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DENND5B (DENN Domain Containing 5B) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include calcium channel activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND5A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005085 | guanyl-nucleotide exchange factor activity | IEA,IDA | 20937701 |
GO:0005515 | protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | RAB GEFs exchange GTP for GDP on RABs |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0050790 | regulation of catalytic activity | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: |
ExUns: | 22 | ^ | 23 | ^ | 24 |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DENND5B 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DENND5B 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DENND5B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DENND5B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dennd5b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dennd5b 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DENND5B 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DENND5B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DENND5B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dennd5b 30 |
|
||
Str.10985 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | dennd5b 30 31 |
|
OneToOne | |
wufb96b01 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7852 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011351 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | lst-6 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2473n54 | CNV | loss | 21841781 |
dgv2474n54 | CNV | gain+loss | 21841781 |
dgv2475n54 | CNV | gain | 21841781 |
esv2659095 | CNV | deletion | 23128226 |
esv2663530 | CNV | deletion | 23128226 |
esv2751046 | CNV | gain | 17911159 |
esv2760267 | CNV | gain+loss | 21179565 |
esv28191 | CNV | loss | 19812545 |
esv3398944 | CNV | insertion | 20981092 |
esv3629047 | CNV | loss | 21293372 |
esv3629048 | CNV | gain | 21293372 |
esv3629049 | CNV | loss | 21293372 |
nsv1070522 | CNV | deletion | 25765185 |
nsv52934 | CNV | deletion | 16902084 |
nsv558088 | CNV | loss | 21841781 |
nsv558089 | CNV | gain+loss | 21841781 |
nsv558090 | CNV | gain+loss | 21841781 |
nsv558092 | CNV | gain | 21841781 |
nsv558099 | CNV | loss | 21841781 |
nsv832364 | CNV | loss | 17160897 |
nsv832365 | CNV | loss | 17160897 |
No disorders were found for DENND5B Gene.