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Aliases for DENND1C Gene

Aliases for DENND1C Gene

  • DENN Domain Containing 1C 2 3 5
  • Connecdenn 3 2 3 4
  • Family With Sequence Similarity 31, Member C 2 3
  • DENN/MADD Domain Containing 1C 2 3
  • FAM31C 3 4
  • DENN Domain-Containing Protein 1C 3
  • Protein FAM31C 4

External Ids for DENND1C Gene

Previous HGNC Symbols for DENND1C Gene

  • FAM31C

Previous GeneCards Identifiers for DENND1C Gene

  • GC19M006419
  • GC19M006230

Summaries for DENND1C Gene

Entrez Gene Summary for DENND1C Gene

  • The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the clathrin machinery. [provided by RefSeq, May 2017]

GeneCards Summary for DENND1C Gene

DENND1C (DENN Domain Containing 1C) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND1B.

UniProtKB/Swiss-Prot for DENND1C Gene

  • Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Additional gene information for DENND1C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DENND1C Gene

Genomics for DENND1C Gene

GeneHancer (GH) Regulatory Elements for DENND1C Gene

Promoters and enhancers for DENND1C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I006480 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.7 676 2.2 HDGF HDAC1 ATF1 RB1 ARID4B YBX1 ZNF48 RAD21 ZNF335 ZNF143 DENND1C SLC25A23 SLC25A41 MLLT1 ENSG00000275234
GH19I006481 Promoter 0.6 EPDnew 550.8 +2.0 2013 0.1 DACH1 DENND1C ENSG00000275234
GH19I005902 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.4 +578.4 578395 3.6 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC VMAC ENSG00000267740 NDUFA11 ENSG00000267314 CAPS DUS3L PTPRS KHSRP SNRPEP4 ENSG00000267571
GH19I006587 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.1 -105.2 -105210 1.5 HDGF PKNOX1 SMAD1 ARNT SIN3A YBX1 ZNF48 ZNF143 ZNF207 ATF7 DUS3L ZNF557 VMAC DENND1C ARHGEF18 SAFB TRIP10 GPR108 CD70 TNFSF9
GH19I006674 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15 -192.6 -192550 1.1 HDGF PKNOX1 SMAD1 YBX1 IRF4 ARID2 ZNF207 ZNF143 ZNF548 FOS TNFSF14 DENND1C C3 TRIP10 GPR108 XAB2 ZNF557 DUS3L KHSRP STXBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DENND1C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DENND1C gene promoter:

Genomic Locations for DENND1C Gene

Genomic Locations for DENND1C Gene
15,354 bases
Minus strand

Genomic View for DENND1C Gene

Genes around DENND1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DENND1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DENND1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DENND1C Gene

Proteins for DENND1C Gene

  • Protein details for DENND1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DENN domain-containing protein 1C
    Protein Accession:
    Secondary Accessions:
    • B4E051
    • D3PFD4
    • Q8NDB1
    • Q9H5Z2

    Protein attributes for DENND1C Gene

    801 amino acids
    Molecular mass:
    87065 Da
    Quaternary structure:
    • Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1.
    • Sequence=BAB15475.1; Type=Frameshift; Positions=788; Evidence={ECO:0000305};

    Alternative splice isoforms for DENND1C Gene


neXtProt entry for DENND1C Gene

Post-translational modifications for DENND1C Gene

  • Ubiquitination at Lys385, Lys460, and Lys469

No data available for DME Specific Peptides for DENND1C Gene

Domains & Families for DENND1C Gene

Gene Families for DENND1C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DENND1C Gene

Suggested Antigen Peptide Sequences for DENND1C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DENND1C: view

No data available for UniProtKB/Swiss-Prot for DENND1C Gene

Function for DENND1C Gene

Molecular function for DENND1C Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Phenotypes From GWAS Catalog for DENND1C Gene

Gene Ontology (GO) - Molecular Function for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with DENND1C: view

Phenotypes for DENND1C Gene

genes like me logo Genes that share phenotypes with DENND1C: view

Animal Models for DENND1C Gene

MGI Knock Outs for DENND1C:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DENND1C Gene

