Aliases for DENND1C Gene
External Ids for DENND1C Gene
Previous HGNC Symbols for DENND1C Gene
Previous GeneCards Identifiers for DENND1C Gene
The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the clathrin machinery. [provided by RefSeq, May 2017]
GeneCards Summary for DENND1C Gene
DENND1C (DENN Domain Containing 1C) is a Protein Coding gene. Diseases associated with DENND1C include Psoriasis 7. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is DENND1A.
UniProtKB/Swiss-Prot Summary for DENND1C Gene
Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.