Aliases for DERA Gene

Aliases for DERA Gene

  • Deoxyribose-Phosphate Aldolase 2 3 4 5
  • 2-Deoxy-D-Ribose 5-Phosphate Aldolase 3 4
  • Phosphodeoxyriboaldolase 3 4
  • Deoxyriboaldolase 3 4
  • EC 4 51
  • CGI-26 2 3
  • DEOC 2 3
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog (C. Elegans) 2
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog 3
  • Deoxyribose-Phosphate Aldolase (Putative) 3
  • Putative Deoxyribose-Phosphate Aldolase 3
  • DERA 5

External Ids for DERA Gene

Previous GeneCards Identifiers for DERA Gene

  • GC12P015956
  • GC12P016064
  • GC12P015833

Summaries for DERA Gene

GeneCards Summary for DERA Gene

DERA (Deoxyribose-Phosphate Aldolase) is a Protein Coding gene. Diseases associated with DERA include Phlebotomus Fever and Bjornstad Syndrome. Among its related pathways are Pentose phosphate pathway and putrescine degradation III. Gene Ontology (GO) annotations related to this gene include lyase activity and deoxyribose-phosphate aldolase activity.

UniProtKB/Swiss-Prot Summary for DERA Gene

  • Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DERA Gene

Genomics for DERA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DERA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J015909 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.0 26 3.3 HNRNPL IKZF1 POLR2A BACH1 LARP7 ZNF143 RBFOX2 PATZ1 IKZF2 ZNF501 DERA piR-31432-111 piR-46662-108 piR-53431-115 piR-56759-105 STRAP SLC15A5
GH12J015931 Enhancer 1 Ensembl ENCODE 8.5 +21.1 21099 2.4 GATAD2A CTCF BACH1 IKZF2 TRIM22 CEBPA YBX1 RELB GATAD2B NFE2 DERA STRAP lnc-STRAP-3 piR-61101-117 SLC15A5
GH12J015927 Enhancer 0.9 Ensembl ENCODE 8.5 +17.5 17499 3.2 PRDM10 PRDM1 IKZF2 ZBTB20 DPF2 RELB JUND RUNX3 GATAD2B USF1 DERA lnc-STRAP-3 piR-61101-117 SLC15A5
GH12J015977 Enhancer 0.8 Ensembl ENCODE 9.2 +69.2 69170 6.3 CTCF SP1 PKNOX1 RAD21 JUND CEBPB RUNX3 YY1 SPI1 ZNF654 DERA EGLN3P1 piR-36588-086 SLC15A5
GH12J015962 Enhancer 0.7 Ensembl ENCODE 10.9 +52.0 51998 2.2 ATF7 CEBPB JUN FOS JUND EP300 ATF2 DERA EGLN3P1 piR-45932-022 SLC15A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DERA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DERA

Top Transcription factor binding sites by QIAGEN in the DERA gene promoter:
  • AML1a
  • CREB
  • ER-alpha
  • FOXJ2 (long isoform)
  • Hlf
  • POU3F2
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP

Genomic Locations for DERA Gene

Genomic Locations for DERA Gene
126,080 bases
Plus strand
126,210 bases
Plus strand

Genomic View for DERA Gene

Genes around DERA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DERA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DERA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DERA Gene

Proteins for DERA Gene

  • Protein details for DERA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxyribose-phosphate aldolase
    Protein Accession:
    Secondary Accessions:
    • Q53HN9
    • Q6PHW2

    Protein attributes for DERA Gene

    318 amino acids
    Molecular mass:
    35231 Da
    Quaternary structure:
    • Interacts with YBX1.
    • Sequence=AAD27735.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH56234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DERA Gene

Selected DME Specific Peptides for DERA Gene


Post-translational modifications for DERA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DERA Gene

Gene Families for DERA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DERA Gene

  • Deoxyribose-phosphate aldolase

Suggested Antigen Peptide Sequences for DERA Gene

GenScript: Design optimal peptide antigens:
  • Phosphodeoxyriboaldolase (DEOC_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
genes like me logo Genes that share domains with DERA: view

Function for DERA Gene

Molecular function for DERA Gene

UniProtKB/Swiss-Prot Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343, ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=; Evidence={ECO:0000269|PubMed:25229427};.

Enzyme Numbers (IUBMB) for DERA Gene

Phenotypes From GWAS Catalog for DERA Gene

Gene Ontology (GO) - Molecular Function for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004139 deoxyribose-phosphate aldolase activity IEA,TAS --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with DERA: view
genes like me logo Genes that share phenotypes with DERA: view

Animal Model Products

CRISPR Products

miRNA for DERA Gene

miRTarBase miRNAs that target DERA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DERA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DERA Gene

Localization for DERA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DERA Gene

Cytoplasm. Cytoplasmic granule. Nucleus. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269 PubMed:25229427}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DERA gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DERA: view

Pathways & Interactions for DERA Gene

genes like me logo Genes that share pathways with DERA: view

Pathways by source for DERA Gene

UniProtKB/Swiss-Prot Q9Y315-DEOC_HUMAN

  • Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006098 pentose-phosphate shunt TAS --
GO:0009264 deoxyribonucleotide catabolic process IEA,IBA 21873635
GO:0016052 carbohydrate catabolic process IBA 21873635
GO:0043312 neutrophil degranulation TAS --
GO:0046121 deoxyribonucleoside catabolic process IDA 9226884
genes like me logo Genes that share ontologies with DERA: view

No data available for SIGNOR curated interactions for DERA Gene

Drugs & Compounds for DERA Gene

(3) Drugs for DERA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Open Form of 2'-Deoxy-Ribofuranose-5'-Phosphate Experimental Pharma Target, Target 0
Glyceraldehyde-3-Phosphate Experimental Pharma 0
acetaldehyde Pharma Activator, Activation 0

(5) Additional Compounds for DERA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Deoxyribose 5-monophosphate
Deoxyribose 5-phosphate
  • 2-Deoxy-alpha-D-ribose 5-phosphate
  • 2-Deoxy-alpha-delta-ribose 5-phosphate
  • 2-Deoxy-D-ribose 5-phosphate
  • 2-Deoxy-D-ribose-5-phosphate
  • 2-Deoxyribose 5-phosphate
genes like me logo Genes that share compounds with DERA: view

Transcripts for DERA Gene

mRNA/cDNA for DERA Gene

9 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DERA

Alternative Splicing Database (ASD) splice patterns (SP) for DERA Gene

No ASD Table

Relevant External Links for DERA Gene

GeneLoc Exon Structure for

Expression for DERA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DERA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DERA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.4) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DERA Gene

Protein tissue co-expression partners for DERA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DERA

SOURCE GeneReport for Unigene cluster for DERA Gene:


mRNA Expression by UniProt/SwissProt for DERA Gene:

Tissue specificity: Mainly expressed in liver, lung and colon.

Evidence on tissue expression from TISSUES for DERA Gene

  • Skin(4.5)
  • Liver(4.5)
  • Nervous system(3.3)
  • Kidney(2.3)
  • Blood(2.3)
  • Intestine(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with DERA: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DERA Gene

Orthologs for DERA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DERA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DERA 30 31
  • 99.27 (n)
(Canis familiaris)
Mammalia DERA 31
  • 93 (a)
(Monodelphis domestica)
Mammalia DERA 31
  • 91 (a)
(Bos Taurus)
Mammalia DERA 30 31
  • 90.67 (n)
(Mus musculus)
Mammalia Dera 30 17 31
  • 85.53 (n)
(Rattus norvegicus)
Mammalia Dera 30
  • 85.01 (n)
(Ornithorhynchus anatinus)
Mammalia DERA 31
  • 69 (a)
(Gallus gallus)
Aves DERA 30 31
  • 73.48 (n)
(Anolis carolinensis)
Reptilia DERA 31
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16254 30
(Danio rerio)
Actinopterygii dera 30 31
  • 69.72 (n)
zgc56677 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG8525 30 31
  • 56.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009161 30
  • 55.06 (n)
(Caenorhabditis elegans)
Secernentea F09E5.3 30 31
  • 58.44 (n)
(Hordeum vulgare)
Liliopsida Hv.1195 30
(Oryza sativa)
Liliopsida Os.15810 30
(Triticum aestivum)
Liliopsida Ta.30529 30
(Zea mays)
Liliopsida Zm.2750 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 68 (a)
Species where no ortholog for DERA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)

Evolution for DERA Gene

Gene Tree for DERA (if available)
Gene Tree for DERA (if available)
Evolutionary constrained regions (ECRs) for DERA: view image

Paralogs for DERA Gene

No data available for Paralogs for DERA Gene

Variants for DERA Gene

Additional dbSNP identifiers (rs#s) for DERA Gene

Structural Variations from Database of Genomic Variants (DGV) for DERA Gene

Variant ID Type Subtype PubMed ID
dgv1395n100 CNV loss 25217958
esv2647271 CNV deletion 19546169
esv2659461 CNV deletion 23128226
esv2760899 CNV gain 21179565
esv3358865 CNV insertion 20981092
esv3580160 CNV loss 25503493
esv3628681 CNV loss 21293372
esv3892147 CNV loss 25118596
nsv1036638 CNV loss 25217958
nsv557636 CNV loss 21841781

Variation tolerance for DERA Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DERA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DERA Gene

Disorders for DERA Gene

MalaCards: The human disease database

(2) MalaCards diseases for DERA Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
bjornstad syndrome
  • bjs
- elite association - COSMIC cancer census association via MalaCards
Search DERA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DERA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DERA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DERA Gene

Publications for DERA Gene

  1. DERA is the human deoxyribose phosphate aldolase and is involved in stress response. (PMID: 25229427) Salleron L … Lane L (Biochimica et biophysica acta 2014) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Phylogenetic analyses of diplomonad genes reveal frequent lateral gene transfers affecting eukaryotes. (PMID: 12546782) Andersson JO … Roger AJ (Current biology : CB 2003) 2 3
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4
  5. Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase. (PMID: 9226884) Sgarrella F … Tozzi MG (Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997) 3 23

Products for DERA Gene

  • Signalway ELISA kits for DERA

Sources for DERA Gene