Aliases for DEXI Gene
Aliases for DEXI Gene
External Ids for DEXI Gene
- HGNC: 13267
- Entrez Gene: 28955
- Ensembl: ENSG00000182108
- OMIM: 617901
- UniProtKB: O95424
Previous GeneCards Identifiers for DEXI Gene
- GC16M010989
- GC16M010930
- GC16M011024
Summaries for DEXI Gene
GeneCards Summary for DEXI Gene
DEXI (Dexi Homolog) is a Protein Coding gene. Diseases associated with DEXI include Angelman Syndrome.
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DEXI Gene
Genomics for DEXI Gene
GeneHancer (GH) Regulatory Elements for DEXI Gene
Promoters and enhancers for DEXI Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DEXI on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DEXI gene promoter:
-
- AREB6
- Egr-4
- Ik-2
- LCR-F1
- Pax-5
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
Genomic Locations for DEXI Gene
Genomic Locations for DEXI Gene
- chr16:10,928,891-10,942,468
- (GRCh38/hg38)
- Size:
- 13,578 bases
- Orientation:
- Minus strand
- chr16:11,022,748-11,036,317
- (GRCh37/hg19)
- Size:
- 13,570 bases
- Orientation:
- Minus strand
Genomic View for DEXI Gene
Genes around DEXI on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.13 by HGNC
- 16p13.13 by Entrez Gene
- 16p13.13 by Ensembl
DEXI Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DEXI Gene
Proteins for DEXI Gene
-
Protein details for DEXI Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95424-DEXI_HUMAN
- Recommended name:
- Dexamethasone-induced protein
- Protein Accession:
- O95424
- B2RAA7
Protein attributes for DEXI Gene
- Size:
- 95 amino acids
- Molecular mass:
- 10429 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for DEXI Gene
No Post-translational modifications
Other Protein References for DEXI Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-DEXI Antibody
- Novus Biologicals Antibodies for DEXI
- Invitrogen Antibodies for DEXI (AFLGC-DEXI)
- antibodies-online: Show 8 available DEXI Antibodies ranked by validation data
Protein Products
- Atlas Antibodies PrEST Antigen DEXI
-
OriGene Purified Proteins for DEXI
- Search Origene for MassSpec and Protein Over-expression Lysates for DEXI
- Origene Custom Protein Services for DEXI
- antibodies-online: Search results for available DEXI related products ranked by validation data
Assay Products
- Aviva Systems Biology DEXI ELISA Kit (Human) (OKEH04268) and DEXI ELISA Kit (Human) (OKCD09458)
- antibodies-online: Search results for available DEXI related products ranked by validation data
No data available for DME Specific Peptides for DEXI Gene
Domains & Families for DEXI Gene
Gene Families for DEXI Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for DEXI Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DEXI Gene
- GenScript: Design optimal peptide antigens:
-
- Protein MYLE (DEXI_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95424- Family:
-
- Belongs to the DEXI family.
Function for DEXI Gene
Molecular function for DEXI Gene
- UniProtKB/Swiss-Prot Induction:
- By dexamethasone.
Phenotypes From GWAS Catalog for DEXI Gene
Phenotypes for DEXI Gene
- GenomeRNAi human phenotypes for DEXI:
Animal Model Products
-
Taconic Biosciences Mouse Models for DEXI
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DEXI - Select products 50% OFF >
- * DEXI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * DEXI CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for DEXI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DEXI
- genomics-online: gRNA clones - Search for available DEXI gRNA products
- Overview of 111 available DEXI gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for DEXI
miRNA for DEXI Gene
- miRTarBase miRNAs that target DEXI
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DEXI
- Browse OriGene Inhibitory RNA Products For DEXI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI
- genomics-online: shRNA clones - Search for available DEXI shRNA products
- Overview of 111 available DEXI gene related products
Clone Products
- Applied Biological Materials (abm): Clones for DEXI - Select products 50% OFF >
- * DEXI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * DEXI tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for DEXI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEXI
- genomics-online: cdna clones - Search for available DEXI CDNA products
- Overview of 111 available DEXI gene related products
- orf clones - Search for available DEXI ORF products
- Overview of 111 available DEXI gene related products
Cell Line Products
-
Horizon Cell Lines for DEXI
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEXI Gene
Localization for DEXI Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| extracellular | 0 |
- Cytosol (2)
- Nuclear speckles (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEXI Gene
Pathways & Interactions for DEXI Gene
Interacting Proteins for DEXI Gene
GPS-Prot Interaction Network for DEXI
No data available for Pathways by source and SIGNOR curated interactions for DEXI Gene
Drugs & Compounds for DEXI Gene
No Compound Related Data Available
Drug Products
- Atlas Antibodies PrEST Antigen DEXI
Transcripts for DEXI Gene
mRNA/cDNA for DEXI Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (177) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000469379 1393 bps (ENST00000469379.5)
- ENST00000331808 1569 bps (ENST00000331808.4)
- ENST00000570992 626 bps (ENST00000570992.1)
- ENST00000570440 5854 bps (ENST00000570440.2)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DEXI - Select products 50% OFF >
- * DEXI CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * DEXI CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for DEXI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DEXI
- genomics-online: gRNA clones - Search for available DEXI gRNA products
- Overview of 111 available DEXI gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for DEXI
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DEXI
- Browse OriGene Inhibitory RNA Products For DEXI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI
- genomics-online: shRNA clones - Search for available DEXI shRNA products
- Overview of 111 available DEXI gene related products
Clone Products
- Applied Biological Materials (abm): Clones for DEXI - Select products 50% OFF >
- * DEXI as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * DEXI tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for DEXI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEXI
- genomics-online: cdna clones - Search for available DEXI CDNA products
- Overview of 111 available DEXI gene related products
- orf clones - Search for available DEXI ORF products
- Overview of 111 available DEXI gene related products
Expression for DEXI Gene
NURSA nuclear receptor signaling pathways regulating expression of DEXI Gene:
DEXISOURCE GeneReport for Unigene cluster for DEXI Gene:
Hs.592051mRNA Expression by UniProt/SwissProt for DEXI Gene:
O95424-DEXI_HUMAN
Tissue specificity:
Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.
Primer Products
-
OriGene qPCR primer pairs for DEXI
-
OriGene qPCR primer pairs and template standards for DEXI
- genomics-online: primer clones - Search for available DEXI Primer products
- Overview of 111 available DEXI gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEXI Gene
Orthologs for DEXI Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DEXI 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DEXI 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DEXI 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dexi 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dexi 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DEXI 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DEXI 32 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dexi 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16631 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dexi 33 32 |
|
OneToOne |
- Species where no ortholog for DEXI was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for DEXI Gene
- ENSEMBL:
- Gene Tree for DEXI (if available)
- TreeFam:
- Gene Tree for DEXI (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DEXI: view image
Paralogs for DEXI Gene
No data available for Paralogs for DEXI Gene
Variants for DEXI Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000227613 | -- | 10,931,084(-) | G/T | intron_variant | |
| rs1000281442 | -- | 10,930,812(-) | C/T | intron_variant | |
| rs1000380527 | -- | 10,936,694(-) | G/C | intron_variant | |
| rs1000438505 | -- | 10,942,262(-) | C/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000555184 | -- | 10,932,273(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.13;
2.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DEXI Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DEXI
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEXI Gene
Disorders for DEXI Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| angelman syndrome |
|
|
Search DEXI in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DEXI
No data available for UniProtKB/Swiss-Prot and Genatlas for DEXI Gene
Publications for DEXI Gene
- Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. (PMID: 11472984) Edgar AJ … Polak JM (American journal of respiratory cell and molecular biology 2001) 2 3 4 23 56
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
- Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. (PMID: 11306815) Kelly M … Wevrick R (Cytogenetics and cell genetics 2001) 2 3 56
- DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway. (PMID: 30478640) Dos Santos RS … Santin I (Diabetologia 2019) 3 56
- Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13. (PMID: 25008175) Tomlinson MJ … Onengut-Gumuscu S (Diabetes 2014) 3 56
ExternalLinks
Products for DEXI Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DEXI
- Search Origene for MassSpec and Protein Over-expression Lysates for DEXI
- Origene Custom Protein Services for DEXI
- Origene sirna, shrna, and RNAi products in human, mouse, rat for DEXI
- Browse OriGene Inhibitory RNA Products For DEXI
- OriGene qPCR primer pairs for DEXI
- OriGene qPCR primer pairs and template standards for DEXI
- OriGene CRISPR knockouts for DEXI
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DEXI
- Sino Biological Human cDNA Clone for DEXI
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DEXI
- Novus Biologicals proteins and lysates for DEXI
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Taconic Biosciences Mouse Models for DEXI
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for DEXI (AFLGC-DEXI)
- antibodies-online: Show 8 available DEXI Antibodies ranked by validation data
- antibodies-online: Search results for available DEXI related products ranked by validation data
- antibodies-online: Search results for available DEXI related products ranked by validation data
- Horizon Cell Lines for DEXI
- genomics-online: cdna clones - Search for available DEXI CDNA products
- Overview of 111 available DEXI gene related products
- orf clones - Search for available DEXI ORF products
- Overview of 111 available DEXI gene related products
- genomics-online: gRNA clones - Search for available DEXI gRNA products
- Overview of 111 available DEXI gene related products
- genomics-online: primer clones - Search for available DEXI Primer products
- Overview of 111 available DEXI gene related products
- genomics-online: shRNA clones - Search for available DEXI shRNA products
- Overview of 111 available DEXI gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DEXI
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DEXI
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DEXI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI
Sources for DEXI Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource