This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, ... See more...

Aliases for DENR Gene

Aliases for DENR Gene

  • Density Regulated Re-Initiation And Release Factor 2 3 5
  • Density-Regulated Protein 2 3 4
  • SMAP-3 2 3 4
  • DRP1 2 3 4
  • DRP 2 3 4
  • Smooth Muscle Cell Associated Protein-3 3
  • Smooth Muscle Cell-Associated Protein 3 4
  • Protein DRP1 4
  • DENR 5

External Ids for DENR Gene

Previous GeneCards Identifiers for DENR Gene

  • GC12U990118
  • GC12M123069
  • GC12P123045
  • GC12P121675
  • GC12P121674
  • GC12P121762
  • GC12P123237
  • GC12P120197

Summaries for DENR Gene

Entrez Gene Summary for DENR Gene

  • This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

GeneCards Summary for DENR Gene

DENR (Density Regulated Re-Initiation And Release Factor) is a Protein Coding gene. Diseases associated with DENR include Optic Atrophy 1 and Optic Nerve Disease. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot Summary for DENR Gene

  • May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Additional gene information for DENR Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DENR Gene

Genomics for DENR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DENR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J122751 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.2 -202 3.8 BRCA1 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ZBTB33 ZNF629 TFE3 DENR HSALNG0094677 lnc-HCAR1-2 ZCCHC8 SETD1B EIF2B1 HCAR1 ENSG00000272849 HCAR3 TMED2-DT
GH12J122678 Enhancer 1.1 Ensembl ENCODE 13.1 -72.6 -72623 7.6 CEBPG GATAD2A TFE3 SOX13 RCOR2 JUND PRDM1 PKNOX1 RXRB REST RF00004-034 HCAR3 HCAR1 HCAR2 ENSG00000256044 DENR SNRNP35 piR-44050 lnc-KNTC1-3 KNTC1
GH12J122637 Enhancer 0.9 Ensembl ENCODE 13.1 -114.8 -114823 0.8 GATAD2A CTCF PKNOX1 REST RAD21 TRIM22 SOX6 SMARCA5 CTBP1 RUNX3 DENR ENSG00000256044 HCAR1 CCDC62 ENSG00000274191 piR-50444-094 HCAR2 KNTC1
GH12J122702 Promoter/Enhancer 0.9 Ensembl ENCODE dbSUPER 12.4 -49.4 -49390 1 CEBPA CEBPB HLF ZNF384 HCAR2 RF00017-1322 HCAR3 ENSG00000256044 DENR HCAR1 ENSG00000256249
GH12J122699 Promoter/Enhancer 0.5 Ensembl dbSUPER 12.4 -51.5 -51523 3 HCAR3 HCAR2 HCAR1 ENSG00000256044 DENR TMED2-DT MIR9902-1 ENSG00000256249 KNTC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DENR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DENR

Top Transcription factor binding sites by QIAGEN in the DENR gene promoter:
  • AP-1
  • Bach2
  • c-Fos
  • c-Jun
  • GATA-1
  • IRF-1
  • POU2F1
  • POU2F1a
  • RORalpha2

Genomic Locations for DENR Gene

Genomic Locations for DENR Gene
chr12:122,752,824-122,771,064
(GRCh38/hg38)
Size:
18,241 bases
Orientation:
Plus strand
chr12:123,237,321-123,255,953
(GRCh37/hg19)
Size:
18,633 bases
Orientation:
Plus strand

Genomic View for DENR Gene

Genes around DENR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENR Gene

Proteins for DENR Gene

  • Protein details for DENR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43583-DENR_HUMAN
    Recommended name:
    Density-regulated protein
    Protein Accession:
    O43583
    Secondary Accessions:
    • Q9H3U6
    • Q9UKZ0

    Protein attributes for DENR Gene

    Size:
    198 amino acids
    Molecular mass:
    22092 Da
    Quaternary structure:
    • Interacts with MCTS1.
    SequenceCaution:
    • Sequence=AAC02985.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DENR Gene

neXtProt entry for DENR Gene

Post-translational modifications for DENR Gene

  • Ubiquitination at Lys59
  • Modification sites at PhosphoSitePlus

Other Protein References for DENR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for DENR

No data available for DME Specific Peptides for DENR Gene

Domains & Families for DENR Gene

Gene Families for DENR Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DENR Gene

InterPro:
Blocks:
  • Translation initiation factor SUI1
ProtoNet:

Suggested Antigen Peptide Sequences for DENR Gene

GenScript: Design optimal peptide antigens:
  • Smooth muscle cell-associated protein 3 (DENR_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43583

UniProtKB/Swiss-Prot:

DENR_HUMAN :
  • Belongs to the DENR family.
Family:
  • Belongs to the DENR family.
genes like me logo Genes that share domains with DENR: view

Function for DENR Gene

Molecular function for DENR Gene

UniProtKB/Swiss-Prot Function:
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
UniProtKB/Swiss-Prot Induction:
Up-regulated with increasing cell-density by HNRNPD. Up-regulated in ovarian and breast cancer cells by ERBB2 overexpression. Not induced by TGFB1.
GENATLAS Biochemistry:
density-regulated protein,expressed in cultured cells at high density but not at low density or during growth arrest

Phenotypes From GWAS Catalog for DENR Gene

Gene Ontology (GO) - Molecular Function for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003729 mRNA binding IBA 21873635
GO:0003743 translation initiation factor activity IEA --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with DENR: view
genes like me logo Genes that share phenotypes with DENR: view

Animal Models for DENR Gene

MGI Knock Outs for DENR:
  • Denr Denr<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for DENR Gene

miRTarBase miRNAs that target DENR

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENR Gene

Localization for DENR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENR gene
Compartment Confidence
cytosol 4
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DENR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DENR Gene

Pathways & Interactions for DENR Gene

PathCards logo

SuperPathways for DENR Gene

No Data Available

Gene Ontology (GO) - Biological Process for DENR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IBA,IDA 20713520
GO:0002188 translation reinitiation IBA 21873635
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0032790 ribosome disassembly IDA 20713520
genes like me logo Genes that share ontologies with DENR: view

No data available for Pathways by source and SIGNOR curated interactions for DENR Gene

Drugs & Compounds for DENR Gene

No Compound Related Data Available

Transcripts for DENR Gene

mRNA/cDNA for DENR Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENR

Alternative Splicing Database (ASD) splice patterns (SP) for DENR Gene

No ASD Table

Relevant External Links for DENR Gene

GeneLoc Exon Structure for
DENR

Expression for DENR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DENR Gene

Protein differential expression in normal tissues from HIPED for DENR Gene

This gene is overexpressed in Lavage (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENR Gene



Protein tissue co-expression partners for DENR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DENR

SOURCE GeneReport for Unigene cluster for DENR Gene:

Hs.22393

mRNA Expression by UniProt/SwissProt for DENR Gene:

O43583-DENR_HUMAN
Tissue specificity: Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.

Evidence on tissue expression from TISSUES for DENR Gene

  • Heart(4.6)
  • Liver(4.5)
  • Nervous system(3.9)
  • Muscle(3)
  • Kidney(2.8)
  • Skin(2.7)
  • Lung(2.4)
  • Blood(2.3)
  • Spleen(2.3)
  • Intestine(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with DENR: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENR Gene

Orthologs for DENR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DENR Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DENR 30 31
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 95 (a)
OneToMany
DENR 30 31
  • 94.44 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia DENR 30 31
  • 93.1 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 90 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia LOC687565 30
  • 92.27 (n)
Oppossum
(Monodelphis domestica)
Mammalia DENR 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Denr 30 17 31
  • 91.58 (n)
OneToOne
Chicken
(Gallus gallus)
Aves DENR 30 31
  • 84.34 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DENR 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia denr 30
  • 79.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii denr 30 31
  • 74.82 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG9099 30 31
  • 55.83 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006125 30
  • 53.88 (n)
Worm
(Caenorhabditis elegans)
Secernentea Y47D3A.21 30 31
  • 54.6 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA22 30 31 33
  • 51.23 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21934g 30
  • 49.89 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACL112C 30
  • 42.07 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G11900 30
  • 52.08 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0195500 30
  • 48.12 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16C6.05 30
  • 52.97 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU02984 30
  • 47.02 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7885 31
  • 47 (a)
OneToOne
Species where no ortholog for DENR was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DENR Gene

ENSEMBL:
Gene Tree for DENR (if available)
TreeFam:
Gene Tree for DENR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DENR: view image

Paralogs for DENR Gene

genes like me logo Genes that share paralogs with DENR: view

No data available for Paralogs for DENR Gene

Variants for DENR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DENR Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
797357 Likely Benign: not provided 122,762,178(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for DENR Gene

Structural Variations from Database of Genomic Variants (DGV) for DENR Gene

Variant ID Type Subtype PubMed ID
nsv975535 CNV duplication 23825009

Variation tolerance for DENR Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DENR Gene

Human Gene Mutation Database (HGMD)
DENR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENR Gene

Disorders for DENR Gene

MalaCards: The human disease database

(6) MalaCards diseases for DENR Gene - From: DISEASES

Disorder Aliases PubMed IDs
optic atrophy 1
  • opa1
optic nerve disease
  • disorder of the second nerve
cranial nerve disease
  • cranial nerve disorder
3-methylglutaconic aciduria, type iii
  • mgca3
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search DENR in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with DENR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DENR Gene

Publications for DENR Gene

  1. drp, a novel protein expressed at high cell density but not during growth arrest. (PMID: 9628587) Deyo JE … Tainsky MA (DNA and cell biology 1998) 2 3 4 23
  2. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. (PMID: 20713520) Skabkin MA … Pestova TV (Genes & development 2010) 2 3 4
  3. MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles. (PMID: 16982740) Reinert LS … Gartenhaus RB (Cancer research 2006) 2 3 4
  4. De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation. (PMID: 27239039) Haas MA … Heng JI (Cell reports 2016) 2 3
  5. Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1. (PMID: 17878526) Mazan-Mamczarz K … Gartenhaus RB (Cancer genomics & proteomics 2007) 3 4

Products for DENR Gene

Sources for DENR Gene