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Aliases for DEPTOR Gene

Aliases for DEPTOR Gene

  • DEP Domain Containing MTOR Interacting Protein 2 3 5
  • DEP Domain-Containing Protein 6 3 4
  • DEP Domain Containing 6 2 3
  • DEPDC6 3 4
  • DEP Domain-Containing MTOR-Interacting Protein 3
  • DEP.6 3

External Ids for DEPTOR Gene

Previous HGNC Symbols for DEPTOR Gene

  • DEPDC6

Previous GeneCards Identifiers for DEPTOR Gene

  • GC08P120886

Summaries for DEPTOR Gene

GeneCards Summary for DEPTOR Gene

DEPTOR (DEP Domain Containing MTOR Interacting Protein) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (Pathway Interaction Database) and Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics.

UniProtKB/Swiss-Prot for DEPTOR Gene

  • Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

Gene Wiki entry for DEPTOR Gene

Additional gene information for DEPTOR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPTOR Gene

Genomics for DEPTOR Gene

GeneHancer (GH) Regulatory Elements for DEPTOR Gene

Promoters and enhancers for DEPTOR Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J119873 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 693 2.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 SP5 ENSG00000245330 DEPTOR DSCC1
GH08J119854 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 -17.6 -17556 2.5 PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 E2F8 ZNF143 DSCC1 DEPTOR TAF2 RN7SL396P LOC105375728
GH08J119981 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 25.4 +109.0 108992 3.8 PKNOX1 CLOCK NFIB NEUROD1 SIN3A ZBTB7B ZNF366 FOS RCOR1 USF2 DEPTOR COL14A1 DSCC1 ENSG00000254343 ENSG00000245330 GC08M119936 GC08P120015
GH08J119968 Enhancer 1.1 Ensembl ENCODE dbSUPER 25.3 +100.6 100613 11.1 HDGF PKNOX1 FOXA2 USF1 FEZF1 ZIC2 RAD21 YY1 ZNF121 ZNF316 DEPTOR COL14A1 DSCC1 ENSG00000254343 ENSG00000245330 GC08M119936 GC08P120015
GH08J119894 Enhancer 0.9 ENCODE dbSUPER 27.8 +22.1 22108 1.8 ELF3 SOX13 TFAP4 FOXA2 MAX RARA HNF4G NR2F6 GATAD2A SOX5 DEPTOR ENSG00000245330 TAF2 DSCC1 GC08M119893 RNA5SP277 PIR41964
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEPTOR on UCSC Golden Path with GeneCards custom track

Genomic Locations for DEPTOR Gene

Genomic Locations for DEPTOR Gene
177,264 bases
Plus strand
177,258 bases
Plus strand

Genomic View for DEPTOR Gene

Genes around DEPTOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPTOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPTOR Gene

Proteins for DEPTOR Gene

  • Protein details for DEPTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DEP domain-containing mTOR-interacting protein
    Protein Accession:
    Secondary Accessions:
    • B2RCL9
    • B4DN97
    • E7EV87
    • Q96EQ1
    • Q9H0R7
    • Q9H894
    • Q9HA07

    Protein attributes for DEPTOR Gene

    409 amino acids
    Molecular mass:
    46294 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR, MAPKAP1 and DEPTOR. Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2.
    • Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPTOR Gene


neXtProt entry for DEPTOR Gene

Post-translational modifications for DEPTOR Gene

  • Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPTOR Gene

No data available for DME Specific Peptides for DEPTOR Gene

Domains & Families for DEPTOR Gene

Gene Families for DEPTOR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DEPTOR Gene

Suggested Antigen Peptide Sequences for DEPTOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DEPTOR: view

No data available for UniProtKB/Swiss-Prot for DEPTOR Gene

Function for DEPTOR Gene

Molecular function for DEPTOR Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
UniProtKB/Swiss-Prot Induction:
Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level).

Phenotypes From GWAS Catalog for DEPTOR Gene

Gene Ontology (GO) - Molecular Function for DEPTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19446321
genes like me logo Genes that share ontologies with DEPTOR: view
genes like me logo Genes that share phenotypes with DEPTOR: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPTOR Gene

Localization for DEPTOR Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEPTOR gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DEPTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DEPTOR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DEPTOR Gene

Pathways & Interactions for DEPTOR Gene

genes like me logo Genes that share pathways with DEPTOR: view

Pathways by source for DEPTOR Gene

1 GeneTex pathway for DEPTOR Gene
1 PharmGKB pathway for DEPTOR Gene
2 KEGG pathways for DEPTOR Gene
1 Cell Signaling Technology pathway for DEPTOR Gene

SIGNOR curated interactions for DEPTOR Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DEPTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IMP 19446321
GO:0032007 negative regulation of TOR signaling IMP 19446321
GO:0035556 intracellular signal transduction IEA --
GO:0045792 negative regulation of cell size IMP 19446321
GO:2001236 regulation of extrinsic apoptotic signaling pathway IMP 19446321
genes like me logo Genes that share ontologies with DEPTOR: view

