Aliases for DENND4C Gene
Aliases for DENND4C Gene
External Ids for DENND4C Gene
- HGNC: 26079
- Entrez Gene: 55667
- Ensembl: ENSG00000137145
- UniProtKB: Q5VZ89
Previous HGNC Symbols for DENND4C Gene
- C9orf55B
- C9orf55
Previous GeneCards Identifiers for DENND4C Gene
- GC09P019281
- GC09P019252
Summaries for DENND4C Gene
GeneCards Summary for DENND4C Gene
DENND4C (DENN Domain Containing 4C) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND4A.
UniProtKB/Swiss-Prot for DENND4C Gene
-
Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
Additional gene information for DENND4C Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND4C Gene
Genomics for DENND4C Gene
GeneHancer (GH) Regulatory Elements for DENND4C Gene
Promoters and enhancers for DENND4C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DENND4C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DENND4C Gene
Genomic Locations for DENND4C Gene
- chr9:19,230,435-19,374,268
- (GRCh38/hg38)
- Size:
- 143,834 bases
- Orientation:
- Plus strand
- chr9:19,230,433-19,374,139
- (GRCh37/hg19)
Genomic View for DENND4C Gene
Genes around DENND4C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p22.1 by Ensembl
- 9p22.1 by Entrez Gene
- 9p22.1 by HGNC
DENND4C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DENND4C Gene
Proteins for DENND4C Gene
-
Protein details for DENND4C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5VZ89-DEN4C_HUMAN
- Recommended name:
- DENN domain-containing protein 4C
- Protein Accession:
- Q5VZ89
- A2A3R1
- A2A3R2
- A2A3R3
- A2A3R9
- Q6AI48
- Q6ZUB3
- Q8NCY7
- Q9H6N4
- Q9NUT1
- Q9NWA5
- Q9NWT3
- R4GN35
- R4GNB2
Protein attributes for DENND4C Gene
- Size:
- 1909 amino acids
- Molecular mass:
- 212711 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA91294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15221.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86313.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10466.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for DENND4C Gene
Post-translational modifications for DENND4C Gene
- Phosphorylated in response to insulin.
- Ubiquitination at Lys51
Other Protein References for DENND4C Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DENND4C
- Novus Biologicals Antibodies for DENND4C
- Invitrogen Antibodies for DENND4C
- GeneTex DENND4C antibody for DENND4C
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DENND4C
- Origene Custom Protein Services for DENND4C
- Novus Biologicals proteins for DENND4C
- Search GeneTex for Proteins for DENND4C
Assay Products
No data available for DME Specific Peptides for DENND4C Gene
Domains & Families for DENND4C Gene
Gene Families for DENND4C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for DENND4C Gene
Suggested Antigen Peptide Sequences for DENND4C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DENND4C Gene
Function for DENND4C Gene
Molecular function for DENND4C Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
Phenotypes From GWAS Catalog for DENND4C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | TAS | -- |
Phenotypes for DENND4C Gene
- MGI mutant phenotypes for DENND4C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DENND4C:
Animal Models for DENND4C Gene
- MGI Knock Outs for DENND4C:
-
- Dennd4c tm1b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DENND4C
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- Search ViGene Biosciences for DENND4C
CRISPR Products
-
OriGene CRISPR knockouts for DENND4C
- genomics-online: gRNA clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
- Applied Biological Materials CRISPR for DENND4C
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND4C
- GenScript: Design CRISPR guide RNA sequences for DENND4C
miRNA for DENND4C Gene
- miRTarBase miRNAs that target DENND4C
-
- hsa-mir-5010-3p (MIRT443175)
- hsa-mir-2113 (MIRT443176)
- hsa-mir-4775 (MIRT443177)
- hsa-mir-550b-2-5p (MIRT443178)
- hsa-mir-1227-3p (MIRT443179)
- hsa-mir-5189-3p (MIRT443180)
- hsa-mir-4714-3p (MIRT443181)
- hsa-mir-7849-3p (MIRT443182)
- hsa-mir-590-3p (MIRT443183)
- hsa-mir-3978 (MIRT448880)
- hsa-mir-6124 (MIRT448881)
- hsa-mir-3148 (MIRT448882)
- hsa-mir-33a-3p (MIRT448883)
- hsa-mir-5582-3p (MIRT448884)
- hsa-mir-548x-3p (MIRT448885)
- hsa-mir-548j-3p (MIRT448886)
- hsa-mir-548aq-3p (MIRT448887)
- hsa-mir-548am-3p (MIRT448888)
- hsa-mir-548aj-3p (MIRT448889)
- hsa-mir-548ah-3p (MIRT448890)
- hsa-mir-548ae-3p (MIRT448891)
- hsa-mir-129-5p (MIRT499092)
- hsa-mir-4776-3p (MIRT499093)
