The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008] See more...

Aliases for DEPP1 Gene

Aliases for DEPP1 Gene

  • DEPP1 Autophagy Regulator 2 3 5
  • Decidual Protein Induced By Progesterone 2 3 4
  • DEPP 2 3 4
  • FIG 2 3 4
  • Fasting-Induced Gene Protein 3 4
  • Fasting Induced 2 3
  • Protein DEPP1 3 4
  • C10orf10 3 4
  • Fseg 2 3
  • Chromosome 10 Open Reading Frame 10 2
  • Fat-Specific Expressed Gene 2
  • Fasting-Induced Protein 3
  • Fat-Specific Expressed 3
  • Protein DEPP 3
  • DEPP1 5

External Ids for DEPP1 Gene

Previous HGNC Symbols for DEPP1 Gene

  • C10orf10

Summaries for DEPP1 Gene

Entrez Gene Summary for DEPP1 Gene

  • The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]

GeneCards Summary for DEPP1 Gene

DEPP1 (DEPP1 Autophagy Regulator) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for DEPP1 Gene

  • Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.

Gene Wiki entry for DEPP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DEPP1 Gene

Genomics for DEPP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DEPP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEPP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DEPP1

Genomic Locations for DEPP1 Gene

Genomic Locations for DEPP1 Gene
chr10:44,970,981-44,978,809
(GRCh38/hg38)
Size:
7,829 bases
Orientation:
Minus strand
chr10:45,466,429-45,474,330
(GRCh37/hg19)
Size:
7,902 bases
Orientation:
Minus strand

Genomic View for DEPP1 Gene

Genes around DEPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPP1 Gene

Proteins for DEPP1 Gene

  • Protein details for DEPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTK1-DEPP1_HUMAN
    Recommended name:
    Protein DEPP1
    Protein Accession:
    Q9NTK1
    Secondary Accessions:
    • B2R6A1
    • O94997
    • Q5T735
    • Q76MX8

    Protein attributes for DEPP1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23406 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DEPP1 Gene

Post-translational modifications for DEPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEPP1 Gene

Domains & Families for DEPP1 Gene

Gene Families for DEPP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DEPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEPP1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ92857, Homo sapiens decidual protein induced by progesterone (DEPP), mRNA (B2R6A1_HUMAN)
  • Fasting-induced gene protein (DEPP_HUMAN)
genes like me logo Genes that share domains with DEPP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DEPP1 Gene

Function for DEPP1 Gene

Molecular function for DEPP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.
UniProtKB/Swiss-Prot Induction:
By progesterone, testosterone and, to a much lower extent, estrogen. Induced by oxidative stress via FOXO3 activation (PubMed:28545464). Up-regulated by hypoxia (at protein level).
genes like me logo Genes that share phenotypes with DEPP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEPP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPP1 Gene

Localization for DEPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEPP1 Gene

Cytoplasm. Peroxisome. Mitochondrion. Note=May localize to aggresomes (PubMed:24530860). {ECO:0000269 PubMed:24530860}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEPP1 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
nucleus 3
extracellular 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DEPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 25261981
GO:0005739 mitochondrion IBA,IDA 25261981
GO:0005777 peroxisome IEA,IDA 25261981
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with DEPP1: view

Pathways & Interactions for DEPP1 Gene

PathCards logo

SuperPathways for DEPP1 Gene

No Data Available

Interacting Proteins for DEPP1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000298295 Q9NTK1-DEPP1_HUMAN for DEPP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DEPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0010506 regulation of autophagy IDA 28545464
genes like me logo Genes that share ontologies with DEPP1: view

No data available for Pathways by source and SIGNOR curated interactions for DEPP1 Gene

Drugs & Compounds for DEPP1 Gene

No Compound Related Data Available

Transcripts for DEPP1 Gene

mRNA/cDNA for DEPP1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DEPP1

Alternative Splicing Database (ASD) splice patterns (SP) for DEPP1 Gene

No ASD Table

Relevant External Links for DEPP1 Gene

GeneLoc Exon Structure for
DEPP1

Expression for DEPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DEPP1

mRNA Expression by UniProt/SwissProt for DEPP1 Gene:

Q9NTK1-DEPP1_HUMAN
Tissue specificity: Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney.

Evidence on tissue expression from TISSUES for DEPP1 Gene

  • Nervous system(5)
  • Intestine(4.6)
  • Lung(4.6)
  • Pancreas(4.4)
  • Liver(3.1)
  • Heart(3)
  • Kidney(2.8)
  • Muscle(2)
genes like me logo Genes that share expression patterns with DEPP1: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEPP1 Gene

Orthologs for DEPP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEPP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C10H10orf10 30
  • 98.27 (n)
C10orf10 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C28H10orf10 30
  • 77.08 (n)
C10orf10 31
  • 67 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC613715 30
  • 76.6 (n)
C28H10ORF10 31
  • 67 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 8430408G22Rik 30 31
  • 71.71 (n)
OneToOne
Depp1 17
Rat
(Rattus norvegicus)
Mammalia LOC500300 30
  • 70.24 (n)
Oppossum
(Monodelphis domestica)
Mammalia C10orf10 31
  • 42 (a)
OneToOne
Species where no ortholog for DEPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for DEPP1 Gene

ENSEMBL:
Gene Tree for DEPP1 (if available)
TreeFam:
Gene Tree for DEPP1 (if available)

Paralogs for DEPP1 Gene

No data available for Paralogs for DEPP1 Gene

Variants for DEPP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DEPP1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
786154 Benign: not provided 44,977,730(-) T/C MISSENSE_VARIANT,INTRON_VARIANT
rs11555140 - p.Ile44Met

Additional dbSNP identifiers (rs#s) for DEPP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DEPP1 Gene

Variant ID Type Subtype PubMed ID
esv3576560 CNV gain 25503493
nsv526734 CNV loss 19592680
nsv831846 CNV loss 17160897

Variation tolerance for DEPP1 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPP1 Gene

Disorders for DEPP1 Gene

No disorders were found for DEPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPP1 Gene

Publications for DEPP1 Gene

  1. A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. (PMID: 16123073) Watanabe H … Fujita J (Molecular human reproduction 2005) 2 3 4 23
  2. C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. (PMID: 28545464) Salcher S … Obexer P (Molecular cancer 2017) 2 3 4
  3. The c10orf10 gene product is a new link between oxidative stress and autophagy. (PMID: 24530860) Stepp MW … Zelko IN (Biochimica et biophysica acta 2014) 2 3 4
  4. C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma. (PMID: 25261981) Salcher S … Obexer P (Molecular cancer 2014) 3 4
  5. FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells. (PMID: 21510935) Chen S … Li H (FEBS letters 2011) 3 4

Products for DEPP1 Gene

Sources for DEPP1 Gene