Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DEPP1 Gene

Aliases for DEPP1 Gene

  • DEPP1, Autophagy Regulator 2 3 5
  • Decidual Protein Induced By Progesterone 2 3 4
  • Fasting-Induced Gene Protein 3 4
  • Fasting Induced 2 3
  • C10orf10 3 4
  • DEPP 3 4
  • FIG 3 4
  • Chromosome 10 Open Reading Frame 10 2
  • Fat-Specific Expressed Gene 2
  • Fasting-Induced Protein 3
  • Fat-Specific Expressed 3
  • Protein DEPP1 3
  • Protein DEPP 3
  • Fseg 3

External Ids for DEPP1 Gene

Previous HGNC Symbols for DEPP1 Gene

  • C10orf10

Summaries for DEPP1 Gene

Entrez Gene Summary for DEPP1 Gene

  • The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1. [provided by RefSeq, Jul 2008]

GeneCards Summary for DEPP1 Gene

DEPP1 (DEPP1, Autophagy Regulator) is a Protein Coding gene. Diseases associated with DEPP1 include Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of.

UniProtKB/Swiss-Prot for DEPP1 Gene

  • Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.

Gene Wiki entry for DEPP1 Gene

Additional gene information for DEPP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPP1 Gene

Genomics for DEPP1 Gene

GeneHancer (GH) Regulatory Elements for DEPP1 Gene

Promoters and enhancers for DEPP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J044971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -1.0 -961 16.9 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 PIR49011 DEPP1 C10orf25 WASHC2C ZNF22 TMEM72-AS1 RASSF4 FAM21FP ENSG00000223462 ENSG00000234504
GH10J045726 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.7 -748.5 -748504 1.6 CLOCK MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 WASHC2C FAM21FP ENSG00000228702 PARGP1 AGAP4 LOC105378289 ZFAND4 ENSG00000273363 AGAP10P DEPP1
GH10J044989 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.8 -15.1 -15077 9.7 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 ARID2 ATF7 RUNX3 NFKBIZ C10orf25 ENSG00000223462 ZFAND4 DEPP1 PIR39907 PIR53874 GC10M045018 RASSF4
GH10J045235 Enhancer 0.6 FANTOM5 ENCODE 1.7 -257.2 -257194 0.4 IKZF1 FOS ENSG00000227683 DEPP1 CUBNP2 ENSG00000278531
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DEPP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DEPP1 Gene

Genomic Locations for DEPP1 Gene
chr10:44,970,981-44,978,882
(GRCh38/hg38)
Size:
7,902 bases
Orientation:
Minus strand
chr10:45,466,429-45,474,330
(GRCh37/hg19)
Size:
7,902 bases
Orientation:
Minus strand

Genomic View for DEPP1 Gene

Genes around DEPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPP1 Gene

Proteins for DEPP1 Gene

  • Protein details for DEPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTK1-DEPP1_HUMAN
    Recommended name:
    Protein DEPP1
    Protein Accession:
    Q9NTK1
    Secondary Accessions:
    • B2R6A1
    • O94997
    • Q5T735
    • Q76MX8

    Protein attributes for DEPP1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23406 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI13066.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DEPP1 Gene

Post-translational modifications for DEPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEPP1 Gene

Domains & Families for DEPP1 Gene

Gene Families for DEPP1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DEPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DEPP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DEPP1: view

No data available for UniProtKB/Swiss-Prot for DEPP1 Gene

Function for DEPP1 Gene

Molecular function for DEPP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.
UniProtKB/Swiss-Prot Induction:
By progesterone, testosterone and, to a much lower extent, estrogen. Induced by oxidative stress via FOXO3 activation (PubMed:28545464). Up-regulated by hypoxia (at protein level).
genes like me logo Genes that share phenotypes with DEPP1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPP1 Gene

Localization for DEPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DEPP1 Gene

Cytoplasm. Peroxisome. Mitochondrion. Note=May localize to aggresomes (PubMed:24530860). {ECO:0000269 PubMed:24530860}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEPP1 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
nucleus 4
extracellular 2
cytosol 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DEPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 25261981
GO:0005739 mitochondrion IEA,IDA 25261981
GO:0005777 peroxisome IDA,IEA 25261981
genes like me logo Genes that share ontologies with DEPP1: view

Pathways & Interactions for DEPP1 Gene

SuperPathways for DEPP1 Gene

No Data Available

Interacting Proteins for DEPP1 Gene

Gene Ontology (GO) - Biological Process for DEPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0010506 regulation of autophagy IDA 28545464
genes like me logo Genes that share ontologies with DEPP1: view

No data available for Pathways by source and SIGNOR curated interactions for DEPP1 Gene

Drugs & Compounds for DEPP1 Gene

No Compound Related Data Available

Transcripts for DEPP1 Gene

mRNA/cDNA for DEPP1 Gene

(1) REFSEQ mRNAs :
(442) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEPP1 Gene

No ASD Table

Relevant External Links for DEPP1 Gene

GeneLoc Exon Structure for
DEPP1
ECgene alternative splicing isoforms for
DEPP1

Expression for DEPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of DEPP1 Gene:

DEPP1

mRNA Expression by UniProt/SwissProt for DEPP1 Gene:

Q9NTK1-DEPP1_HUMAN
Tissue specificity: Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney.

Evidence on tissue expression from TISSUES for DEPP1 Gene

  • Nervous system(5)
  • Intestine(4.7)
  • Lung(4.6)
  • Pancreas(4.4)
  • Liver(3.6)
  • Heart(3.1)
  • Kidney(2.8)
  • Stomach(2.8)
  • Muscle(2.6)
  • Thyroid gland(2.5)
  • Adrenal gland(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with DEPP1: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DEPP1 Gene

Orthologs for DEPP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DEPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf10 33
  • 98.27 (n)
C10orf10 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C28H10orf10 33
  • 77.08 (n)
C10orf10 34
  • 67 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC613715 33
  • 76.6 (n)
C28H10ORF10 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 8430408G22Rik 34 33
  • 71.71 (n)
OneToOne
Depp1 16
rat
(Rattus norvegicus)
Mammalia LOC500300 33
  • 70.24 (n)
oppossum
(Monodelphis domestica)
Mammalia C10orf10 34
  • 42 (a)
OneToOne
Species where no ortholog for DEPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DEPP1 Gene

ENSEMBL:
Gene Tree for DEPP1 (if available)
TreeFam:
Gene Tree for DEPP1 (if available)

Paralogs for DEPP1 Gene

No data available for Paralogs for DEPP1 Gene

Variants for DEPP1 Gene

Sequence variations from dbSNP and Humsavar for DEPP1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1001161369 -- 44,975,959(-) T/C downstream_transcript_variant
rs1001230161 -- 44,976,253(-) C/T downstream_transcript_variant
rs1001450998 -- 44,975,997(-) G/C/T downstream_transcript_variant
rs1002398081 -- 44,979,881(-) G/A upstream_transcript_variant
rs1003351331 -- 44,979,048(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DEPP1 Gene

Variant ID Type Subtype PubMed ID
esv3576560 CNV gain 25503493
nsv526734 CNV loss 19592680
nsv831846 CNV loss 17160897

Variation tolerance for DEPP1 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DEPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPP1 Gene

Disorders for DEPP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DEPP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acyl-coa dehydrogenase, very long-chain, deficiency of
  • acadvld
- elite association - COSMIC cancer census association via MalaCards
Search DEPP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DEPP1

genes like me logo Genes that share disorders with DEPP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DEPP1 Gene

Publications for DEPP1 Gene

  1. A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. (PMID: 16123073) Watanabe H … Fujita J (Molecular human reproduction 2005) 2 3 4 22 58
  2. C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. (PMID: 28545464) Salcher S … Obexer P (Molecular cancer 2017) 2 3 4 58
  3. The c10orf10 gene product is a new link between oxidative stress and autophagy. (PMID: 24530860) Stepp MW … Zelko IN (Biochimica et biophysica acta 2014) 2 3 4 58
  4. C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma. (PMID: 25261981) Salcher S … Obexer P (Molecular cancer 2014) 3 4 58
  5. FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells. (PMID: 21510935) Chen S … Li H (FEBS letters 2011) 3 4 58

Products for DEPP1 Gene

Sources for DEPP1 Gene

Content
Loading form....