- hsa-mir-1263 (MIRT499094)
- hsa-mir-150-3p (MIRT499095)
- hsa-mir-4659b-5p (MIRT499096)
- hsa-mir-4659a-5p (MIRT499097)
- hsa-mir-5590-5p (MIRT499098)
- hsa-mir-302f (MIRT499099)
- hsa-mir-5692a (MIRT499100)
- hsa-mir-633 (MIRT524189)
- hsa-mir-223-5p (MIRT524190)
- hsa-mir-496 (MIRT524191)
- hsa-mir-4781-3p (MIRT524192)
- hsa-mir-1304-3p (MIRT783672)
- hsa-mir-215-3p (MIRT784234)
- hsa-mir-3664-5p (MIRT785075)
- hsa-mir-3672 (MIRT785125)
- hsa-mir-4639-3p (MIRT786252)
- hsa-mir-6773-3p (MIRT788648)
- hsa-mir-6794-3p (MIRT788764)
- hsa-mir-6864-3p (MIRT789130)
- hsa-mir-6879-3p (MIRT789269)
- hsa-mir-8055 (MIRT789664)
miRNA Products
- Search ViGene Biosciences for DENND4C
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for DENND4C
- Browse OriGene Inhibitory RNA Products For DENND4C
- genomics-online: shRNA clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DENND4C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DENND4C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DENND4C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DENND4C
-
ViGene Biosciences adenoviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENND4C Gene
Localization for DENND4C Gene
Subcellular locations from UniProtKB/Swiss-Prot for DENND4C Gene
- Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| golgi apparatus | 2 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Golgi apparatus (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005886 | plasma membrane | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for DENND4C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | RAB GEFs exchange GTP for GDP on RABs | ||
Pathways by source for DENND4C Gene
3 Reactome pathways for DENND4C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0032869 | cellular response to insulin stimulus | ISS | -- |
| GO:0065009 | regulation of molecular function | IEA | -- |
| GO:0072659 | protein localization to plasma membrane | ISS | -- |
No data available for SIGNOR curated interactions for DENND4C Gene
Transcripts for DENND4C Gene
mRNA/cDNA for DENND4C Gene
- (10) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DENND4C Gene
CRISPR Products
-
OriGene CRISPR knockouts for DENND4C
- genomics-online: gRNA clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
- Applied Biological Materials CRISPR for DENND4C
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND4C
- GenScript: Design CRISPR guide RNA sequences for DENND4C
miRNA Products
- Search ViGene Biosciences for DENND4C
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for DENND4C
- Browse OriGene Inhibitory RNA Products For DENND4C
- genomics-online: shRNA clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for DENND4C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DENND4C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DENND4C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 18c | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for DENND4C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (17.0) and CD8 Tcells (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENND4C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DENND4C Gene:
DENND4CSOURCE GeneReport for Unigene cluster for DENND4C Gene:
Hs.249591Evidence on tissue expression from TISSUES for DENND4C Gene
- Liver(4.2)
- Lymph node(4.2)
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for DENND4C
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND4C Gene
Orthologs for DENND4C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DENND4C 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | DENND4C 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | DENND4C 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Dennd4c 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1308489 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DENND4C 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | DENND4C 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DENND4C 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dennd4c 33 |
|
||
| Str.16012 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | dennd4c 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Crag 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | denn-4 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1014 34 |
|
OneToMany |
- Species where no ortholog for DENND4C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for DENND4C Gene
Paralogs for DENND4C Gene
(2) SIMAP similar genes for DENND4C Gene using alignment to 4 proteins:
