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Aliases for DENND5B Gene
Aliases for DENND5B Gene
External Ids for DENND5B Gene
- HGNC: 28338
- NCBI Entrez Gene: 160518
- Ensembl: ENSG00000170456
- OMIM®: 617279
- UniProtKB/Swiss-Prot: Q6ZUT9
Previous GeneCards Identifiers for DENND5B Gene
- GC12M031426
- GC12M031535
- GC12M031287
- GC12M031384
- GC12M031385
- GC12M031394
- GC12M031395
- GC12M031393
- GC12M031392
- GC12M031386
- GC12M031387
- GC12M031388
- GC12M031389
- GC12M031390
Summaries for DENND5B Gene
GeneCards Summary for DENND5B Gene
DENND5B (DENN Domain Containing 5B) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include calcium channel activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND5A.
UniProtKB/Swiss-Prot Summary for DENND5B Gene
-
Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Additional gene information for DENND5B Gene
- HGNC (28338)
- NCBI Entrez Gene (160518)
- Ensembl (ENSG00000170456)
- OMIM® (617279)
- UniProtKB/Swiss-Prot (Q6ZUT9)
- Open Targets Platform(ENSG00000170456)
- Search for DENND5B at DataMed
- Search for DENND5B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DENND5B Gene
Genomics for DENND5B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DENND5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DENND5B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DENND5B
- Top Transcription factor binding sites by QIAGEN in the DENND5B gene promoter:
-
- HNF-1
- HNF-1A
- Pax-3
- RP58
Genomic Locations for DENND5B Gene
Latest Assembly
- chr12:31,382,226-31,591,136
- (GRCh38/hg38)
- Size:
- 208,911 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:31,535,160-31,744,070
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 208,911 bases
- Orientation:
- Minus strand
- chr12:31,535,157-31,744,031
- (GRCh37/hg19 by Ensembl)
- Size:
- 208,875 bases
- Orientation:
- Minus strand
Genomic View for DENND5B Gene
Genes around DENND5B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.21 by HGNC
- 12p11.21 by Entrez Gene
- 12p11.21 by Ensembl
DENND5B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DENND5B Gene
Proteins for DENND5B Gene
-
Protein details for DENND5B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZUT9-DEN5B_HUMAN
- Recommended name:
- DENN domain-containing protein 5B
- Protein Accession:
- Q6ZUT9
- B5ME75
- Q59FW8
- Q68CZ7
- Q6NUJ0
- Q7Z3F9
- Q8N973
- Q8WUC8
Protein attributes for DENND5B Gene
- Size:
- 1274 amino acids
- Molecular mass:
- 145020 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC04583.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for DENND5B Gene
Post-translational modifications for DENND5B Gene
Other Protein References for DENND5B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for DENND5B
- Novus Biologicals Antibodies for DENND5B
- Invitrogen Antibodies for DENND5B (AFLGC-DENND5B)
- antibodies-online: Show 9 available DENND5B Antibodies ranked by validation data
-
Biorbyt antibodies for DENND5B
-
Custom Antibody ServicesProSci Antibodies for DENND5B
Protein products for research
-
OriGene Purified Proteins for DENND5B
- Search Origene for MassSpec and Protein Over-expression Lysates for DENND5B
- Origene Custom Protein Services for DENND5B
- Novus Biologicals proteins for DENND5B
Assay products for research
No data available for DME Specific Peptides for DENND5B Gene
Domains & Families for DENND5B Gene
Gene Families for DENND5B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for DENND5B Gene
- InterPro:
- Blocks:
-
- Lipoxygenase, LH2 domain
- ProtoNet:
Suggested Antigen Peptide Sequences for DENND5B Gene
- GenScript: Design optimal peptide antigens:
-
- Rab6IP1-like protein (DEN5B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6ZUT9- Family:
-
- Belongs to the RAB6IP1 family.
