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Aliases for DET1 Gene

Aliases for DET1 Gene

  • DET1, COP1 Ubiquitin Ligase Partner 2 3
  • De-Etiolated Homolog 1 (Arabidopsis) 2 5
  • De-Etiolated-1 Homolog 4

External Ids for DET1 Gene

Previous GeneCards Identifiers for DET1 Gene

  • GC15M086786
  • GC15M086856
  • GC15M089055
  • GC15M065167
  • GC15M088493

Summaries for DET1 Gene

GeneCards Summary for DET1 Gene

DET1 (DET1, COP1 Ubiquitin Ligase Partner) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for DET1 Gene

  • Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.

Additional gene information for DET1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DET1 Gene

Genomics for DET1 Gene

GeneHancer (GH) Regulatory Elements for DET1 Gene

Promoters and enhancers for DET1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I088545 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.1 +0.2 210 1.8 PKNOX1 ARID4B SIN3A DMAP1 IRF4 YY1 CBX5 E2F8 ZNF143 ZNF548 DET1 POLG FANCI ENSG00000173867 PIR61736
GH15I088536 Promoter 0.7 EPDnew 550.4 +11.5 11513 0.1 ZNF362 TRIM24 SETDB1 DET1 PIR61736 ENSG00000173867
GH15I088547 Enhancer 0.2 ENCODE 550.8 -0.9 -901 0.1 DET1 ENSG00000259569
GH15I089383 Enhancer 1.1 ENCODE dbSUPER 9.7 -837.0 -837007 0.9 SMAD1 FEZF1 ZNF2 GLIS2 ZNF213 ZNF302 ZNF214 YY2 ZNF662 TSHZ1 RPL36AP43 NIFKP5 ENSG00000173867 ARPIN ENSG00000228998 POLG WDR93 DET1 MIR9-3HG GC15P089381
GH15I089124 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -586.4 -586380 16.2 HDGF FOXA2 ZFP64 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS ABHD2 LOC102724566 DET1 ISG20 HMGB1P8 GC15M089136 RNU7-195P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DET1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DET1 gene promoter:

Genomic Locations for DET1 Gene

Genomic Locations for DET1 Gene
chr15:88,494,440-88,546,698
(GRCh38/hg38)
Size:
52,259 bases
Orientation:
Minus strand
chr15:89,054,790-89,089,912
(GRCh37/hg19)

Genomic View for DET1 Gene

Genes around DET1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DET1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DET1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DET1 Gene

Proteins for DET1 Gene

  • Protein details for DET1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5Y6-DET1_HUMAN
    Recommended name:
    DET1 homolog
    Protein Accession:
    Q7L5Y6
    Secondary Accessions:
    • B3KNN6
    • Q2VPC0
    • Q9NWD5

    Protein attributes for DET1 Gene

    Size:
    550 amino acids
    Molecular mass:
    63848 Da
    Quaternary structure:
    • Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.
    SequenceCaution:
    • Sequence=BAA91447.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DET1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DET1 Gene

Post-translational modifications for DET1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DET1 Gene

Domains & Families for DET1 Gene

Gene Families for DET1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DET1 Gene

Suggested Antigen Peptide Sequences for DET1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L5Y6

UniProtKB/Swiss-Prot:

DET1_HUMAN :
  • Belongs to the DET1 family.
Family:
  • Belongs to the DET1 family.
genes like me logo Genes that share domains with DET1: view

Function for DET1 Gene

Molecular function for DET1 Gene

UniProtKB/Swiss-Prot Function:
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.

