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Aliases for DERA Gene

Aliases for DERA Gene

  • Deoxyribose-Phosphate Aldolase 2 3 5
  • 2-Deoxy-D-Ribose 5-Phosphate Aldolase 3 4
  • Phosphodeoxyriboaldolase 3 4
  • Deoxyriboaldolase 3 4
  • EC 4 56
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog (C. Elegans) 2
  • 2-Deoxyribose-5-Phosphate Aldolase Homolog 3
  • Deoxyribose-Phosphate Aldolase (Putative) 3
  • Putative Deoxyribose-Phosphate Aldolase 3
  • CGI-26 3
  • DEOC 3

External Ids for DERA Gene

Previous GeneCards Identifiers for DERA Gene

  • GC12P015956
  • GC12P016064
  • GC12P015833

Summaries for DERA Gene

GeneCards Summary for DERA Gene

DERA (Deoxyribose-Phosphate Aldolase) is a Protein Coding gene. Diseases associated with DERA include Phlebotomus Fever. Among its related pathways are Glycosaminoglycan metabolism and Innate Immune System. Gene Ontology (GO) annotations related to this gene include lyase activity and deoxyribose-phosphate aldolase activity.

UniProtKB/Swiss-Prot for DERA Gene

  • Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Additional gene information for DERA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DERA Gene

Genomics for DERA Gene

GeneHancer (GH) Regulatory Elements for DERA Gene

Promoters and enhancers for DERA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I015909 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.0 22 3.1 SIN3A DMAP1 ZNF48 GLIS2 ZNF143 ATF7 SP3 MXD4 SMARCB1 NFIL3 DERA SUPT16HP1 STRAP EGLN3P1
GH12I015977 Enhancer 0.9 Ensembl ENCODE 9.2 +68.2 68227 4.1 CTCF PKNOX1 RXRA JUN ZNF644 RAD21 YY1 JUND PRDM6 POLR2A DERA EGLN3P1 GC12M015990
GH12I015927 Enhancer 0.9 Ensembl ENCODE 8.5 +17.5 17451 2.1 USF1 ZBTB6 JUN EBF1 BATF IRF4 ZFHX2 PRDM10 FOS IKZF2 DERA EGLN3P1
GH12I015962 Enhancer 0.5 ENCODE 10.9 +52.0 52045 2 JUND JUN CEBPB ATF7 FOS EP300 ATF2 DERA EGLN3P1
GH12I015919 Enhancer 0.3 ENCODE 10.7 +8.5 8478 0.9 FEZF1 DERA EGLN3P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DERA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DERA gene promoter:

Genomic Locations for DERA Gene

Genomic Locations for DERA Gene
126,210 bases
Plus strand

Genomic View for DERA Gene

Genes around DERA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DERA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DERA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DERA Gene

Proteins for DERA Gene

  • Protein details for DERA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxyribose-phosphate aldolase
    Protein Accession:
    Secondary Accessions:
    • Q53HN9
    • Q6PHW2

    Protein attributes for DERA Gene

    318 amino acids
    Molecular mass:
    35231 Da
    Quaternary structure:
    • Interacts with YBX1.
    • Sequence=AAD27735.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH56234.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96261.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DERA Gene

Selected DME Specific Peptides for DERA Gene


Post-translational modifications for DERA Gene

No Post-translational modifications

Domains & Families for DERA Gene

Gene Families for DERA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DERA Gene

Suggested Antigen Peptide Sequences for DERA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
  • Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
genes like me logo Genes that share domains with DERA: view

Function for DERA Gene

Molecular function for DERA Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
UniProtKB/Swiss-Prot Function:
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation.

Enzyme Numbers (IUBMB) for DERA Gene

Phenotypes From GWAS Catalog for DERA Gene

Gene Ontology (GO) - Molecular Function for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004139 deoxyribose-phosphate aldolase activity IEA,TAS --
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with DERA: view
genes like me logo Genes that share phenotypes with DERA: view

Animal Model Products

CRISPR Products

miRNA for DERA Gene

miRTarBase miRNAs that target DERA

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DERA Gene

Localization for DERA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DERA Gene

Cytoplasm. Cytoplasmic granule. Nucleus. Note=Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation. {ECO:0000269 PubMed:25229427}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DERA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with DERA: view

Pathways & Interactions for DERA Gene

genes like me logo Genes that share pathways with DERA: view

Pathways by source for DERA Gene

UniProtKB/Swiss-Prot Q9Y315-DEOC_HUMAN

  • Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for DERA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006098 pentose-phosphate shunt TAS --
GO:0009264 deoxyribonucleotide catabolic process IEA,IBA --
GO:0016052 carbohydrate catabolic process IBA --
GO:0043312 neutrophil degranulation TAS --
GO:0046121 deoxyribonucleoside catabolic process IDA 9226884
genes like me logo Genes that share ontologies with DERA: view