Function for DENND5B Gene
Molecular function for DENND5B Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Phenotypes From GWAS Catalog for DENND5B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,IDA | 20937701 |
| GO:0005515 | protein binding | IEA | -- |
Phenotypes for DENND5B Gene
- MGI mutant phenotypes for DENND5B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DENND5B:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DENND5B - Starting at $85 >
- * DENND5B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for DENND5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DENND5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND5B
miRNA for DENND5B Gene
- miRTarBase miRNAs that target DENND5B
-
- mmu-miR-541-5p (MIRT008262)
- hsa-miR-1298-5p (MIRT185923)
- hsa-miR-20a-5p (MIRT440826)
- hsa-miR-106b-5p (MIRT440828)
- hsa-miR-8061 (MIRT443106)
- hsa-miR-4760-5p (MIRT443107)
- hsa-miR-548s (MIRT443108)
- hsa-miR-3926 (MIRT443109)
- hsa-miR-4276 (MIRT478168)
- hsa-miR-2053 (MIRT478169)
- hsa-miR-569 (MIRT478170)
- hsa-miR-3152-3p (MIRT478171)
- hsa-miR-3650 (MIRT478172)
- hsa-miR-493-3p (MIRT478173)
- hsa-miR-5190 (MIRT478174)
- hsa-miR-4705 (MIRT478175)
- hsa-miR-5094 (MIRT478176)
- hsa-miR-8084 (MIRT478177)
- hsa-miR-4724-5p (MIRT478178)
- hsa-miR-3121-3p (MIRT478179)
- hsa-miR-655-3p (MIRT478180)
- hsa-miR-429 (MIRT478181)
- hsa-miR-374c-5p (MIRT478182)
- hsa-miR-200c-3p (MIRT478183)
- hsa-miR-200b-3p (MIRT478184)
- mmu-miR-3065-5p (MIRT590256)
- mmu-miR-3081-3p (MIRT590257)
- mmu-miR-582-3p (MIRT590258)
- mmu-miR-3473d (MIRT599180)
- mmu-miR-674-5p (MIRT599181)
- mmu-miR-222-3p (MIRT605077)
- mmu-miR-221-3p (MIRT605078)
- mmu-miR-1928 (MIRT605079)
- mmu-miR-697 (MIRT605080)
- mmu-miR-3058-5p (MIRT605081)
- hsa-miR-1304-5p (MIRT610120)
- hsa-miR-1238-3p (MIRT610121)
- hsa-miR-670-3p (MIRT610122)
- hsa-miR-6881-3p (MIRT610123)
- hsa-miR-6780a-3p (MIRT610124)
- hsa-miR-7111-3p (MIRT610125)
- hsa-miR-6086 (MIRT610126)
- hsa-miR-377-5p (MIRT610127)
- hsa-miR-655-5p (MIRT610128)
- hsa-miR-1251-5p (MIRT610129)
- hsa-miR-329-5p (MIRT610130)
- hsa-miR-4538 (MIRT610131)
- hsa-miR-4453 (MIRT610132)
- hsa-miR-4284 (MIRT618486)
- hsa-miR-4772-3p (MIRT618487)
- hsa-miR-4638-5p (MIRT618488)
- hsa-miR-1307-3p (MIRT618489)
- hsa-miR-1304-3p (MIRT618490)
- hsa-miR-6741-3p (MIRT618491)
- hsa-miR-1914-5p (MIRT618492)
- hsa-miR-660-3p (MIRT618493)
- hsa-miR-6890-3p (MIRT618494)
- hsa-miR-1306-5p (MIRT618495)
- hsa-let-7g-3p (MIRT633059)
- hsa-let-7a-2-3p (MIRT633060)
- hsa-miR-7151-3p (MIRT633061)
- hsa-miR-5095 (MIRT633062)
- hsa-miR-6829-3p (MIRT633063)
- hsa-miR-6791-3p (MIRT633064)
- hsa-miR-1976 (MIRT633065)
- hsa-miR-3653-5p (MIRT633066)
- hsa-miR-486-5p (MIRT633067)
- hsa-miR-6747-3p (MIRT633068)
- hsa-miR-6727-3p (MIRT633069)
- hsa-miR-4722-3p (MIRT633070)
- hsa-miR-4438 (MIRT633071)
- hsa-miR-4279 (MIRT639285)
- hsa-miR-122-3p (MIRT639286)
- hsa-miR-6833-3p (MIRT659120)
- hsa-miR-6873-3p (MIRT659121)
- hsa-miR-4768-5p (MIRT659122)
- hsa-miR-6868-3p (MIRT659123)
- hsa-miR-6853-3p (MIRT659124)
- hsa-miR-3182 (MIRT659125)
- hsa-miR-6817-3p (MIRT659126)
- hsa-miR-7110-3p (MIRT659127)
- hsa-miR-1248 (MIRT659128)
- hsa-miR-1237-3p (MIRT659129)
- hsa-miR-4290 (MIRT659130)
- hsa-miR-4740-3p (MIRT659131)
- hsa-miR-4687-5p (MIRT659132)
- hsa-miR-449b-3p (MIRT659133)
- hsa-miR-6856-3p (MIRT659134)
- hsa-miR-8485 (MIRT659135)
- hsa-miR-4662a-5p (MIRT704279)
- hsa-miR-582-5p (MIRT704280)
- hsa-miR-600 (MIRT704281)
- hsa-miR-323b-3p (MIRT704282)
- hsa-miR-708-3p (MIRT704283)
- hsa-miR-144-3p (MIRT704284)
- hsa-miR-101-3p (MIRT704285)
- hsa-miR-93-5p (MIRT727880)
- hsa-miR-519d-3p (MIRT727881)
- hsa-miR-20b-5p (MIRT727882)
- hsa-miR-17-5p (MIRT727883)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DENND5B
- Browse OriGene Inhibitory RNA Products For DENND5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND5B
Clone products for research
- Applied Biological Materials (abm): Clones for DENND5B - Starting at $45 >
- * DENND5B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for DENND5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DENND5B
Cell Lines for research
-
Horizon Cell Lines for DENND5B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND5B Gene
Localization for DENND5B Gene
Subcellular locations from UniProtKB/Swiss-Prot for DENND5B Gene
- Membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Microtubules (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for DENND5B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | RAB GEFs exchange GTP for GDP on RABs | ||
Pathways by source for DENND5B Gene
3 Reactome pathways for DENND5B Gene
Interacting Proteins for DENND5B Gene
GPS-Prot Interaction Network for DENND5B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0050790 | regulation of catalytic activity | IEA | -- |
No data available for SIGNOR curated interactions for DENND5B Gene
Transcripts for DENND5B Gene
mRNA/cDNA for DENND5B Gene
- 6 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354285 3132 nts (view in UCSC)
- ENST00000389082 9506 nts (view in UCSC)
- ENST00000536562 4291 nts (view in UCSC)
- ENST00000537061 578 nts (view in UCSC)
- ENST00000544698 643 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DENND5B - Starting at $85 >
- * DENND5B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for DENND5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DENND5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND5B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DENND5B
- Browse OriGene Inhibitory RNA Products For DENND5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND5B
Clone products for research
- Applied Biological Materials (abm): Clones for DENND5B - Starting at $45 >