Localization for DENND1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DENND1C Gene

Cytoplasm, cytosol. Cytoplasmic vesicle, clathrin-coated vesicle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DENND1C gene
Compartment Confidence
cytosol 5
plasma membrane 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0030136 clathrin-coated vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with DENND1C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DENND1C Gene

Pathways & Interactions for DENND1C Gene

genes like me logo Genes that share pathways with DENND1C: view

Pathways by source for DENND1C Gene

Interacting Proteins for DENND1C Gene

Gene Ontology (GO) - Biological Process for DENND1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with DENND1C: view

No data available for SIGNOR curated interactions for DENND1C Gene

Drugs & Compounds for DENND1C Gene

No Compound Related Data Available

Transcripts for DENND1C Gene

Unigene Clusters for DENND1C Gene

DENN/MADD domain containing 1C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DENND1C Gene

No ASD Table

Relevant External Links for DENND1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DENND1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DENND1C Gene

mRNA differential expression in normal tissues according to GTEx for DENND1C Gene

This gene is overexpressed in Whole Blood (x19.3) and Spleen (x7.1).

Protein differential expression in normal tissues from HIPED for DENND1C Gene

This gene is overexpressed in Lymph node (16.0), NK cells (13.8), CD8 Tcells (10.7), Blymphocyte (10.2), and Peripheral blood mononuclear cells (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DENND1C Gene

Protein tissue co-expression partners for DENND1C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DENND1C Gene:


SOURCE GeneReport for Unigene cluster for DENND1C Gene:


Evidence on tissue expression from TISSUES for DENND1C Gene

  • Lymph node(4.4)
  • Intestine(4.3)
  • Liver(4.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with DENND1C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DENND1C Gene

Orthologs for DENND1C Gene

This gene was present in the common ancestor of animals.

Orthologs for DENND1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DENND1C 33 34
  • 95.53 (n)
(Canis familiaris)
Mammalia DENND1C 33 34
  • 84.47 (n)
(Bos Taurus)
Mammalia DENND1C 33 34
  • 82.47 (n)
(Mus musculus)
Mammalia Dennd1c 33 16 34
  • 75.69 (n)
(Rattus norvegicus)
Mammalia Dennd1c 33
  • 73.11 (n)
(Monodelphis domestica)
Mammalia DENND1C 34
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 10 (a)
(Anolis carolinensis)
Reptilia DENND1C 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dennd1c 33
  • 59.38 (n)
(Danio rerio)
Actinopterygii si:dkey-76b14.2 33
  • 55.9 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18659 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea rme-4 34
  • 27 (a)
Species where no ortholog for DENND1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DENND1C Gene

Gene Tree for DENND1C (if available)
Gene Tree for DENND1C (if available)

Paralogs for DENND1C Gene

(2) SIMAP similar genes for DENND1C Gene using alignment to 7 proteins: Pseudogenes for DENND1C Gene

genes like me logo Genes that share paralogs with DENND1C: view

Variants for DENND1C Gene

Sequence variations from dbSNP and Humsavar for DENND1C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs751257354 uncertain-significance, not specified 6,477,249(-) A/G coding_sequence_variant, missense_variant
rs1000017818 -- 6,470,674(-) T/C intron_variant
rs1000244407 -- 6,473,064(-) T/C intron_variant
rs1000418310 -- 6,468,643(-) G/A coding_sequence_variant, synonymous_variant
rs1000468877 -- 6,478,460(-) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DENND1C Gene

Variant ID Type Subtype PubMed ID
nsv833727 CNV loss 17160897
nsv1149440 CNV deletion 26484159
esv2161777 CNV deletion 18987734

Variation tolerance for DENND1C Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DENND1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DENND1C Gene

Disorders for DENND1C Gene

Additional Disease Information for DENND1C

No disorders were found for DENND1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DENND1C Gene

Publications for DENND1C Gene

  1. The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. (PMID: 20154091) Marat AL … McPherson PS (The Journal of biological chemistry 2010) 3 4 58
  2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for DENND1C Gene

Sources for DENND1C Gene

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