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DEXI Gene(Protein Coding)

Dexi Homolog

GCID:
GC16M010928
GIFtS:
35
Genes Participants
UDN Logo

Aliases for DEXI Gene

Aliases for DEXI Gene

  • Dexi Homolog 2 3 5
  • Dexamethasone-Induced Transcript 2 3
  • MYLE 3 4
  • Dexamethasone-Induced Protein 3
  • Dexi Homolog (Mouse) 2
  • Protein MYLE 4

External Ids for DEXI Gene

Previous GeneCards Identifiers for DEXI Gene

  • GC16M010989
  • GC16M010930
  • GC16M011024

Summaries for DEXI Gene

GeneCards Summary for DEXI Gene

DEXI (Dexi Homolog) is a Protein Coding gene. Diseases associated with DEXI include Angelman Syndrome.

Additional gene information for DEXI Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEXI Gene

Genomics for DEXI Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for DEXI Gene

Promoters and enhancers for DEXI Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH16J010936 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +2.2 2158 6.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A YY1 SLC30A9 ZNF213 ZNF207 ZNF143 GC16M010938 DEXI PRM2 PRM1 GC16M010936 CIITA GC16P010485
GH16J011296 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -355.8 -355790 4.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YBX1 PIR58691 RMI2 SOCS1 ENSG00000212228 PRM2 PRM3 TNP2 DEXI CLEC16A LOC105371083
GH16J011223 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -282.7 -282652 3 HDGF PKNOX1 ATF1 ARID4B ZNF48 ZNF207 ZNF143 ATF7 RUNX3 RXRA RMI2 HNRNPCP4 CLEC16A TNP2 PRM3 ENSG00000212228 PRM2 DEXI LOC105371083 LITAF
GH16J011370 Enhancer 1.2 Ensembl ENCODE 10.5 -428.9 -428885 2.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 TCF12 SLC30A9 ZNF143 ATF7 RMI2 PRM3 ENSG00000212228 TNP2 CLEC16A DEXI ENSG00000262703 LOC105371083 LOC100420951 LOC105371082
GH16J011161 Enhancer 1 Ensembl ENCODE dbSUPER 10.7 -219.7 -219735 1.6 L3MBTL2 CBFA2T3 ELF1 GATA3 ATF4 GATA2 EGR1 ADNP GATA1 CBFA2T2 RMI2 TNP2 ENSG00000212228 PRM3 DEXI CLEC16A PIR34996 LOC105371081 GC16P010485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DEXI on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DEXI gene promoter:

Genomic Locations for DEXI Gene

Genomic Locations for DEXI Gene
chr16:10,928,891-10,942,460
(GRCh38/hg38)
Size:
13,570 bases
Orientation:
Minus strand
chr16:11,022,748-11,036,317
(GRCh37/hg19)

Genomic View for DEXI Gene

Genes around DEXI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEXI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEXI Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DEXI Gene

Proteins for DEXI Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DEXI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95424-DEXI_HUMAN
    Recommended name:
    Dexamethasone-induced protein
    Protein Accession:
    O95424
    Secondary Accessions:
    • B2RAA7

    Protein attributes for DEXI Gene

    Size:
    95 amino acids
    Molecular mass:
    10429 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEXI Gene

Post-translational modifications for DEXI Gene

No Post-translational modifications

Other Protein References for DEXI Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEXI Gene

Domains & Families for DEXI Gene

Gene Families for DEXI Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DEXI Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEXI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95424

UniProtKB/Swiss-Prot:

DEXI_HUMAN :
  • Belongs to the DEXI family.
Family:
  • Belongs to the DEXI family.
genes like me logo Genes that share domains with DEXI: view

Function for DEXI Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DEXI Gene

UniProtKB/Swiss-Prot Induction:
By dexamethasone.