Drugs & Compounds for DEPTOR Gene

(3) Drugs for DEPTOR Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
OSI-027 Investigational Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
AZD8055 Pharma inhibitor MTOR inhibitor, Kinase Inhibitors 0
MLN0128 Pharma inhibitor Kinase Inhibitors 0
genes like me logo Genes that share compounds with DEPTOR: view

Transcripts for DEPTOR Gene


Unigene Clusters for DEPTOR Gene

DEP domain containing MTOR-interacting protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEPTOR Gene

No ASD Table

Relevant External Links for DEPTOR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEPTOR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEPTOR Gene

mRNA differential expression in normal tissues according to GTEx for DEPTOR Gene

This gene is overexpressed in Muscle - Skeletal (x9.7).

Protein differential expression in normal tissues from HIPED for DEPTOR Gene

This gene is overexpressed in Skin (21.5), Bone marrow stromal cell (13.7), and Salivary gland (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DEPTOR Gene

NURSA nuclear receptor signaling pathways regulating expression of DEPTOR Gene:


SOURCE GeneReport for Unigene cluster for DEPTOR Gene:


Evidence on tissue expression from TISSUES for DEPTOR Gene

  • Thyroid gland(4.4)
  • Nervous system(4.4)
  • Liver(4.3)
  • Heart(4.2)
  • Intestine(4.2)
  • Muscle(2.9)
genes like me logo Genes that share expression patterns with DEPTOR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEPTOR Gene

Orthologs for DEPTOR Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPTOR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEPTOR 34 33
  • 99.84 (n)
(Canis familiaris)
Mammalia DEPTOR 34 33
  • 92.79 (n)
(Ornithorhynchus anatinus)
Mammalia DEPTOR 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Deptor 33
  • 90.42 (n)
(Monodelphis domestica)
Mammalia DEPTOR 34
  • 90 (a)
(Mus musculus)
Mammalia Deptor 16 34 33
  • 89.98 (n)
(Bos Taurus)
Mammalia DEPTOR 34 33
  • 87.03 (n)
(Gallus gallus)
Aves DEPDC6 34 33
  • 80.5 (n)
(Anolis carolinensis)
Reptilia DEPTOR 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493830 33
  • 74.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5956 33
(Danio rerio)
Actinopterygii deptor 34 33
  • 74.51 (n)
Dr.26865 33
Species where no ortholog for DEPTOR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPTOR Gene

Gene Tree for DEPTOR (if available)
Gene Tree for DEPTOR (if available)
Evolutionary constrained regions (ECRs) for DEPTOR: view image

Paralogs for DEPTOR Gene

(1) SIMAP similar genes for DEPTOR Gene using alignment to 2 proteins:

  • E7EV87_HUMAN
genes like me logo Genes that share paralogs with DEPTOR: view

No data available for Paralogs for DEPTOR Gene

Variants for DEPTOR Gene

Sequence variations from dbSNP and Humsavar for DEPTOR Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000017333 -- 119,895,251(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000022216 -- 120,035,173(+) A/G intron_variant
rs1000025658 -- 119,966,429(+) G/A/C intron_variant
rs1000031136 -- 120,010,856(+) ATTGTTTTTATT/ATT intron_variant
rs1000032938 -- 119,935,751(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DEPTOR Gene

Variant ID Type Subtype PubMed ID
dgv3894n106 CNV deletion 24896259
esv2678781 CNV deletion 23128226
esv3418648 CNV insertion 20981092
esv3544111 CNV deletion 23714750
esv3572963 CNV loss 25503493
esv3891474 CNV gain 25118596
nsv1018953 CNV loss 25217958
nsv1077064 CNV deletion 25765185
nsv1125953 CNV tandem duplication 24896259
nsv1128450 CNV deletion 24896259
nsv1144233 CNV deletion 24896259
nsv524750 CNV loss 19592680
nsv528628 CNV loss 19592680
nsv528705 CNV loss 19592680
nsv612111 CNV gain 21841781

Variation tolerance for DEPTOR Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.83; 89.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEPTOR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPTOR Gene

Disorders for DEPTOR Gene

Additional Disease Information for DEPTOR

No disorders were found for DEPTOR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPTOR Gene

Publications for DEPTOR Gene

  1. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. (PMID: 19446321) Peterson TR … Sabatini DM (Cell 2009) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia. (PMID: 27593934) Hu Y … Qing G (Oncogene 2017) 3 58
  5. DEPTOR maintains plasma cell differentiation and favorably affects prognosis in multiple myeloma. (PMID: 28420429) Quwaider D … Gutiérrez NC (Journal of hematology & oncology 2017) 3 58

Products for DEPTOR Gene

Sources for DEPTOR Gene

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