Phenotypes From GWAS Catalog for DET1 Gene

Gene Ontology (GO) - Molecular Function for DET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14739464
GO:0031625 ubiquitin protein ligase binding IMP 14739464
GO:0032403 protein complex binding IDA 14739464
GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination IPI 14739464
genes like me logo Genes that share ontologies with DET1: view
genes like me logo Genes that share phenotypes with DET1: view

Animal Model Products

miRNA for DET1 Gene

miRTarBase miRNAs that target DET1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DET1 Gene

Localization for DET1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DET1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DET1 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA 14739464
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DET1: view

Pathways & Interactions for DET1 Gene

genes like me logo Genes that share pathways with DET1: view

Gene Ontology (GO) - Biological Process for DET1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IDA 14739464
GO:0016567 protein ubiquitination IPI 14739464
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IPI 14739464
genes like me logo Genes that share ontologies with DET1: view

No data available for SIGNOR curated interactions for DET1 Gene

Drugs & Compounds for DET1 Gene

(1) Additional Compounds for DET1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DET1: view

Transcripts for DET1 Gene

Unigene Clusters for DET1 Gene

De-etiolated homolog 1 (Arabidopsis):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DET1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2:
SP3:

Relevant External Links for DET1 Gene

GeneLoc Exon Structure for
DET1
ECgene alternative splicing isoforms for
DET1

Expression for DET1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DET1 Gene

Protein differential expression in normal tissues from HIPED for DET1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.7) and Testis (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DET1 Gene



Protein tissue co-expression partners for DET1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DET1 Gene:

DET1

SOURCE GeneReport for Unigene cluster for DET1 Gene:

Hs.690871

mRNA Expression by UniProt/SwissProt for DET1 Gene:

Q7L5Y6-DET1_HUMAN
Tissue specificity: Highly expressed in the ovary, some lymphoid organs and resting leukocytes.

Evidence on tissue expression from TISSUES for DET1 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with DET1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DET1 Gene

Orthologs for DET1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DET1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DET1 33 34
  • 99.76 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 94 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DET1 33 34
  • 91.82 (n)
rat
(Rattus norvegicus)
Mammalia Det1 33
  • 89.32 (n)
mouse
(Mus musculus)
Mammalia Det1 33 16 34
  • 89.15 (n)
cow
(Bos Taurus)
Mammalia DET1 33 34
  • 87.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DET1 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves DET1 33 34
  • 80.85 (n)
lizard
(Anolis carolinensis)
Reptilia DET1 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia det1 33
  • 77.07 (n)
Str.4076 33
zebrafish
(Danio rerio)
Actinopterygii det1 33 34
  • 75.45 (n)
wufc18d06 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.492 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001900 33
  • 57.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta abo 34
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons DET1 33
  • 46.24 (n)
rice
(Oryza sativa)
Liliopsida Os01g0104600 33
  • 47.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14008 33
Species where no ortholog for DET1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DET1 Gene

ENSEMBL:
Gene Tree for DET1 (if available)
TreeFam:
Gene Tree for DET1 (if available)

Paralogs for DET1 Gene

No data available for Paralogs for DET1 Gene

Variants for DET1 Gene

Sequence variations from dbSNP and Humsavar for DET1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000015123 -- 88,539,144(-) C/T intron_variant
rs1000081009 -- 88,503,800(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000102029 -- 88,522,390(-) A/T intron_variant
rs1000114309 -- 88,512,338(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000154076 -- 88,538,984(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DET1 Gene

Variant ID Type Subtype PubMed ID
esv2749993 CNV deletion 23290073
nsv509581 CNV insertion 20534489
nsv833085 CNV gain+loss 17160897

Variation tolerance for DET1 Gene

Residual Variation Intolerance Score: 7.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DET1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DET1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DET1 Gene

Disorders for DET1 Gene

Additional Disease Information for DET1

No disorders were found for DET1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DET1 Gene

Publications for DET1 Gene

  1. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. (PMID: 14739464) Wertz IE … Dixit VM (Science (New York, N.Y.) 2004) 2 3 4 58
  2. Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PMID: 17452440) Pick E … Wei N (Molecular and cellular biology 2007) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DET1 Gene

Sources for DET1 Gene

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