Variants for DENND4C Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004981 | -- | 19,362,801(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000006132 | -- | 19,313,697(+) | A/G | intron_variant | |
| rs1000049000 | -- | 19,235,861(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000065884 | -- | 19,285,548(+) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000071821 | -- | 19,273,975(+) | C/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1074852 | CNV | deletion | 25765185 |
| nsv466286 | CNV | gain | 19166990 |
| nsv613729 | CNV | gain | 21841781 |
| nsv613730 | CNV | gain | 21841781 |
| nsv824872 | CNV | loss | 20364138 |
| nsv1030736 | CNV | gain | 25217958 |
| nsv1029922 | CNV | gain | 25217958 |
| nsv1024948 | CNV | loss | 25217958 |
| esv3619909 | CNV | loss | 21293372 |
| esv3619908 | CNV | loss | 21293372 |
| esv3619907 | CNV | gain | 21293372 |
| esv3619906 | CNV | loss | 21293372 |
| esv3619905 | CNV | gain | 21293372 |
| esv3619904 | CNV | loss | 21293372 |
| esv3619903 | CNV | loss | 21293372 |
| esv3619902 | CNV | loss | 21293372 |
| esv3619901 | CNV | gain | 21293372 |
| esv3619900 | CNV | loss | 21293372 |
| esv3573165 | CNV | loss | 25503493 |
| esv3544634 | CNV | deletion | 23714750 |
| esv3544632 | CNV | deletion | 23714750 |
| esv28580 | CNV | loss | 19812545 |
| esv2738259 | CNV | deletion | 23290073 |
| esv2677622 | CNV | deletion | 23128226 |
| esv2668263 | CNV | deletion | 23128226 |
| esv2665168 | CNV | deletion | 23128226 |
| esv24621 | CNV | loss | 19812545 |
| esv2302206 | CNV | deletion | 18987734 |
| esv1745994 | CNV | deletion | 17803354 |
| esv1060561 | CNV | insertion | 17803354 |
Residual Variation Intolerance Score:
11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.86;
83.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DENND4C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DENND4C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND4C Gene
Disorders for DENND4C Gene
Additional Disease Information for DENND4C
No disorders were found for DENND4C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND4C Gene
Publications for DENND4C Gene
- Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C. (PMID: 21454697) Sano H … Lienhard GE (The Journal of biological chemistry 2011) 2 3 58
- Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
Products for DENND4C Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for DENND4C
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DENND4C
- Origene Custom Protein Services for DENND4C
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DENND4C
- Browse OriGene Inhibitory RNA Products For DENND4C
- OriGene qPCR primer pairs for DENND4C
- OriGene CRISPR knockouts for DENND4C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DENND4C
- GenScript: Next-day shipping of latest version cDNA ORF clones for DENND4C in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DENND4C
- GenScript Custom Assay Services for DENND4C
- GenScript Custom overexpressing Cell Line Services for DENND4C
- GenScript: Design CRISPR guide RNA sequences for DENND4C
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DENND4C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for DENND4C
- Novus Biologicals proteins for DENND4C
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for DENND4C
- Cyagen custom Knockout/knockin (KOKI) mouse models for DENND4C
- VectorBuilder custom plasmid, inducible vectors for DENND4C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DENND4C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- GeneTex DENND4C antibody for DENND4C
- Search GeneTex for Proteins for DENND4C
- ViGene Biosciences adenoviral particle packaged cDNA for DENND4C gene
- ViGene Biosciences lentiviral particle packaged cDNA for DENND4C gene
- ViGene Biosciences ready-to-package AAV shRNAs for DENND4C gene
- Search ViGene Biosciences for DENND4C
- Horizon Cell Lines for DENND4C
- genomics-online: cdna clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
- orf clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
- genomics-online: gRNA clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
- genomics-online: primer clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
- genomics-online: shRNA clones - Search results for 51 available DENND4C gene related products
- Overview of 51 available DENND4C gene related products
Sources for DENND4C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew