Aliases for DENND2D Gene
Aliases for DENND2D Gene
External Ids for DENND2D Gene
- HGNC: 26192
- Entrez Gene: 79961
- Ensembl: ENSG00000162777
- OMIM: 615111
- UniProtKB: Q9H6A0
Previous GeneCards Identifiers for DENND2D Gene
- GC01M111442
- GC01M111531
- GC01M111729
- GC01M109601
Summaries for DENND2D Gene
GeneCards Summary for DENND2D Gene
DENND2D (DENN Domain Containing 2D) is a Protein Coding gene. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is ST5.
UniProtKB/Swiss-Prot for DENND2D Gene
-
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Additional gene information for DENND2D Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND2D Gene
Genomics for DENND2D Gene
GeneHancer (GH) Regulatory Elements for DENND2D Gene
Promoters and enhancers for DENND2D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DENND2D on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DENND2D gene promoter:
-
- oct-B2
- POU2F2C
- Oct-B1
- oct-B3
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- POU2F2B
- AREB6
Regulatory Element Products
Genomic Locations for DENND2D Gene
Genomic Locations for DENND2D Gene
- chr1:111,185,969-111,204,791
- (GRCh38/hg38)
- Size:
- 18,823 bases
- Orientation:
- Minus strand
- chr1:111,729,796-111,747,157
- (GRCh37/hg19)
- Size:
- 17,362 bases
- Orientation:
- Minus strand
Genomic View for DENND2D Gene
Genes around DENND2D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3-p13.2 by Entrez Gene
- 1p13.3-p13.2 by HGNC
- 1p13.2 by Ensembl
DENND2D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DENND2D Gene
Proteins for DENND2D Gene
-
Protein details for DENND2D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H6A0-DEN2D_HUMAN
- Recommended name:
- DENN domain-containing protein 2D
- Protein Accession:
- Q9H6A0
- Q5T5V6
- Q9BSU0
Protein attributes for DENND2D Gene
- Size:
- 471 amino acids
- Molecular mass:
- 53672 Da
- Quaternary structure:
- No Data Available
Protein Expression for DENND2D Gene
Post-translational modifications for DENND2D Gene
Other Protein References for DENND2D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for DENND2D
- Invitrogen Antibodies for DENND2D (AFLGC-DENND2D)
- GeneTex DENND2D Antibody for DENND2D
-
Santa Cruz Biotechnology (SCBT) Antibodies for DENND2D
Protein Products
-
OriGene Purified Proteins for DENND2D
- Search Origene for MassSpec and Protein Over-expression Lysates for DENND2D
- Origene Custom Protein Services for DENND2D
- Novus Biologicals proteins for DENND2D
- Search GeneTex for Proteins for DENND2D
Assay Products
No data available for DME Specific Peptides for DENND2D Gene
Domains & Families for DENND2D Gene
Gene Families for DENND2D Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DENND2D Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DENND2D Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for DENND2D Gene
Function for DENND2D Gene
Molecular function for DENND2D Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Phenotypes From GWAS Catalog for DENND2D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | IDA | 20937701 |
Phenotypes for DENND2D Gene
- MGI mutant phenotypes for DENND2D:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DENND2D:
Animal Models for DENND2D Gene
- MGI Knock Outs for DENND2D:
-
- Dennd2d Dennd2d<tm2b(KOMP)Mbp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DENND2D
-
CRISPR Products
-
OriGene CRISPR knockouts for DENND2D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DENND2D
- genomics-online: gRNA clones - Search results for 106 available DENND2D gene related products
- Overview of 106 available DENND2D gene related products
- Applied Biological Materials CRISPR for DENND2D
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND2D
- GenScript: Design CRISPR guide RNA sequences for DENND2D
miRNA for DENND2D Gene
- miRTarBase miRNAs that target DENND2D
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DENND2D
- Browse OriGene Inhibitory RNA Products For DENND2D
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- genomics-online: shRNA clones - Search results for 106 available DENND2D gene related products
- Overview of 106 available DENND2D gene related products
Clone Products
- Sino Biological Human cDNA Clone for DENND2D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DENND2D
- Applied Biological Materials Clones for DENND2D
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DENND2D
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DENND2D Gene
Localization for DENND2D Gene
Subcellular locations from UniProtKB/Swiss-Prot for DENND2D Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for DENND2D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | RAB GEFs exchange GTP for GDP on RABs | ||
Pathways by source for DENND2D Gene
3 Reactome pathways for DENND2D Gene
Interacting Proteins for DENND2D Gene
Selected Interacting proteins:
ENSP00000350266
Q9H6A0-DEN2D_HUMAN
for DENND2D Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for DENND2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0065009 | regulation of molecular function | IEA | -- |
No data available for SIGNOR curated interactions for DENND2D Gene
Transcripts for DENND2D Gene
mRNA/cDNA for DENND2D Gene
- (16) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (218) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000468692 950 bps (uc057jhi.1)
- ENST00000357640 2077 bps (uc001eak.3)
- ENST00000369752 1894 bps (uc001eal.3)
- ENST00000473682 3207 bps (uc057jhj.1)
- ENST00000463713 737 bps (uc057jhk.1)
Unigene Clusters for DENND2D Gene
CRISPR Products
-
OriGene CRISPR knockouts for DENND2D
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DENND2D
- genomics-online: gRNA clones - Search results for 106 available DENND2D gene related products
- Overview of 106 available DENND2D gene related products
- Applied Biological Materials CRISPR for DENND2D
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DENND2D
- GenScript: Design CRISPR guide RNA sequences for DENND2D
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DENND2D
- Browse OriGene Inhibitory RNA Products For DENND2D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND2D
- genomics-online: shRNA clones - Search results for 106 available DENND2D gene related products
- Overview of 106 available DENND2D gene related products
Clone Products
- Sino Biological Human cDNA Clone for DENND2D
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DENND2D
- Applied Biological Materials Clones for DENND2D
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | · | 10f | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - |
| ExUns: | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | |||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: | |||||||||||||||||
| SP14: |
Expression for DENND2D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Adipose (Muscoskeletal System)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for DENND2D Gene
This gene is overexpressed in Whole Blood (x8.7) and Spleen (x4.7).
This gene is overexpressed in CD8 Tcells (17.0), Peripheral blood mononuclear cells (15.6), and NK cells (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DENND2D Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DENND2D Gene:
DENND2DSOURCE GeneReport for Unigene cluster for DENND2D Gene:
Hs.557850mRNA Expression by UniProt/SwissProt for DENND2D Gene:
Q9H6A0-DEN2D_HUMAN
Tissue specificity:
In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.
Evidence on tissue expression from TISSUES for DENND2D Gene
- Liver(4.1)
- Intestine(2.1)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for DENND2D
-
OriGene qPCR primer pairs and template standards for DENND2D
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND2D Gene
Orthologs for DENND2D Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DENND2D 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DENND2D 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DENND2D 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dennd2d 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dennd2d 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DENND2D 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DENND2D 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DENND2D 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DENND2D 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dennd2d 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dennd2da 34 33 |
|
OneToMany | |
| dennd2db 34 |
|
OneToMany |
- Species where no ortholog for DENND2D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for DENND2D Gene
- ENSEMBL:
- Gene Tree for DENND2D (if available)
- TreeFam:
- Gene Tree for DENND2D (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DENND2D: view image
Paralogs for DENND2D Gene
Paralogs for DENND2D Gene
(4) SIMAP similar genes for DENND2D Gene using alignment to 1 proteins:
- DEN2D_HUMAN
Variants for DENND2D Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000014248 | -- | 111,201,067(-) | A/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000052281 | -- | 111,205,291(-) | T/C | upstream_transcript_variant | |
| rs1000107183 | -- | 111,192,518(-) | T/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000172709 | -- | 111,205,065(-) | T/C | upstream_transcript_variant | |
| rs1000310503 | -- | 111,192,859(-) | A/G | genic_downstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.85;
34.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DENND2D Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DENND2D
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND2D Gene
Disorders for DENND2D Gene
Additional Disease Information for DENND2D
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for DENND2D Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND2D Gene
Publications for DENND2D Gene
- Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D. (PMID: 23182661) Ling B … Zhang K (Lung cancer (Amsterdam, Netherlands) 2013) 3 4 58
- Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for DENND2D Gene
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- OriGene Purified Proteins for DENND2D
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Tissue Microarrays
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- genomics-online: gRNA clones - Search results for 106 available DENND2D gene related products
- Overview of 106 available DENND2D gene related products
- genomics-online: primer clones - Search results for 106 available DENND2D gene related products
- Overview of 106 available DENND2D gene related products
- genomics-online: shRNA clones - Search results for 106 available DENND2D gene related products
- Overview of 106 available DENND2D gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DENND2D
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- GeneCopoeia miRNA 3'UTR Target clone products for DENND2D
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DENND2D
Sources for DENND2D Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
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