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Aliases for DEPDC7 Gene

Aliases for DEPDC7 Gene

  • DEP Domain Containing 7 2 3 5
  • DJ85M6.4 (Novel 58.3 KDA Protein) 3
  • DEP Domain-Containing Protein 7 3
  • Novel 58.3 KDA Protein 3
  • Protein TR2/D15 4
  • DJ85M6.4 3
  • TR2 3

External Ids for DEPDC7 Gene

Previous GeneCards Identifiers for DEPDC7 Gene

  • GC11P032732

Summaries for DEPDC7 Gene

GeneCards Summary for DEPDC7 Gene

DEPDC7 (DEP Domain Containing 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. An important paralog of this gene is DEPDC1B.

Additional gene information for DEPDC7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DEPDC7 Gene

Genomics for DEPDC7 Gene

GeneHancer (GH) Regulatory Elements for DEPDC7 Gene

Promoters and enhancers for DEPDC7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I033015 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 559 +1.4 1394 4 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B SP3 NFYC DEPDC7 LOC105376615 PIGCP1 TCP11L1 GC11M032953
GH11I033159 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 5.1 +145.5 145452 3.4 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CSTF3 CSTF3-AS1 NAT10 EIF3M QSER1 HIPK3 CAPRIN1 TCP11L1 PIGCP1 DEPDC7
GH11I033289 Enhancer 0.7 ENCODE dbSUPER 14 +275.4 275396 3.1 SRF PRDM6 NR2F1 NBN ATF7 ZBTB33 NR2F2 DEPDC7 TCP11L1 CSTF3 HIPK3 GC11P033247 KIAA1549L
GH11I033043 Enhancer 1 Ensembl ENCODE 8.5 +29.0 29036 3.6 SIN3A FEZF1 BRCA1 RFX5 ZNF366 RCOR1 KLF7 FOS CEBPB PPARG TCP11L1 PIGCP1 DEPDC7 LINC00294 GC11M032953
GH11I033295 Enhancer 0.4 dbSUPER 14.6 +280.5 280459 2.1 ZNF639 GTF2A2 DEPDC7 HIPK3 GC11P033247 KIAA1549L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DEPDC7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DEPDC7 gene promoter:

Genomic Locations for DEPDC7 Gene

Genomic Locations for DEPDC7 Gene
17,719 bases
Plus strand

Genomic View for DEPDC7 Gene

Genes around DEPDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DEPDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DEPDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DEPDC7 Gene

Proteins for DEPDC7 Gene

  • Protein details for DEPDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DEP domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • G5E941
    • Q8N602
    • Q8NCU9
    • Q9UGK5

    Protein attributes for DEPDC7 Gene

    511 amino acids
    Molecular mass:
    58310 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAM22871.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DEPDC7 Gene


neXtProt entry for DEPDC7 Gene

Post-translational modifications for DEPDC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DEPDC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DEPDC7 Gene

Domains & Families for DEPDC7 Gene

Gene Families for DEPDC7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DEPDC7 Gene

Suggested Antigen Peptide Sequences for DEPDC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DEPDC7 family.
  • Belongs to the DEPDC7 family.
genes like me logo Genes that share domains with DEPDC7: view

Function for DEPDC7 Gene

Phenotypes From GWAS Catalog for DEPDC7 Gene

Gene Ontology (GO) - Molecular Function for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005096 GTPase activator activity TAS --
genes like me logo Genes that share ontologies with DEPDC7: view
genes like me logo Genes that share phenotypes with DEPDC7: view

Animal Model Products

miRNA for DEPDC7 Gene

miRTarBase miRNAs that target DEPDC7

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DEPDC7 Gene

Localization for DEPDC7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DEPDC7 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DEPDC7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DEPDC7 Gene

Pathways & Interactions for DEPDC7 Gene

genes like me logo Genes that share pathways with DEPDC7: view

Pathways by source for DEPDC7 Gene

3 Reactome pathways for DEPDC7 Gene

Gene Ontology (GO) - Biological Process for DEPDC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0008150 biological_process ND --
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with DEPDC7: view

No data available for SIGNOR curated interactions for DEPDC7 Gene

Drugs & Compounds for DEPDC7 Gene

No Compound Related Data Available

Transcripts for DEPDC7 Gene

Unigene Clusters for DEPDC7 Gene

DEP domain containing 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DEPDC7 Gene

No ASD Table

Relevant External Links for DEPDC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DEPDC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DEPDC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DEPDC7 Gene

This gene is overexpressed in Liver (x15.2) and Testis (x5.3).

