Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DENND6B Gene

Aliases for DENND6B Gene

  • DENN Domain Containing 6B 2 3 5
  • Family With Sequence Similarity 116, Member B 2 3
  • DENN Domain-Containing Protein 6B 3 4
  • DENN/MADD Domain Containing 6B 2 3
  • FAM116B 3 4
  • Protein DENND6B 3
  • Protein FAM116B 3
  • AFI1B 3

External Ids for DENND6B Gene

Previous HGNC Symbols for DENND6B Gene

  • FAM116B

Previous GeneCards Identifiers for DENND6B Gene

  • GC22M050751

Summaries for DENND6B Gene

GeneCards Summary for DENND6B Gene

DENND6B (DENN Domain Containing 6B) is a Protein Coding gene. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND6A.

UniProtKB/Swiss-Prot for DENND6B Gene

  • Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.

Additional gene information for DENND6B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND6B Gene

Genomics for DENND6B Gene

GeneHancer (GH) Regulatory Elements for DENND6B Gene

Promoters and enhancers for DENND6B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J050326 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 665.4 -0.1 -57 1.6 HDGF ATF1 ARNT SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF121 ZNF207 DENND6B PPP6R2
GH22J050341 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 661.2 -16.7 -16663 3.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF766 GLIS2 ZNF207 DENND6B PPP6R2 PLXNB2 GC22P050372
GH22J050292 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +26.0 25982 17.7 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 PIM3 BRD1 PLXNB2 NCAPH2 RABL2B TYMP TUBGCP6 DENND6B LOC105373100 ODF3B
GH22J049957 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +364.0 364032 11.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 PIM3 MIR6821 ALG12 ZBED4 RABL2B BRD1 PLXNB2 CHKB LMF2 ENSG00000273192
GH22J050626 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.3 -300.9 -300934 2.4 HDGF ZNF493 ARID4B SIN3A YBX1 GLI4 ZNF2 ZNF280A GLIS2 KLF7 ARSA BRD1 ZBED4 RABL2B ENSG00000272836 TUBGCP6 PLXNB2 ALG12 CHKB LOC105373095
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DENND6B on UCSC Golden Path with GeneCards custom track

Genomic Locations for DENND6B Gene

Genomic Locations for DENND6B Gene
18,060 bases
Minus strand
18,031 bases
Minus strand

Genomic View for DENND6B Gene

Genes around DENND6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND6B Gene

Proteins for DENND6B Gene

  • Protein details for DENND6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DENND6B
    Protein Accession:
    Secondary Accessions:
    • A6X8I5

    Protein attributes for DENND6B Gene

    585 amino acids
    Molecular mass:
    66464 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DENND6B Gene

Post-translational modifications for DENND6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DENND6B Gene

Domains & Families for DENND6B Gene

Gene Families for DENND6B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DENND6B Gene

Suggested Antigen Peptide Sequences for DENND6B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DENND6 family.
  • Belongs to the DENND6 family.
genes like me logo Genes that share domains with DENND6B: view

Function for DENND6B Gene

Molecular function for DENND6B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.

Phenotypes From GWAS Catalog for DENND6B Gene

Gene Ontology (GO) - Molecular Function for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IEA,TAS --
genes like me logo Genes that share ontologies with DENND6B: view

Phenotypes for DENND6B Gene

genes like me logo Genes that share phenotypes with DENND6B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND6B Gene

Localization for DENND6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND6B Gene

Recycling endosome. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND6B gene
Compartment Confidence
cytosol 5
plasma membrane 3
endosome 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0055037 recycling endosome IBA --
genes like me logo Genes that share ontologies with DENND6B: view

Pathways & Interactions for DENND6B Gene

genes like me logo Genes that share pathways with DENND6B: view

Pathways by source for DENND6B Gene

Interacting Proteins for DENND6B Gene

Selected Interacting proteins: Q8NEG7-DEN6B_HUMAN for DENND6B Gene via IID

Gene Ontology (GO) - Biological Process for DENND6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with DENND6B: view

No data available for SIGNOR curated interactions for DENND6B Gene

Drugs & Compounds for DENND6B Gene

No Compound Related Data Available

Transcripts for DENND6B Gene

mRNA/cDNA for DENND6B Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DENND6B Gene

DENN/MADD domain containing 6B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND6B Gene

No ASD Table

Relevant External Links for DENND6B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DENND6B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DENND6B Gene

NURSA nuclear receptor signaling pathways regulating expression of DENND6B Gene:


SOURCE GeneReport for Unigene cluster for DENND6B Gene:


Evidence on tissue expression from TISSUES for DENND6B Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with DENND6B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND6B Gene

Orthologs for DENND6B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND6B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM116B 33
  • 89.37 (n)
  • 58 (a)
(Bos Taurus)
Mammalia FAM116B 33
  • 88 (n)
  • 86 (a)
(Rattus norvegicus)
Mammalia Dennd6b 33
  • 86.95 (n)
(Mus musculus)
Mammalia Dennd6b 16 34 33
  • 86.15 (n)
(Monodelphis domestica)
Mammalia DENND6B 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia DENND6B 34
  • 73 (a)
(Gallus gallus)
Aves FAM116B 33
  • 76.3 (n)
  • 70 (a)
(Anolis carolinensis)
Reptilia DENND6B 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd6b 33
  • 65.38 (n)
(Danio rerio)
Actinopterygii dennd6b 34 33
  • 69.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3309 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea CELE_F53H1.3 33
  • 51.62 (n)
F53H1.3 34
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for DENND6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND6B Gene

Gene Tree for DENND6B (if available)
Gene Tree for DENND6B (if available)
Evolutionary constrained regions (ECRs) for DENND6B: view image

Paralogs for DENND6B Gene

Paralogs for DENND6B Gene

(2) SIMAP similar genes for DENND6B Gene using alignment to 2 proteins:

  • H0Y7N0_HUMAN
genes like me logo Genes that share paralogs with DENND6B: view

Variants for DENND6B Gene

Sequence variations from dbSNP and Humsavar for DENND6B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000154582 -- 50,311,810(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000228583 -- 50,310,782(-) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000255006 -- 50,311,668(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000666891 -- 50,311,125(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000839053 -- 50,320,739(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DENND6B Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
nsv589209 CNV loss 21841781
nsv955199 CNV deletion 24416366

Variation tolerance for DENND6B Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.46; 85.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DENND6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND6B Gene

Disorders for DENND6B Gene

Additional Disease Information for DENND6B

No disorders were found for DENND6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND6B Gene

Publications for DENND6B Gene

  1. DENN domain proteins: regulators of Rab GTPases. (PMID: 21330364) Marat AL … McPherson PS (The Journal of biological chemistry 2011) 2 3 4 58
  2. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A … Barr FA (Developmental cell 2012) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N … Gallagher E (The EMBO journal 2014) 3 58

Products for DENND6B Gene

Sources for DENND6B Gene

Loading form....