No data available for SIGNOR curated interactions for DERA Gene

Drugs & Compounds for DERA Gene

(2) Drugs for DERA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceraldehyde-3-Phosphate Experimental Pharma 0
ACETALDEHYDE Pharma Activation, Activator 0

(5) Additional Compounds for DERA Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Deoxyribose 5-monophosphate
Deoxyribose 5-phosphate
  • 2-Deoxy-alpha-D-ribose 5-phosphate
  • 2-Deoxy-alpha-delta-ribose 5-phosphate
  • 2-Deoxy-D-ribose 5-phosphate
  • 2-Deoxy-D-ribose-5-phosphate
  • 2-Deoxyribose 5-phosphate
genes like me logo Genes that share compounds with DERA: view

Transcripts for DERA Gene

Unigene Clusters for DERA Gene

Deoxyribose-phosphate aldolase (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DERA Gene

No ASD Table

Relevant External Links for DERA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DERA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DERA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DERA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.4) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DERA Gene

Protein tissue co-expression partners for DERA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DERA Gene:


SOURCE GeneReport for Unigene cluster for DERA Gene:


mRNA Expression by UniProt/SwissProt for DERA Gene:

Tissue specificity: Mainly expressed in liver, lung and colon.

Evidence on tissue expression from TISSUES for DERA Gene

  • Liver(4.3)
  • Skin(4.3)
  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with DERA: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DERA Gene

Orthologs for DERA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DERA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DERA 33 34
  • 99.27 (n)
(Canis familiaris)
Mammalia DERA 34
  • 93 (a)
(Monodelphis domestica)
Mammalia DERA 34
  • 91 (a)
(Bos Taurus)
Mammalia DERA 33 34
  • 90.67 (n)
(Mus musculus)
Mammalia Dera 33 16 34
  • 85.53 (n)
(Rattus norvegicus)
Mammalia Dera 33
  • 85.01 (n)
(Ornithorhynchus anatinus)
Mammalia DERA 34
  • 69 (a)
(Gallus gallus)
Aves DERA 33 34
  • 73.48 (n)
(Anolis carolinensis)
Reptilia DERA 34
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16254 33
(Danio rerio)
Actinopterygii dera 33 34
  • 69.72 (n)
zgc56677 33
fruit fly
(Drosophila melanogaster)
Insecta CG8525 33 34
  • 56.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009161 33
  • 55.06 (n)
(Caenorhabditis elegans)
Secernentea F09E5.3 33 34
  • 58.44 (n)
(Hordeum vulgare)
Liliopsida Hv.1195 33
(Oryza sativa)
Liliopsida Os.15810 33
(Triticum aestivum)
Liliopsida Ta.30529 33
(Zea mays)
Liliopsida Zm.2750 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 68 (a)
Species where no ortholog for DERA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for DERA Gene

Gene Tree for DERA (if available)
Gene Tree for DERA (if available)

Paralogs for DERA Gene

No data available for Paralogs for DERA Gene

Variants for DERA Gene

Sequence variations from dbSNP and Humsavar for DERA Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000013391 -- 16,008,487(+) C/T intron_variant
rs1000018454 -- 15,990,510(+) G/A/T intron_variant
rs1000033884 -- 16,034,868(+) G/T intron_variant
rs1000053510 -- 15,909,221(+) G/C upstream_transcript_variant
rs1000073933 -- 15,949,556(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DERA Gene

Variant ID Type Subtype PubMed ID
nsv557636 CNV loss 21841781
nsv1036638 CNV loss 25217958
esv3892147 CNV loss 25118596
esv3628681 CNV loss 21293372
esv3580160 CNV loss 25503493
esv3358865 CNV insertion 20981092
esv2760899 CNV gain 21179565
esv2659461 CNV deletion 23128226
esv2647271 CNV deletion 19546169
dgv1395n100 CNV loss 25217958

Variation tolerance for DERA Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DERA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DERA Gene

Disorders for DERA Gene

MalaCards: The human disease database

(1) MalaCards diseases for DERA Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search DERA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DERA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DERA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DERA Gene

Publications for DERA Gene

  1. DERA is the human deoxyribose phosphate aldolase and is involved in stress response. (PMID: 25229427) Salleron L … Lane L (Biochimica et biophysica acta 2014) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Phylogenetic analyses of diplomonad genes reveal frequent lateral gene transfers affecting eukaryotes. (PMID: 12546782) Andersson JO … Roger AJ (Current biology : CB 2003) 2 3 58
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 58
  5. Channelling of deoxyribose moiety of exogenous DNA into carbohydrate metabolism: role of deoxyriboaldolase. (PMID: 9226884) Sgarrella F … Tozzi MG (Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997) 3 22 58

Products for DERA Gene

Sources for DERA Gene

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