Aliases for DENND6B Gene

Aliases for DENND6B Gene

  • DENN Domain Containing 6B 2 3 5
  • Family With Sequence Similarity 116, Member B 2 3
  • DENN Domain-Containing Protein 6B 3 4
  • DENN/MADD Domain Containing 6B 2 3
  • Protein DENND6B 3 4
  • FAM116B 3 4
  • AFI1B 2 3
  • Protein FAM116B 3
  • MGC33692 2
  • DENND6B 5

External Ids for DENND6B Gene

Previous HGNC Symbols for DENND6B Gene

  • FAM116B

Previous GeneCards Identifiers for DENND6B Gene

  • GC22M050751

Summaries for DENND6B Gene

GeneCards Summary for DENND6B Gene

DENND6B (DENN Domain Containing 6B) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND6A.

UniProtKB/Swiss-Prot Summary for DENND6B Gene

  • Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DENND6B Gene

Genomics for DENND6B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DENND6B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DENND6B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DENND6B

Genomic Locations for DENND6B Gene

Latest Assembly
chr22:50,309,030-50,327,016
(GRCh38/hg38)
Size:
17,987 bases
Orientation:
Minus strand

Previous Assembly
chr22:50,747,459-50,765,441
(GRCh37/hg19 by Entrez Gene)
Size:
17,983 bases
Orientation:
Minus strand

chr22:50,747,459-50,765,489
(GRCh37/hg19 by Ensembl)
Size:
18,031 bases
Orientation:
Minus strand

Genomic View for DENND6B Gene

Genes around DENND6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND6B Gene

Proteins for DENND6B Gene

  • Protein details for DENND6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEG7-DEN6B_HUMAN
    Recommended name:
    Protein DENND6B
    Protein Accession:
    Q8NEG7
    Secondary Accessions:
    • A6X8I5

    Protein attributes for DENND6B Gene

    Size:
    585 amino acids
    Molecular mass:
    66464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DENND6B Gene

Post-translational modifications for DENND6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DENND6B Gene

Domains & Families for DENND6B Gene

Gene Families for DENND6B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DENND6B Gene

InterPro:
Blocks:
  • Protein of unknown function DUF1630

Suggested Antigen Peptide Sequences for DENND6B Gene

GenScript: Design optimal peptide antigens:
  • Family with sequence similarity 116, member B (A6X8I4_HUMAN)
  • Protein FAM116B (F116B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEG7

UniProtKB/Swiss-Prot:

DEN6B_HUMAN :
  • Belongs to the DENND6 family.
Family:
  • Belongs to the DENND6 family.
genes like me logo Genes that share domains with DENND6B: view

Function for DENND6B Gene

Molecular function for DENND6B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.

Phenotypes From GWAS Catalog for DENND6B Gene

Gene Ontology (GO) - Molecular Function for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IBA,IDA 22595670
GO:0017112 Rab guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with DENND6B: view

Phenotypes for DENND6B Gene

genes like me logo Genes that share phenotypes with DENND6B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND6B Gene

Localization for DENND6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND6B Gene

Recycling endosome. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND6B gene
Compartment Confidence
cytosol 4
endosome 3
plasma membrane 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0055037 recycling endosome IBA 21873635
genes like me logo Genes that share ontologies with DENND6B: view

Pathways & Interactions for DENND6B Gene

genes like me logo Genes that share pathways with DENND6B: view

Pathways by source for DENND6B Gene

Interacting Proteins for DENND6B Gene

Gene Ontology (GO) - Biological Process for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with DENND6B: view

No data available for SIGNOR curated interactions for DENND6B Gene

Drugs & Compounds for DENND6B Gene

No Compound Related Data Available

Transcripts for DENND6B Gene

mRNA/cDNA for DENND6B Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND6B

Alternative Splicing Database (ASD) splice patterns (SP) for DENND6B Gene

No ASD Table

Relevant External Links for DENND6B Gene

GeneLoc Exon Structure for
DENND6B

Expression for DENND6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DENND6B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DENND6B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DENND6B

SOURCE GeneReport for Unigene cluster for DENND6B Gene:

Hs.530380

Evidence on tissue expression from TISSUES for DENND6B Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with DENND6B: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND6B Gene

Orthologs for DENND6B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND6B Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia FAM116B 29
  • 89.37 (n)
DENND6B 30
  • 58 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM116B 29
  • 88 (n)
DENND6B 30
  • 86 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dennd6b 29
  • 86.95 (n)
Mouse
(Mus musculus)
Mammalia Dennd6b 29 16 30
  • 86.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DENND6B 30
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DENND6B 30
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM116B 29
  • 76.3 (n)
DENND6B 30
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DENND6B 30
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dennd6b 29
  • 65.38 (n)
Zebrafish
(Danio rerio)
Actinopterygii dennd6b 29 30
  • 69.28 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG3309 30
  • 41 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea CELE_F53H1.3 29
  • 51.62 (n)
F53H1.3 30
  • 41 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToMany
Species where no ortholog for DENND6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DENND6B Gene

ENSEMBL:
Gene Tree for DENND6B (if available)
TreeFam:
Gene Tree for DENND6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DENND6B: view image
Alliance of Genome Resources:
Additional Orthologs for DENND6B

Paralogs for DENND6B Gene

Paralogs for DENND6B Gene

(2) SIMAP similar genes for DENND6B Gene using alignment to 2 proteins:

  • DEN6B_HUMAN
  • H0Y7N0_HUMAN
genes like me logo Genes that share paralogs with DENND6B: view

Variants for DENND6B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DENND6B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DENND6B Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
nsv589209 CNV loss 21841781
nsv955199 CNV deletion 24416366

Variation tolerance for DENND6B Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.46; 85.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DENND6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DENND6B
Leiden Open Variation Database (LOVD)
DENND6B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DENND6B Gene

Disorders for DENND6B Gene

Additional Disease Information for DENND6B

No disorders were found for DENND6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND6B Gene

Publications for DENND6B Gene

  1. DENN domain proteins: regulators of Rab GTPases. (PMID: 21330364) Marat AL … McPherson PS (The Journal of biological chemistry 2011) 2 3 4
  2. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A … Barr FA (Developmental cell 2012) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3

Products for DENND6B Gene

Sources for DENND6B Gene