Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DENND5B Gene

Aliases for DENND5B Gene

  • DENN Domain Containing 5B 2 3 5
  • DENN/MADD Domain Containing 5B 2
  • Rab6IP1-Like Protein 4

External Ids for DENND5B Gene

Previous GeneCards Identifiers for DENND5B Gene

  • GC12M031426
  • GC12M031535
  • GC12M031287
  • GC12M031384
  • GC12M031385
  • GC12M031386
  • GC12M031387
  • GC12M031388
  • GC12M031389
  • GC12M031390

Summaries for DENND5B Gene

GeneCards Summary for DENND5B Gene

DENND5B (DENN Domain Containing 5B) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include calcium channel activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND5A.

UniProtKB/Swiss-Prot for DENND5B Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Additional gene information for DENND5B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND5B Gene

Genomics for DENND5B Gene

GeneHancer (GH) Regulatory Elements for DENND5B Gene

Promoters and enhancers for DENND5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I031587 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.4 +0.9 875 4.8 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS DENND5B DENND5B-AS1 AK4P3
GH12I031316 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.8 +269.0 269042 10.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SINHCAF IPO8 FLJ13224 KIAA1551 DDX11 H3F3C DENND5B DENND5B-AS1 RNU5F-4P ENSG00000256176
GH12I031368 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +220.7 220747 3.7 PKNOX1 FOXA2 ARID4B ZNF121 KLF7 ATF7 REST TSHZ1 PPARG GLIS1 LINC02387 DENND5B DENND5B-AS1 RNU5F-4P SINHCAF AK4P3 DDX11 ETFBKMT GC12M031383
GH12I031516 Enhancer 1.3 Ensembl ENCODE dbSUPER 15.8 +71.8 71775 4.6 FOXA2 ZNF133 SIN3A FEZF1 ZNF2 BRCA1 ZNF121 FOS REST TSHZ1 DENND5B RNU5F-4P DENND5B-AS1 RNU6-618P ETFBKMT AK4P3 ENSG00000201228 GC12M031506 ENSG00000225349
GH12I031522 Enhancer 1 Ensembl ENCODE dbSUPER 16.4 +68.3 68313 1.5 CTCF PKNOX1 GFI1B MZF1 FEZF1 SP1 CTBP1 PRDM6 ZSCAN5C ZNF580 DENND5B DENND5B-AS1 RNU5F-4P AK4P3 ENSG00000225349 GC12M031506 ENSG00000201228
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DENND5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DENND5B gene promoter:

Genomic Locations for DENND5B Gene

Genomic Locations for DENND5B Gene
208,875 bases
Minus strand

Genomic View for DENND5B Gene

Genes around DENND5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND5B Gene

Proteins for DENND5B Gene

  • Protein details for DENND5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 5B
    Protein Accession:
    Secondary Accessions:
    • B5ME75
    • Q59FW8
    • Q68CZ7
    • Q6NUJ0
    • Q7Z3F9
    • Q8N973
    • Q8WUC8

    Protein attributes for DENND5B Gene

    1274 amino acids
    Molecular mass:
    145020 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04583.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND5B Gene


neXtProt entry for DENND5B Gene

Post-translational modifications for DENND5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DENND5B Gene

Domains & Families for DENND5B Gene

Gene Families for DENND5B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DENND5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RAB6IP1 family.
  • Belongs to the RAB6IP1 family.
genes like me logo Genes that share domains with DENND5B: view

Function for DENND5B Gene

Molecular function for DENND5B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Gene Ontology (GO) - Molecular Function for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005262 calcium channel activity IBA --
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with DENND5B: view
genes like me logo Genes that share phenotypes with DENND5B: view

miRNA for DENND5B Gene

miRTarBase miRNAs that target DENND5B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DENND5B Gene

Localization for DENND5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND5B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND5B gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IBA,IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DENND5B: view

Pathways & Interactions for DENND5B Gene

genes like me logo Genes that share pathways with DENND5B: view

Pathways by source for DENND5B Gene

Gene Ontology (GO) - Biological Process for DENND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050982 detection of mechanical stimulus IBA --
GO:0065009 regulation of molecular function IEA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with DENND5B: view

No data available for SIGNOR curated interactions for DENND5B Gene

Drugs & Compounds for DENND5B Gene

No Compound Related Data Available

Transcripts for DENND5B Gene

Unigene Clusters for DENND5B Gene

DENN/MADD domain containing 5B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND5B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2: - - -

ExUns: 22 ^ 23 ^ 24

Relevant External Links for DENND5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DENND5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DENND5B Gene

This gene is overexpressed in Breast (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENND5B Gene

NURSA nuclear receptor signaling pathways regulating expression of DENND5B Gene:


SOURCE GeneReport for Unigene cluster for DENND5B Gene:


Evidence on tissue expression from TISSUES for DENND5B Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with DENND5B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND5B Gene

Orthologs for DENND5B Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DENND5B 33 34
  • 99.84 (n)
(Ornithorhynchus anatinus)
Mammalia DENND5B 34
  • 97 (a)
(Bos Taurus)
Mammalia DENND5B 33 34
  • 92.75 (n)
(Canis familiaris)
Mammalia DENND5B 33 34
  • 92.61 (n)
(Mus musculus)
Mammalia Dennd5b 33 16 34
  • 90.66 (n)
(Rattus norvegicus)
Mammalia Dennd5b 33
  • 89.13 (n)
(Monodelphis domestica)
Mammalia DENND5B 34
  • 88 (a)
(Gallus gallus)
Aves DENND5B 33 34
  • 80.51 (n)
(Anolis carolinensis)
Reptilia DENND5B 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd5b 33
  • 74.99 (n)
Str.10985 33
(Danio rerio)
Actinopterygii dennd5b 33 34
  • 68.15 (n)
wufb96b01 33
fruit fly
(Drosophila melanogaster)
Insecta CG7852 33 34
  • 52.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011351 33
  • 50.78 (n)
(Caenorhabditis elegans)
Secernentea lst-6 34
  • 32 (a)
Species where no ortholog for DENND5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND5B Gene

Gene Tree for DENND5B (if available)
Gene Tree for DENND5B (if available)

Paralogs for DENND5B Gene

(8) SIMAP similar genes for DENND5B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DENND5B: view

Variants for DENND5B Gene

Sequence variations from dbSNP and Humsavar for DENND5B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000013498 -- 31,395,303(-) C/T intron_variant
rs1000018207 -- 31,523,025(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000021250 -- 31,385,980(-) G/A 3_prime_UTR_variant
rs1000029459 -- 31,553,704(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000038128 -- 31,514,514(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DENND5B Gene

Variant ID Type Subtype PubMed ID
dgv2473n54 CNV loss 21841781
dgv2474n54 CNV gain+loss 21841781
dgv2475n54 CNV gain 21841781
esv2659095 CNV deletion 23128226
esv2663530 CNV deletion 23128226
esv2751046 CNV gain 17911159
esv2760267 CNV gain+loss 21179565
esv28191 CNV loss 19812545
esv3398944 CNV insertion 20981092
esv3629047 CNV loss 21293372
esv3629048 CNV gain 21293372
esv3629049 CNV loss 21293372
nsv1070522 CNV deletion 25765185
nsv52934 CNV deletion 16902084
nsv558088 CNV loss 21841781
nsv558089 CNV gain+loss 21841781
nsv558090 CNV gain+loss 21841781
nsv558092 CNV gain 21841781
nsv558099 CNV loss 21841781
nsv832364 CNV loss 17160897
nsv832365 CNV loss 17160897

Variation tolerance for DENND5B Gene

Residual Variation Intolerance Score: 8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.12; 96.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DENND5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND5B Gene

Disorders for DENND5B Gene

Additional Disease Information for DENND5B

No disorders were found for DENND5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND5B Gene

Publications for DENND5B Gene

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for DENND5B Gene

Sources for DENND5B Gene

Loading form....