Phenotypes From GWAS Catalog for DEXI Gene

genes like me logo Genes that share phenotypes with DEXI: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DEXI

CRISPR Products

miRNA for DEXI Gene

miRTarBase miRNAs that target DEXI

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEXI Gene

Localization for DEXI Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEXI gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DEXI Gene

Pathways & Interactions for DEXI Gene

SuperPathways for DEXI Gene

PathCards logo More details on SuperPathways for DEXI
No Data Available

Interacting Proteins for DEXI Gene

Selected Interacting proteins: O95424-DEXI_HUMAN for DEXI Gene via IID

Symbol External ID(s) Details
GOLM1
TBCD
GPS-Prot Interaction Network for DEXI

Gene Ontology (GO) - Biological Process for DEXI Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DEXI Gene

Drugs & Compounds for DEXI Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DEXI Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DEXI Gene

(177) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DEXI Gene

Dexi homolog (mouse):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEXI

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEXI Gene

No ASD Table

Relevant External Links for DEXI Gene

GeneLoc Exon Structure for
DEXI
ECgene alternative splicing isoforms for
DEXI

Expression for DEXI Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEXI Gene

mRNA expression in normal human tissues for DEXI Gene
mRNA expression by GTEx for DEXI GenemRNA expression by BioGPS for DEXI Gene

NURSA nuclear receptor signaling pathways regulating expression of DEXI Gene:

DEXI

SOURCE GeneReport for Unigene cluster for DEXI Gene:

Hs.592051

mRNA Expression by UniProt/SwissProt for DEXI Gene:

O95424-DEXI_HUMAN
Tissue specificity: Highest levels in heart. Also expressed in brain, liver, pancreas, placenta and lung. Up-regulated in emphysematous lung compared to normal lung.
genes like me logo Genes that share expression patterns with DEXI: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEXI Gene

Orthologs for DEXI Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEXI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DEXI 34 33
  • 100 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia DEXI 34 33
  • 96.14 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia DEXI 34 33
  • 95.79 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dexi 16 34 33
  • 90.88 (n)
rat
(Rattus norvegicus)
 Mammalia Dexi 33
  • 90.53 (n)
oppossum
(Monodelphis domestica)
 Mammalia DEXI 34
  • 89 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DEXI 33
  • 81.36 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia dexi 33
  • 75.98 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.16631 33
zebrafish
(Danio rerio)
 Actinopterygii dexi 34 33
  • 71.57 (n)
 OneToOne
Species where no ortholog for DEXI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEXI Gene

ENSEMBL:
Gene Tree for DEXI (if available)
TreeFam:
Gene Tree for DEXI (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DEXI: view image

Paralogs for DEXI Gene

No data available for Paralogs for DEXI Gene

Variants for DEXI Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for DEXI Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000227613 -- 10,931,084(-) G/T intron_variant
rs1000281442 -- 10,930,812(-) C/T intron_variant
rs1000380527 -- 10,936,694(-) G/C intron_variant
rs1000438505 -- 10,942,262(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000555184 -- 10,932,273(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DEXI Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv571452 CNV loss 21841781
nsv977902 CNV duplication 23825009

Variation tolerance for DEXI Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEXI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEXI

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEXI Gene

Disorders for DEXI Gene

MalaCards: The human disease database

(1) MalaCards diseases for DEXI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
angelman syndrome
  • as
- elite association - COSMIC cancer census association via MalaCards
Search DEXI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DEXI

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DEXI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DEXI Gene

Publications for DEXI Gene

  1. Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. (PMID: 11472984) Edgar AJ … Polak JM (American journal of respiratory cell and molecular biology 2001) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Analysis of DEXI/Dexi refines the organization of the mouse 7C and human 15q11-->q13 imprinting clusters. (PMID: 11306815) Kelly M … Wevrick R (Cytogenetics and cell genetics 2001) 2 3 58
  4. Fine mapping and functional studies of risk variants for type 1 diabetes at chromosome 16p13.13. (PMID: 25008175) Tomlinson MJ … Onengut-Gumuscu S (Diabetes 2014) 3 58
  5. Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus. (PMID: 23151489) Leikfoss IS … Berge T (Genes and immunity 2013) 3 58

Products for DEXI Gene

Sources for DEXI Gene

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