Protein differential expression in normal tissues from HIPED for DEPDC7 Gene

This gene is overexpressed in Testis (60.7) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DEPDC7 Gene

Protein tissue co-expression partners for DEPDC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of DEPDC7 Gene:


SOURCE GeneReport for Unigene cluster for DEPDC7 Gene:


mRNA Expression by UniProt/SwissProt for DEPDC7 Gene:

Tissue specificity: Expressed in liver.

Evidence on tissue expression from TISSUES for DEPDC7 Gene

  • Bone marrow(4.2)
  • Kidney(4.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with DEPDC7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DEPDC7 Gene

Orthologs for DEPDC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DEPDC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DEPDC7 33 34
  • 99.61 (n)
(Canis familiaris)
Mammalia DEPDC7 33 34
  • 90.98 (n)
(Bos Taurus)
Mammalia DEPDC7 33 34
  • 90.61 (n)
(Rattus norvegicus)
Mammalia Depdc7 33
  • 85.4 (n)
(Mus musculus)
Mammalia Depdc7 33 16 34
  • 84.93 (n)
(Monodelphis domestica)
Mammalia DEPDC7 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia DEPDC7 34
  • 71 (a)
(Gallus gallus)
Aves DEPDC7 33 34
  • 71.57 (n)
(Anolis carolinensis)
Reptilia DEPDC7 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia depdc7 33
  • 64.16 (n)
Str.6544 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25329 33
(Danio rerio)
Actinopterygii depdc7 33 34
  • 58.02 (n)
DEPDC7 (1 of 2) 34
  • 39 (a)
wufe36f02 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for DEPDC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DEPDC7 Gene

Gene Tree for DEPDC7 (if available)
Gene Tree for DEPDC7 (if available)

Paralogs for DEPDC7 Gene

Paralogs for DEPDC7 Gene

(1) SIMAP similar genes for DEPDC7 Gene using alignment to 1 proteins: Pseudogenes for DEPDC7 Gene

genes like me logo Genes that share paralogs with DEPDC7: view

Variants for DEPDC7 Gene

Sequence variations from dbSNP and Humsavar for DEPDC7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000093722 -- 33,017,494(+) G/A intron_variant
rs1000329550 -- 33,020,795(+) G/C intron_variant
rs1000439372 -- 33,027,708(+) T/A coding_sequence_variant, missense_variant
rs1000513915 -- 33,029,134(+) T/C intron_variant
rs1000668074 -- 33,022,253(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DEPDC7 Gene

Variant ID Type Subtype PubMed ID
dgv1093n100 CNV gain 25217958
esv24235 CNV gain 19812545
esv2759815 CNV gain 17122850
esv2762904 CNV gain 21179565
esv3625869 CNV gain 21293372
esv3625870 CNV loss 21293372
nsv1040484 CNV gain 25217958
nsv553993 CNV loss 21841781

Variation tolerance for DEPDC7 Gene

Residual Variation Intolerance Score: 52.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.33; 63.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DEPDC7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DEPDC7 Gene

Disorders for DEPDC7 Gene

Additional Disease Information for DEPDC7

No disorders were found for DEPDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DEPDC7 Gene

Publications for DEPDC7 Gene

  1. A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1. (PMID: 10568747) Gawin B … Gessler M (Genome research 1999) 2 3 4 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  4. Further evidence of DEPDC7 DNA hypomethylation in depression: A study in adult twins. (PMID: 25952135) Córdova-Palomera A … Fañanás L (European psychiatry : the journal of the Association of European Psychiatrists 2015) 3 58
  5. The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-κB activation. (PMID: 25541973) D'Andrea EL … Stilo R (PloS one 2014) 3 58

Products for DEPDC7 Gene

Sources for DEPDC7 Gene

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