- * DENND5B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for DENND5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DENND5B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 22 | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: |
Relevant External Links for DENND5B Gene
- GeneLoc Exon Structure for
- DENND5B
Expression for DENND5B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Bone (Muscoskeletal System)
This gene is overexpressed in Breast (60.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENND5B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DENND5B
SOURCE GeneReport for Unigene cluster for DENND5B Gene:
Hs.118166Evidence on tissue expression from TISSUES for DENND5B Gene
- Nervous system(4.7)
- Liver(4.2)
Primer products for research
-
OriGene qPCR primer pairs for DENND5B
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND5B Gene
Orthologs for DENND5B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DENND5B 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DENND5B 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DENND5B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DENND5B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dennd5b 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dennd5b 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | DENND5B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DENND5B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DENND5B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dennd5b 30 |
|
||
| Str.10985 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | dennd5b 30 31 |
|
OneToOne | |
| wufb96b01 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG7852 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011351 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | lst-6 31 |
|
OneToMany |
- Species where no ortholog for DENND5B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for DENND5B Gene
- ENSEMBL:
- Gene Tree for DENND5B (if available)
- TreeFam:
- Gene Tree for DENND5B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DENND5B: view image
Paralogs for DENND5B Gene
Paralogs for DENND5B Gene
(8) SIMAP similar genes for DENND5B Gene using alignment to 4 proteins:
- DEN5B_HUMAN
- F5H4A0_HUMAN
- G3V1S3_HUMAN
- H0YGE5_HUMAN
Variants for DENND5B Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2473n54 | CNV | loss | 21841781 |
| dgv2474n54 | CNV | gain+loss | 21841781 |
| dgv2475n54 | CNV | gain | 21841781 |
| esv2659095 | CNV | deletion | 23128226 |
| esv2663530 | CNV | deletion | 23128226 |
| esv2751046 | CNV | gain | 17911159 |
| esv2760267 | CNV | gain+loss | 21179565 |
| esv28191 | CNV | loss | 19812545 |
| esv3398944 | CNV | insertion | 20981092 |
| esv3629047 | CNV | loss | 21293372 |
| esv3629048 | CNV | gain | 21293372 |
| esv3629049 | CNV | loss | 21293372 |
| nsv1070522 | CNV | deletion | 25765185 |
| nsv52934 | CNV | deletion | 16902084 |
| nsv558088 | CNV | loss | 21841781 |
| nsv558089 | CNV | gain+loss | 21841781 |
| nsv558090 | CNV | gain+loss | 21841781 |
| nsv558092 | CNV | gain | 21841781 |
| nsv558099 | CNV | loss | 21841781 |
| nsv832364 | CNV | loss | 17160897 |
| nsv832365 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.12;
96.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DENND5B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DENND5B
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND5B Gene
Disorders for DENND5B Gene
Additional Disease Information for DENND5B
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for DENND5B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND5B Gene
Publications for DENND5B Gene
- Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
- Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
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ExternalLinks
Products for DENND5B Gene
- Custom Antibody ServicesOriGene Antibodies for DENND5B
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- Custom Assay Services
- OriGene Purified Proteins for DENND5B
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for DENND5B
- Novus Biologicals proteins for DENND5B
- Browse Antibodies
- Browse Peptides and Proteins
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- Invitrogen Antibodies for DENND5B (AFLGC-DENND5B)
- VectorBuilder Custom and pre-made DNA vectors for DENND5B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DENND5B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DENND5B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DENND5B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DENND5B
- antibodies-online: Show 9 available DENND5B Antibodies ranked by validation data
- antibodies-online: Search results for available DENND5B related products ranked by validation data
- antibodies-online: Search results for available DENND5B related products ranked by validation data
- Custom Antibody ServicesProSci Antibodies for DENND5B
- Search for DENND5B Proteins at ProSci
- Horizon Cell Lines for DENND5B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DENND5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DENND5B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DENND5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND5B
- Biorbyt antibodies for DENND5B
Sources for DENND5B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (107) UMLS
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- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
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- (115) NCBI Bookshelf
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- (117) Gene Damage Index
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- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB