Aliases for DENND4C Gene
External Ids for DENND4C Gene
Previous HGNC Symbols for DENND4C Gene
Previous GeneCards Identifiers for DENND4C Gene
GeneCards Summary for DENND4C Gene
DENND4C (DENN Domain Containing 4C) is a Protein Coding gene. Diseases associated with DENND4C include Alkuraya-Kucinskas Syndrome and Koolen-De Vries Syndrome. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND4A.
UniProtKB/Swiss-Prot Summary for DENND4C Gene
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.