Aliases for DEXI Gene

Aliases for DEXI Gene

  • Dexi Homolog 2 3 5
  • Dexamethasone-Induced Transcript 2 3
  • Dexamethasone-Induced Protein 3 4
  • MYLE 3 4
  • Dexi Homolog (Mouse) 2
  • Protein MYLE 4

External Ids for DEXI Gene

Previous GeneCards Identifiers for DEXI Gene

  • GC16M010989
  • GC16M010930
  • GC16M011024

Summaries for DEXI Gene

GeneCards Summary for DEXI Gene

DEXI (Dexi Homolog) is a Protein Coding gene. Diseases associated with DEXI include Angelman Syndrome.

Additional gene information for DEXI Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DEXI Gene

Genomics for DEXI Gene

GeneHancer (GH) Regulatory Elements for DEXI Gene

Promoters and enhancers for DEXI Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEXI on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DEXI gene promoter:
  • AREB6
  • Egr-4
  • Ik-2
  • LCR-F1
  • Pax-5
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for DEXI Gene

Genomic Locations for DEXI Gene
chr16:10,928,891-10,942,468
(GRCh38/hg38)
Size:
13,578 bases
Orientation:
Minus strand
chr16:11,022,748-11,036,317
(GRCh37/hg19)
Size:
13,570 bases
Orientation:
Minus strand

Genomic View for DEXI Gene

Genes around DEXI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEXI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEXI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEXI Gene

Proteins for DEXI Gene

  • Protein details for DEXI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95424-DEXI_HUMAN
    Recommended name:
    Dexamethasone-induced protein
    Protein Accession:
    O95424
    Secondary Accessions:
    • B2RAA7

    Protein attributes for DEXI Gene

    Size:
    95 amino acids
    Molecular mass:
    10429 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEXI Gene

Post-translational modifications for DEXI Gene

No Post-translational modifications

Other Protein References for DEXI Gene

No data available for DME Specific Peptides for DEXI Gene

Domains & Families for DEXI Gene

Gene Families for DEXI Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DEXI Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEXI Gene

GenScript: Design optimal peptide antigens:
  • Protein MYLE (DEXI_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95424

UniProtKB/Swiss-Prot:

DEXI_HUMAN :
  • Belongs to the DEXI family.
Family:
  • Belongs to the DEXI family.
genes like me logo Genes that share domains with DEXI: view

Function for DEXI Gene

Molecular function for DEXI Gene

UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Phenotypes From GWAS Catalog for DEXI Gene

genes like me logo Genes that share phenotypes with DEXI: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DEXI

CRISPR Products

miRNA for DEXI Gene

miRTarBase miRNAs that target DEXI

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEXI Gene

Localization for DEXI Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEXI gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEXI Gene

Pathways & Interactions for DEXI Gene

PathCards logo

SuperPathways for DEXI Gene

No Data Available

Interacting Proteins for DEXI Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000330509 O95424-DEXI_HUMAN for DEXI Gene via STRING IID

Gene Ontology (GO) - Biological Process for DEXI Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DEXI Gene

Drugs & Compounds for DEXI Gene

No Compound Related Data Available

Transcripts for DEXI Gene

mRNA/cDNA for DEXI Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEXI Gene

No ASD Table

Relevant External Links for DEXI Gene

GeneLoc Exon Structure for
DEXI
ECgene alternative splicing isoforms for
DEXI

Expression for DEXI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEXI Gene

NURSA nuclear receptor signaling pathways regulating expression of DEXI Gene:

DEXI

SOURCE GeneReport for Unigene cluster for DEXI Gene:

Hs.592051

mRNA Expression by UniProt/SwissProt for DEXI Gene:

O95424-DEXI_HUMAN
Tissue specificity: Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.
genes like me logo Genes that share expression patterns with DEXI: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEXI Gene

Orthologs for DEXI Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEXI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DEXI 33 32
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DEXI 33 32
  • 96.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DEXI 33 32
  • 95.79 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dexi 17 33 32
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Dexi 32
  • 90.53 (n)
oppossum
(Monodelphis domestica)
Mammalia DEXI 33
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves DEXI 32
  • 81.36 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia dexi 32
  • 75.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16631 32
zebrafish
(Danio rerio)
Actinopterygii dexi 33 32
  • 71.57 (n)
OneToOne
Species where no ortholog for DEXI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEXI Gene

ENSEMBL:
Gene Tree for DEXI (if available)
TreeFam:
Gene Tree for DEXI (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DEXI: view image

Paralogs for DEXI Gene

No data available for Paralogs for DEXI Gene

Variants for DEXI Gene

Sequence variations from dbSNP and Humsavar for DEXI Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000227613 -- 10,931,084(-) G/T intron_variant
rs1000281442 -- 10,930,812(-) C/T intron_variant
rs1000380527 -- 10,936,694(-) G/C intron_variant
rs1000438505 -- 10,942,262(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000555184 -- 10,932,273(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DEXI Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv571452 CNV loss 21841781
nsv977902 CNV duplication 23825009

Variation tolerance for DEXI Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEXI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEXI

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEXI Gene

Disorders for DEXI Gene

MalaCards: The human disease database

(1) MalaCards diseases for DEXI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
angelman syndrome
  • as
- elite association - COSMIC cancer census association via MalaCards
Search DEXI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DEXI

genes like me logo Genes that share disorders with DEXI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DEXI Gene

Publications for DEXI Gene

  1. Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. (PMID: 11472984) Edgar AJ … Polak JM (American journal of respiratory cell and molecular biology 2001) 2 3 4 23 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. (PMID: 11306815) Kelly M … Wevrick R (Cytogenetics and cell genetics 2001) 2 3 56
  4. DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway. (PMID: 30478640) Dos Santos RS … Santin I (Diabetologia 2019) 3 56
  5. Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13. (PMID: 25008175) Tomlinson MJ … Onengut-Gumuscu S (Diabetes 2014) 3 56

Products for DEXI Gene

Sources for DEXI Gene