for DEXI Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DEXI Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DEXI on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DEXI
- Top Transcription factor binding sites by QIAGEN in the DEXI gene promoter:
-
- AREB6
- Egr-4
- Ik-2
- LCR-F1
- Pax-5
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
Genomic Locations for DEXI Gene
Genomic Locations for DEXI Gene
- chr16:10,928,891-10,942,468
- (GRCh38/hg38)
- Size:
- 13,578 bases
- Orientation:
- Minus strand
- chr16:11,022,748-11,036,317
- (GRCh37/hg19)
- Size:
- 13,570 bases
- Orientation:
- Minus strand
Genomic View for DEXI Gene
Genes around DEXI on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.13 by HGNC
- 16p13.13 by Entrez Gene
- 16p13.13 by Ensembl
DEXI Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DEXI Gene
Proteins for DEXI Gene
-
Protein details for DEXI Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95424-DEXI_HUMAN
- Recommended name:
- Dexamethasone-induced protein
- Protein Accession:
- O95424
- B2RAA7
Protein attributes for DEXI Gene
- Size:
- 95 amino acids
- Molecular mass:
- 10429 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for DEXI Gene
No Post-translational modifications
Other Protein References for DEXI Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DEXI
- Invitrogen Antibodies for DEXI (AFLGC-Dexi)
- antibodies-online: Show 8 available DEXI Antibodies ranked by validation data
-
Boster Bio Antibodies for DEXI
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DEXI
- Origene Custom Protein Services for DEXI
- antibodies-online: Search results for available DEXI related products ranked by validation data
-
Signalway Proteins for DEXI
Assay Products
- antibodies-online: Search results for available DEXI related products ranked by validation data
-
Signalway ELISA kits for DEXI
No data available for DME Specific Peptides for DEXI Gene
Domains & Families for DEXI Gene
Gene Families for DEXI Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for DEXI Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DEXI Gene
- GenScript: Design optimal peptide antigens:
-
- Protein MYLE (DEXI_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95424- Family:
-
- Belongs to the DEXI family.
Function for DEXI Gene
Molecular function for DEXI Gene
- UniProtKB/Swiss-Prot Induction:
- By dexamethasone.
Phenotypes From GWAS Catalog for DEXI Gene
Phenotypes for DEXI Gene
- MGI mutant phenotypes for DEXI:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DEXI:
Animal Model Products
-
Taconic Biosciences Mouse Models for DEXI
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DEXI - Select products 50% OFF >
- * DEXI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DEXI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DEXI
-
Santa Cruz Biotechnology (SCBT) CRISPR for DEXI
miRNA for DEXI Gene
- miRTarBase miRNAs that target DEXI
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DEXI
- Browse OriGene Inhibitory RNA Products For DEXI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI
Clone Products
- Applied Biological Materials (abm): Clones for DEXI - Select products 50% OFF >
- * DEXI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DEXI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEXI
Cell Line Products
-
Horizon Cell Lines for DEXI
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEXI Gene
Localization for DEXI Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (2)
- Nuclear speckles (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEXI Gene
Pathways & Interactions for DEXI Gene
Interacting Proteins for DEXI Gene
Selected Interacting proteins:
O95424-DEXI_HUMAN
ENSP00000330509
for DEXI Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for DEXI
No data available for Pathways by source and SIGNOR curated interactions for DEXI Gene
Transcripts for DEXI Gene
mRNA/cDNA for DEXI Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000469379 1393 nts (view in UCSC)
- ENST00000331808 1569 nts (view in UCSC)
- ENST00000570992 626 nts (view in UCSC)
- ENST00000570440 5854 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DEXI - Select products 50% OFF >
- * DEXI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DEXI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DEXI
-
Santa Cruz Biotechnology (SCBT) CRISPR for DEXI
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DEXI
- Browse OriGene Inhibitory RNA Products For DEXI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI
Clone Products
- Applied Biological Materials (abm): Clones for DEXI - Select products 50% OFF >
- * DEXI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DEXI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEXI
Relevant External Links for DEXI Gene
- GeneLoc Exon Structure for
- DEXI
Expression for DEXI Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DEXI
SOURCE GeneReport for Unigene cluster for DEXI Gene:
Hs.592051mRNA Expression by UniProt/SwissProt for DEXI Gene:
O95424-DEXI_HUMAN
Tissue specificity:
Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.
Evidence on tissue expression from TISSUES for DEXI Gene
- Nervous system(2.5)
- Muscle(2.4)
- Skin(2.1)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for DEXI
-
OriGene qPCR primer pairs and template standards for DEXI
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEXI Gene
Orthologs for DEXI Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DEXI 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DEXI 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DEXI 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dexi 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dexi 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DEXI 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DEXI 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dexi 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16631 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dexi 30 31 |
|
OneToOne |
- Species where no ortholog for DEXI was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DEXI Gene
- ENSEMBL:
- Gene Tree for DEXI (if available)
- TreeFam:
- Gene Tree for DEXI (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DEXI: view image
Paralogs for DEXI Gene
No data available for Paralogs for DEXI Gene
Variants for DEXI Gene
Residual Variation Intolerance Score:
55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.13;
2.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DEXI Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DEXI
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DEXI Gene
Disorders for DEXI Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| angelman syndrome |
|
|
Search DEXI in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DEXI
No data available for UniProtKB/Swiss-Prot and Genatlas for DEXI Gene
Publications for DEXI Gene
- Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. (PMID: 11472984) Edgar AJ … Polak JM (American journal of respiratory cell and molecular biology 2001) 2 3 4 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. (PMID: 11306815) Kelly M … Wevrick R (Cytogenetics and cell genetics 2001) 2 3
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway. (PMID: 30478640) Dos Santos RS … Santin I (Diabetologia 2019) 3
ExternalLinks
Products for DEXI Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for DEXI
- Origene Custom Protein Services for DEXI
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DEXI
- Browse OriGene Inhibitory RNA Products For DEXI
- OriGene qPCR primer pairs for DEXI
- OriGene qPCR primer pairs and template standards for DEXI
- OriGene CRISPR knockouts for DEXI
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DEXI
- Sino Biological Human cDNA Clone for DEXI
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DEXI
- Novus Biologicals proteins and lysates for DEXI
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for DEXI
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DEXI (AFLGC-Dexi)
- VectorBuilder Custom and pre-made DNA vectors for DEXI (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DEXI (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DEXI (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DEXI CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DEXI
- antibodies-online: Show 8 available DEXI Antibodies ranked by validation data
- antibodies-online: Search results for available DEXI related products ranked by validation data
- antibodies-online: Search results for available DEXI related products ranked by validation data
- Horizon Cell Lines for DEXI
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DEXI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEXI
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DEXI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI
- Boster Bio Antibodies for DEXI
- Browse Boster Bio ELISA Kits
Sources for DEXI Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB